Clinical Trials Sponsored by Wellcome Trust United Kingdom

Total 372 results

University College London Hospitals
Wellcome Trust; Department of Health, United Kingdom

Unknown

Surrogate of Adequate Perfusion: Bladder Tissue Oxygen Monitoring (SoAP-BOx)

Sepsis | Shock | Surgery

United Kingdom
Nottingham University Hospitals NHS Trust
Wellcome Trust; National Institute for Health Research, United Kingdom

Unknown

The Use of Interactive Binocular Treatment (I-BiT) for the Management of Anisometropic, Strabismic and Mixed Amblyopia in Children Aged 3.5 - 12 Years (I-BiT Plus)

Strabismus | Amblyopia
University College, London
Wellcome Trust; National Institute for Health Research, United Kingdom

Unknown

Predictors of Blood Pressure Control and Associations With Cardiovascular Diseases in Individuals With High Blood Pressure: a CALIBER Study

Myocardial Infarction | Heart Failure | Stroke | Stable Angina Pectoris

United Kingdom
University College, London
Wellcome Trust; National Institute for Health Research, United Kingdom

Unknown

Social Deprivation and Initial Presentation of 12 Cardiovascular Diseases: a CALIBER Study (IP4)

Myocardial Infarction | Heart Failure | Stroke | Ischemic Stroke | Peripheral Arterial Disease | Transient Ischemic Attack | Stable Angina Pectoris | Unstable Angina | Abdominal Aortic Aneurysm | Intracerebral Haemorrhage | Subarachnoid Haemorrhage | Coronary Heart Disease NOS | Unheralded Corronary Death | Cardiac...

United Kingdom
Imperial College London
Wellcome Trust; National Institute for Health Research, United Kingdom

Completed

The Safety and Immunogenicity of a Potential HIV Vaccine

HIV Infections

United Kingdom
University College, London
Wellcome Trust; National Institute for Health Research, United Kingdom

Unknown

Heart Rate and Cardiovascular Diseases Prognosis in People With Stable Coronary Artery Disease

Myocardial Infarction | Heart Failure | Stroke | Peripheral Arterial Disease | Atrial Fibrillation | Bleeding | Coronary Heart Disease | Stable Angina | Death, Sudden, Cardiac

United Kingdom
University College, London
Wellcome Trust; National Institute for Health Research, United Kingdom

Unknown

Heart Rate and Initial Presentation of Cardiovascular Diseases (Caliber)

Myocardial Infarction | Heart Failure | Stroke | Ischemic Stroke | Peripheral Arterial Disease | Transient Ischemic Attack | Stable Angina Pectoris | Unstable Angina | Abdominal Aortic Aneurysm | Intracerebral Haemorrhage | Subarachnoid Haemorrhage | Coronary Heart Disease NOS | Cardiac Arrest, Sudden Cardiac Death and other conditions

United Kingdom
University College, London
Wellcome Trust; National Institute for Health Research, United Kingdom

Unknown

Understanding the Role of Autoimmune Disorders on the Initial Presentation of Cardiovascular Disease

Myocardial Infarction | Heart Failure | Stroke | Ischemic Stroke | Peripheral Arterial Disease | Venous Thrombosis | Transient Ischemic Attack | Stable Angina Pectoris | Unstable Angina | Abdominal Aortic Aneurysm | Subarachnoid Haemorrhage

United Kingdom
University of Oxford
Wellcome Trust; Department of Health, United Kingdom; 180 Therapeutics LP

Completed

Repurposing Anti-TNF for Treating Dupuytren's Disease (RIDD)

Dupuytren's Disease

United Kingdom, Netherlands
University of Exeter
Wellcome Trust; University of Dundee; Department of Health, United Kingdom

Completed

Using Pharmacogenetics to Improve Treatment in Early-onset Diabetes (UNITED)

Diabetes

United Kingdom
London School of Hygiene and Tropical Medicine
Wellcome Trust; National Health Service, United Kingdom

Completed

Text Messaging Reminders for Influenza Vaccine in Primary Care (TXT4FLUJAB)

Influenza

United Kingdom
The Children's Trust, United Kingdom
Temple University

Recruiting

Evaluation of the MuSICCA for Measuring Awareness

Disorder of Consciousness

United States, United Kingdom
University of Oxford
Wellcome Trust; National Institute for Health Research, United Kingdom; Arthritis...

Completed

Epidemiology and Outcomes of Upper Limb Surgery: Analysis of Routine Data

Osteoarthritis | Rotator Cuff Tear | Avascular Necrosis | Inflammatory Arthritis | Shoulder Dislocation | Dupuytren Contracture | Impingement Syndrome, Shoulder | Elbow Arthropathy | Trigger Digit | Shoulder Arthropathy | Upper Limb Nerve Lesion | Wrist Arthropathy | Fracture Elbow | Dislocations | Fracture, Shoulder | Arthropathy... and other conditions
University of Leicester
Wellcome Trust; University Hospitals, Leicester; National Institute for Health...

Recruiting

Cardiac Rehabilitation Participation and South Asian Service Users

Cardiac Rehabilitation | South Asian Service Users

United Kingdom
University of Oxford
Wellcome Trust; National Institute for Health Research, United Kingdom; University...

Active, not recruiting

Investigating Immune Responses to Aerosol BCG Challenge in Healthy UK Adults

Tuberculosis

United Kingdom
Imperial College London
Medical Research Council; Wellcome Trust; National Institute for Health Research...

Terminated

A Study of Protective Immunity Against RSV and Influenza in Experimental Human Challenge of Volunteers

Influenza, Human | Respiratory Syncytial Virus Infections

United Kingdom
University College, London
Medical Research Council; Wellcome Trust; National Institute for Health Research...

Unknown

Serum Uric Acid Levels and Onset of Cardiovascular Diseases: a CALIBER Study

Myocardial Infarction | Heart Failure | Ischemic Stroke | Peripheral Arterial Disease | Atrial Fibrillation | Cardiac Arrest | Subarachnoid Hemorrhage | Stable Angina | Unstable Angina | Abdominal Aortic Aneurysm | Intracerebral Hemorrhage | Unheralded Coronary Heart Disease Death | Transient Ischaemic Attack
Royal Marsden NHS Foundation Trust
Wellcome Trust; Institute of Cancer Research, United Kingdom; Biomedical Research...

Completed

A Phase I, First in Man Study to Evaluate the Safety and Tolerability of a panRAF Inhibitor (CCT3833/BAL3833)in Patients With Solid Tumours (PanRAF)

Melanoma | Cancer

United Kingdom
Anna Griffiths, MRC
Medical Research Council; Wellcome Trust; Department for International Development... and other collaborators

Completed

Reduction of EArly mortaLITY in HIV-infected Adults and Children Starting Antiretroviral Therapy (REALITY)

Human Immunodeficiency Virus

Malawi, Zimbabwe, Kenya, Uganda
Royal Marsden NHS Foundation Trust
Institute of Cancer Research, United Kingdom; National Health Service, United...

Active, not recruiting

Conventional Care Versus Radioablation (Stereotactic Body Radiotherapy) for Extracranial Oligometastases (CORE)

Breast Cancer | Carcinoma, Non-Small-Cell Lung | Prostate Cancer

United Kingdom, Australia
Oxford University Clinical Research Unit, Vietnam
Medical Research Council; University of Oxford; Wellcome Trust; Department for...

Recruiting

The Azithromycin and Cefixime Treatment of Typhoid in South Asia Trial (ACT-South Asia Trial) (ACT-South Asia)

Typhoid Fever

Nepal
University of Cambridge
Imperial College London; Cambridge University Hospitals NHS Foundation Trust; Wellcome Trust and other collaborators

Active, not recruiting

PET Imaging of Giant Cell and Takayasu Arteritis (PITA)

Giant Cell Arteritis | Takayasu Arteritis

United Kingdom
Institute of Cancer Research, United Kingdom
Royal Marsden NHS Foundation Trust; National Institute for Health Research,...

Completed

Imaging in Clinical Trials - a Questionnaire Study to Assess Impact of Imaging Regimes on Patient Participation (ASK)

Cancer

United Kingdom
Royal Marsden NHS Foundation Trust
Institute of Cancer Research, United Kingdom; National Institute for Health...

Unknown

Development of a Personalised Care Plan Designed to Reduce Chronic Post-Operative Pain Following Breast Surgery

Neuropathic Pain | Cancer Pain | Persistent Post-surgical Pain

United Kingdom
Royal Marsden NHS Foundation Trust
Institute of Cancer Research, United Kingdom; National Institute for Health...

Enrolling by invitation

Biological Characteristics of Older Women (> 70 Years) With ER Positive, HER2 Negative Early Breast Cancer (BOLD-70)

Breast Cancer Female

United Kingdom
Royal Marsden NHS Foundation Trust
Institute of Cancer Research, United Kingdom; National Institute for Health...

Active, not recruiting

Whole Body Magnetic Resonance Imaging Study (WISE)

Advanced Prostate Cancer

United Kingdom
Institute of Cancer Research, United Kingdom
Royal Marsden NHS Foundation Trust; National Institute for Health Research,...

Completed

Imaging NSCLC Treatment Response to Immunotherapy

Cancer

United Kingdom
Barts & The London NHS Trust
National Health Service, United Kingdom

Completed

Trial of Vitamin D Supplementation in Asthma (ViDiAs)

Asthma

United Kingdom
Liverpool University Hospitals NHS Foundation Trust
Kidney Research United Kingdom

Not yet recruiting

Expanding the Scope of Post-transplant HLA-specific Antibody Detection and Monitoring in Renal Transplant Recipients (HLA-AB)

Frailty | Kidney Transplant Rejection | Renal Transplant | Diagnosis | Kidney Transplant; Complications | Kidney Transplant | Renal Transplant Failure | Transplant Dysfunction

United Kingdom
Barts & The London NHS Trust
National Health Service, United Kingdom

Completed

Trial of Vitamin D Supplementation for the Prevention of Influenza and Other Respiratory Infections (ViDiFlu) (ViDiFlu)

Respiratory Tract Infections | Influenza

United Kingdom
Barts & The London NHS Trust
National Health Service, United Kingdom

Completed

Trial of Vitamin D Supplementation in Chronic Obstructive Pulmonary Disease (ViDiCO)

Chronic Obstructive Pulmonary Disease

United Kingdom
Cambridge University Hospitals NHS Foundation Trust
Juvenile Diabetes Research Foundation; Wellcome Trust; University of Cambridge; National Institute for Health Research, United Kingdom

Completed

Regulatory T Cells in Type 1 Diabetes Patients Treated With IL-2 (DILT1D)

Type 1 Diabetes

United Kingdom
University College, London
London School of Hygiene and Tropical Medicine; Wellcome Trust; National Institute...

Completed

Ethnicity and Onset of Cardiovascular Disease: A CALIBER Study

Myocardial Infarction | Heart Failure | Stroke | Ischemic Stroke | Peripheral Arterial Disease | Transient Ischemic Attack | Coronary Heart Disease | Cardiac Arrest | Stable Angina Pectoris | Unstable Angina | Sudden Cardiac Death | Abdominal Aortic Aneurysm | Intracerebral Haemorrhage | Subarachnoid Haemorrhage
Institute of Cancer Research, United Kingdom
Royal Marsden NHS Foundation Trust

Not yet recruiting

SBRT Alone or Followed by Niraparib for Oligometastases or Oligoprogression in Ovarian Cancer Following PARPi Therapy (SOPRANO)

Ovarian Cancer Recurrent

United Kingdom
Royal Marsden NHS Foundation Trust
Institute of Cancer Research, United Kingdom

Recruiting

Single Modality Trans Oral Robotic Surgery for Primary Oropharyngeal Cancer: Exploring the Impact of Surgical Margins on Local Disease Recurrence (STORM)

Head and Neck Squamous Cell Carcinoma

United Kingdom
Royal Marsden NHS Foundation Trust
Institute of Cancer Research, United Kingdom

Recruiting

A Trial Assessing Post-Operative Use of ProSpare, a Rectal Obturator in Prostate Cancer Radiotherapy (POPS)

Cancer

United Kingdom
Institute of Cancer Research, United Kingdom
Royal Marsden NHS Foundation Trust

Unknown

TOPARP: A Phase II Trial of Olaparib in Patients With Advanced Castration Resistant Prostate Cancer (TOPARP)

Adenocarcinoma of the Prostate

United Kingdom
Institute of Cancer Research, United Kingdom
Royal Marsden NHS Foundation Trust

Unknown

A Trial of Cediranib in the Treatment of Patients With Alveolar Soft Part Sarcoma (CASPS) (CASPS)

Alveolar Soft-part Sarcoma

Australia, United Kingdom, Spain
Royal Marsden NHS Foundation Trust
Institute of Cancer Research, United Kingdom

Unknown

HRQoL in Advanced Soft Tissue Sarcoma Patients Treated With Chemotherapy.

Quality of Life

United Kingdom
Institute of Cancer Research, United Kingdom
Royal Marsden NHS Foundation Trust

Unknown

A Study of Enzalutamide in Combination With AZD5363 in Patients With mCRPC (RE-AKT)

Adenocarcinoma of the Prostate

United Kingdom
Royal Marsden NHS Foundation Trust
Institute of Cancer Research, United Kingdom

Completed

FR in Stored Plasma

Ovarian Cancer

United Kingdom
Institute of Cancer Research, United Kingdom
Royal Marsden NHS Foundation Trust

Recruiting

Myeloma Novel Drug Discovery Ver 1.2 (DISCO)

Multiple Myeloma

United Kingdom
Institute of Cancer Research, United Kingdom
Royal Marsden NHS Foundation Trust

Recruiting

The Active Surveillance Study (AS)

Prostate Cancer

United Kingdom
Institute of Cancer Research, United Kingdom
Royal Marsden NHS Foundation Trust

Recruiting

CORONADO (Circulating tumOur pROtein quaNtification cApillary blooD cOvid-19)

Multiple Myeloma

United Kingdom
Institute of Cancer Research, United Kingdom
Royal Marsden NHS Foundation Trust

Completed

A Trial Looking at Nilotinib to Treat Acral and Mucosal Melanoma Skin Cancer That Has Spread (NICAM)

Mucosal Lentiginous Melanoma | Acral Lentiginous Malignant Melanoma

United Kingdom
Royal Marsden NHS Foundation Trust
Institute of Cancer Research, United Kingdom

Unknown

Multifunctional Magnetic Resonance (MR) for Radiotherapy Planning in Prostate Cancer

Prostate Cancer

United Kingdom
Royal Marsden NHS Foundation Trust
Institute of Cancer Research, United Kingdom

Unknown

Adaptive Planning in Bladder Cancer (APPLY)

Bladder Cancer

United Kingdom
Newcastle-upon-Tyne Hospitals NHS Trust
Newcastle University; National Institute for Health Research, United Kingdom; Department of Health, United Kingdom

Completed

B-Cell Depleting Therapy (Rituximab) as a Treatment for Fatigue in Primary Biliary Cirrhosis (RITPBC)

Fatigue | Primary Biliary Cirrhosis

United Kingdom
Royal Marsden NHS Foundation Trust
Institute of Cancer Research, United Kingdom; Oracle Cancer Trust

Recruiting

Evaluation of Tongue Base MucOsectomy & Step sErial Sectioning (MOSES)

Squamous Cell Carcinoma of the Oropharynx

United Kingdom
Institute of Cancer Research, United Kingdom
Royal Marsden NHS Foundation Trust

Recruiting

Precision Medicine in the Prostate Cancer Care Pathway (PMPRC)

Prostate Cancer | Genetic Predisposition

United Kingdom

Clinical Trials Sponsored by Wellcome Trust United Kingdom

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