Once-daily Oral Seviteronel in Patients With Castration-Resistant Prostate Cancer Progressing on Enzalutamide or Abiraterone.

A Phase 2 Open-label Study to Evaluate the Efficacy and Safety of Seviteronel in Subjects With Castration-Resistant Prostate Cancer Progressing on Enzalutamide or Abiraterone

The goal of this clinical study is to determine the efficacy and safety of Seviteronel, a lyase-selective inhibitor of CYP17 and an androgen receptor antagonist, in patients with castration-resistant prostate cancer (CRPC) who have been previously treated with enzalutamide and/or abiraterone.

Study Overview

• Status: Completed
• Conditions: Prostate Cancer
• Intervention / Treatment: Drug: Seviteronel: given orally once daily in 28-day cycles

Detailed Description

This is a phase 2 clinical trial of Seviteronel (an oral, potent and lyase-selective CYP17 inhibitor) in men with castration-resistant prostate cancer (CRPC) progressing on enzalutamide or abiraterone. Approximately 197 subjects will be used to assess treatment efficacy. The study will be conducted in two different clinical cohorts separated by prior exposure to enzalutamide or abiraterone, or prior exposure to enzalutamide and abiraterone.

• Study Type: Interventional
• Enrollment (Anticipated): 197
• Phase: Phase 2

Contacts and Locations

Study Locations

• United States
  • Alabama
    • Birmingham, Alabama, United States, 35249
      • University of Alabama
  • Arizona
    • Scottsdale, Arizona, United States, 85054
      • Mayo Clinic
  • California
    • Los Angeles, California, United States, 90095
      • University of California at Los Angeles
  • Connecticut
    • New Haven, Connecticut, United States, 06519
      • Yale University
  • Florida
    • Jacksonville, Florida, United States, 32224
      • Mayo Clinic - Jacksonville
    • Tampa, Florida, United States, 33612
      • Moffitt Cancer Center
  • Louisiana
    • New Orleans, Louisiana, United States, 70112
      • Tulane University
  • Massachusetts
    • Boston, Massachusetts, United States, 02215
      • Beth Israel Deaconess Medical Center
    • Boston, Massachusetts, United States, 02215
      • Dana-Farber Cancer Institute
  • Michigan
    • Detroit, Michigan, United States, 48201
      • Karmanos Cancer Institute
  • Minnesota
    • Minneapolis, Minnesota, United States, 55455
      • University of Minnesota
  • Missouri
    • Saint Louis, Missouri, United States, 63110
      • Washington University
  • Nebraska
    • Omaha, Nebraska, United States, 68130
      • GU Research Network
  • New Mexico
    • Albuquerque, New Mexico, United States, 87106
      • New Mexico Cancer Care Alliance
  • New York
    • New York, New York, United States, 10065
      • Memorial Sloan Kettering Cancer Center
  • North Carolina
    • Chapel Hill, North Carolina, United States, 27514
      • University of North Carolina
  • South Carolina
    • Myrtle Beach, South Carolina, United States, 29572
      • Carolina Urologic Research Center
  • Virginia
    • Charlottesville, Virginia, United States, 22903
      • University of Virginia
    • Hampton, Virginia, United States, 23666
      • Virginia Oncology Associates
  • Washington
    • Seattle, Washington, United States, 98109
      • University of Washington
  • Wisconsin
    • Madison, Wisconsin, United States, 53715
      • University of Wisconsin Carbone Cancer Center

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (ADULT, OLDER_ADULT)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: Male

Description

Inclusion Criteria

1. Subjects must be ≥18 years of age.
2. Subjects or their legal representatives must be able to provide written informed consent.
3. Subjects must have documented histological or cytological evidence of adenocarcinoma of the prostate.
4. Subjects must have an ECOG Performance Score of 0-1.
5. Subjects must have undergone orchiectomy, or have ongoing LHRH analogue therapy prior to drug initiation. Subjects on LHRH analogues must remain on these agents for the duration of the study.

6. Subjects must have castrate levels of testosterone (≤50 ng/dl [1.7 nmol/L]) and have progressive disease at Screening defined as PSA rise determined by a minimum of 2 rising PSA values ≥1 week between each assessment. The PSA value at the Screening visit must be ≥2ng/mL with or without:

   • Soft tissue disease progression defined by RECIST 1.1 at Screening or ≤ 28 days of C1D1. Measurable disease is not required for entry. Lymph nodes ≥ 1.5cm (short axis) are considered measurable disease (PCWG3)
   • Bone disease progression defined by ≥2 new lesions on bone scan at Screening, or ≤28 days of C1D1
7. Subjects must have received abiraterone and/or enzalutamide. Subject must have received either abiraterone or enzalutamide for ≥12 weeks. Other second generation CYP17 inhibitors/androgen receptor antagonists including but not limited to TAK-700 (orteronel), TOK-001 (galeterone) may have been taken in place of abiraterone and ARN-509 (apalutamide) may have been taken in place of enzalutamide.

8. Subjects must have adequate hematopoietic function as evidenced by:

   • WBC ≥3,000/µl
   • ANC ≥1,500/µl
   • Platelet count ≥100,000/µl
   • HGB ≥10 g/dl and not transfusion dependent

9. Subjects must have adequate liver function, including all of the following:

   • Total serum bilirubin ≤2.0 x ULN unless the subject has documented Gilbert syndrome;
   • Aspartate and alanine aminotransferase (AST & ALT) ≤3.0 x ULN or ≤5.0 x ULN if subject has liver metastasis;
   • Alkaline phosphatase ≤2.0 x ULN or ≤5 x ULN in case of bone metastasis and/or hepatic metastasis
10. Subjects must have adequate renal function as evidenced by a serum creatinine of <2.0 mg/dl.
11. Subjects must have potassium (K+) >3.5 mEq/l.
12. Subject and his female partner who is of childbearing potential must use 2 acceptable methods of birth control (one of which must include a condom as a barrier method of contraception) starting a Screening and continuing throughout the study period and for 3 months after final study drug administration • Two acceptable forms of birth control include:

1. Condom (barrier method of contraception), and 2. One of the following:

1. Oral, injected or implanted hormonal contraception
2. Placement of an intrauterine device (IUD) or intrauterine system (ISU)
3. Additional barrier methods of contraception: Occlusive cap (diaphragm or cervical/vault caps) with spermicidal foam/gel/film/cream/suppository.
4. Vasectomy or surgical castration ≥ 6 months prior to Screening. 13. Subjects able to swallow study medication 14. Subjects able to comply with study requirements

Exclusion Criteria

1. Subjects who have completed sipuleucel-T (Provenge ®) treatment within 28 days of study drug initiation.
2. Subjects on 5-alpha reductase inhibitors such as finasteride (PROSCAR®, PROPECIA®), or dutasteride (AVODART®) within 28 days of study drug initiation.
3. Subjects who received any investigational agent ≤28 days of study drug initiation.
4. Subjects who received palliative radiotherapy ≤2 weeks of study drug initiation.
5. Subjects with symptomatic CNS metastases.
6. Subjects with a history of another invasive malignancy ≤3 years of study drug initiation.
7. Subjects with a QTcF interval of >470 msec; if the Screening ECG QTcF interval is >470 msec, it may be repeated, and if repeat <470 msec, the subject may be enrolled.
8. Subject with clinically significant cardiac arrhythmias (e.g., ventricular tachycardia, ventricular fibrillation, torsades de pointes, second degree or third degree atrioventricular heart block without a permanent pacemaker in place)
9. Subject that started a bone modifying agent (e.g. bisphosphonates, denosumab) ≤ 28 days of study drug initiation (note: ongoing bone modifying agents administered > 28 days are allowed).
10. Subject with any medical condition that could preclude subject participation in the study, pose an undue medical hazard, or which could interfere with study results.
11. Subject with Class III or IV Congestive Heart Failure as defined by the New York Heart Association (NYHA) functional classification system within the previous 6 months.
12. Subject with a history of loss of consciousness or transient ischemic attack ≤ 12 months of study drug initiation.
13. Subject with known active HIV, Hepatitis B, or Hepatitis C infections.
14. Subject with known or suspected hypersensitivity to seviteronel, or any components of the formulation
15. Subject with any other condition which in the opinion of the investigator would preclude participation in the study.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: TREATMENT
• Allocation: NON_RANDOMIZED
• Interventional Model: PARALLEL
• Masking: NONE

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
EXPERIMENTAL: Prior Abiraterone or Enzalutamide; Seviteronel: given orally once daily in 28-day cycles	Drug: Seviteronel: given orally once daily in 28-day cycles; Oral Seviteronel given once daily, in continuous 28-day cycles at the recommended Phase 2 dose; Other Names: Seviteronel
EXPERIMENTAL: Prior Abiraterone and Enzalutamide; Seviteronel: given orally once daily in 28-day cycles	Drug: Seviteronel: given orally once daily in 28-day cycles; Oral Seviteronel given once daily, in continuous 28-day cycles at the recommended Phase 2 dose; Other Names: Seviteronel

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Proportion of patients who have a PSA response by while on study from starting treatment with seviteronel	PSA response at any time whilst on study from the start of treatment within seviteronel defined by a ≥ 50% decrease in serum PSA.	6 months
The time to radiographic disease progression by RECIST 1.1 or PCWG3	Median time to radiographic disease progression evaluated by computerized tomography (CT scan) or magnetic resonance imaging (MRI) and radionuclide bone scans by RECIST 1.1 or Prostate Cancer Clinical Trials Working Group 3 (PCWG3)	10 months

Collaborators and Investigators

• Sponsor: Innocrin Pharmaceutical
• Collaborators: Prostate Cancer Foundation; Prostate Cancer Clinical Trials Consortium

Study record dates

Study Major Dates

• Study Start: May 1, 2015
• Primary Completion (ACTUAL): December 1, 2018
• Study Completion (ACTUAL): January 1, 2019

Study Registration Dates

• First Submitted: May 13, 2015
• First Submitted That Met QC Criteria: May 14, 2015
• First Posted (ESTIMATE): May 15, 2015

Study Record Updates

• Last Update Posted (ACTUAL): February 1, 2019
• Last Update Submitted That Met QC Criteria: January 31, 2019
• Last Verified: January 1, 2019

More Information

Terms related to this study

• Keywords: mCRPC; metastatic; castration-resistant prostate cancer
• Additional Relevant MeSH Terms: Neoplasms; Urogenital Neoplasms; Neoplasms by Site; Genital Neoplasms, Male; Prostatic Diseases; Prostatic Neoplasms; Molecular Mechanisms of Pharmacological Action; Enzyme Inhibitors; Antineoplastic Agents; Cytochrome P-450 Enzyme Inhibitors; Seviteronel
• Other Study ID Numbers: INO-VT-464-CL-003; VMT-VT-464-CL-003 (OTHER: Innocrin)