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Exemestan s nebo bez entinostatu při léčbě pacientek s recidivujícím karcinomem prsu s pozitivním hormonálním receptorem, který je lokálně pokročilý nebo metastatický

21. října 2026 aktualizováno: National Cancer Institute (NCI)

Randomizovaná studie fáze III s endokrinní terapií plus Entinostat/placebo u pacientek s pokročilým karcinomem prsu s pozitivními hormonálními receptory

This randomized phase III trial studies exemestane and entinostat to see how well they work compared to exemestane alone in treating patients with hormone receptor-positive breast cancer that has spread to nearby tissue or lymph nodes (locally advanced) or another place in the body (metastatic). Estrogen can cause the growth of breast cancer cells. Endocrine therapy using exemestane may fight breast cancer by lowering the amount of estrogen the body makes. Entinostat may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. It is not yet known whether exemestane is more effective with or without entinostat in treating breast cancer.

Přehled studie

Postavení

Aktivní, ne nábor

Podmínky

Intervence / Léčba

Detailní popis

PRIMARY OBJECTIVES:

I. To evaluate whether the addition of entinostat to endocrine therapy (exemestane) improves progression-free survival (PFS) and/or overall survival (OS) in patients with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative locally advanced or metastatic breast cancer who have previously progressed on a non-steroidal aromatase inhibitor (Al).

SECONDARY OBJECTIVES:

I. To evaluate the safety and tolerability of entinostat in combination with exemestane, and to compare the safety profile to that of endocrine therapy with placebo.

II. To evaluate the objective response rate of exemestane in combination with entinostat or placebo.

III. To evaluate whether the efficacy of exemestane with entinostat varies with changes in acetylation status in peripheral blood mononuclear cells (PBMCs).

IV. To evaluate the time to treatment deterioration (as defined by decrease in health-related quality of life [HRQL], progression, death) of exemestane + entinostat versus exemestane + placebo arms.

V. To evaluate the differences in overall health-related quality of life (HRQL) between the exemestane + entinostat versus exemestane + placebo arms.

VI. To evaluate the difference with respect to specific symptoms that are associated with entinostat, i.e., fatigue, nausea, anorexia and diarrhea, between the exemestane + entinostat versus exemestane + placebo arms.

VII. To measure adherence to protocol therapy. VIII. To evaluate the pharmacokinetics of entinostat in patients with advanced breast cancer.

IX. To evaluate what, if any, patient variables alter the pharmacokinetic profile of entinostat in patients with advanced breast cancer.

EXPLORATORY OBJECTIVES:

I. To collect archival tumor samples and germline deoxyribonucleic acid (DNA) to explore other potential biomarkers of therapeutic efficacy.

II. To collect patient ratings of adverse events (AEs) using select patient-reported outcomes (PRO)-Common Terminology Criteria for Adverse Events (CTCAE) items to evaluate the psychometric properties of PRO-CTCAE items and explore the incorporation of PRO-CTCAE items into a phase III double-blind placebo-controlled trial.

OUTLINE: Patients are randomized to 1 of 2 treatment arms.

ARM A: Patients receive exemestane orally (PO) once daily (QD) on days 1-28 and entinostat PO on days 1, 8, 15, and 22. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients also undergo computed tomography (CT) or magnetic resonance imaging (MRI) at baseline, at the end of cycle 3, every 3 cycles, at treatment discontinuation, and during follow-up, collection of blood samples at baseline and day 15 of cycle 1, and collection of archived tissue at baseline.

ARM B: Patients receive exemestane as in Arm A and placebo PO on days 1, 8, 15, and 22. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients also undergo CT or MRI at baseline, at the end of cycle 3, every 3 cycles, at treatment discontinuation, and during follow-up, collection of blood samples at baseline and day 15 of cycle 1, and collection of archived tissue at baseline.

In both arms, pre/perimenopausal female patients and all male patients also receive goserelin acetate subcutaneously (SC) on day 1.

After completion of study treatment, patients are followed up every 3 months for 2 years, every 6 months for 3 years, and then annually for 5 years.

Typ studie

Intervenční

Zápis (Aktuální)

608

Fáze

Fáze 3

Kontakty a umístění

Tato část poskytuje kontaktní údaje pro ty, kteří studii provádějí, a informace o tom, kde se tato studie provádí.

Studijní místa

Jižní Afrika
- - Pretoria, Jižní Afrika, 0002
    - University Of Pretoria
Spojené státy
- Alabama
  - Birmingham, Alabama, Spojené státy, 35233
    - University of Alabama at Birmingham Cancer Center
- Arkansas
  - Jonesboro, Arkansas, Spojené státy, 72401
    - NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
- California
  - Carmichael, California, Spojené státy, 95608
    - Mercy San Juan Medical Center
  - Chico, California, Spojené státy, 95973
    - Adventist Health Cancer Care Center Chico
  - Chico, California, Spojené státy, 95926
    - Enloe Medical Center
  - Clovis, California, Spojené státy, 93611
    - Community Cancer Institute
  - Clovis, California, Spojené státy, 93611
    - University Oncology Associates
  - Rancho Mirage, California, Spojené státy, 92270
    - Eisenhower Medical Center
  - Sacramento, California, Spojené státy, 95816
    - Mercy Cancer Center - Sacramento
  - St. Helena, California, Spojené státy, 94574
    - Saint Helena Hospital
  - Whittier, California, Spojené státy, 90602
    - Presbyterian Intercommunity Hospital
  - Woodland, California, Spojené státy, 95695
    - Woodland Memorial Hospital
- Colorado
  - Aurora, Colorado, Spojené státy, 80012
    - Rocky Mountain Cancer Centers-Aurora
  - Aurora, Colorado, Spojené státy, 80012
    - The Medical Center of Aurora
  - Boulder, Colorado, Spojené státy, 80303
    - Boulder Community Foothills Hospital
  - Boulder, Colorado, Spojené státy, 80304
    - Rocky Mountain Cancer Centers-Boulder
  - Colorado Springs, Colorado, Spojené státy, 80907
    - Penrose-Saint Francis Healthcare
  - Colorado Springs, Colorado, Spojené státy, 80909
    - UCHealth Memorial Hospital Central
  - Colorado Springs, Colorado, Spojené státy, 80907
    - Rocky Mountain Cancer Centers-Penrose
  - Denver, Colorado, Spojené státy, 80218
    - Presbyterian - Saint Lukes Medical Center - Health One
  - Denver, Colorado, Spojené státy, 80220
    - Rose Medical Center
  - Denver, Colorado, Spojené státy, 80218
    - Rocky Mountain Cancer Centers-Midtown
  - Denver, Colorado, Spojené státy, 80220
    - Rocky Mountain Cancer Centers-Rose
  - Denver, Colorado, Spojené státy, 80218
    - Colorado Blood Cancer Institute
  - Denver, Colorado, Spojené státy, 80218
    - Saint Joseph Hospital - Cancer Centers of Colorado
  - Denver, Colorado, Spojené státy, 80210
    - AdventHealth Porter
  - Durango, Colorado, Spojené státy, 81301
    - Mercy Medical Center
  - Durango, Colorado, Spojené státy, 81301
    - CommonSpirit Cancer Center Mercy
  - Englewood, Colorado, Spojené státy, 80113
    - Mountain Blue Cancer Care Center - Swedish
  - Englewood, Colorado, Spojené státy, 80113
    - Swedish Medical Center
  - Golden, Colorado, Spojené státy, 80401
    - Mountain Blue Cancer Care Center
  - Greeley, Colorado, Spojené státy, 80631
    - Banner North Colorado Medical Center
  - Greenwood Village, Colorado, Spojené státy, 80111
    - Rocky Mountain Cancer Centers-Greenwood Village
  - Lakewood, Colorado, Spojené státy, 80228
    - Rocky Mountain Cancer Centers-Lakewood
  - Lakewood, Colorado, Spojené státy, 80228
    - CommonSpirit Saint Anthony Hospital Cancer Center
  - Littleton, Colorado, Spojené státy, 80120
    - Rocky Mountain Cancer Centers-Littleton
  - Littleton, Colorado, Spojené státy, 80122
    - AdventHealth Littleton
  - Lone Tree, Colorado, Spojené státy, 80124
    - Sky Ridge Medical Center
  - Lone Tree, Colorado, Spojené státy, 80124
    - Rocky Mountain Cancer Centers-Sky Ridge
  - Longmont, Colorado, Spojené státy, 80501
    - Longmont United Hospital
  - Longmont, Colorado, Spojené státy, 80501
    - Rocky Mountain Cancer Centers-Longmont
  - Loveland, Colorado, Spojené státy, 80539
    - Banner North Colorado Medical Center - Loveland Campus
  - Parker, Colorado, Spojené státy, 80138
    - Rocky Mountain Cancer Centers-Parker
  - Parker, Colorado, Spojené státy, 80138
    - AdventHealth Parker
  - Pueblo, Colorado, Spojené státy, 81004
    - Saint Mary Corwin Medical Center
  - Pueblo, Colorado, Spojené státy, 81008
    - Rocky Mountain Cancer Centers - Pueblo
  - Thornton, Colorado, Spojené státy, 80260
    - Rocky Mountain Cancer Centers-Thornton
  - Wheat Ridge, Colorado, Spojené státy, 80401
    - Intermountain Health Lutheran Hospital
- Connecticut
  - Guilford, Connecticut, Spojené státy, 06437
    - Smilow Cancer Hospital Care Center - Guilford
  - Hartford, Connecticut, Spojené státy, 06105
    - Smilow Cancer Hospital Care Center at Saint Francis
  - Manchester, Connecticut, Spojené státy, 06040
    - Manchester Memorial Hospital
  - Middletown, Connecticut, Spojené státy, 06457
    - Middlesex Hospital
  - New Britain, Connecticut, Spojené státy, 06050
    - The Hospital of Central Connecticut
  - New Haven, Connecticut, Spojené státy, 06520
    - Yale University
  - Orange, Connecticut, Spojené státy, 06477
    - Smilow Cancer Hospital-Orange Care Center
  - Torrington, Connecticut, Spojené státy, 06790
    - Smilow Cancer Hospital-Torrington Care Center
  - Waterford, Connecticut, Spojené státy, 06385
    - Smilow Cancer Hospital Care Center - Waterford
- Delaware
  - Dover, Delaware, Spojené státy, 19901
    - Bayhealth Hospital Kent Campus
  - Lewes, Delaware, Spojené státy, 19958
    - Beebe Medical Center
  - Newark, Delaware, Spojené státy, 19713
    - Helen F Graham Cancer Center
  - Newark, Delaware, Spojené státy, 19713
    - Medical Oncology Hematology Consultants PA
  - Newark, Delaware, Spojené státy, 19718
    - Christiana Care Health System-Christiana Hospital
  - Rehoboth Beach, Delaware, Spojené státy, 19971
    - Beebe Health Campus
  - Seaford, Delaware, Spojené státy, 19973
    - TidalHealth Nanticoke / Allen Cancer Center
  - Wilmington, Delaware, Spojené státy, 19801
    - Christiana Care Health System-Wilmington Hospital
- District of Columbia
  - Washington D.C., District of Columbia, Spojené státy, 20010
    - MedStar Washington Hospital Center
  - Washington D.C., District of Columbia, Spojené státy, 20007
    - MedStar Georgetown University Hospital
  - Washington D.C., District of Columbia, Spojené státy, 20016
    - Sibley Memorial Hospital
- Florida
  - Deerfield Beach, Florida, Spojené státy, 33442
    - UM Sylvester Comprehensive Cancer Center at Deerfield Beach
  - Gainesville, Florida, Spojené státy, 32610
    - UF Health Cancer Institute - Gainesville
  - Jacksonville, Florida, Spojené státy, 32207
    - Baptist MD Anderson Cancer Center
  - Lakeland, Florida, Spojené státy, 33805
    - Lakeland Regional Health Hollis Cancer Center
  - Miami, Florida, Spojené státy, 33136
    - University of Miami Miller School of Medicine-Sylvester Cancer Center
  - Miami, Florida, Spojené státy, 33176
    - UM Sylvester Comprehensive Cancer Center at Kendall
  - Plantation, Florida, Spojené státy, 33324
    - UM Sylvester Comprehensive Cancer Center at Plantation
  - Weston, Florida, Spojené státy, 33331
    - Cleveland Clinic-Weston
- Georgia
  - Atlanta, Georgia, Spojené státy, 30308
    - Emory University Hospital Midtown
  - Atlanta, Georgia, Spojené státy, 30322
    - Emory University Hospital/Winship Cancer Institute
  - Atlanta, Georgia, Spojené státy, 30342
    - Emory Saint Joseph's Hospital
  - Atlanta, Georgia, Spojené státy, 30303
    - Grady Health System
  - Columbus, Georgia, Spojené státy, 31904
    - John B Amos Cancer Center
  - Macon, Georgia, Spojené státy, 31201
    - Atrium Health Navicent
  - Savannah, Georgia, Spojené státy, 31405
    - Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
- Hawaii
  - Honolulu, Hawaii, Spojené státy, 96813
    - Queen's Medical Center
  - Honolulu, Hawaii, Spojené státy, 96813
    - Hawaii Cancer Care Inc - Waterfront Plaza
  - Honolulu, Hawaii, Spojené státy, 96813
    - Queen's Cancer Cenrer - POB I
  - Honolulu, Hawaii, Spojené státy, 96813
    - Straub Clinic and Hospital
  - Honolulu, Hawaii, Spojené státy, 96813
    - University of Hawaii Cancer Center
  - Honolulu, Hawaii, Spojené státy, 96817
    - Hawaii Cancer Care Inc-Liliha
  - Honolulu, Hawaii, Spojené státy, 96817
    - Queen's Cancer Center - Kuakini
  - ‘Aiea, Hawaii, Spojené státy, 96701
    - Pali Momi Medical Center
  - ‘Aiea, Hawaii, Spojené státy, 96701
    - Queen's Cancer Center - Pearlridge
- Idaho
  - Boise, Idaho, Spojené státy, 83706
    - Saint Alphonsus Cancer Care Center-Boise
  - Boise, Idaho, Spojené státy, 83712
    - Saint Luke's Cancer Institute - Boise
  - Coeur d'Alene, Idaho, Spojené státy, 83814
    - Kootenai Health - Coeur d'Alene
  - Fruitland, Idaho, Spojené státy, 83619
    - Saint Luke's Cancer Institute - Fruitland
  - Post Falls, Idaho, Spojené státy, 83854
    - Kootenai Clinic Cancer Services - Post Falls
  - Sandpoint, Idaho, Spojené státy, 83864
    - Kootenai Clinic Cancer Services - Sandpoint
  - Twin Falls, Idaho, Spojené státy, 83301
    - Saint Luke's Cancer Institute - Twin Falls
- Illinois
  - Aurora, Illinois, Spojené státy, 60504
    - Rush-Copley Medical Center
  - Bloomington, Illinois, Spojené státy, 61704
    - Illinois CancerCare-Bloomington
  - Bloomington, Illinois, Spojené státy, 61701
    - OSF Saint Joseph Medical Center
  - Canton, Illinois, Spojené státy, 61520
    - Illinois CancerCare-Canton
  - Carbondale, Illinois, Spojené státy, 62902
    - Memorial Hospital of Carbondale
  - Carthage, Illinois, Spojené státy, 62321
    - Illinois CancerCare-Carthage
  - Centralia, Illinois, Spojené státy, 62801
    - Centralia Oncology Clinic
  - Chicago, Illinois, Spojené státy, 60611
    - Northwestern University
  - Chicago, Illinois, Spojené státy, 60637
    - University of Chicago Comprehensive Cancer Center
  - Chicago, Illinois, Spojené státy, 60612
    - John H Stroger Jr Hospital of Cook County
  - Chicago, Illinois, Spojené státy, 60657
    - UChicago Medicine Comprehensive Cancer Center - Saint Joseph Hospital
  - Chicago, Illinois, Spojené státy, 60625
    - Swedish Covenant Hospital
  - Chicago, Illinois, Spojené státy, 60640
    - Weiss Memorial Hospital
  - Danville, Illinois, Spojené státy, 61832
    - Carle at The Riverfront
  - Decatur, Illinois, Spojené státy, 62526
    - Decatur Memorial Hospital
  - Decatur, Illinois, Spojené státy, 62526
    - Cancer Care Specialists of Illinois - Decatur
  - Effingham, Illinois, Spojené státy, 62401
    - Crossroads Cancer Center
  - Effingham, Illinois, Spojené státy, 62401
    - Carle Physician Group-Effingham
  - Elk Grove Village, Illinois, Spojené státy, 60007
    - Ascension Alexian Brothers - Elk Grove Village
  - Elmhurst, Illinois, Spojené státy, 60126
    - Elmhurst Memorial Hospital
  - Eureka, Illinois, Spojené státy, 61530
    - Illinois CancerCare-Eureka
  - Evanston, Illinois, Spojené státy, 60202
    - Saint Francis Hospital
  - Freeport, Illinois, Spojené státy, 61032
    - Freeport Memorial Hospital/Leonard C Ferguson Cancer Center
  - Galesburg, Illinois, Spojené státy, 61401
    - Western Illinois Cancer Treatment Center
  - Galesburg, Illinois, Spojené státy, 61401
    - Illinois CancerCare-Galesburg
  - Geneva, Illinois, Spojené státy, 60134
    - Northwestern Medicine Cancer Center Delnor
  - Harvey, Illinois, Spojené státy, 60426
    - Ingalls Memorial Hospital
  - Joliet, Illinois, Spojené státy, 60435
    - Duly Health and Care Joliet
  - Kankakee, Illinois, Spojené státy, 60901
    - Presence Saint Mary's Hospital
  - Kewanee, Illinois, Spojené státy, 61443
    - Illinois CancerCare-Kewanee Clinic
  - Macomb, Illinois, Spojené státy, 61455
    - Illinois CancerCare-Macomb
  - Mattoon, Illinois, Spojené státy, 61938
    - Carle Physician Group-Mattoon/Charleston
  - Maywood, Illinois, Spojené státy, 60153
    - Loyola University Medical Center
  - Mount Vernon, Illinois, Spojené státy, 62864
    - SSM Health Good Samaritan
  - Naperville, Illinois, Spojené státy, 60540
    - Edward Hospital/Cancer Center
  - Normal, Illinois, Spojené státy, 61761
    - Carle Cancer Institute Normal
  - Oak Lawn, Illinois, Spojené státy, 60453-2699
    - Advocate Christ Medical Center
  - Ottawa, Illinois, Spojené státy, 61350
    - Illinois CancerCare-Ottawa Clinic
  - Ottawa, Illinois, Spojené státy, 61350
    - Radiation Oncology of Northern Illinois
  - Pekin, Illinois, Spojené státy, 61554
    - Illinois CancerCare-Pekin
  - Pekin, Illinois, Spojené státy, 61554
    - OSF Saint Francis Radiation Oncology at Pekin
  - Peoria, Illinois, Spojené státy, 61636
    - Methodist Medical Center of Illinois
  - Peoria, Illinois, Spojené státy, 61637
    - OSF Saint Francis Medical Center
  - Peoria, Illinois, Spojené státy, 61615
    - Illinois CancerCare-Peoria
  - Peoria, Illinois, Spojené státy, 61615
    - OSF Saint Francis Radiation Oncology at Peoria Cancer Center
  - Peru, Illinois, Spojené státy, 61354
    - Illinois CancerCare-Peru
  - Peru, Illinois, Spojené státy, 61354
    - Valley Radiation Oncology
  - Plainfield, Illinois, Spojené státy, 60585
    - Edward Hospital/Cancer Center?Plainfield
  - Princeton, Illinois, Spojené státy, 61356
    - Illinois CancerCare-Princeton
  - River Forest, Illinois, Spojené státy, 60305
    - West Suburban Medical Center
  - Rockford, Illinois, Spojené státy, 61114
    - UW Health Carbone Cancer Center Rockford
  - Springfield, Illinois, Spojené státy, 62702
    - Southern Illinois University School of Medicine
  - Springfield, Illinois, Spojené státy, 62702
    - Springfield Clinic
  - Springfield, Illinois, Spojené státy, 62702
    - Central Illinois Hematology Oncology Center
  - Springfield, Illinois, Spojené státy, 62781
    - Springfield Memorial Hospital
  - Urbana, Illinois, Spojené státy, 61801
    - Carle Cancer Center
  - Urbana, Illinois, Spojené státy, 61801
    - The Carle Foundation Hospital
  - Warrenville, Illinois, Spojené státy, 60555
    - Northwestern Medicine Cancer Center Warrenville
  - Yorkville, Illinois, Spojené státy, 60560
    - Rush-Copley Healthcare Center
- Indiana
  - Carmel, Indiana, Spojené státy, 46032
    - IU Health North Hospital
  - Fishers, Indiana, Spojené státy, 46037
    - IU Health Central Indiana Cancer Centers-Fishers
  - Fort Wayne, Indiana, Spojené státy, 46845
    - Fort Wayne Medical Oncology and Hematology Inc-Parkview
  - Indianapolis, Indiana, Spojené státy, 46237
    - Franciscan Health Indianapolis
  - Indianapolis, Indiana, Spojené státy, 46202
    - Indiana University/Melvin and Bren Simon Cancer Center
  - Indianapolis, Indiana, Spojené státy, 46202
    - Sidney and Lois Eskenazi Hospital
  - Indianapolis, Indiana, Spojené státy, 46219
    - IU Health Central Indiana Cancer Centers-East
  - Indianapolis, Indiana, Spojené státy, 46290
    - Springmill Medical Center
  - Indianapolis, Indiana, Spojené státy, 46202
    - IU Health Methodist Hospital
  - Lafayette, Indiana, Spojené státy, 47904
    - IU Health Arnett Cancer Care
  - Michigan City, Indiana, Spojené státy, 46360
    - Woodland Cancer Care Center
  - Mooresville, Indiana, Spojené státy, 46158
    - Franciscan Health Mooresville
  - Muncie, Indiana, Spojené státy, 47303
    - IU Health Ball Memorial Hospital
  - Richmond, Indiana, Spojené státy, 47374
    - Reid Health
  - Terre Haute, Indiana, Spojené státy, 47804
    - Union Hospital
- Iowa
  - Ames, Iowa, Spojené státy, 50010
    - Mary Greeley Medical Center
  - Ames, Iowa, Spojené státy, 50010
    - McFarland Clinic - Ames
  - Bettendorf, Iowa, Spojené státy, 52722
    - University of Iowa Healthcare Cancer Services Quad Cities
  - Boone, Iowa, Spojené státy, 50036
    - McFarland Clinic - Boone
  - Cedar Rapids, Iowa, Spojené státy, 52403
    - Mercy Hospital
  - Cedar Rapids, Iowa, Spojené státy, 52403
    - Oncology Associates at Mercy Medical Center
  - Clive, Iowa, Spojené státy, 50325
    - Mercy Cancer Center-West Lakes
  - Clive, Iowa, Spojené státy, 50325
    - UI Health Care Mission Cancer and Blood - West Des Moines Clinic
  - Council Bluffs, Iowa, Spojené státy, 51503
    - Alegent Health Mercy Hospital
  - Davenport, Iowa, Spojené státy, 52803
    - MercyOne Genesis Davenport Medical Center
  - Des Moines, Iowa, Spojené státy, 50309
    - Iowa Methodist Medical Center
  - Des Moines, Iowa, Spojené státy, 50314
    - Mercy Medical Center - Des Moines
  - Des Moines, Iowa, Spojené státy, 50314
    - Broadlawns Medical Center
  - Des Moines, Iowa, Spojené státy, 50309
    - UI Health Care Mission Cancer and Blood - Des Moines Clinic
  - Des Moines, Iowa, Spojené státy, 50314
    - UI Health Care Mission Cancer and Blood - Laurel Clinic
  - Fort Dodge, Iowa, Spojené státy, 50501
    - McFarland Clinic - Trinity Cancer Center
  - Fort Dodge, Iowa, Spojené státy, 50501
    - UI Healthcare Mission Cancer and Blood - Fort Dodge
  - Iowa City, Iowa, Spojené státy, 52242
    - University of Iowa/Holden Comprehensive Cancer Center
  - Jefferson, Iowa, Spojené státy, 50129
    - McFarland Clinic - Jefferson
  - Marshalltown, Iowa, Spojené státy, 50158
    - McFarland Clinic - Marshalltown
  - Mason City, Iowa, Spojené státy, 50401
    - Mercy Medical Center - North Iowa
  - Sioux City, Iowa, Spojené státy, 51101
    - Siouxland Regional Cancer Center
  - West Des Moines, Iowa, Spojené státy, 50266
    - Mercy Medical Center-West Lakes
- Kansas
  - Chanute, Kansas, Spojené státy, 66720
    - Cancer Center of Kansas - Chanute
  - Dodge City, Kansas, Spojené státy, 67801
    - Cancer Center of Kansas - Dodge City
  - El Dorado, Kansas, Spojené státy, 67042
    - Cancer Center of Kansas - El Dorado
  - Fort Scott, Kansas, Spojené státy, 66701
    - Cancer Center of Kansas - Fort Scott
  - Garden City, Kansas, Spojené státy, 67846
    - Saint Catherine Hospital
  - Great Bend, Kansas, Spojené státy, 67530
    - Central Care Cancer Center - Great Bend
  - Great Bend, Kansas, Spojené státy, 67530
    - Saint Rose Ambulatory and Surgery Center
  - Hays, Kansas, Spojené státy, 67601
    - HaysMed
  - Independence, Kansas, Spojené státy, 67301
    - Cancer Center of Kansas-Independence
  - Kansas City, Kansas, Spojené státy, 66112
    - University of Kansas Cancer Center-West
  - Kingman, Kansas, Spojené státy, 67068
    - Cancer Center of Kansas-Kingman
  - Lawrence, Kansas, Spojené státy, 66044
    - Lawrence Memorial Hospital
  - Lenexa, Kansas, Spojené státy, 66219
    - Kansas Institute of Medicine Cancer and Blood Center
  - Lenexa, Kansas, Spojené státy, 66219
    - Minimally Invasive Surgery Hospital
  - Liberal, Kansas, Spojené státy, 67905
    - Cancer Center of Kansas-Liberal
  - Manhattan, Kansas, Spojené státy, 66502
    - Cancer Center of Kansas-Manhattan
  - McPherson, Kansas, Spojené státy, 67460
    - Cancer Center of Kansas - McPherson
  - Newton, Kansas, Spojené státy, 67114
    - Cancer Center of Kansas - Newton
  - Olathe, Kansas, Spojené státy, 66061
    - The University of Kansas Cancer Center - Olathe
  - Overland Park, Kansas, Spojené státy, 66210
    - University of Kansas Cancer Center-Overland Park
  - Overland Park, Kansas, Spojené státy, 66209
    - Menorah Medical Center
  - Parsons, Kansas, Spojené státy, 67357
    - Cancer Center of Kansas - Parsons
  - Pratt, Kansas, Spojené státy, 67124
    - Cancer Center of Kansas - Pratt
  - Salina, Kansas, Spojené státy, 67401
    - Salina Regional Health Center
  - Salina, Kansas, Spojené státy, 67401
    - Cancer Center of Kansas - Salina
  - Topeka, Kansas, Spojené státy, 66606
    - University of Kansas Health System Saint Francis Campus
  - Wellington, Kansas, Spojené státy, 67152
    - Cancer Center of Kansas - Wellington
  - Wichita, Kansas, Spojené státy, 67214
    - Ascension Via Christi Hospitals Wichita
  - Wichita, Kansas, Spojené státy, 67208
    - Cancer Center of Kansas-Wichita Medical Arts Tower
  - Wichita, Kansas, Spojené státy, 67214
    - Cancer Center of Kansas - Wichita
  - Wichita, Kansas, Spojené státy, 67208
    - Associates In Womens Health
  - Winfield, Kansas, Spojené státy, 67156
    - Cancer Center of Kansas - Winfield
- Kentucky
  - Bardstown, Kentucky, Spojené státy, 40004
    - CommonSpirit Saint Joseph Hospital - Bardstown
  - Corbin, Kentucky, Spojené státy, 40701
    - Baptist Health Corbin
  - Crestview Hills, Kentucky, Spojené státy, 41017
    - Oncology Hematology Care Inc-Crestview
  - Edgewood, Kentucky, Spojené státy, 41017
    - Saint Elizabeth Healthcare Edgewood
  - Elizabethtown, Kentucky, Spojené státy, 42701
    - Baptist Health Hardin
  - Fort Thomas, Kentucky, Spojené státy, 41075
    - Saint Elizabeth Healthcare Fort Thomas
  - Lexington, Kentucky, Spojené státy, 40536
    - University of Kentucky/Markey Cancer Center
  - Lexington, Kentucky, Spojené státy, 40504
    - Saint Joseph Radiation Oncology Resource Center
  - Lexington, Kentucky, Spojené státy, 40503
    - Baptist Health Lexington
  - Lexington, Kentucky, Spojené státy, 40509
    - CommonSpirit Saint Joseph Medical Center - East Lexington
  - Louisville, Kentucky, Spojené státy, 40202
    - Jewish Hospital
  - Louisville, Kentucky, Spojené státy, 40245
    - UofL Health Medical Center Northeast
  - Louisville, Kentucky, Spojené státy, 40207
    - Baptist Health Louisville
  - Madisonville, Kentucky, Spojené státy, 42431
    - Baptist Health Madisonville/Merle Mahr Cancer Center
  - Paducah, Kentucky, Spojené státy, 42003
    - Baptist Health Paducah
- Louisiana
  - Baton Rouge, Louisiana, Spojené státy, 70805
    - LSU Health Baton Rouge-North Clinic
  - Baton Rouge, Louisiana, Spojené státy, 70809
    - Louisiana Hematology Oncology Associates LLC
  - Baton Rouge, Louisiana, Spojené státy, 70809
    - Mary Bird Perkins Cancer Center
  - Baton Rouge, Louisiana, Spojené státy, 70809
    - Ochsner Health Center-Summa
  - Baton Rouge, Louisiana, Spojené státy, 70816
    - Medical Center of Baton Rouge
  - Baton Rouge, Louisiana, Spojené státy, 70809
    - Hematology/Oncology Clinic PLLC
  - Baton Rouge, Louisiana, Spojené státy, 70808
    - Our Lady of the Lake Physician Group
  - Covington, Louisiana, Spojené státy, 70433
    - Mary Bird Perkins Cancer Center - Covington
  - Covington, Louisiana, Spojené státy, 70433
    - Northshore Oncology Associates-Covington
  - Houma, Louisiana, Spojené státy, 70360
    - Mary Bird Perkins Cancer Center - Houma
  - Houma, Louisiana, Spojené státy, 70360
    - Oncology Center of The South Incorporated
  - New Orleans, Louisiana, Spojené státy, 70121
    - Ochsner Medical Center Jefferson
  - New Orleans, Louisiana, Spojené státy, 70112
    - University Medical Center New Orleans
  - New Orleans, Louisiana, Spojené státy, 70112
    - Louisiana State University Health Science Center
- Maine
  - Augusta, Maine, Spojené státy, 04330
    - Harold Alfond Center for Cancer Care
  - Bangor, Maine, Spojené státy, 04401
    - Eastern Maine Medical Center
  - Brewer, Maine, Spojené státy, 04412
    - Lafayette Family Cancer Center-EMMC
  - Rockport, Maine, Spojené státy, 04856
    - Penobscot Bay Medical Center
  - York Village, Maine, Spojené státy, 03909
    - York Hospital
- Maryland
  - Annapolis, Maryland, Spojené státy, 21401
    - Luminis Health Anne Arundel Medical Center
  - Baltimore, Maryland, Spojené státy, 21237
    - MedStar Franklin Square Medical Center/Weinberg Cancer Institute
  - Baltimore, Maryland, Spojené státy, 21287
    - Johns Hopkins University/Sidney Kimmel Cancer Center
  - Baltimore, Maryland, Spojené státy, 21215
    - Sinai Hospital of Baltimore
  - Baltimore, Maryland, Spojené státy, 21204
    - Greater Baltimore Medical Center
  - Baltimore, Maryland, Spojené státy, 21201
    - University of Maryland/Greenebaum Cancer Center
  - Bel Air, Maryland, Spojené státy, 21014
    - UM Upper Chesapeake Medical Center
  - Cumberland, Maryland, Spojené státy, 21502
    - UPMC Western Maryland
  - Easton, Maryland, Spojené státy, 21601
    - University of Maryland Shore Medical Center at Easton
  - Olney, Maryland, Spojené státy, 20832
    - MedStar Montgomery Medical Center
  - Randallstown, Maryland, Spojené státy, 21133
    - Northwest Hospital Center
- Massachusetts
  - Beverly, Massachusetts, Spojené státy, 01915
    - Beverly Hospital
  - Burlington, Massachusetts, Spojené státy, 01805
    - Lahey Clinic
  - Fall River, Massachusetts, Spojené státy, 02721
    - Saint Anne's Hospital
  - Gloucester, Massachusetts, Spojené státy, 01930
    - Addison Gilbert Hospital
  - Newton, Massachusetts, Spojené státy, 02462
    - Newton-Wellesley Hospital
  - Pittsfield, Massachusetts, Spojené státy, 01201
    - Berkshire Medical Center - Cancer Center
  - Winchester, Massachusetts, Spojené státy, 01890
    - Beth Israel Deaconess Medical Center/Winchester Center for Cancer Care
  - Worcester, Massachusetts, Spojené státy, 01655
    - UMass Memorial Medical Center - University Campus
- Michigan
  - Adrian, Michigan, Spojené státy, 49221
    - Hickman Cancer Center
  - Ann Arbor, Michigan, Spojené státy, 48106
    - Trinity Health Saint Joseph Mercy Hospital Ann Arbor
  - Brownstown, Michigan, Spojené státy, 48183
    - Henry Ford Cancer Institute-Downriver
  - Chelsea, Michigan, Spojené státy, 48118
    - Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
  - Clinton Township, Michigan, Spojené státy, 48038
    - Henry Ford Macomb Hospital-Clinton Township
  - Dearborn, Michigan, Spojené státy, 48126
    - Henry Ford Medical Center-Fairlane
  - Dearborn, Michigan, Spojené státy, 48124
    - Corewell Health Dearborn Hospital
  - Detroit, Michigan, Spojené státy, 48202
    - Henry Ford Hospital
  - Detroit, Michigan, Spojené státy, 48201
    - Wayne State University/Karmanos Cancer Institute
  - Detroit, Michigan, Spojené státy, 48236
    - Henry Ford Health Saint John Hospital
  - Escanaba, Michigan, Spojené státy, 49829
    - OSF Saint Francis Hospital and Medical Group
  - Farmington Hills, Michigan, Spojené státy, 48334
    - Weisberg Cancer Treatment Center
  - Flint, Michigan, Spojené státy, 48503
    - Hurley Medical Center
  - Flint, Michigan, Spojené státy, 48503
    - Genesys Hurley Cancer Institute
  - Grand Rapids, Michigan, Spojené státy, 49503
    - Corewell Health Grand Rapids Hospitals - Butterworth Hospital
  - Grosse Pointe, Michigan, Spojené státy, 48230
    - William Beaumont Hospital-Grosse Pointe
  - Jackson, Michigan, Spojené státy, 49201
    - Allegiance Health
  - Kalamazoo, Michigan, Spojené státy, 49007
    - West Michigan Cancer Center
  - Kalamazoo, Michigan, Spojené státy, 49048
    - Beacon Kalamazoo
  - Livonia, Michigan, Spojené státy, 48154
    - Trinity Health Saint Mary Mercy Livonia Hospital
  - Novi, Michigan, Spojené státy, 48377
    - Henry Ford Medical Center-Columbus
  - Pontiac, Michigan, Spojené státy, 48341
    - Trinity Health Saint Joseph Mercy Oakland Hospital
  - Port Huron, Michigan, Spojené státy, 48060
    - Lake Huron Medical Center
  - Royal Oak, Michigan, Spojené státy, 48073
    - Corewell Health William Beaumont University Hospital
  - Saginaw, Michigan, Spojené státy, 48601
    - MyMichigan Medical Center Saginaw
  - Troy, Michigan, Spojené státy, 48085
    - Corewell Health Beaumont Troy Hospital
  - Warren, Michigan, Spojené státy, 48093
    - Henry Ford Health Warren Hospital
  - West Bloomfield, Michigan, Spojené státy, 48322
    - Henry Ford West Bloomfield Hospital
- Minnesota
  - Bemidji, Minnesota, Spojené státy, 56601
    - Sanford Joe Lueken Cancer Center
  - Brainerd, Minnesota, Spojené státy, 56401
    - Essentia Health Saint Joseph's Medical Center
  - Coon Rapids, Minnesota, Spojené státy, 55433
    - Mercy Hospital
  - Duluth, Minnesota, Spojené státy, 55805
    - Essentia Health Cancer Center
  - Fergus Falls, Minnesota, Spojené státy, 56537
    - Lake Region Healthcare Corporation-Cancer Care
  - Maplewood, Minnesota, Spojené státy, 55109
    - Saint John's Hospital - Healtheast
  - Maplewood, Minnesota, Spojené státy, 55109
    - Minnesota Oncology Hematology PA-Maplewood
  - Minneapolis, Minnesota, Spojené státy, 55407
    - Abbott-Northwestern Hospital
  - Minneapolis, Minnesota, Spojené státy, 55454
    - Health Partners Inc
  - New Ulm, Minnesota, Spojené státy, 56073
    - New Ulm Medical Center
  - Saint Cloud, Minnesota, Spojené státy, 56303
    - Coborn Cancer Center at Saint Cloud Hospital
  - Saint Paul, Minnesota, Spojené státy, 55101
    - Regions Hospital
  - Stillwater, Minnesota, Spojené státy, 55082
    - Lakeview Hospital
  - Willmar, Minnesota, Spojené státy, 56201
    - Rice Memorial Hospital
- Mississippi
  - Columbus, Mississippi, Spojené státy, 39705
    - Baptist Memorial Hospital and Cancer Center-Golden Triangle
  - Grenada, Mississippi, Spojené státy, 38901
    - Baptist Cancer Center-Grenada
  - Hattiesburg, Mississippi, Spojené státy, 39401
    - Hattiesburg Clinic - Hematology/Oncology Clinic
  - Hattiesburg, Mississippi, Spojené státy, 39404
    - Forrest General Hospital / Cancer Center
  - Jackson, Mississippi, Spojené státy, 39216
    - University of Mississippi Medical Center
  - New Albany, Mississippi, Spojené státy, 38652
    - Baptist Memorial Hospital and Cancer Center-Union County
  - Oxford, Mississippi, Spojené státy, 38655
    - Baptist Memorial Hospital and Cancer Center-Oxford
  - Pascagoula, Mississippi, Spojené státy, 39581
    - Singing River Hospital
  - Southhaven, Mississippi, Spojené státy, 38671
    - Baptist Memorial Hospital and Cancer Center-Desoto
- Missouri
  - Ballwin, Missouri, Spojené státy, 63011
    - Mercy Oncology and Hematology - Clayton-Clarkson
  - Bonne Terre, Missouri, Spojené státy, 63628
    - Parkland Health Center-Bonne Terre
  - Branson, Missouri, Spojené státy, 65616
    - Cox Cancer Center Branson
  - Cape Girardeau, Missouri, Spojené státy, 63703
    - Saint Francis Medical Center
  - Cape Girardeau, Missouri, Spojené státy, 63703
    - Mercy Cancer Center - Cape Girardeau
  - Chesterfield, Missouri, Spojené státy, 63017
    - Saint Luke's Hospital
  - City of Saint Peters, Missouri, Spojené státy, 63376
    - Siteman Cancer Center at Saint Peters Hospital
  - Columbia, Missouri, Spojené státy, 65212
    - MU Health - University Hospital/Ellis Fischel Cancer Center
  - Creve Coeur, Missouri, Spojené státy, 63141
    - Siteman Cancer Center at West County Hospital
  - Independence, Missouri, Spojené státy, 64057
    - Centerpoint Medical Center LLC
  - Jefferson City, Missouri, Spojené státy, 65109
    - MU Health Care Goldschmidt Cancer Center
  - Kansas City, Missouri, Spojené státy, 64154
    - University of Kansas Cancer Center - North
  - Kansas City, Missouri, Spojené státy, 64131
    - The University of Kansas Cancer Center-South
  - Kansas City, Missouri, Spojené státy, 64132
    - Research Medical Center
  - Kansas City, Missouri, Spojené státy, 64108
    - University Health Truman Medical Center
  - Lee's Summit, Missouri, Spojené státy, 64064
    - University of Kansas Cancer Center - Lee's Summit
  - Sainte Genevieve, Missouri, Spojené státy, 63670
    - Sainte Genevieve County Memorial Hospital
  - Springfield, Missouri, Spojené státy, 65807
    - CoxHealth South Hospital
  - Springfield, Missouri, Spojené státy, 65804
    - Mercy Hospital Springfield
  - St Louis, Missouri, Spojené státy, 63110
    - Washington University School of Medicine
  - St Louis, Missouri, Spojené státy, 63131
    - Missouri Baptist Medical Center
  - St Louis, Missouri, Spojené státy, 63109
    - Mercy Infusion Center - Chippewa
  - St Louis, Missouri, Spojené státy, 63141
    - Mercy Hospital Saint Louis
  - Sullivan, Missouri, Spojené státy, 63080
    - Missouri Baptist Sullivan Hospital
- Montana
  - Billings, Montana, Spojené státy, 59101
    - Saint Vincent Healthcare
  - Bozeman, Montana, Spojené státy, 59715
    - Bozeman Health Deaconess Hospital
  - Butte, Montana, Spojené státy, 59701
    - Saint James Community Hospital and Cancer Treatment Center
  - Great Falls, Montana, Spojené státy, 59405
    - Benefis Sletten Cancer Institute
  - Helena, Montana, Spojené státy, 59601
    - Saint Peter's Community Hospital
  - Kalispell, Montana, Spojené státy, 59901
    - Logan Health Medical Center
  - Missoula, Montana, Spojené státy, 59802
    - Saint Patrick Hospital - Community Hospital
- Nebraska
  - Grand Island, Nebraska, Spojené státy, 68803
    - Nebraska Cancer Specialists/Oncology Hematology West PC
  - Kearney, Nebraska, Spojené státy, 68847
    - CHI Health Good Samaritan
  - Omaha, Nebraska, Spojené státy, 68124
    - Alegent Health Bergan Mercy Medical Center
  - Omaha, Nebraska, Spojené státy, 68122
    - Alegent Health Immanuel Medical Center
  - Omaha, Nebraska, Spojené státy, 68130
    - Alegent Health Lakeside Hospital
- New Hampshire
  - Dover, New Hampshire, Spojené státy, 03820
    - Wentworth-Douglass Hospital
  - Keene, New Hampshire, Spojené státy, 03431
    - Cheshire Medical Center-Dartmouth-Hitchcock Keene
  - Lebanon, New Hampshire, Spojené státy, 03756
    - Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
  - Manchester, New Hampshire, Spojené státy, 03104
    - Dartmouth Cancer Center - Manchester/ DCC Manchester
  - Nashua, New Hampshire, Spojené státy, 03060
    - Saint Joseph Hospital
  - Nashua, New Hampshire, Spojené státy, 03063
    - Dartmouth Cancer Center - Nashua
- New Jersey
  - Cape May Court House, New Jersey, Spojené státy, 08210
    - AtlantiCare Health Park-Cape May Court House
  - Egg Harbor, New Jersey, Spojené státy, 08234
    - AtlantiCare Surgery Center
  - Englewood, New Jersey, Spojené státy, 07631
    - Englewood Hospital and Medical Center
  - Hackensack, New Jersey, Spojené státy, 07601
    - Hackensack University Medical Center
  - Hamilton, New Jersey, Spojené státy, 08690
    - The Cancer Institute of New Jersey Hamilton
  - Long Branch, New Jersey, Spojené státy, 07740
    - Monmouth Medical Center
  - Mount Holly, New Jersey, Spojené státy, 08060
    - Virtua Memorial
  - Mullica Hill, New Jersey, Spojené státy, 08062
    - Inspira Medical Center Mullica Hill
  - Neptune City, New Jersey, Spojené státy, 07753
    - Jersey Shore Medical Center
  - Somerville, New Jersey, Spojené státy, 08876
    - Robert Wood Johnson University Hospital Somerset
  - Vineland, New Jersey, Spojené státy, 08360
    - Inspira Medical Center Vineland
  - Voorhees Township, New Jersey, Spojené státy, 08043
    - Virtua Voorhees
- New Mexico
  - Albuquerque, New Mexico, Spojené státy, 87109
    - New Mexico Oncology Hematology Consultants
  - Albuquerque, New Mexico, Spojené státy, 87106
    - University of New Mexico Cancer Center
  - Albuquerque, New Mexico, Spojené státy, 87110
    - Presbyterian Kaseman Hospital
  - Las Cruces, New Mexico, Spojené státy, 88011
    - Memorial Medical Center-Las Cruces
  - Santa Fe, New Mexico, Spojené státy, 87505
    - Christus Saint Vincent Regional Cancer Center
- New York
  - Auburn, New York, Spojené státy, 13021
    - Hematology Oncology Associates of Central New York-Auburn
  - Brooklyn, New York, Spojené státy, 11203
    - Kings County Hospital
  - Brooklyn, New York, Spojené státy, 11203
    - State University of New York Downstate Medical Center
  - Buffalo, New York, Spojené státy, 14263
    - Roswell Park Cancer Institute
  - Camillus, New York, Spojené státy, 13031
    - Hematology Oncology Associates of CNY at Camillus
  - East Syracuse, New York, Spojené státy, 13057
    - Hematology Oncology Associates of Central New York-East Syracuse
  - Elmira, New York, Spojené státy, 14905
    - Arnot Ogden Medical Center/Falck Cancer Center
  - New York, New York, Spojené státy, 10019
    - Mount Sinai West
  - New York, New York, Spojené státy, 10032
    - NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
  - New York, New York, Spojené státy, 10065
    - NYP/Weill Cornell Medical Center
  - New York, New York, Spojené státy, 10003
    - Mount Sinai Union Square
  - Rochester, New York, Spojené státy, 14642
    - University of Rochester
  - Staten Island, New York, Spojené státy, 10305
    - Staten Island University Hospital
  - The Bronx, New York, Spojené státy, 10461
    - Montefiore Medical Center-Einstein Campus
  - The Bronx, New York, Spojené státy, 10467
    - Montefiore Medical Center - Moses Campus
  - The Bronx, New York, Spojené státy, 10461
    - Montefiore Medical Center-Weiler Hospital
  - White Plains, New York, Spojené státy, 10601
    - Dickstein Cancer Treatment Center
- North Carolina
  - Asheboro, North Carolina, Spojené státy, 27203
    - Randolph Hospital
  - Asheville, North Carolina, Spojené státy, 28801
    - Mission Hospital
  - Asheville, North Carolina, Spojené státy, 28816
    - Hope Women's Cancer Centers-Asheville
  - Asheville, North Carolina, Spojené státy, 28806
    - Messino Cancer Centers
  - Burlington, North Carolina, Spojené státy, 27215
    - Cone Health Cancer Center at Alamance Regional
  - Chapel Hill, North Carolina, Spojené státy, 27599
    - UNC Lineberger Comprehensive Cancer Center
  - Clinton, North Carolina, Spojené státy, 28328
    - Southeastern Medical Oncology Center-Clinton
  - Goldsboro, North Carolina, Spojené státy, 27534
    - Southeastern Medical Oncology Center-Goldsboro
  - Goldsboro, North Carolina, Spojené státy, 27534
    - Wayne Memorial Hospital
  - Greensboro, North Carolina, Spojené státy, 27403
    - Cone Health Cancer Center
  - Hendersonville, North Carolina, Spojené státy, 28791
    - Margaret R Pardee Memorial Hospital
  - Jacksonville, North Carolina, Spojené státy, 28546
    - Southeastern Medical Oncology Center-Jacksonville
  - Kinston, North Carolina, Spojené státy, 28501
    - ECU Health Oncology Kinston
  - Mebane, North Carolina, Spojené státy, 27302
    - Cone Heath Cancer Center at Mebane
  - Reidsville, North Carolina, Spojené státy, 27320
    - Annie Penn Memorial Hospital
  - Washington, North Carolina, Spojené státy, 27889
    - Marion L Shepard Cancer Center - ECU Health Beaufort Hospital
  - Winston-Salem, North Carolina, Spojené státy, 27157
    - Wake Forest University Health Sciences
- North Dakota
  - Bismarck, North Dakota, Spojené státy, 58501
    - Sanford Bismarck Medical Center
  - Fargo, North Dakota, Spojené státy, 58122
    - Sanford Roger Maris Cancer Center
  - Fargo, North Dakota, Spojené státy, 58103
    - Essentia Health Cancer Center-South University Clinic
  - Fargo, North Dakota, Spojené státy, 58122
    - Sanford Broadway Medical Center
  - Grand Forks, North Dakota, Spojené státy, 58201
    - Altru Cancer Center
  - Minot, North Dakota, Spojené státy, 58701
    - Trinity Cancer Care Center
- Ohio
  - Akron, Ohio, Spojené státy, 44307
    - Cleveland Clinic Akron General
  - Akron, Ohio, Spojené státy, 44304
    - Summa Health System - Akron Campus
  - Belpre, Ohio, Spojené státy, 45714
    - Strecker Cancer Center-Belpre
  - Bowling Green, Ohio, Spojené státy, 43402
    - Toledo Clinic Cancer Centers-Bowling Green
  - Chillicothe, Ohio, Spojené státy, 45601
    - Adena Regional Medical Center
  - Cincinnati, Ohio, Spojené státy, 45220
    - Good Samaritan Hospital - Cincinnati
  - Cincinnati, Ohio, Spojené státy, 45242
    - Bethesda North Hospital
  - Cincinnati, Ohio, Spojené státy, 45242
    - Oncology Hematology Care Inc-Blue Ash
  - Cincinnati, Ohio, Spojené státy, 45202
    - Oncology Hematology Care Inc-Eden Park
  - Cincinnati, Ohio, Spojené státy, 45211
    - Oncology Hematology Care Inc-Mercy West
  - Cincinnati, Ohio, Spojené státy, 45230
    - Oncology Hematology Care Inc-Anderson
  - Cincinnati, Ohio, Spojené státy, 45236
    - Oncology Hematology Care Inc-Kenwood
  - Cincinnati, Ohio, Spojené státy, 45247
    - TriHealth Cancer Institute-Westside
  - Cincinnati, Ohio, Spojené státy, 45255
    - TriHealth Cancer Institute-Anderson
  - Cleveland, Ohio, Spojené státy, 44195
    - Cleveland Clinic Foundation
  - Cleveland, Ohio, Spojené státy, 44111
    - Cleveland Clinic Cancer Center/Fairview Hospital
  - Columbus, Ohio, Spojené státy, 43214
    - Riverside Methodist Hospital
  - Columbus, Ohio, Spojené státy, 43210
    - Ohio State University Comprehensive Cancer Center
  - Columbus, Ohio, Spojené státy, 43219
    - The Mark H Zangmeister Center
  - Columbus, Ohio, Spojené státy, 43214
    - Columbus Oncology and Hematology Associates Inc
  - Columbus, Ohio, Spojené státy, 43228
    - Doctors Hospital
  - Columbus, Ohio, Spojené státy, 43213
    - Mount Carmel East Hospital
  - Columbus, Ohio, Spojené státy, 43215
    - Grant Medical Center
  - Columbus, Ohio, Spojené státy, 43222
    - Mount Carmel Health Center West
  - Delaware, Ohio, Spojené státy, 43015
    - Delaware Health Center-Grady Cancer Center
  - Delaware, Ohio, Spojené státy, 43015
    - Delaware Radiation Oncology
  - Delaware, Ohio, Spojené státy, 43015
    - Grady Memorial Hospital
  - Fairfield, Ohio, Spojené státy, 45014
    - Oncology Hematology Care Inc-Healthplex
  - Independence, Ohio, Spojené státy, 44131
    - Cleveland Clinic Cancer Center Independence
  - Lancaster, Ohio, Spojené státy, 43130
    - Fairfield Medical Center
  - Lima, Ohio, Spojené státy, 45801
    - Saint Rita's Medical Center
  - Mansfield, Ohio, Spojené státy, 44906
    - Cleveland Clinic Cancer Center Mansfield
  - Marietta, Ohio, Spojené státy, 45750
    - Marietta Memorial Hospital
  - Marion, Ohio, Spojené státy, 43302
    - OhioHealth Marion General Hospital
  - Maumee, Ohio, Spojené státy, 43537
    - Toledo Clinic Cancer Centers-Maumee
  - Mayfield Heights, Ohio, Spojené státy, 44124
    - Hillcrest Hospital Cancer Center
  - Mount Vernon, Ohio, Spojené státy, 43050
    - Knox Community Hospital
  - Newark, Ohio, Spojené státy, 43055
    - Licking Memorial Hospital
  - Newark, Ohio, Spojené státy, 43055
    - Newark Radiation Oncology
  - Oregon, Ohio, Spojené státy, 43616
    - Saint Charles Hospital
  - Oregon, Ohio, Spojené státy, 43616
    - Toledo Clinic Cancer Centers-Oregon
  - Perrysburg, Ohio, Spojené státy, 43551
    - Mercy Health - Perrysburg Hospital
  - Portsmouth, Ohio, Spojené státy, 45662
    - Southern Ohio Medical Center
  - Sandusky, Ohio, Spojené státy, 44870
    - North Coast Cancer Care
  - Springfield, Ohio, Spojené státy, 45504
    - Springfield Regional Cancer Center
  - Springfield, Ohio, Spojené státy, 45504
    - Springfield Regional Medical Center
  - Strongsville, Ohio, Spojené státy, 44136
    - Cleveland Clinic Cancer Center Strongsville
  - Sylvania, Ohio, Spojené státy, 43560
    - ProMedica Flower Hospital
  - Toledo, Ohio, Spojené státy, 43623
    - Mercy Health - Saint Anne Hospital
  - Toledo, Ohio, Spojené státy, 43623
    - Toledo Clinic Cancer Centers-Toledo
  - Toledo, Ohio, Spojené státy, 43617
    - Toledo Community Hospital Oncology Program CCOP
  - Troy, Ohio, Spojené státy, 45373
    - Upper Valley Medical Center
  - Warrensville Heights, Ohio, Spojené státy, 44122
    - South Pointe Hospital
  - Westerville, Ohio, Spojené státy, 43081
    - Saint Ann's Hospital
  - Wooster, Ohio, Spojené státy, 44691
    - Cleveland Clinic Wooster Family Health and Surgery Center
  - Wright-Patterson Air Force Base, Ohio, Spojené státy, 45433
    - Wright-Patterson Medical Center
  - Zanesville, Ohio, Spojené státy, 43701
    - Genesis Healthcare System Cancer Care Center
- Oklahoma
  - Lawton, Oklahoma, Spojené státy, 73505
    - Cancer Centers of Southwest Oklahoma Research
  - Oklahoma City, Oklahoma, Spojené státy, 73104
    - University of Oklahoma Health Sciences Center
- Oregon
  - Bend, Oregon, Spojené státy, 97701
    - Saint Charles Health System
  - Clackamas, Oregon, Spojené státy, 97015
    - Providence Cancer Institute Clackamas Clinic
  - Coos Bay, Oregon, Spojené státy, 97420
    - Bay Area Hospital
  - Medford, Oregon, Spojené státy, 97504
    - Asante Rogue Regional Medical Center
  - Newberg, Oregon, Spojené státy, 97132
    - Providence Newberg Medical Center
  - Oregon City, Oregon, Spojené státy, 97045
    - Providence Willamette Falls Medical Center
  - Portland, Oregon, Spojené státy, 97213
    - Providence Portland Medical Center
  - Portland, Oregon, Spojené státy, 97225
    - Providence Saint Vincent Medical Center
- Pennsylvania
  - Bryn Mawr, Pennsylvania, Spojené státy, 19010
    - Bryn Mawr Hospital
  - Chadds Ford, Pennsylvania, Spojené státy, 19317
    - Christiana Care Health System-Concord Health Center
  - Danville, Pennsylvania, Spojené státy, 17822
    - Geisinger Medical Center
  - Doylestown, Pennsylvania, Spojené státy, 18901
    - Doylestown Hospital
  - Harrisburg, Pennsylvania, Spojené státy, 17109
    - UPMC Pinnacle Cancer Center/Community Osteopathic Campus
  - Hazleton, Pennsylvania, Spojené státy, 18201
    - Geisinger Medical Center-Cancer Center Hazleton
  - Hershey, Pennsylvania, Spojené státy, 17033-0850
    - Penn State Milton S Hershey Medical Center
  - Jefferson Hills, Pennsylvania, Spojené státy, 15025
    - Jefferson Hospital
  - Lancaster, Pennsylvania, Spojené státy, 17602
    - Lancaster General Hospital
  - Lewisburg, Pennsylvania, Spojené státy, 17837
    - Geisinger Medical Oncology-Lewisburg
  - Lewistown, Pennsylvania, Spojené státy, 17044
    - Lewistown Hospital
  - Media, Pennsylvania, Spojené státy, 19063
    - Riddle Memorial Hospital
  - Monroeville, Pennsylvania, Spojené státy, 15146
    - Forbes Hospital
  - Natrona Heights, Pennsylvania, Spojené státy, 15065
    - Allegheny Valley Hospital
  - Paoli, Pennsylvania, Spojené státy, 19301
    - Paoli Memorial Hospital
  - Philadelphia, Pennsylvania, Spojené státy, 19111
    - Fox Chase Cancer Center
  - Philadelphia, Pennsylvania, Spojené státy, 19140
    - Temple University Hospital
  - Philadelphia, Pennsylvania, Spojené státy, 19141
    - Einstein Medical Center Philadelphia
  - Phoenixville, Pennsylvania, Spojené státy, 19460
    - Reading Hospital McGlinn Cancer Institute at Phoenixville
  - Pittsburgh, Pennsylvania, Spojené státy, 15212
    - Allegheny General Hospital
  - Pittsburgh, Pennsylvania, Spojené státy, 15224
    - West Penn Hospital
  - Pittsburgh, Pennsylvania, Spojené státy, 15232
    - UPMC Hillman Cancer Center
  - Pottsville, Pennsylvania, Spojené státy, 17901
    - Geisinger Cancer Services-Pottsville
  - Reading, Pennsylvania, Spojené státy, 19605
    - Penn State Health Saint Joseph Medical Center
  - Sayre, Pennsylvania, Spojené státy, 18840
    - Guthrie Medical Group PC-Robert Packer Hospital
  - State College, Pennsylvania, Spojené státy, 16801
    - Geisinger Medical Group
  - State College, Pennsylvania, Spojené státy, 16803
    - Mount Nittany Medical Center
  - West Chester, Pennsylvania, Spojené státy, 19380
    - Chester County Hospital
  - West Reading, Pennsylvania, Spojené státy, 19611
    - Reading Hospital
  - Wexford, Pennsylvania, Spojené státy, 15090
    - Wexford Health and Wellness Pavilion
  - Wilkes-Barre, Pennsylvania, Spojené státy, 18711
    - Geisinger Wyoming Valley/Henry Cancer Center
  - Williamsport, Pennsylvania, Spojené státy, 17701
    - UPMC Susquehanna
  - Wynnewood, Pennsylvania, Spojené státy, 19096
    - Lankenau Medical Center
- Rhode Island
  - Providence, Rhode Island, Spojené státy, 02905
    - Women and Infants Hospital
- South Carolina
  - Anderson, South Carolina, Spojené státy, 29621
    - AnMed Health Cancer Center
  - Boiling Springs, South Carolina, Spojené státy, 29316
    - Prisma Health Cancer Institute - Spartanburg
  - Charleston, South Carolina, Spojené státy, 29425
    - Medical University of South Carolina
  - Easley, South Carolina, Spojené státy, 29640
    - Prisma Health Cancer Institute - Easley
  - Gaffney, South Carolina, Spojené státy, 29341
    - Gibbs Cancer Center-Gaffney
  - Greenville, South Carolina, Spojené státy, 29605
    - Prisma Health Cancer Institute - Faris
  - Greenville, South Carolina, Spojené státy, 29607
    - Saint Francis Cancer Center
  - Greenville, South Carolina, Spojené státy, 29615
    - Prisma Health Cancer Institute - Eastside
  - Greenville, South Carolina, Spojené státy, 29605
    - Prisma Health Cancer Institute - Butternut
  - Greenville, South Carolina, Spojené státy, 29601
    - Saint Francis Hospital
  - Greer, South Carolina, Spojené státy, 29650
    - Prisma Health Cancer Institute - Greer
  - Greer, South Carolina, Spojené státy, 29651
    - Gibbs Cancer Center-Pelham
  - Seneca, South Carolina, Spojené státy, 29672
    - Prisma Health Cancer Institute - Seneca
  - Spartanburg, South Carolina, Spojené státy, 29303
    - Spartanburg Medical Center
- South Dakota
  - Aberdeen, South Dakota, Spojené státy, 57401
    - Avera Cancer Institute-Aberdeen
  - Rapid City, South Dakota, Spojené státy, 57701
    - Rapid City Regional Hospital
  - Sioux Falls, South Dakota, Spojené státy, 57105
    - Avera Cancer Institute
  - Sioux Falls, South Dakota, Spojené státy, 57117-5134
    - Sanford USD Medical Center - Sioux Falls
  - Sioux Falls, South Dakota, Spojené státy, 57104
    - Sanford Cancer Center Oncology Clinic
- Tennessee
  - Jackson, Tennessee, Spojené státy, 38301
    - Jackson-Madison County General Hospital
  - Kingsport, Tennessee, Spojené státy, 37660
    - Ballad Health Cancer Care - Kingsport
  - Kingsport, Tennessee, Spojené státy, 37660
    - Wellmont Holston Valley Hospital and Medical Center
  - Memphis, Tennessee, Spojené státy, 38120
    - Baptist Memorial Hospital and Cancer Center-Memphis
  - Memphis, Tennessee, Spojené státy, 38120
    - Baptist Memorial Hospital for Women
  - Memphis, Tennessee, Spojené státy, 38120
    - Family Cancer Center-Memphis
  - Nashville, Tennessee, Spojené státy, 37208
    - Meharry Medical College
- Texas
  - Abilene, Texas, Spojené státy, 79601
    - Hendrick Medical Center
  - Dallas, Texas, Spojené státy, 75235
    - Parkland Memorial Hospital
  - Dallas, Texas, Spojené státy, 75390
    - UT Southwestern/Simmons Cancer Center-Dallas
  - El Paso, Texas, Spojené státy, 79905
    - Texas Tech University Health Sciences Center-El Paso
  - Fort Worth, Texas, Spojené státy, 76104
    - UT Southwestern/Simmons Cancer Center-Fort Worth
  - Tyler, Texas, Spojené státy, 75708
    - University of Texas Health Science Center at Tyler
- Vermont
  - Saint Johnsbury, Vermont, Spojené státy, 05819
    - Dartmouth Cancer Center - North
- Virginia
  - Charlottesville, Virginia, Spojené státy, 22908
    - University of Virginia Cancer Center
  - Fredericksburg, Virginia, Spojené státy, 22408
    - Hematology Oncology Associates of Fredericksburg Inc
  - Lynchburg, Virginia, Spojené státy, 24501
    - Centra Alan B Pearson Regional Cancer Center
  - Martinsville, Virginia, Spojené státy, 24112
    - Sovah Health Martinsville
  - Mechanicsville, Virginia, Spojené státy, 23116
    - Bon Secours Memorial Regional Medical Center
  - Midlothian, Virginia, Spojené státy, 23114
    - Bon Secours Saint Francis Medical Center
  - Norton, Virginia, Spojené státy, 24273
    - Ballad Health Cancer Care - Norton
  - Richmond, Virginia, Spojené státy, 23229
    - Virginia Cancer Institute
  - Richmond, Virginia, Spojené státy, 23226
    - Bon Secours Saint Mary's Hospital
  - Richmond, Virginia, Spojené státy, 23298
    - VCU Massey Comprehensive Cancer Center
  - South Hill, Virginia, Spojené státy, 23970
    - VCU Community Memorial Health Center
  - Winchester, Virginia, Spojené státy, 22601
    - Shenandoah Oncology PC
- Washington
  - Burien, Washington, Spojené státy, 98166
    - Saint Anne Hospital
  - Edmonds, Washington, Spojené státy, 98026
    - Swedish Cancer Institute-Edmonds
  - Issaquah, Washington, Spojené státy, 98029
    - Swedish Cancer Institute-Issaquah
  - Kennewick, Washington, Spojené státy, 99336
    - Kadlec Clinic Hematology and Oncology
  - Kirkland, Washington, Spojené státy, 98034
    - FHCC at EvergreenHealth
  - Longview, Washington, Spojené státy, 98632
    - PeaceHealth Saint John Medical Center
  - Mount Vernon, Washington, Spojené státy, 98274
    - Skagit Valley Hospital
  - Mount Vernon, Washington, Spojené státy, 98274
    - Skagit Regional Health Cancer Care Center
  - Poulsbo, Washington, Spojené státy, 98370
    - Harrison HealthPartners Hematology and Oncology-Poulsbo
  - Seattle, Washington, Spojené státy, 98107
    - Swedish Medical Center-Ballard Campus
  - Seattle, Washington, Spojené státy, 98122
    - Swedish Medical Center-First Hill
  - Seattle, Washington, Spojené státy, 98195
    - University of Washington Medical Center - Montlake
  - Seattle, Washington, Spojené státy, 98112
    - Kaiser Permanente Washington
  - Seattle, Washington, Spojené státy, 98104
    - Minor and James Medical PLLC
  - Seattle, Washington, Spojené státy, 98109
    - Fred Hutchinson Cancer Center
  - Silverdale, Washington, Spojené státy, 98383
    - Saint Joseph Medical Center Hematology and Oncology - Silverdale
  - Tacoma, Washington, Spojené státy, 98405
    - Northwest Medical Specialties PLLC
  - Tacoma, Washington, Spojené státy, 98405
    - Franciscan Research Center-Northwest Medical Plaza
  - Vancouver, Washington, Spojené státy, 98664
    - PeaceHealth Southwest Medical Center
  - Walla Walla, Washington, Spojené státy, 99362
    - Providence Saint Mary Regional Cancer Center
  - Yakima, Washington, Spojené státy, 98902
    - North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
- West Virginia
  - Charleston, West Virginia, Spojené státy, 25304
    - Vandalia Health/CAMC Institute for Academic Medicine
  - Huntington, West Virginia, Spojené státy, 25701
    - Edwards Comprehensive Cancer Center
  - Morgantown, West Virginia, Spojené státy, 26506
    - West Virginia University Healthcare
- Wisconsin
  - Antigo, Wisconsin, Spojené státy, 54409
    - Aspirus Cancer Care-Antigo-Volm Cancer Center
  - Burlington, Wisconsin, Spojené státy, 53105
    - Aurora Cancer Care-Southern Lakes VLCC
  - Chippewa Falls, Wisconsin, Spojené státy, 54729
    - Marshfield Clinic-Chippewa Center
  - Eau Claire, Wisconsin, Spojené státy, 54701
    - Marshfield Clinic Cancer Center at Sacred Heart
  - Fond du Lac, Wisconsin, Spojené státy, 54937
    - Aurora Health Center-Fond du Lac
  - Germantown, Wisconsin, Spojené státy, 53022
    - Aurora Health Care Germantown Health Center
  - Grafton, Wisconsin, Spojené státy, 53024
    - Aurora Cancer Care-Grafton
  - Green Bay, Wisconsin, Spojené státy, 54311
    - Aurora BayCare Medical Center
  - Green Bay, Wisconsin, Spojené státy, 54301
    - Saint Vincent Hospital Cancer Center Green Bay
  - Green Bay, Wisconsin, Spojené státy, 54303
    - Saint Vincent Hospital Cancer Center at Saint Mary's
  - Green Bay, Wisconsin, Spojené státy, 54301
    - Bellin Memorial Hospital
  - Janesville, Wisconsin, Spojené státy, 53548
    - Mercyhealth Hospital and Cancer Center - Janesville
  - Johnson Creek, Wisconsin, Spojené státy, 53038
    - University of Wisconsin Carbone Cancer Center - Johnson Creek
  - Kenosha, Wisconsin, Spojené státy, 53142
    - Aurora Cancer Care-Kenosha South
  - La Crosse, Wisconsin, Spojené státy, 54601
    - Gundersen Lutheran Medical Center
  - Madison, Wisconsin, Spojené státy, 53792
    - University of Wisconsin Carbone Cancer Center - University Hospital
  - Manitowoc, Wisconsin, Spojené státy, 54221
    - Holy Family Memorial Hospital
  - Marinette, Wisconsin, Spojené státy, 54143
    - Aurora Bay Area Medical Group-Marinette
  - Marinette, Wisconsin, Spojené státy, 54143
    - Saint Vincent Hospital Cancer Center at Marinette
  - Marshfield, Wisconsin, Spojené státy, 54449
    - Marshfield Medical Center-Marshfield
  - Milwaukee, Wisconsin, Spojené státy, 53209
    - Aurora Cancer Care-Milwaukee
  - Milwaukee, Wisconsin, Spojené státy, 53215
    - Aurora Saint Luke's Medical Center
  - Milwaukee, Wisconsin, Spojené státy, 53233
    - Aurora Sinai Medical Center
  - Minocqua, Wisconsin, Spojené státy, 54548
    - Marshfield Medical Center - Minocqua
  - Mukwonago, Wisconsin, Spojené státy, 53149
    - ProHealth D N Greenwald Center
  - New Richmond, Wisconsin, Spojené státy, 54017
    - Cancer Center of Western Wisconsin
  - Oconomowoc, Wisconsin, Spojené státy, 53066
    - ProHealth Oconomowoc Memorial Hospital
  - Oconto Falls, Wisconsin, Spojené státy, 54154
    - Saint Vincent Hospital Cancer Center at Oconto Falls
  - Oshkosh, Wisconsin, Spojené státy, 54904
    - Vince Lombardi Cancer Clinic - Oshkosh
  - Racine, Wisconsin, Spojené státy, 53406
    - Aurora Cancer Care-Racine
  - Racine, Wisconsin, Spojené státy, 53405
    - Ascension All Saints Hospital-Spring Street-Racine
  - Rhinelander, Wisconsin, Spojené státy, 54501
    - Aspirus Cancer Care-Rhinelander-James Beck Cancer Center
  - Rice Lake, Wisconsin, Spojené státy, 54868
    - Marshfield Medical Center-Rice Lake
  - Sheboygan, Wisconsin, Spojené státy, 53081
    - Vince Lombardi Cancer Clinic-Sheboygan
  - Sheboygan, Wisconsin, Spojené státy, 53081
    - HSHS Saint Nicholas Hospital
  - Stevens Point, Wisconsin, Spojené státy, 54482
    - Marshfield Medical Center-River Region at Stevens Point
  - Stevens Point, Wisconsin, Spojené státy, 54481
    - Aspirus Cancer Care - Stevens Point
  - Sturgeon Bay, Wisconsin, Spojené státy, 54235-1495
    - Saint Vincent Hospital Cancer Center at Sturgeon Bay
  - Summit, Wisconsin, Spojené státy, 53066
    - Aurora Medical Center in Summit
  - Two Rivers, Wisconsin, Spojené státy, 54241
    - Vince Lombardi Cancer Clinic-Two Rivers
  - Waukesha, Wisconsin, Spojené státy, 53188
    - UW Cancer Center at ProHealth Care
  - Waukesha, Wisconsin, Spojené státy, 53188
    - ProHealth Waukesha Memorial Hospital
  - Waukesha, Wisconsin, Spojené státy, 53188
    - Aurora Cancer Care-Waukesha
  - Wausau, Wisconsin, Spojené státy, 54401
    - Marshfield Clinic-Wausau Center
  - Wausau, Wisconsin, Spojené státy, 54401
    - Aspirus Cancer Care-Wausau
  - Wauwatosa, Wisconsin, Spojené státy, 53226
    - Aurora Cancer Care-Milwaukee West
  - West Allis, Wisconsin, Spojené státy, 53227
    - Aurora West Allis Medical Center
  - Weston, Wisconsin, Spojené státy, 54476
    - Marshfield Medical Center - Weston
  - Wisconsin Rapids, Wisconsin, Spojené státy, 54494
    - Aspirus Cancer Care - Wisconsin Rapids
  - Wisconsin Rapids, Wisconsin, Spojené státy, 54494
    - Marshfield Clinic - Wisconsin Rapids Center
- Wyoming
  - Cheyenne, Wyoming, Spojené státy, 82001
    - Cheyenne Regional Medical Center-West

Kritéria účasti

Výzkumníci hledají lidi, kteří odpovídají určitému popisu, kterému se říká kritéria způsobilosti. Některé příklady těchto kritérií jsou celkový zdravotní stav osoby nebo předchozí léčba.

Kritéria způsobilosti

Věk způsobilý ke studiu

18 let a starší (Dospělý, Starší dospělý)

Přijímá zdravé dobrovolníky

Pohlaví způsobilá ke studiu

Všechno

Popis

Inclusion Criteria:

Estrogen receptor (ER) and/or progesterone receptor (PR) positive histologically confirmed adenocarcinoma of the breast with staining of >= 1% cells will be considered positive; receptor status may be based on any time during treatment prior to study randomization, and from any site (i.e. primary, recurrent, or metastatic)
Patients whose tumors have HER2 immunohistochemistry (IHC) 3+, in situ hybridization (ISH) >= 2.0, or average HER2 copy number >= 6.0 signals per cell are not eligible; receptor status may be based on any time during treatment prior to study randomization, and from any site (i.e. primary, recurrent, or metastatic)
Patients must have measurable or non-measurable stage III/locally advanced or metastatic carcinoma of the breast where local therapy with curative intent is not possible; lesions must be evaluated =< 4 weeks prior to study randomization; diagnostic-quality computed tomography (CT) scans with both oral and intravenous (IV) contrast are the expected radiologic method, unless an alternative is approved
- NOTE: Where baseline imaging has already been performed =< 6 weeks prior to study randomization, repeat imaging may not be required
- NOTE: As of October 16, 2016, accrual of new patients having non-measurable disease has stopped; the planned accrual for this target population has been reached
Pre/peri- and postmenopausal women and all men are eligible for this trial; postmenopausal is defined as:
- Age >= 55 years and one year or more of amenorrhea
- Age < 55 years and one year or more of amenorrhea, with estradiol < 20 pg/ml
- Age < 55 with prior hysterectomy but intact ovaries, with estradiol < 20 pg/ml
- Prior bilateral oophorectomy
  - NOTE: Women who do not fit the criteria for being postmenopausal as above are deemed pre-or peri-menopausal; pre/perimenopausal women and all men can enroll provided they agree to receive concomitant luteinizing hormone-releasing hormone (LHRH) agonist; pre/perimenopausal women must have commenced treatment with LHRH agonist at least 4 weeks prior to randomization; if patients have received alternative LHRH agonist prior to study entry, they must switch to goserelin for the duration of the trial
Sexually active males and pre/perimenopausal women must agree to use an accepted and effective method of contraception or to abstain from sexual intercourse for the duration of their participation in the study and for 3 months after discontinuation of therapy
Women must not be pregnant or breast-feeding; all females of childbearing potential must have a blood test or urine study =< 2 weeks prior to randomization
- A female of childbearing potential is any woman, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria: 1) has not undergone a hysterectomy or bilateral oophorectomy; or 2) has not been naturally postmenopausal for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months)
Patients must not have known central nervous system metastasis or a history of central nervous system (CNS) metastases; patients with leptomeningeal disease are not eligible
Patients must be disease-free of prior invasive malignancies for > 5 years with the exception of curatively-treated basal cell or squamous cell carcinoma of the skin or carcinoma in situ of the cervix
- NOTE: If there is a history of prior malignancy, patients must not be receiving other specific treatment for that cancer
Patients must meet at least one of the following criteria:
- Disease progression any time after non-steroidal AI use in the advanced disease setting
- Relapse while on or within =< 12 months of end of adjuvant non-steroidal AI therapy with or without prior endocrine therapy for advanced disease
- NOTE: In either setting, treatment with any prior endocrine therapy must be completed >= 2 weeks prior to cycle 1 day 1 (C1D1) of study treatment with the exception of exemestane which is permitted in the advanced disease setting within =< 4 weeks immediately prior to C1D1; prior adjuvant exemestane is allowed if the disease free interval is > 12 months from the discontinuation of exemestane; prior faslodex, everolimus, palbociclib or other cyclin-dependent kinase (CDK) inhibitor (e.g. ribociclib, abemaciclib) use are allowed and must have been completed >= 2 weeks prior to C1D1; failure to adhere to this washout guideline will result in a protocol violation
Patients may have received only one prior chemotherapy regimen for metastatic disease provided treatment was completed >= 3 weeks prior to randomization
Patients may be treated with bone modifying agents such as bisphosphonates or RANK-ligand agents (e.g. denosumab) per American Society of Clinical Oncology (ASCO) guidelines; whenever possible, patients requiring bone modifying agents should start treatment >= 7 days prior to study therapy and should continue the same agent throughout study unless clinically compelled to change
Prior radiotherapy must in general have been completed >= 2 weeks prior to randomization and patients must have recovered from the toxicity of the radiation
- NOTE: Patients may receive concurrent radiation therapy to painful sites of bony disease or areas of impending fracture as long as sites of measurable or non-measurable disease outside the radiation therapy port are available to follow
Patients must NOT receive concurrent anti-cancer therapy or investigational agent unless specified in protocol
Patients must NOT be receiving valproic acid, an histone deacetylase (HDAC) inhibitor, and may not have previously received any HDAC inhibitor prior to enrollment (e.g. valproic acid, entinostat, vorinostat) unless discussed with the study chair; patients must not have received prior HDAC therapy for the treatment of their malignancy
Patients must have no known allergies to exemestane, entinostat, or medications that have a benzamide structure (e.g., tiapride, remoxipride, clebropride)
Patients must NOT suffer from medical or psychiatric conditions that would interfere with protocol compliance, the ability to provide informed consent, or assessment of response or anticipated toxicities; this includes uncontrolled intercurrent illness including, but not limited to ongoing or active infection
Patients must have recovered from all clinically relevant adverse events to grade 1 or baseline due to previous agents administered (except alopecia)
Patients must have adequate hematologic, liver and renal function =< 28 days prior to randomization
- NOTE: It is preferred that laboratory values for eligibility be assessed after the last dose of prior treatment, especially in cases where most-recent treatment prior to study entry is chemotherapy
Hemoglobin (HgB) >= 9.0 g/dL (=< 28 days prior to randomization)
Platelet count >= 100,000/mcL (=< 28 days prior to randomization)
Absolute neutrophil count >= 1,500/mcL (=< 28 days prior to randomization)
Creatinine =< 2.0 mg/dL (=< 28 days prior to randomization)
Total bilirubin < 1.5 x institutional upper limit of normal (=< 3 mg/dL in case of Gilbert's syndrome) (=< 28 days prior to randomization)
Transaminases (alanine aminotransferase [ALT], aspartate aminotransferase [AST]) =< 2.5 x institutional upper limit normal (=< 28 days prior to randomization)
Known human immunodeficiency virus (HIV)-positive patients should have a cluster of differentiation (CD)4 count > 250/mm^3
Patients must have Eastern Cooperative Oncology Group (ECOG) performance status 0-1
Patients must have a life expectancy >= 12 weeks
Patients must be able to swallow tablets

Studijní plán

Tato část poskytuje podrobnosti o studijním plánu, včetně toho, jak je studie navržena a co studie měří.

Jak je studie koncipována?

Detaily designu

Primární účel: Léčba
Přidělení: Randomizované
Intervenční model: Paralelní přiřazení
Maskování: Dvojnásobek

Zbraně a zásahy

Skupina účastníků / Arm Skupina účastníků / Arm Skupina nebo podskupina účastníků klinické studie, která podle protokolu studie dostává konkrétní intervenci/léčbu nebo žádnou intervenci.	Intervence / Léčba Intervence / Léčba Proces nebo akce, na které se klinická studie zaměřuje. Intervence zahrnují léky, zdravotnická zařízení, postupy, vakcíny a další produkty, které jsou buď zkoušené nebo již dostupné. Intervence mohou také zahrnovat neinvazivní přístupy, jako je edukace nebo úprava stravy a cvičení.
Experimentální: Arm A (exemestane, entinostat) Patients receive exemestane PO QD on days 1-28 and entinostat PO on days 1, 8, 15, and 22. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients also undergo CT or MRI at baseline, at the end of cycle 3, every 3 cycles, at treatment discontinuation, and during follow-up, collection of blood samples at baseline and day 15 of cycle 1, and collection of archived tissue at baseline. Pre/perimenopausal female patients and all male patients also receive goserelin acetate SC on day 1.	Lék: Exemestane Given PO Ostatní jména: Aromasin FCE-24304 Jiný: Quality-of-Life Assessment Ancillary studies Ostatní jména: Hodnocení kvality života Postup: Computed Tomography Undergo CT Ostatní jména: ČT KOČKA CAT skenování Počítačová axiální tomografie Počítačová tomografie CT vyšetření tomografie Počítačová axiální tomografie (postup) Počítačová tomografie (CT). Diagnostické skenování CAT Typ služby diagnostického skenování CAT Postup: Magnetic Resonance Imaging Undergo MRI Ostatní jména: MRI Magnetická rezonance Skenování magnetickou rezonancí Lékařské zobrazování, magnetická rezonance / nukleární magnetická rezonance PAN MR zobrazování MRI skenování NMR zobrazování NMRI Nukleární magnetická rezonance Zobrazování magnetickou rezonancí (MRI) sMRI Magnetická rezonance (postup) Strukturální MRI Lék: Goserelin Acetate Given SC Ostatní jména: ZDX Zoladex Postup: Biospecimen Collection Undergo collection of blood and archived tissue samples Ostatní jména: Sběr biologických vzorků Odebrán biovzorek Sbírka vzorků Lék: Entinostat Given PO Ostatní jména: HDAC inhibitor SNDX-275 MS 27-275 MS-275 SNDX-275 MS275 MS 275 SNDX 275 SNDX275 Lék: Goserelin Given PO Ostatní jména: ICI-118630
Komparátor placeba: Arm B (exemestane, placebo) Patients receive exemestane as in Arm A and placebo PO on days 1, 8, 15, and 22. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients also undergo CT or MRI at baseline, at the end of cycle 3, every 3 cycles, at treatment discontinuation, and during follow-up, collection of blood samples at baseline and day 15 of cycle 1, and collection of archived tissue at baseline. Pre/perimenopausal female patients and all male patients also receive goserelin acetate SC on day 1.	Lék: Exemestane Given PO Ostatní jména: Aromasin FCE-24304 Jiný: Quality-of-Life Assessment Ancillary studies Ostatní jména: Hodnocení kvality života Postup: Computed Tomography Undergo CT Ostatní jména: ČT KOČKA CAT skenování Počítačová axiální tomografie Počítačová tomografie CT vyšetření tomografie Počítačová axiální tomografie (postup) Počítačová tomografie (CT). Diagnostické skenování CAT Typ služby diagnostického skenování CAT Postup: Magnetic Resonance Imaging Undergo MRI Ostatní jména: MRI Magnetická rezonance Skenování magnetickou rezonancí Lékařské zobrazování, magnetická rezonance / nukleární magnetická rezonance PAN MR zobrazování MRI skenování NMR zobrazování NMRI Nukleární magnetická rezonance Zobrazování magnetickou rezonancí (MRI) sMRI Magnetická rezonance (postup) Strukturální MRI Jiný: Placebo Administration Given PO Lék: Goserelin Acetate Given SC Ostatní jména: ZDX Zoladex Postup: Biospecimen Collection Undergo collection of blood and archived tissue samples Ostatní jména: Sběr biologických vzorků Odebrán biovzorek Sbírka vzorků Lék: Goserelin Given PO Ostatní jména: ICI-118630

Skupina účastníků / Arm

Intervence / Léčba

Experimentální: Arm A (exemestane, entinostat)

Patients receive exemestane PO QD on days 1-28 and entinostat PO on days 1, 8, 15, and 22. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients also undergo CT or MRI at baseline, at the end of cycle 3, every 3 cycles, at treatment discontinuation, and during follow-up, collection of blood samples at baseline and day 15 of cycle 1, and collection of archived tissue at baseline.

Pre/perimenopausal female patients and all male patients also receive goserelin acetate SC on day 1.

Lék: Exemestane

Given PO

Ostatní jména:

Aromasin
FCE-24304

Jiný: Quality-of-Life Assessment

Ancillary studies

Ostatní jména:

Hodnocení kvality života

Postup: Computed Tomography

Undergo CT

Ostatní jména:

ČT
KOČKA
CAT skenování
Počítačová axiální tomografie
Počítačová tomografie
CT vyšetření
tomografie
Počítačová axiální tomografie (postup)
Počítačová tomografie (CT).
Diagnostické skenování CAT
Typ služby diagnostického skenování CAT

Postup: Magnetic Resonance Imaging

Undergo MRI

Ostatní jména:

MRI
Magnetická rezonance
Skenování magnetickou rezonancí
Lékařské zobrazování, magnetická rezonance / nukleární magnetická rezonance
PAN
MR zobrazování
MRI skenování
NMR zobrazování
NMRI
Nukleární magnetická rezonance
Zobrazování magnetickou rezonancí (MRI)
sMRI
Magnetická rezonance (postup)
Strukturální MRI

Lék: Goserelin Acetate

Given SC

Ostatní jména:

ZDX
Zoladex

Postup: Biospecimen Collection

Undergo collection of blood and archived tissue samples

Ostatní jména:

Sběr biologických vzorků
Odebrán biovzorek
Sbírka vzorků

Lék: Entinostat

Given PO

Ostatní jména:

HDAC inhibitor SNDX-275
MS 27-275
MS-275
SNDX-275
MS275
MS 275
SNDX 275
SNDX275

Lék: Goserelin

Given PO

Ostatní jména:

ICI-118630

Komparátor placeba: Arm B (exemestane, placebo)

Patients receive exemestane as in Arm A and placebo PO on days 1, 8, 15, and 22. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients also undergo CT or MRI at baseline, at the end of cycle 3, every 3 cycles, at treatment discontinuation, and during follow-up, collection of blood samples at baseline and day 15 of cycle 1, and collection of archived tissue at baseline.

Pre/perimenopausal female patients and all male patients also receive goserelin acetate SC on day 1.

Lék: Exemestane

Given PO

Ostatní jména:

Aromasin
FCE-24304

Jiný: Quality-of-Life Assessment

Ancillary studies

Ostatní jména:

Hodnocení kvality života

Postup: Computed Tomography

Undergo CT

Ostatní jména:

ČT
KOČKA
CAT skenování
Počítačová axiální tomografie
Počítačová tomografie
CT vyšetření
tomografie
Počítačová axiální tomografie (postup)
Počítačová tomografie (CT).
Diagnostické skenování CAT
Typ služby diagnostického skenování CAT

Postup: Magnetic Resonance Imaging

Undergo MRI

Ostatní jména:

MRI
Magnetická rezonance
Skenování magnetickou rezonancí
Lékařské zobrazování, magnetická rezonance / nukleární magnetická rezonance
PAN
MR zobrazování
MRI skenování
NMR zobrazování
NMRI
Nukleární magnetická rezonance
Zobrazování magnetickou rezonancí (MRI)
sMRI
Magnetická rezonance (postup)
Strukturální MRI

Jiný: Placebo Administration

Given PO

Lék: Goserelin Acetate

Given SC

Ostatní jména:

ZDX
Zoladex

Postup: Biospecimen Collection

Undergo collection of blood and archived tissue samples

Ostatní jména:

Sběr biologických vzorků
Odebrán biovzorek
Sbírka vzorků

Lék: Goserelin

Given PO

Ostatní jména:

ICI-118630

Co je měření studie?

Primární výstupní opatření

Měření výsledku	Popis opatření	Časové okno
Progression-free Survival (PFS) Časové okno: Assessed at baseline, then every 12 weeks until treatment discontinuation, then every 3 months within 2 years from study entry, every 6 months between 2-5 years and annually between 6-10 years from study entry, until first disease progression	Progression-free survival (PFS) was defined to be time from randomization to the earliest documented disease progression as defined by the RECIST criteria, new primary breast cancer, or death without progression. Disease assessment was to continue until disease progression, even after non-protocol anti-cancer therapy was started. Cases with incomplete follow up or without adequate disease evaluations were censored at the date last documented to be free of progression, regardless of whether non-protocol anti-cancer therapy was started or not. Disease progression was based on central review, and defined as at least a 20% increase in the sum of the diameters of target lesions, taking as reference the smallest sum on study. In addition to the relative increase of 20%, the sum must also demonstrate an absolute increase of at least 5 mm. In addition, the appearance of one or more new lesions was also considered progression. Kaplan-Meier method was used to estimate PFS rate.	Assessed at baseline, then every 12 weeks until treatment discontinuation, then every 3 months within 2 years from study entry, every 6 months between 2-5 years and annually between 6-10 years from study entry, until first disease progression
Overall Survival (OS) Časové okno: Assessed every 3 months within 2 years from study entry, every 6 months between 2-5 years and annually between 6-10 years from study entry, until death	Overall survival (OS) was defined to be time from randomization to death from any cause. Cases who were still alive were censored at the date last known alive.	Assessed every 3 months within 2 years from study entry, every 6 months between 2-5 years and annually between 6-10 years from study entry, until death

Sekundární výstupní opatření

Měření výsledku	Popis opatření	Časové okno
Objective Response Rate (ORR) Časové okno: Assessed at baseline, then every 12 weeks until treatment discontinuation, then every 3 months within 2 years from study entry, every 6 months between 2-5 years and annually between 6-10 years from study entry, until first disease progression	Objective response rate was defined as number of patients with complete response (CR) or partial response (PR) divided by all randomized patients. Responses were evaluated using the revised Response Evaluation Criteria in Solid Tumors (RECIST) guideline. CR was defined as disappearance of all target and non-target lesions. PR was defined as at least a 30% decrease in the sum of the diameters of target lesions (taking as reference the baseline sum diameters), and/or persistence of one or more non-target lesion(s).	Assessed at baseline, then every 12 weeks until treatment discontinuation, then every 3 months within 2 years from study entry, every 6 months between 2-5 years and annually between 6-10 years from study entry, until first disease progression
Time-to-treatment Deterioration (TTD) Časové okno: Disease assessed at baseline, then every 12 weeks until treatment discontinuation, then every 3 months within 2 years from study entry, every 6 months between 2-5 years and annually between 6-10 years from study entry, until first disease progression	Time-to-treatment deterioration (TTD) was defined as time from randomization to disease progression or death or worsening of symptoms, whichever occurred first. Disease progression was assessed per RECIST v1.1. Symptoms deterioration was measured by 6 items (GP1, GP2, GP4, GF7, B1, P2, scored 0-24) from the 8-item FACT-Breast Symptom Index (FBSI). Symptom deterioration was defined as two consecutive available decreases of at least 3 points from baseline using the 6-item FBSI in this trial, and the second visit time was used as the time of symptom deterioration in this case, unless it was the final score, for which one decrease was sufficient. Kaplan-Meier method was used to estimate the median TTD and TTD rate at a certain time point. Symptoms were assessed every cycle for the first six months after randomization, every two cycles between 6 months and 1 year. It then were assessed based on the same schedule for tumor assessments until disease progression as specified below.	Disease assessed at baseline, then every 12 weeks until treatment discontinuation, then every 3 months within 2 years from study entry, every 6 months between 2-5 years and annually between 6-10 years from study entry, until first disease progression
Lysine Acetylation Change in CD45 Blood Mononuclear Cells Between C1D1 and C1D15 and PFS in Patients on Arm A Časové okno: Disease assessed at baseline, then every 12 weeks until treatment discontinuation, then every 3 months within 2 years from study entry, every 6 months between 2-5 years and annually between 6-10 years from study entry, until first disease progression	Peripheral blood samples (PBMCs) were collected prior to therapy and on Days 8 and 15 of cycle 1, for assessment of lysine acetylation, using an assay developed by the Trepel Laboratory, NCI/NIH. CD45 blood mononuclear cells were measured. Patients with lysine acetylation change of 1.5 folds or higher were compared to patients with lysine acetylation change of less than 1.5 folds.	Disease assessed at baseline, then every 12 weeks until treatment discontinuation, then every 3 months within 2 years from study entry, every 6 months between 2-5 years and annually between 6-10 years from study entry, until first disease progression
Patient-reported Health-related Quality of Life Časové okno: Assessed at baseline and end of cycle 3	Health-related quality of life (HRQL) was measured using Functional Assessment of Cancer Therapy - General (FACT-G). The primary endpoint for HRQL was the FACT-G Trial Outcome Index (TOI) which was an aggregate score of 5 items from the FACT-G-Physical subscale (GP2, GP3, GP4, GP6, and GP7) and 6 items from the FACT-G-Functional subscale (GF1, GF2, GF3, GF4, GF6, and GF7). All items were rated on a 5-point Likert scale from 0 to 4. FACT-G TOI subscale score was calculated based on the scoring manual, subscale score ranges from 0 to 44, and higher scores indicate better quality of life. The primary comparison of HRQL between treatment arms was based on the end of cycle 3 assessment.	Assessed at baseline and end of cycle 3
Patient-reported Diarrhea Časové okno: Assessed at baseline and end of cycle 3	Diarrhea was measured by Functional Assessment of Chronic Illness Therapy for Patients With Diarrhea (FACIT-Diarrhea) subscale form, which had 11 items, all items were rated on a 5-point Likert scale from 0 to 4. FACIT-Diarrhea subscale score was calculated based on the scoring manual, subscale score ranges from 0 to 44, and higher score indicates less diarrhea. The primary comparison of patient-reported diarrhea between treatment arms was based on the end of cycle 3 assessment.	Assessed at baseline and end of cycle 3
Patient-reported Fatigue Časové okno: Assessed at baseline and end of cycle 3	Fatigue was measured by PROMIS Fatigue short form, it had 7 items and all items were rated on a 5-point Likert scale from 1 to 5. The PROMIS Fatigue total score and T score were calculated based on the scoring manual. The total score ranges from 7 to 35, the T score ranges from 29.4 to 83.2, higher scores indicate more fatigue. The PROMIS Fatigue T score was used for arm comparison. The primary comparison of patient-reported fatigue between treatment arms was based on the end of cycle 3 assessment.	Assessed at baseline and end of cycle 3
Patient-reported Nausea and Anorexia Časové okno: Assessed at baseline and end of cycle 3	Nausea and anorexia were measured by The Functional Assessment of Anorexia/Cachexia Treatment (FAACT)-additional concerns, which had 12 items, all items were rated on a 5-point Likert scale from 0 to 4. FAACT-additional concerns subscale score was calculated based on scoring manual. Subscale score ranges from 0 to 48, and higher scores indicate less nausea and anorexia. The primary comparison of patient-reported nausea and anorexia between treatment arms was based on the end of cycle 3 assessment.	Assessed at baseline and end of cycle 3

Spolupracovníci a vyšetřovatelé

Zde najdete lidi a organizace zapojené do této studie.

Sponzor

National Cancer Institute (NCI)

Vyšetřovatelé

Vrchní vyšetřovatel: Roisin M Connolly, ECOG-ACRIN Cancer Research Group

Publikace a užitečné odkazy

Osoba odpovědná za zadávání informací o studiu tyto publikace poskytuje dobrovolně. Mohou se týkat čehokoli, co souvisí se studiem.

Obecné publikace

Connolly RM, Zhao F, Miller KD, Lee MJ, Piekarz RL, Smith KL, Brown-Glaberman UA, Winn JS, Faller BA, Onitilo AA, Burkard ME, Budd GT, Levine EG, Royce ME, Kaufman PA, Thomas A, Trepel JB, Wolff AC, Sparano JA. E2112: Randomized Phase III Trial of Endocrine Therapy Plus Entinostat or Placebo in Hormone Receptor-Positive Advanced Breast Cancer. A Trial of the ECOG-ACRIN Cancer Research Group. J Clin Oncol. 2021 Oct 1;39(28):3171-3181. doi: 10.1200/JCO.21.00944. Epub 2021 Aug 6.

Užitečné odkazy

<p>Data Available: Select individual patient-level data from this trial can be requested from the NCTN/NCORP Data Archive.</p>

Termíny studijních záznamů

Tato data sledují průběh záznamů studie a předkládání souhrnných výsledků na ClinicalTrials.gov. Záznamy ze studií a hlášené výsledky jsou před zveřejněním na veřejné webové stránce přezkoumány Národní lékařskou knihovnou (NLM), aby se ujistily, že splňují specifické standardy kontroly kvality.

Hlavní termíny studia

Začátek studia (Aktuální)

29. března 2014

Primární dokončení (Aktuální)

5. května 2020

Dokončení studie (Odhadovaný)

2. června 2027

Termíny zápisu do studia

První předloženo

14. dubna 2014

První předloženo, které splnilo kritéria kontroly kvality

14. dubna 2014

První zveřejněno (Odhadovaný)

16. dubna 2014

Aktualizace studijních záznamů

Poslední zveřejněná aktualizace (Aktuální)

22. října 2026

Odeslaná poslední aktualizace, která splnila kritéria kontroly kvality

21. října 2026

Naposledy ověřeno

1. června 2026

Více informací

Termíny související s touto studií

Další relevantní podmínky MeSH

Další identifikační čísla studie

NCI-2014-00746
U10CA180820 (Grant/smlouva NIH USA)
U24CA196172 (Grant/smlouva NIH USA)
U10CA021115 (Grant/smlouva NIH USA)
NCI-2014-00746 (Identifikátor registru: CTRP (Clinical Trial Reporting Program))
E2112 (Jiný identifikátor: CTEP)
ECOG-E2112
E2112 (Jiný identifikátor: ECOG-ACRIN Cancer Research Group)

Tyto informace byly beze změn načteny přímo z webu clinicaltrials.gov. Máte-li jakékoli požadavky na změnu, odstranění nebo aktualizaci podrobností studie, kontaktujte prosím register@clinicaltrials.gov. Jakmile bude změna implementována na clinicaltrials.gov, bude automaticky aktualizována i na našem webu .

Exemestan s nebo bez entinostatu při léčbě pacientek s recidivujícím karcinomem prsu s pozitivním hormonálním receptorem, který je lokálně pokročilý nebo metastatický

Randomizovaná studie fáze III s endokrinní terapií plus Entinostat/placebo u pacientek s pokročilým karcinomem prsu s pozitivními hormonálními receptory

Přehled studie

Postavení

Podmínky

Intervence / Léčba

Detailní popis

Typ studie

Zápis (Aktuální)

Fáze

Kontakty a umístění

Studijní místa

Kritéria účasti

Kritéria způsobilosti

Věk způsobilý ke studiu

Přijímá zdravé dobrovolníky

Pohlaví způsobilá ke studiu

Popis

Studijní plán

Jak je studie koncipována?

Detaily designu

Počet zbraní

Zbraně a zásahy

Skupina účastníků / Arm

Intervence / Léčba

Co je měření studie?

Primární výstupní opatření

Měření výsledku

Popis opatření

Časové okno

Sekundární výstupní opatření

Měření výsledku

Popis opatření

Časové okno

Spolupracovníci a vyšetřovatelé

Sponzor

Vyšetřovatelé

Publikace a užitečné odkazy

Obecné publikace

Užitečné odkazy

Termíny studijních záznamů

Hlavní termíny studia

Začátek studia (Aktuální)

Primární dokončení (Aktuální)

Dokončení studie (Odhadovaný)

Termíny zápisu do studia

První předloženo

První předloženo, které splnilo kritéria kontroly kvality

První zveřejněno (Odhadovaný)

Aktualizace studijních záznamů

Poslední zveřejněná aktualizace (Aktuální)

Odeslaná poslední aktualizace, která splnila kritéria kontroly kvality

Naposledy ověřeno

Více informací

Termíny související s touto studií

Další relevantní podmínky MeSH

Další identifikační čísla studie