Heart Rate and Cardiovascular Diseases Prognosis in People With Stable Coronary Artery Disease

Association of Heart Rate With Cardiovascular Disease Prognosis of Patients With Stable Coronary Artery Disease: A CALIBER Study

The Cardiovascular disease research using Linked Bespoke studies and Electronic Records (CALIBER) e-health database was the data resource for this study. CALIBER links patient records from four different data sources: Clinical Practice Research Database (CPRD), MINAP (Myocardial Ischaemia National Audit Project registry) Hospital Episodes Statistics (HES), the Office for National Statistics (ONS).

Study Overview

• Status: Unknown
• Conditions: Myocardial Infarction; Heart Failure; Stroke; Peripheral Arterial Disease; Atrial Fibrillation; Bleeding; Coronary Heart Disease; Stable Angina; Death, Sudden, Cardiac

Detailed Description

This study is part of the CALIBER (Cardiovascular disease research using linked bespoke studies and electronic records) programme funded over 5 years from the NIHR and Wellcome Trust. The central theme of the CALIBER research is linkage of the Myocardial Ischaemia National Audit Project (MINAP) with primary care (GPRD) and other resources. The overarching aim of CALIBER is to better understand the aetiology and prognosis of specific coronary phenotypes across a range of causal domains, particularly where electronic records provide a contribution beyond traditional studies. CALIBER has received both Ethics approval (ref 09/H0810/16) and ECC approval (ref ECC 2-06(b)/2009 CALIBER dataset).

• Study Type: Observational
• Enrollment (Actual): 51703

Contacts and Locations

Study Locations

• United Kingdom
  • London, United Kingdom, NW1 2DA
    • Farr Institute, University College London

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Child; Adult; Older Adult
• Accepts Healthy Volunteers: Yes

• Sampling Method: Non-Probability Sample

Study Population

An open cohort of 2,23 million people covering approximately 5% of the UK population was drawn from registrants to 225 GP practices who consented to data linkage.

Description

Inclusion Criteria:

• Aged >=30 years at study entry ->=1 year registration prior to the 'index date'

Exclusion Criteria:

• Free from previous atherosclerotic events
• No heart rate measurement after their 'index date' of eligibility to entry the study

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Risk of cardiovascular diseases in patients with low and high heart rate and stable coronary artery disease	Participants were followed until their first cardiovascular or complication event after their studyentry and after at least one previous cardiovascular event. Hazard ratios will be presenting associations between heart rate (analysed as quintiles and as continuous per 10bpm) and 8 different cardiovascular diseases (including mortality outcomes, complications such as bleeding events and composite cerebrovascular and coronary heart disease endpoints).	expected average of 3 years

Collaborators and Investigators

• Sponsor: University College, London
• Collaborators: Wellcome Trust; National Institute for Health Research, United Kingdom
• Investigators: Study Director: Harry Hemingway, Professor, Farr Institute

Study record dates

Study Major Dates

• Study Start: September 1, 2013
• Primary Completion (Actual): December 1, 2013
• Study Completion (Anticipated): December 1, 2014

Study Registration Dates

• First Submitted: September 17, 2014
• First Submitted That Met QC Criteria: September 18, 2014
• First Posted (Estimate): September 19, 2014

Study Record Updates

• Last Update Posted (Estimate): September 19, 2014
• Last Update Submitted That Met QC Criteria: September 18, 2014
• Last Verified: September 1, 2014

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Ischemia; Pathologic Processes; Necrosis; Myocardial Ischemia; Vascular Diseases; Arteriosclerosis; Arterial Occlusive Diseases; Pain; Neurologic Manifestations; Atherosclerosis; Arrhythmias, Cardiac; Death; Infarction; Chest Pain; Angina Pectoris; Heart Arrest; Myocardial Infarction; Heart Diseases; Coronary Artery Disease; Coronary Disease; Cardiovascular Diseases; Peripheral Arterial Disease; Peripheral Vascular Diseases; Atrial Fibrillation; Angina, Stable; Death, Sudden, Cardiac; Death, Sudden
• Other Study ID Numbers: 12_153R_IP24; RP-PG-0407-10314 (Other Grant/Funding Number: Wellcome Trust); 086091/Z/08/Z (Other Grant/Funding Number: Wellcome Trust)