Search clinical trials for: HZN-457

Total 6659 results

Morphic Therapeutic, Inc

Active, not recruiting

A Phase 2a Open-Label Study to Evaluate the Efficacy and Safety of MORF-057 in Adults With UC

Inflammatory Bowel Diseases | Colitis, Ulcerative

United States, Poland
Fochon Pharmaceuticals, Ltd.

Completed

Study of FCN-437c in Patients With Advanced Solid Tumors (FCN-437c)

Solid Tumor, Adult

United States
Hutchison Medipharma Limited

Unknown

A Study of HMPL-453 in Patients With Advanced Solid Malignancies

Solid Tumor, Adult

China
Hutchison Medipharma Limited

Terminated

A Dose Escalation Study to Assess the Safety and Tolerability of HMPL-453 in Patients With Advanced Solid Malignancies

Solid Tumor

Australia
Amgen

Completed

A Study of AMG 557 in Adults With Systemic Lupus Erythematosus

Systemic Lupus Erythematosus

United States, Canada
MedImmune LLC

Terminated

Study of MEDI-547 to Evaluate the Safety, Tolerability, and Biologic Activity of IV Administration in Subjects With Relapsed or Refractory Solid Tumors (MEDI-547)

Cancer

United States
Wyeth is now a wholly owned subsidiary of Pfizer

Terminated

A Study of the Safety of PAZ-417 in Healthy Elderly Adults

Healthy

United States
Wyeth is now a wholly owned subsidiary of Pfizer

Completed

Study Evaluating the Safety, Tolerability, and Pharmacokinetics (PK) of HKI-357 Administered Orally to Healthy Subjects

Healthy
Aveta Biomics, Inc.

Recruiting

Safety and Efficacy of APG-157 in Head and Neck Cancer

Head and Neck Cancer | Squamous Cell Carcinoma of the Oropharynx | Squamous Cell Carcinoma of Oral Cavity

United States
Hutchmed

Recruiting

Phase 2 Study of HMPL-453 Tartrate in Advanced Intrahepatic Cholangiocarcinoma

Advanced Intrahepatic Cholangiocarcinoma

China
Aclaris Therapeutics, Inc.

Terminated

Study of ATI-450 in Patients With Cryopyrin-Associated Periodic Syndrome (CAPS)

Cryopyrin-Associated Periodic Syndrome

United States
AbbVie

Terminated

A Study of the Safety and Tolerability of ABBV-467 in Adult Participants With Relapsed/Refractory (R/R) Multiple Myeloma

Cancer | Multiple Myeloma (MM)

United States, Australia, France, Israel, Japan, Spain, Taiwan
Curis, Inc.

Terminated

Phase I Study to Assess the Safety, Tolerability and Pharmacokinetics of CUDC-427 When Given to Patients With Advanced and Refractory Solid Tumors or Lymphoma

Lymphoma

United States
Wyeth is now a wholly owned subsidiary of Pfizer

Completed

Study Evaluating PAZ-417 in Healthy Young/Elderly

Alzheimer Disease

United States
Zahedan University of Medical Sciences

Completed

The Effects of Vacuum-Compression Therapy on the Healing of Diabetic Foot Ulcers (VCT)

Diabetic Foot Ulcer

Iran, Islamic Republic of
Hospital Israelita Albert Einstein
Colgate Palmolive

Completed

Evaluation of SARS-COV-2 Viral Load of Covid-19 Patients After Rinsing With Oral Antimicrobial Mouthwashes

Covid19

Brazil
Assiut University

Not yet recruiting

Minerals Status in Relation to Overweight and Obese Adolescent

Mineral Deficiency

Egypt
GlaxoSmithKline

Active, not recruiting

A Study to Evaluate the Safety and Immunogenicity of GlaxoSmithKline's Herpes Zoster Subunit Vaccine (HZ/su) When Given on a Two-dose Schedule to Adults at Least 50 Years of Age (YOA) Who Had Prior Episode of Shingles

Herpes Zoster

Spain, Panama, Mexico, Russian Federation, Finland, Estonia, Hong Kong, United Kingdom
University of Alabama at Birmingham
Oregon Health and Science University

Completed

Safety and Effectiveness of Live Zoster Vaccine in Anti-Tumor Necrosis Factor (TNF) Users (VERVE Trial)

Arthritis | Rheumatoid Arthritis | Psoriasis | Crohn's Disease | Inflammatory Arthritis | Psoriatic Arthritis | Ankylosing Spondylitis | Enteropathic Arthritis

United States
National Cancer Institute (NCI)

Completed

EZN-2208 (Pegylated SN-38) in Combination With Bevacizumab in Refractory Solid Tumors

Neoplasms

United States
Horizon Pharma Ireland, Ltd., Dublin Ireland

Completed

Study of the Safety, Pharmacokinetics and Efficacy of HPN-100, in Pediatric Subjects With Urea Cycle Disorders (UCDs)

Urea Cycle Disorders

United States
University of Florida

Not yet recruiting

Gaze and Gait Training With rTMS

Mild Cognitive Impairment
Kallyope Inc.

Active, not recruiting

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of K-757 and K-833 in Overweight/Obese Patients With Type 2 Diabetes

Obesity | Type 2 Diabetes Mellitus (T2DM)

United States
Jazz Pharmaceuticals
Children's Oncology Group (COG)

Completed

An Open-Label Study of JZP-458 (RC-P) in Patients With Acute Lymphoblastic Leukemia (ALL)/Lymphoblastic Lymphoma (LBL)

Acute Lymphoblastic Leukemia | Lymphoblastic Leukemia

United States, Canada
Celgene
Impact Biomedicines, Inc., a wholly owned subsidiary of Celgene Corporation

Completed

Effect of Rifampin and Efavirenz on the Pharmacokinetics of Fedratinib in Healthy Adult Subjects

Healthy Volunteers

United States
Guangdong Hengrui Pharmaceutical Co., Ltd

Not yet recruiting

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of SHR-4597 Inhalation in Healthy Subjects and Asthmatic Patients

Healthy Subjects | Asthmatic Patients
Agomab Spain S.L.

Recruiting

Phase I Study to Assess Safety, Tolerability, PK and PD of AGMB-447 in Healthy Participants and Participants With IPF

IPF

United Kingdom
Jiangsu HengRui Medicine Co., Ltd.

Not yet recruiting

Phase 1/2 Clinical Study of HRS-4357 in Patients With Advanced Prostate Cancer

Advanced Prostate Cancer
Morphic Therapeutic, Inc

Recruiting

A Study to Evaluate MORF-057 in Adults With Moderately to Severely Active UC (EMERALD-2)

Inflammatory Bowel Diseases | Colitis, Ulcerative

United States, Germany, Korea, Republic of, Italy, Poland, Australia, Georgia, Austria, Bulgaria, Czechia, Estonia, France, Hungary, India, Israel, Latvia, Lithuania, Romania, Serbia, Slovakia, Taiwan
MedImmune LLC

Terminated

Intranasal Challenge of Healthy Adults With Respiratory Syncytial Virus (RSV)

RSV Infection

United Kingdom
Bial - Portela C S.A.

Completed

Absorption, Distribution, Metabolism and Excretion of [14C]- Labeled BIA 5-453 and Metabolites

Hypertension | Congestive Heart Failure

Switzerland
Amgen

Terminated

Study to Evaluate the Safety, Tolerability, and Action of AMG 357 in Females With Rheumatoid Arthritis

Rheumatoid Arthritis

United States
Amgen

Completed

A Phase I Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK), Pharmacodynamics (PD), Food Effect of AMG 357 in Healthy Subjects

Inflammatory Disease

New Zealand
Aspen Medical Products

Completed

Effectiveness of Inelastic LSO Versus Standard Medical Treatment for Back Pain Associated With Kyphosis (ARISE)

Back Pain | Kyphosis
Wyeth is now a wholly owned subsidiary of Pfizer

Completed

Study Evaluating the Safety, Tolerability and Activity of One Dose of PAZ-417 Given to Healthy Japanese Subjects

Healthy | Alzheimer Disease

Japan
Clinical Research Consultants, Inc.
Alcon Research; WaveLight AG

Completed

Safety and Efficacy Study of Topography-Guided LASIK to Treat Myopia and Hyperopia

Myopia | Hyperopia

United States
Biohaven Pharmaceuticals, Inc.

Enrolling by invitation

Long-term Safety Study of Adjunctive Troriluzole in Subjects With Obsessive Compulsive Disorder

Obsessive Compulsive Disorder

Canada, United States, Spain, United Kingdom, Italy, Netherlands
Magenta Therapeutics, Inc.

Completed

MGTA-456 in Patients With Inherited Metabolic Disorders Undergoing Hematopoietic Stem Cell Transplantation (HSCT)

Inherited Metabolic Disorders (IMD)

United States
AbbVie

Completed

A Study to Assess the Safety, Tolerability and Pharmacokinetics of Multiple Subcutaneous Injections of ABBV-257 in Subjects With Rheumatoid Arthritis

Rheumatoid Arthritis

Germany
Wyeth is now a wholly owned subsidiary of Pfizer

Completed

Study Evaluating the Safety and Pharmacokinetics (PK) of Ascending Single IV Doses of ERB-257 in Healthy Japanese Males

Healthy Subjects

Japan
Wyeth is now a wholly owned subsidiary of Pfizer

Completed

Study Evaluating the Safety of FXR-450 in Healthy Subjects

Healthy

United States
Mitsubishi Tanabe Pharma Corporation

Completed

Safety and Efficacy of MCC-257 in the Treatment of Diabetic Polyneuropathy

Diabetic Polyneuropathy
University of California, San Francisco
FDA Office of Orphan Products Development

Terminated

Efficacy and Safety Study of Nexagon for Persistent Corneal Epithelial Defects (NTX-PED-001)

Persistent Corneal Epithelial Defects
Morphic Therapeutic, Inc

Recruiting

A Phase 2 Study to Evaluate MORF-057 in Adults With Moderately to Severely Active Crohn's Disease (GARNET)

Inflammatory Bowel Diseases | Crohn's Disease

United States, Georgia
Biohaven Pharmaceuticals, Inc.

Available

Expanded Access Protocol of Troriluzole in Patients With Spinocerebellar Ataxia (SCA)

Spinocerebellar Ataxias | SCA
AbbVie

Terminated

Safety, Tolerability and the Effects on Cerebrospinal Fluid Spectrin Breakdown Product-145 Levels of ABT-957 in Subjects With Mild Alzheimer's Disease and Mild Cognitive Impairment

Mild Cognitive Impairment | Alzheimer's Disease

United States
Liminal BioSciences Ltd.
Syneos Health

Terminated

Single Ascending Dose Study of PBI-4547 in Healthy Subjects

Healthy Subjects

Canada
Boston Pharmaceuticals

Completed

Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Single and Repeat Topical Administration of BOS-475 in Healthy Subjects and Patients With Psoriasis

Psoriasis

Australia
Akros Pharma Inc.

Completed

Study to Evaluate Safety,Tolerability,Pharmacodynamics & Pharmacokinetics of JTE-451 in Active Plaque Psoriasis Subjects

Skin Diseases | Psoriasis | Plaque Psoriasis

Canada
Amgen

Completed

A Study to Evaluate the Safety, Pharmacokinetics and Pharmacodynamics of AMG 557 in Subjects With Systemic Lupus Erythematosus

Systemic Lupus Erythematosus

United States, United Kingdom

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