Search clinical trials for: Severe hepatic impairment

Total 18668 results

CTI BioPharma
PPD

Recruiting

Study to Evaluate the Safety, Tolerability, and PK of Pacritinib

Hepatic Impairment

United States
BioVersys AG
CRU Hungary Kft

Recruiting

A Study to Assess the Phamacokinetics of BV100 in Participants With Varying Degrees of Hepatic Impairment

Healthy Participants

Hungary
Centre Hospitalier Régional Metz-Thionville

Recruiting

Long-term Quality of Life and Prognostic Factors in Severe COVID-19 Patients and Their Relatives (QUALICOVID)

COVID-19 | Quality of Life | Cognitive Impairment | Posttraumatic Stress Disorder | Social Behavior

France
Izmir Katip Celebi University

Recruiting

Effectiveness of Transcranial Magnetic Stimulation in Subacute Stroke Patients With Severe Upper Limb Paresis

Stroke Rehabilitation

Turkey
Vir Biotechnology, Inc.

Recruiting

Effect of Hepatic Impairment on the Pharmacokinetics and Safety of VIR-2218 and VIR-3434

Cirrhosis | Hepatic Impairment

United States
Assistance Publique - Hôpitaux de Paris

Not yet recruiting

Validation of a Prognostic Score for Steroid Therapy Response in Acute Severe Autoimmune Hepatitis (PRO-SURFASA)

Liver Failure, Acute | Hepatitis, Autoimmune | Risk Factors | Organ Dysfunction Scores

France
Centre Hospitalier Universitaire de Nīmes
CHU Arnaud de Villeneuve MONTPELLIER

Recruiting

Tolerability and Safety of CARDIOMEMS™ Intracardiac Continuous Cardiac Hemodynamic Monitoring Device in Patients With Cardio Renal Syndrome With Severe Renal Impairment (CARDIOMEMS)

Heart Failure | Renal Insufficiency

France
Rigshospitalet, Denmark

Recruiting

BILACO Trial: Biliary Atresia - a Severe Complex Congenital Liver Disease (BILACO)

Cognitive Impairment | Biliary Atresia

Denmark
Novartis Pharmaceuticals

Recruiting

A Phase 1 Study to Evaluate the Pharmacokinetics of JDQ443 in Participants With Hepatic Impairment Compared to Matched Healthy Control Participants.

Small Cell Lung Carcinoma

United States
Alexion

Recruiting

Study of ALXN2050 in Participants With Hepatic Impairment

Healthy | Impaired Hepatic Function

United States
Children's Memorial Health Institute, Poland
Siemens Healthcare Sp. z o.o.

Recruiting

Pediatric Patient Experience on a Diagnostic Path

Demyelinating Diseases | Urinary Incontinence | Brain Tumor | Headache | Visual Impairment | Growth Deficiency | Psychomotor Retardation, Mild to Severe

Poland
Beijing Ditan Hospital

Recruiting

Fu Zheng Jie Du Hua Yu Principle For Treatment Of Severe HBV Related Hepatocellular Carcinoma (FZJDHYPFTOSHBVHCC)

Hepatocellular Carcinoma

China
Assistance Publique - Hôpitaux de Paris

Recruiting

Deafness and Cognition in Middle-aged Adults (SURDICOG)

Mild Cognitive Impairment in Middle-aged Adults

France
Hellenic Society of Hematology
Sanofi

Not yet recruiting

A Phase 2 Study of Isatuximab in Combination With Bortezomib, Cyclophosphamide and Dexamethasone Followed by Isatuximab and Lenalidomide Maintenance in Newly Diagnosed Patients With Multiple Myeloma and Severe Renal Impairment

Neoplasms | Neoplasms by Histologic Type | Hematologic Diseases | Multiple Myeloma | Neoplasms, Plasma Cell | Paraproteinemias | Blood Protein Disorders | Renal Impairment

Greece
PharmaMar

Recruiting

Clinical Pharmacokinetic Study of Lurbinectedin in Patients With Advanced Solid Tumors and Varying Degrees of Hepatic Impairment

Hepatic Impairment | Advanced Solid Tumor

Spain
Merck Sharp & Dohme LLC

Not yet recruiting

Ulonivirine (MK-8507) in Participants With Mild or Moderate Hepatic Impairment (MK-8507-014)

Hepatic Insufficiency
M.D. Anderson Cancer Center

Recruiting

ctDNA-Directed Post-Hepatectomy Chemotherapy for Patients With Resectable Colorectal Liver Metastases

Liver Metastases

United States
Zydus Therapeutics Inc.

Recruiting

Hepatic Impairment With Cirrhosis Due to Cholestatic Liver Disease

Cirrhosis | Hepatic Impairment | Cholestatic Liver Disease

United States
Pontificia Universidad Catolica de Chile
National Institute of Allergy and Infectious Diseases (NIAID)

Recruiting

Long-term Neurocognitive and Psychiatric Consequences in Severe COVID-19 Survivors. (NPQCOVID)

Covid19 | Neurocognitive Dysfunction

Chile
Astex Pharmaceuticals, Inc.

Recruiting

Study to Evaluate the Pharmacokinetics and Safety of Oral Decitabine and Cedazuridine in Cancer Patients With Hepatic Impairment

Acute Myeloid Leukemia | Myelodysplastic Syndromes

Spain, Poland, Bulgaria, Lithuania, Slovakia, Romania
CymaBay Therapeutics, Inc.

Recruiting

An Open-Label Study Following Oral Dosing of Seladelpar to Subjects With Primary Biliary Cholangitis (PBC) and Hepatic Impairment (HI)

Hepatic Impairment | Compensated Cirrhosis | Primary Biliary Cholangitis

Korea, Republic of, United States, Spain, United Kingdom
Idorsia Pharmaceuticals Ltd.

Recruiting

A Study to Investigate the Effect of Hepatic Impairment on the Pharmacokinetics of a Single Dose of Cenerimod

Healthy | Hepatic Impairment

Portugal, Hungary
The University of Texas Health Science Center,...

Not yet recruiting

BreEStim for Motor Recovery in Chronic Stroke With Severe Impairment (Pilot)

Motor Recovery

United States
University of Cincinnati

Recruiting

Optimizing Training in Severe Post-Stroke Walking Impairment (BLT2b)

Stroke | Gait, Hemiplegic | Chronic Stroke | Walking, Difficulty

United States
Jiangsu HengRui Medicine Co., Ltd.

Recruiting

An Investigational Study of SHR3680 in Participants With Mild to Moderate Liver Impairment and Healthy Participants

Hepatic Impairment | Healthy Participants

China
University Hospital, Tours

Recruiting

Impact of a Phone-based Cognitive and Behavioral Therapy on Food Addiction in Patients With Severe or Morbid Obesity (ADALOB)

Obesity | Food Addiction

France
Gilead Sciences

Recruiting

Study of Sacituzumab Govitecan in Participants With Advanced or Metastatic Solid Tumor and Moderate Liver Impairment

Liver Failure | Advanced or Metastatic Solid Tumor

France, United States
European Foundation for Study of Chronic Liver...

Recruiting

Liver Transplantation in Patients With CirrHosis and Severe Acute-on-Chronic Liver Failure: iNdications and outComEs (CHANCE)

Liver Diseases | Liver Cirrhosis | Acute-On-Chronic Liver Failure | Liver Transplant; Complications

Spain, United States, Germany, Belgium, United Kingdom, Japan, Mexico, Taiwan, Korea, Republic of, Canada, France, Australia, Italy, Argentina, Austria, Brazil, Colombia, Czechia, Hong Kong, India, Netherlands, New Zealand, Poland, Po... and more
HK inno.N Corporation

Recruiting

A Study to Evaluate Pharmacokinetics and Safety of Tegoprazan in Subjects With Hepatic Impairment and Healthy Controls

Healthy | Hepatic Impairment

Korea, Republic of
Zydus Therapeutics Inc.

Recruiting

Hepatic Impairment, Cholestatic Liver Disease, & NASH With Advanced Fibrosis & Normal Hepatic Function

Hepatic Impairment

United States
Zydus Therapeutics Inc.

Recruiting

A Pharmacokinetic Study of Saroglitazar Magnesium in Subjects With Severe Renal Impairment and Normal Renal Function

Renal Impairment

United States
GlaxoSmithKline

Recruiting

A Study of Belantamab Mafodotin in Multiple Myeloma Participants With Normal and Impaired Hepatic Function (DREAMM 13)

Multiple Myeloma

Greece, Korea, Republic of, United States
Eisai Co., Ltd.

Recruiting

Study to Evaluate the Pharmacokinetics (PK) of E7090 (Herein Referred to as Tasurgratinib) and Its Metabolite in Participants With Mild and Moderate Hepatic Impairment Compared to Healthy Participants

Hepatic Impairment

Japan
Karyopharm Therapeutics Inc

Recruiting

Relative Bioavailability/Bioequivalence of Different Formulations of Selinexor, the Impact of Hepatic Impairment on Selinexor Pharmacokinetics, Tolerability and Antitumor Activity of Selinexor Combination Treatment (SPRINT)

Other Solid Tumors | Colorectal Cancer (CRC) | Non-Small Cell Lung Carcinoma (NSCLC)

Israel
Mayo Clinic
Regeneron Pharmaceuticals

Recruiting

Dupilumab for the Treatment of Moderate to Severe Chronic Hepatic Pruritus

Pruritus

United States
Institut Mutualiste Montsouris
Ministry of Health, France; National Cancer Institute, France

Recruiting

Effect of the Laparoscopic Approach in Reducing Postoperative Severe Complications Following Hepatectomy for Colorectal Liver Metastases (METALAP)

Postoperative Complications | Liver Metastasis Colon Cancer

France
Kessler Foundation
National Institute on Disability, Independent Living, and Rehabilitation...

Recruiting

Strategy Based Technique to Enhance Memory (STEM) for Improving New Learning and Memory (NLM) in Moderate to Severe TBI (STEM)

Cognitive Impairment | Traumatic Brain Injury

United States
Amicus Therapeutics

Recruiting

A Study to Evaluate Migalastat in Fabry Subjects With Amenable GLA Variant and Renal Disease

Fabry Disease

Spain, United States, Japan, Australia, France, Portugal
Lykos Therapeutics

Not yet recruiting

MDMA in Subjects With Moderate Hepatic Impairment and Subjects With Normal Hepatic Function

Pharmacokinetics | Hepatic Impairment

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Recruiting

Combination Chemotherapy and Bevacizumab With the NovoTTF-100L(P) System in Treating Participants With Advanced, Recurrent, or Refractory Hepatic Metastatic Cancer

Metastatic Malignant Neoplasm in the Liver | Advanced Malignant Neoplasm | Refractory Malignant Neoplasm | Colorectal Carcinoma Metastatic in the Liver

United States
Semmelweis University Heart and Vascular Center
Semmelweis University

Recruiting

The Role and Dynamics of Liver Dysfunction in Patients Undergoing Cardiac Surgery

Heart Failure | Cardiac Surgery | Hepatic Impairment

Hungary
Principia Biopharma, a Sanofi Company

Completed

A Study to Evaluate the Effect of Mild and Moderate Hepatic Impairment on the Single-Dose Pharmacokinetics of Rilzabrutinib (PRN1008)

Healthy Volunteers | Hepatic Function Abnormal

United States
Novartis Pharmaceuticals

Completed

A Study to Investigate the Pharmacokinetics and Safety of Remibrutinib in Participants With Hepatic Impairment Compared With Matched Healthy Participants

Hepatic Impairment

Hungary
Chipscreen Biosciences, Ltd.

Completed

Pharmacokinetics of Chiglitazar in Subjects With Hepatic Impairment and Normal Hepatic Function

Hepatic Impairment

China
Merck Sharp & Dohme LLC

Completed

A Study to Evaluate Molnupiravir (MK-4482) in Participants With Moderate Hepatic Impairment (MK-4482-016)

Hepatic Impairment

United States
Madrigal Pharmaceuticals, Inc.

Enrolling by invitation

A Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of Multiple Oral Doses (6 Days) of 100 mg Resmetirom in Subjects With Severe Renal Impairment and in Matched Healthy Control Subjects With Normal Renal Function

Renal Impairment

United States
Kyowa Kirin Co., Ltd.
Kyowa Hakko Kirin Pharma, Inc.

Completed

Effect of Mild Hepatic Impairment on the Pharmacokinetics of Istradefylline

Hepatic Impairment

United States
Kyowa Kirin, Inc.

Completed

Single-dose Study to Investigate the Plasma PK of KW-6356 and Its Major Metabolite

Hepatic Impairment

United States
Intercept Pharmaceuticals

Active, not recruiting

Study of OCA in Combination With BZF Evaluating Efficacy, Safety, and Tolerability in Participants With PBC

Primary Biliary Cholangitis

Netherlands, United Kingdom, Korea, Republic of, Germany, Australia, Estonia, Belgium, France, Czechia, Croatia, Greece, Hungary, Israel, Lithuania, Norway, Poland, Spain
Chiesi Farmaceutici S.p.A.

Completed

Clinical Study to Investigate the Pharmacokinetics, Safety and Tolerability Following Single Administration of CHF6001 in Subjects With Mild, Moderate and Severe Liver Impairment in Comparison With Matched Healthy Control Subjects

Chronic Obstructive Pulmonary Disease

Bulgaria

Search clinical trials for: Severe hepatic impairment

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