Minerals Status in Relation to Overweight and Obese Adolescent

June 3, 2024 updated by: Dalia Hussien Abdelmoneim Hassan, Assiut University

Effect of Body Composition on Some Blood Minerals Status in Obese and Overweight Adolescent; Cross Sectional Study

Evaluation of the concentration of serum Mn, Se, iron, Cu & Zn levels in obese and overweight adolescents, Correlate the body composition parameters with these minerals' concentration, Study the association between the metabolic risk factors and the disturbance in minerals levels in these patients.

Study Overview

Status

Not yet recruiting

Conditions

Intervention / Treatment

Detailed Description

Obesity in the population tends to be a notable public health threat on the global scale . individuals with higher body mass index (BMI) are considered to have a lower life expectancy . Among the obesity-related indicators, visceral adipose tissue (VAT) is acknowledged an emerging and sensitive predictor for the risk of metabolic syndrome and cardiovascular disease . Therefore, adverse VAT accumulation can influence metabolic health in the population, and its related risk factors should be further investigated.

Micronutrients in obese people are explored because of an excess energy consumption, and therefore, an inadequate intake of trace elements and minerals. This imbalance among energy consumption and the intake is known as hidden hunger. Obesity can lead to nutritional metabolic disorders, in which the general state of trace elements and minerals are altered.

Only a few studies on child and adolescents obesity concerned Trace Elements (TE). TE is involved in the pathogenesis of obesity and obesity related diseases. We tried to assess trace elements status [ Manganese (Mn), selenium (Se) copper (Cu),zinc (Zn)] in obese children and their relationships with VAT and metabolic risk factors of obesity.

Manganese (Mn) is an essential trace element . It plays an important role in fat metabolism.

Selenium (Se) is an essential micronutrient that acts as an antioxidant and possesses multiple metabolic properties.

Copper (Cu) is a trace element that is vital. Cu has been reported to play a role in fat metabolism.

Zinc (Zn) plays an important role. Its deficiency impairs growth, metabolism and immunity.

Iron (Fe) is an essential trace element to sustain all forms of life. Existing research indicates iron deficiency is one of the comorbidities associated with obesity .

Study Type

Observational

Enrollment (Estimated)

84

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Egypt
    • Governorate
      • Assiut, Governorate, Egypt, 71111
        • Assiut University Hospital

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Child
  • Adult

Accepts Healthy Volunteers

N/A

Sampling Method

Non-Probability Sample

Study Population

Normal,overweight and obese adolescents

Description

Inclusion Criteria:

  1. Patients in adolescent age (12-18 years old)
  2. Patients with BMI over 25.

Exclusion Criteria:

  1. Patients younger than 12 years old or older than 18 years old.
  2. Patients with history of chronic use of mineral and /or vitamin supplements .
  3. Patients with syndromal obesity , endocrine disorder and history of any chronic diseases ,
  4. Patients under special diets or chronic use of medication .

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
Obese
Patients with BMI more than 30
Diagnostic test: serum Mn, Se, iron, Cu & Zn levels
Evaluate the concentration of serum Mn, Se, iron, Cu & Zn levels in obese and overweight adolescents.
Overweight
Patients with BMI 25-30
Diagnostic test: serum Mn, Se, iron, Cu & Zn levels
Evaluate the concentration of serum Mn, Se, iron, Cu & Zn levels in obese and overweight adolescents.
Control
Patients with BMI less than 25
Diagnostic test: serum Mn, Se, iron, Cu & Zn levels
Evaluate the concentration of serum Mn, Se, iron, Cu & Zn levels in obese and overweight adolescents.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
concentration of serum Manganese
Time Frame: 1 year
Evaluate the concentration of serum Mn levels in obese and overweight adolescents.
1 year
Concentration of serum selenium
Time Frame: 1 year
Evaluate the concentration of serum Se levels in obese and overweight adolescents.
1 year
Concentration of serum Iron
Time Frame: 1 year
Evaluate the concentration of serum Iron levels in obese and overweight adolescents.
1 year
Concentration of serum copper
Time Frame: 1 year
Evaluate the concentration of serum Cu levels in obese and overweight adolescents.
1 year
Concentration of serum Zinc
Time Frame: 1 year
Evaluate the concentration of serum Zn levels in obese and overweight adolescents.
1 year

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
BMI and its relation to mineral levels
Time Frame: 1 year
Correlate the BMI with these minerals' concentration.
1 year
Visceral fat and it's relation to mineral levels
Time Frame: 1 year
Correlate Visceral fat with these minerals' concentration.
1 year
Basal metabolic rate and it's relation to mineral levels
Time Frame: 1 year
Correlate basal metabolic rate with these minerals' concentration.
1 year
Body fat percentage and it's relation to mineral level
Time Frame: 1 year
Correlate body fat percentage with these minerals' concentration.
1 year

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Assiut University

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

Helpful Links

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Estimated)

June 1, 2024

Primary Completion (Estimated)

May 1, 2025

Study Completion (Estimated)

June 1, 2025

Study Registration Dates

First Submitted

May 16, 2024

First Submitted That Met QC Criteria

June 3, 2024

First Posted (Actual)

June 7, 2024

Study Record Updates

Last Update Posted (Actual)

June 7, 2024

Last Update Submitted That Met QC Criteria

June 3, 2024

Last Verified

June 1, 2024

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • Minerals in Adolescent

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

UNDECIDED

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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