Search clinical trials for: Oral Proteolytic and Hydrolytic Enzymes

Total 472936 results

Bausch Health Americas, Inc.

Completed

Effects of MNTX on CYP450 2D6 in Metabolizers of Dextromethorphan

Healthy Adults

United States
Janssen-Cilag International NV

Withdrawn

A Study of Esketamine Nasal Spray Plus a New Standard-of-care Oral Antidepressant or Placebo Nasal Spray Plus a New Standard-of-care Oral Antidepressant in Adult and Elderly Participants With Treatment-resistant Depression

Depressive Disorder, Treatment-Resistant
Medicines for Malaria Venture

Completed

Absolute BA and OZ439 PK Effect of Different OZ439 Dose Volumes and Cobicistat Co-administration Study

Malaria

Netherlands
University of Maryland, Baltimore
US Department of Veterans Affairs

Completed

A Comparison of Bupropion SR and Placebo for Smoking Cessation

Tobacco Use Disorder

United States
National Taiwan University Hospital

Completed

eGFR Evolution in HCV Patients Receiving SOF-based or SOF-free DAAs

Hepatitis C | Viral Hepatitis C | Renal Disease

Taiwan
Merck Sharp & Dohme LLC

Completed

Safety and Pharmacokinetics of Intravenous and Oral Posaconazole in Immunocompromised Children (MK-5592-097)

Neutropenia
Bayer

Completed

A Randomized Phase IIa Efficacy and Safety Study of Radium-223 Dichloride With Abiraterone Acetate or Enzalutamide in Metastatic Castration-resistant Prostate Cancer (CRPC)

Prostatic Neoplasms

United States
Scynexis, Inc.
ethica Clinical Research Inc.

Completed

Safety and Efficacy of Oral Ibrexafungerp (SCY-078) vs. Oral Fluconazole in Subjects With Vulvovaginal Candidiasis

Vulvovaginal Candidiasis

Dominican Republic
Bangabandhu Sheikh Mujib Medical University, Dhaka...

Unknown

This Study Include Chronic Obstructive Pulmonary Disease(COPD) Patients . Patients Were Vitamin D Deficient Age Range 40 to 80 Years, Smokers Patients Were Advised to Take Either Placebo or Vitamin D3 . Antioxidant Enzymes Were Assessed at Baseline and at 26th Weeks. (BSMMU)

Chronic Obstructive Pulmonary Disease

Bangladesh
Pfizer

Completed

Effect of Multiple Doses of Itraconazole on the Pharmacokinetics of a Single-Dose of PF-06651600 in Healthy Participants

Healthy Participants

Belgium
Weill Medical College of Cornell University

Completed

Pharmacokinetics of Sublingual Versus Oral Tacrolimus in Patients Awaiting Kidney Transplantation

Kidney Failure, Chronic

United States
Kaohsiung Veterans General Hospital.

Completed

Comparing the Efficacy of Reverse Hybrid Therapy and Bismuth Quadruple Therapy

Helicobacter Pylori Infection

Taiwan
Hospital de Clinicas de Porto Alegre

Unknown

Use Of Oral Itraconazole In Patients With Locally Limited Basocellular Carcinoma Of Skin.

Basal Cell Carcinoma | Hedgehog Pathway

Brazil
Xian-Janssen Pharmaceutical Ltd.

Terminated

A Study Comparing the Efficacy of Intravenous Followed by Oral Itraconazole With Intravenous Caspofungin For Empiric Antifungal Therapy in Neutropenic Participants With Hematological Malignancy

Hematologic Neoplasms

China
Arrevus Inc.

Terminated

Safety and Efficacy of CEM-102 With Rifampin Compared to Standard Therapy in Patients With Prosthetic Joint Infections or Spacer Infection

Prosthetic Joint Infections of Hip | Prosthetic Joint Infections of Knee | Infected Spacers

United States
University of Zimbabwe
State University of New York at Buffalo; Biomedical Research and Training Institute

Completed

Moringa Oleifera- Antiretroviral Pharmacokinetic Drug Interaction

HIV

Zimbabwe
Boehringer Ingelheim

Completed

Effect of Multiple Doses of Itraconazole on the Pharmacokinetics of a Single Oral Dose of BI 1026706 in Healthy Male Subjects

Healthy

Germany
Makerere University
University of Pittsburgh; University of Nebraska; University of Liverpool

Unknown

Darunavir and Rilpivirine Interactions With Levonorgestrel Implant (DRIVE-2)

Contraception | HIV-1-infection

Uganda
Instituto Nacional de Ciencias Medicas y Nutricion...
National Council of Science and Technology, Mexico

Unknown

Prophylactic Trimethoprim/Sulfamethoxazole to Prevent Severe Infections in Patients With Lupus Erythematous

Lupus Erythematosus, Systemic

Mexico
University of California, San Francisco
National Eye Institute (NEI); Dartmouth-Hitchcock Medical Center; Aravind Eye... and other collaborators

Completed

The Mycotic Ulcer Treatment Trial II: A Randomized Trial Comparing Oral Voriconazole vs Placebo (MUTTII)

Corneal Ulcer | Eye Infections, Fungal

United States, India, Nepal
Fundación Pública Andaluza para la Investigación...
Merck Sharp & Dohme LLC

Unknown

Raltegravir One Thousand Two Hundred vs Darunavir-cb in Immnunosupressed Patients: ROTDIP Study (ROTDIP)

HIV Infections
Innocrin Pharmaceutical
Prostate Cancer Foundation; Prostate Cancer Clinical Trials Consortium

Completed

Once-daily Oral Seviteronel in Patients With Castration-Resistant Prostate Cancer Progressing on Enzalutamide or Abiraterone.

Prostate Cancer

United States
Innocrin Pharmaceutical

Completed

A Study to Evaluate Oral VT-464 in Patients With Castration-Resistant Prostate Cancer

Castration-resistant Prostate Cancer | CRPC

United States, Greece, Switzerland, United Kingdom
St. Jude Children's Research Hospital
Eisai Inc.; Medicines for Malaria Venture; Global Health Innovative Technology...

Completed

First-in-Human Study of an Oral Plasmodium Falciparum Plasma Membrane Protein Inhibitor

Malaria

United States
R-Pharm
Almedis

Completed

Efficacy and Safety of All-Oral Combination of Narlaprevir/Ritonavir and Daclatasvir in Treatment-Naїve Patients With Chronic Hepatitis C Genotype 1b

Chronic Hepatitis C Genotype 1b

Russian Federation
Damascus Hospital

Withdrawn

Comparison Efficacy of 14-day Concomitant Therapy:Clarithromycin vs.Levofloxacin in Eradication of H.Pylori

Helicobacter Pylori Gastrointestinal Tract Infection

Syrian Arab Republic
Seoul National University Hospital

Completed

A Study to Evaluate the Appropriateness of the Voriconazole Dosing Regimen

Fungal Infection

Korea, Republic of
Matinas BioPharma Nanotechnologies, Inc.

Completed

Safety and Efficacy of Oral Encochleated Amphotericin B (CAMB/MAT2203) in the Treatment of Vulvovaginal Candidiasis (VVC)

Vulvovaginitis | Candidiasis, Vulvovaginal | Yeast Infection | Yeast Infection Vaginal

United States
Global Alliance for TB Drug Development

Completed

A Phase 1 Study to Evaluate Safety, Tolerability, PK, and PK Interactions of TBA-7371

Tuberculosis | Tuberculosis, Pulmonary

United States
Merck Sharp & Dohme LLC

Completed

Pharmacokinetics and Safety of Oral Posaconazole (MK-5592)Tablets in Chinese Participants at High Risk for Invasive Fungal Infections (MK-5592-117)

Fungal Infection
Otsuka Pharmaceutical Development & Commercialization...

Completed

Safety and Tolerability of Oral OPC-34712 as Adjunctive Therapy in Adults With Major Depressive Disorder (the Orion Trial) (Orion)

Mental Disorders | Depressive Disorder | Depression | Mood Disorders | Depressive Disorder, Major

United States, France, Poland, Russian Federation, Romania, Ukraine, Germany, Hungary, Slovakia, Serbia, Canada
Boston Medical Center

Withdrawn

Otiprio Versus Ciprodex Tympanostomy Tube Outcomes

Otitis Media With Effusion in Children | Otorrhea

United States
Eisai Inc.
Purdue Pharma LP

Completed

Study to Assess the Pharmacokinetic Drug-Drug Interactions of Lemborexant When Coadministered With an Oral Contraceptive, Famotidine, or Fluconazole in Healthy Subjects

Healthy Subjects

United States
Merck Sharp & Dohme LLC

Terminated

A Study of the Safety, Tolerance, and Pharmacokinetics of Oral Posaconazole in Immunocompromised Children (P03579)

Fungal Infections
Merck Sharp & Dohme LLC

Completed

A Study of the Use of Oral Posaconazole (POS) in the Treatment of Asymptomatic Chronic Chagas Disease (P05267) (STOP CHAGAS)

Chagas Disease
Achaogen, Inc.

Completed

A Study of Plazomicin Compared With Meropenem for the Treatment of Complicated Urinary Tract Infection (cUTI) Including Acute Pyelonephritis (AP) (EPIC)

Acute Pyelonephritis | Complicated Urinary Tract Infection
Viamet

Completed

A Study to Evaluate the Efficacy and Safety of Oral VT-1161 in Patients With Acute Vaginal Candidiasis (Yeast Infection)

Candidiasis, Vulvovaginal

United States
Loyola University

Terminated

Efficacy of Oral Antibiotic Therapy Compared to Intravenous Antibiotic Therapy for Osteomyelitis (CRO-OSTEO)

Osteomyelitis

United States
Janssen Pharmaceutical K.K.

Completed

A Study to Evaluate the Pharmacokinetics (PK) of Darunavir (DRV) and Cobicistat (COBI) After a Single Oral Administration of Darunavir/Cobicistat Fixed-Dose Combination in Healthy Japanese Adult Participants

Healthy

Japan
AIDS Clinical Trials Group
National Institute of Allergy and Infectious Diseases (NIAID)

Completed

Evaluating Pharmacokinetic Interactions With Vaginal Ring Contraceptives and ART

HIV-1 Infection

United States, Peru, Puerto Rico, Brazil, Botswana, Kenya, South Africa, Thailand
Dartmouth-Hitchcock Medical Center

Completed

Effect of Ketoconazole on Breathlessness (KetoRLB)

Chronic Obstructive Pulmonary Disease

United States
Jason Hsu, MD

Completed

The Effect of Glaucoma Drops on of the Duration of a Pure Intraocular Gas Bubble

Scleral Buckling

United States
Bristol-Myers Squibb

Completed

PRINCE: Study of Atazanavir (ATV)/Ritonavir (RTV) (PRINCE1)

HIV Infections

Thailand, Chile, Peru, Brazil, Mexico, South Africa
Anthera Pharmaceuticals

Completed

SIMPLICITY: Studying Impacts on Malabsorption With Liprotamase in Cystic Fibrosis (SIMPLICITY)

Cystic Fibrosis | Exocrine Pancreatic Insufficiency

United States
Innocrin Pharmaceutical
National Cancer Institute (NCI)

Completed

Oral VT-464 in Patients With Castration-Resistant Prostate Cancer Previously Treated With Enzalutamide, Androgen Receptor Positive Triple-Negative Breast Cancer Patients, and Men With ER Positive Breast Cancer

Prostate Cancer

United States
Seoul National University Hospital

Unknown

Effects of Oral Steroid in Mycoplasma Pneumoniae Pneumonia

Mycoplasma Pneumoniae Pneumonia

Korea, Republic of
Rio de Janeiro State University

Completed

Hot Flash as a Marker of Cardiovascular Risk in Recent Postmenopause: Effects of Non-hormonal Treatments

Endothelial Dysfunction | Cardiovascular Risk Factor | Postmenopausal Flushing

Brazil
Corcept Therapeutics

Completed

Mifepristone Drug-Drug Interaction Study With CYP3A Inhibitor

Healthy | Drug Interaction Potentiation

United States
F2G Biotech GmbH
The Clinical Trials Centre Cologne; Klinik für Hämatologie, Aachen; Medizinische...

Withdrawn

Safety and Pharmacokinetics of Oral F901318 (Fluconazole and Posaconazole) IN Aml Leukaemia (SAFEGUARDFP)

Acute Myeloid Leukemia
Assiut University

Unknown

Comparison Between Rifampicin and Gemifloxacin and Ciprofloxacin in Treatment of Rhinoscleroma

Rhinoscleroma

Egypt

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