Clinical Trials on Primary Systemic Amyloidosis

Total 228324 results

Taipei Veterans General Hospital, Taiwan
Apollo Medical Optics, Ltd

Completed

Application of High Resolution Optical Coherence Tomography in Skin Disease: Amyloidosis and Differential Diagnosis

Amyloidosis

Taiwan
Queen Mary University of London

Unknown

The Role of Occult Cardiac Amyloid in the Elderly With Aortic Stenosis. (ATTRact-AS)

Aortic Stenosis | Cardiac Amyloidosis

United Kingdom
Eidos Therapeutics, a BridgeBio company

Withdrawn

Efficacy and Safety of Acoramidis (AG10) in Subjects With Transthyretin Amyloid Polyneurophathy (ATTRibute-PN)

Transthyretin-Related (ATTR) Familial Amyloid Polyneuropathy
First Affiliated Hospital Xi'an Jiaotong University

Enrolling by invitation

The Diagnostic Pattern and Prognosis of Multiple Myeloma Patients With Myocardial Amyloidosis Were Evaluated by NMR Based Metabolomics

Multiple Myeloma | Amyloidosis Cardiac

China
Memorial Sloan Kettering Cancer Center
Millennium Pharmaceuticals, Inc.

Completed

Bortezomib/Dexamethasone (BD), Followed By Autologous Stem Cell Transplantation and Maintenance Bortezomib/Dexamethasone For the Initial Treatment of Monoclonal Immunoglobulin Deposition Disease (MIDD) Associated With Multiple Myeloma and AL Amyloidosis

Amyloidosis | Light Chain Deposition Disease (LCDD or MIDD) | Light Chain and Heavy Chain Deposition Disease (LHCDD or MIDD) | Monoclonal Immunoglobulin Deposition Disease (MIDD)

United States
Pfizer

Completed

Vyndaqel Drug Use Investigation (Regulatory Post Marketing Commitment Plan)

Transthyretin Familial Amyloid Poluneuropathy
Ionis Pharmaceuticals, Inc.

Completed

Extension Study Assessing Long Term Safety and Efficacy of IONIS-TTR Rx in Familial Amyloid Polyneuropathy (FAP)

Amyloidosis | Familial Amyloid Polyneuropathy | FAP | TTR | Transthyretin

United States, Spain, Argentina, Brazil, France, Germany, Italy, Portugal, United Kingdom
Ionis Pharmaceuticals, Inc.

Completed

Efficacy and Safety of Inotersen in Familial Amyloid Polyneuropathy

Amyloidosis | Familial Amyloid Polyneuropathy | FAP | TTR | Transthyretin

New Zealand, United States, Spain, Argentina, Brazil, France, Germany, Italy, Portugal, United Kingdom
Pfizer

Completed

An Extension of Study Fx-005 Evaluating Long-Term Safety And Clinical Outcomes Of Fx-1006A In Patients With Transthyretin Amyloid Polyneuropathy

Familial Amyloid Polyneuropathy | ATTR-PN

Sweden, Brazil, Germany, Argentina, France, Portugal
Javier López Pais

Unknown

Impact of Amyloidosis on TAVI Patients (AMY-TAVI)

Amyloidosis Cardiac | Valve Stenoses, Aortic

Spain
Washington University School of Medicine
Karyopharm Therapeutics Inc

Recruiting

Selinexor and Lenalidomide for Consolidation and Maintenance Treatment in Multiple Myeloma Post-transplant

Multiple Myeloma | Myeloma-Associated Amyloidosis

United States
Mayo Clinic
National Cancer Institute (NCI)

Active, not recruiting

Ixazomib With Cyclophosphamide and Dexamethasone in Patients With Previously Untreated Symptomatic Multiple Myeloma or Light Chain Amyloidosis

Amyloidosis | Plasma Cell Myeloma

United States
University of Texas Southwestern Medical Center
Mid America Heart Institute

Withdrawn

Targeted Testing for ATTR Among Aortic Stenosis Patients-Pilot

Aortic Valve Stenosis | Cardiac Amyloidosis
Aarhus University Hospital Skejby
Regional Hospital Holstebro

Completed

Prevalence of Wild Type Transthyretin Cardiac Amyloidosis in Patients Operated for Idiopathic Carpal Tunnel Syndrome (CACTuS)

Carpal Tunnel Syndrome | Amyloidosis Cardiac

Denmark
Alnylam Pharmaceuticals

Completed

The Study of an Investigational Drug, Patisiran (ALN-TTR02), for the Treatment of Transthyretin (TTR)-Mediated Amyloidosis in Participants Who Have Already Been Treated With ALN-TTR02 (Patisiran)

Amyloidosis

United States, Canada, Argentina, Australia, Bulgaria, Cyprus, Italy, Japan, Malaysia, Netherlands, Portugal, Spain, Sweden, Taiwan, United Kingdom, Germany, France, Korea, Republic of, Brazil, Mexico, Turkey
University Hospital, Toulouse

Terminated

Transthyretin Cardiac Amyloidosis in Patients With Idiopathic Carpal Tunnel Syndrome Referred for Release Surgery (PRATHYC)

Carpal Tunnel Syndrome | Transthyretin Amyloidosis

France
Pfizer

Completed

The Effect Of Tafamidis For The Transthyretin Amyloid Polyneuropathy Patients With V30M Or Non-V30M Transthyretin

Transthyretin Familial Amyloid Polyneuropathy

Japan
University of Edinburgh

Completed

Positron Emission Tomography / Magnetic Resonance Imaging in Aortic Stenosis (PASS)

Aortic Stenosis | Transthyretin Amyloidosis

United Kingdom
Bellus Health Inc
FDA Office of Orphan Products Development

Completed

Study of the Safety and Efficacy of NC-503 in Secondary (AA) Amyloidosis

Gastrointestinal Diseases | Kidney Diseases | Rheumatoid Arthritis | Nephrotic Syndrome | Secondary (AA) Amyloidosis | Familial Mediterranean Syndrome

United States, Israel, Finland, France, Italy, Lithuania, Netherlands, Poland, Russian Federation, Spain, Turkey, United Kingdom
Eidos Therapeutics, a BridgeBio company

Withdrawn

Efficacy and Safety of AG10 in Subjects With Transthyretin Amyloid Polyneurophathy (ATTRibute-PN)

Transthyretin-Related (ATTR) Familial Amyloid Polyneuropathy

United States
SOM Innovation Biotech SA
Hospital Vall d'Hebron

Completed

Study of SOM0226 in Familial Amyloid Polyneuropathy

Familial Amyloid Polyneuropathy (FAP)

Spain
Brigham and Women's Hospital
GlaxoSmithKline; Ionis Pharmaceuticals, Inc.

Withdrawn

The Effect of an Antisense Oligonucleotide to Lower Transthyretin (TTR) Levels on the Progression of -Wild-type TTR Involving the Heart

Amyloidosis
Medical University of Vienna
Medical University of South Carolina; IRCCS Azienda Ospedaliero-Universitaria... and other collaborators

Recruiting

Aortic Stenosis and Cardiac Amyloidosis

Aortic Stenosis | Cardiac Amyloidosis

Austria, United Kingdom
Peking University People's Hospital

Recruiting

Daratumumab, Bortezomib, Cyclophosphamide, and Dexamethasone Therapy for Patients With MIDD

Monoclonal Gammopathy of Renal Significance

China
Boston University

Completed

Safety and Effect of Doxycycline in Patients With Amyloidosis

Amyloidosis

United States
University of Pennsylvania

Recruiting

Molecular Imaging of the Underlying Mechanism of Cardiotoxicity in Patients With Light Chain Amyloidosis Using PET/CT

Cardiac Amyloidosis

United States
French Cardiology Society
Pfizer; Henri Mondor University Hospital

Active, not recruiting

Prevalence and Post-surgical Outcomes of CARdiac Wild-type TransthyrEtin amyloidoSIs in Elderly Patients With Aortic steNosis Referred for Valvular Replacement. (AMYLOCARTESIAN)

Aortic Valve Stenosis | Amyloidosis | Aging | Heart Disease

France
Barbara Ann Karmanos Cancer Institute

Completed

COVID-19 VAX Booster Dosing in Patients With Hematologic Malignancies

Multiple Myeloma | AL Amyloidosis | Chronic Lymphocytic Leukemia

United States
University Hospital Inselspital, Berne

Active, not recruiting

ATTR Amyloidosis in Elderly Patients With Aortic Stenosis

Aortic Stenosis Symptomatic | Amyloidosis Cardiac

Switzerland
Steen Hvitfeldt Poulsen

Completed

The Effect of Trimetazidine on Mitochondrial Function, Myocardial Performance, and Invasive Hemodynamics in Patients Diagnosed With Wild-Type Transthyretin Cardiac Amyloidosis (CACTuS - TMZ)

Transthyretin Amyloid Cardiopathy | Mitochondrial Pathology

Denmark
Insel Gruppe AG, University Hospital Bern
Luzerner Kantonsspital; Cantonal Hospital of St. Gallen; Triemli Hospital

Recruiting

Swiss Cardiac Amyloidosis REgistry (Swiss-CARE) (B-CARE)

Amyloid Cardiomyopathy

Switzerland
Philippe Meyer

Recruiting

Effect of Radiotherapy on ATTR Cardiac Amyloidosis : a Proof of Concept Study

Amyloid Cardiomyopathy

Switzerland
Massachusetts General Hospital

Completed

Characteristics of Patients With Amyloidosis & Heart Failure Being Evaluated for a Heart Transplant

Cardiomyopathy
University Hospital of Ferrara

Recruiting

Analysis of Calcium Score of Severe Aortic Stenosis in Patients With and Without Cardiac Amyloidosis (CAUSATIVE Study) (CAUSATIVE)

Aortic Stenosis, Severe | Amyloidosis Cardiac

Italy
University Hospital, Toulouse
MSDAVENIR

Active, not recruiting

Cognitive Function and Prevalence of Amyloid Marker in Frail Older Adults (COGFRAIL)

Frail Elderly

France
Fundación Pública Andaluza para la gestión de la...

Recruiting

Registry of Patients With Suspected Amyloidosis in Heart Failure (Regamic)

Heart Failure

Spain
Fundación Pública Andaluza para la gestión de la...

Unknown

Prevalence of Amyloidosis in Heart Failure (PREVAMIC) (PREVAMIC)

Heart Failure

Spain
Assistance Publique - Hôpitaux de Paris

Completed

Early Diagnosis of TTR Amyloidosis by Use of Molecular Biology (ADDITION)

Diagnosis | Polyneuropathy | Idiopathic Progressive Neuropathy

France
City of Hope Medical Center
National Cancer Institute (NCI)

Active, not recruiting

Daratumumab After Stem Cell Transplant in Treating Patients With Multiple Myeloma

Plasma Cell Myeloma | Secondary Amyloidosis

United States
Jordan Collaborating Cardiology Group

Not yet recruiting

Prevalence of ATTR Cardiac Amyloidosis in Patients Undergoing TAVR

Aortic Valve Stenosis | Severe Aortic Stenosis | ATTR Amyloidosis Wild Type | Middle East Studies
National Center for Research Resources (NCRR)
Indiana University School of Medicine

Unknown

Study of Systemic Amyloidosis Presentation and Prognosis

Amyloidosis

United States
Fondazione I.R.C.C.S. Istituto Neurologico Carlo...

Recruiting

SEarchiNg biomarkErs Cerebral Amyloid Angiopathy (SENECA) (SENECA)

Cerebral Amyloid Angiopathy

Italy
Pfizer

Completed

Study Evaluating the Safety,Tolerability and Efficacy of PF-04360365 in Adults With Probable Cerebral Amyloid Angiopathy

Cerebral Amyloid Angiopathy

Canada, United States, Netherlands, France, United Kingdom
Mathew S. Maurer
National Heart, Lung, and Blood Institute (NHLBI); Yale University; Boston Medical... and other collaborators

Recruiting

Screening for Cardiac Amyloidosis With Nuclear Imaging for Minority Populations (SCAN-MP)

Amyloid Cardiomyopathy, Transthyretin-Related

United States
Pfizer

Active, not recruiting

A Study to Learn About the Study Medicine Called Tafamidis 61mg in People Diagnosed With Transthyretin Amyloid Cardiomyopathy (ATTR-CM)

Transthyretin Amyloid Cardiomyopathy

Korea, Republic of
Pfizer

Completed

A Study to Assess the Safety and Efficacy Of Tafamidis In Chinese Participants With Transthyretin Amyloid Cardiomyopathy (ATTR-CM)

Transthyretin Amyloid Cardiomyopathy

China
University of Leipzig

Active, not recruiting

Native T1 CMR Imaging for Diagnosis of Cardiac Amyloidosis (CMR for CA)

Heart Failure NYHA Class II | Heart Failure NYHA Class III | Heart Failure With Preserved Ejection Fraction | Hypertrophy, Left Ventricular | Heart Failure NYHA Class IV | Cardiac Amyloidosis | Heart Failure With Mid Range Ejection Fraction

Germany
Centre Hospitalier Régional d'Orléans

Recruiting

Amyloidosis TTR Flow Reserve Evaluation (AMYTRE)

Amyloid Cardiomyopathy

France
Institut Mutualiste Montsouris

Recruiting

Orthopaedic Specimen Pathology and Early Diagnosis of ATTR Cardiopathy (ATTR-ORTHO) (ATTR-ORTHO)

Carpal Tunnel Syndrome | Knee Prosthesis | ATTR Amyloidosis | Cardiopathy | Hip Prosthesis | Lumbar Spine Stenosis

France
Janssen Research & Development, LLC

Recruiting

A Study of JNJ-79635322 in Participants With Relapsed or Refractory Multiple Myeloma or Previously Treated Amyloid Light-chain (AL) Amyloidosis

Relapsed or Refractory Multiple Myeloma | Previously Treated Amyloid Light-chain (AL) Amyloidosis

Belgium, United States, United Kingdom, Spain, France, Netherlands

Clinical Trials on Primary Systemic Amyloidosis

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