Ta strona została przetłumaczona automatycznie i dokładność tłumaczenia nie jest gwarantowana. Proszę odnieść się do angielska wersja za tekst źródłowy.

Eksemestan z entinostatem lub bez w leczeniu pacjentów z nawracającym rakiem piersi z ekspresją receptorów hormonalnych, miejscowo zaawansowanym lub z przerzutami

21 października 2026 zaktualizowane przez: National Cancer Institute (NCI)

Randomizowane badanie fazy III terapii hormonalnej plus entinostat/placebo u pacjentów z zaawansowanym rakiem piersi z ekspresją receptorów hormonalnych

This randomized phase III trial studies exemestane and entinostat to see how well they work compared to exemestane alone in treating patients with hormone receptor-positive breast cancer that has spread to nearby tissue or lymph nodes (locally advanced) or another place in the body (metastatic). Estrogen can cause the growth of breast cancer cells. Endocrine therapy using exemestane may fight breast cancer by lowering the amount of estrogen the body makes. Entinostat may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. It is not yet known whether exemestane is more effective with or without entinostat in treating breast cancer.

Przegląd badań

Status

Aktywny, nie rekrutujący

Warunki

Interwencja / Leczenie

Szczegółowy opis

PRIMARY OBJECTIVES:

I. To evaluate whether the addition of entinostat to endocrine therapy (exemestane) improves progression-free survival (PFS) and/or overall survival (OS) in patients with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative locally advanced or metastatic breast cancer who have previously progressed on a non-steroidal aromatase inhibitor (Al).

SECONDARY OBJECTIVES:

I. To evaluate the safety and tolerability of entinostat in combination with exemestane, and to compare the safety profile to that of endocrine therapy with placebo.

II. To evaluate the objective response rate of exemestane in combination with entinostat or placebo.

III. To evaluate whether the efficacy of exemestane with entinostat varies with changes in acetylation status in peripheral blood mononuclear cells (PBMCs).

IV. To evaluate the time to treatment deterioration (as defined by decrease in health-related quality of life [HRQL], progression, death) of exemestane + entinostat versus exemestane + placebo arms.

V. To evaluate the differences in overall health-related quality of life (HRQL) between the exemestane + entinostat versus exemestane + placebo arms.

VI. To evaluate the difference with respect to specific symptoms that are associated with entinostat, i.e., fatigue, nausea, anorexia and diarrhea, between the exemestane + entinostat versus exemestane + placebo arms.

VII. To measure adherence to protocol therapy. VIII. To evaluate the pharmacokinetics of entinostat in patients with advanced breast cancer.

IX. To evaluate what, if any, patient variables alter the pharmacokinetic profile of entinostat in patients with advanced breast cancer.

EXPLORATORY OBJECTIVES:

I. To collect archival tumor samples and germline deoxyribonucleic acid (DNA) to explore other potential biomarkers of therapeutic efficacy.

II. To collect patient ratings of adverse events (AEs) using select patient-reported outcomes (PRO)-Common Terminology Criteria for Adverse Events (CTCAE) items to evaluate the psychometric properties of PRO-CTCAE items and explore the incorporation of PRO-CTCAE items into a phase III double-blind placebo-controlled trial.

OUTLINE: Patients are randomized to 1 of 2 treatment arms.

ARM A: Patients receive exemestane orally (PO) once daily (QD) on days 1-28 and entinostat PO on days 1, 8, 15, and 22. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients also undergo computed tomography (CT) or magnetic resonance imaging (MRI) at baseline, at the end of cycle 3, every 3 cycles, at treatment discontinuation, and during follow-up, collection of blood samples at baseline and day 15 of cycle 1, and collection of archived tissue at baseline.

ARM B: Patients receive exemestane as in Arm A and placebo PO on days 1, 8, 15, and 22. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients also undergo CT or MRI at baseline, at the end of cycle 3, every 3 cycles, at treatment discontinuation, and during follow-up, collection of blood samples at baseline and day 15 of cycle 1, and collection of archived tissue at baseline.

In both arms, pre/perimenopausal female patients and all male patients also receive goserelin acetate subcutaneously (SC) on day 1.

After completion of study treatment, patients are followed up every 3 months for 2 years, every 6 months for 3 years, and then annually for 5 years.

Typ studiów

Interwencyjne

Zapisy (Rzeczywisty)

608

Faza

Faza 3

Kontakty i lokalizacje

Ta sekcja zawiera dane kontaktowe osób prowadzących badanie oraz informacje o tym, gdzie badanie jest przeprowadzane.

Lokalizacje studiów

Afryka Południowa
- - Pretoria, Afryka Południowa, 0002
    - University Of Pretoria
Stany Zjednoczone
- Alabama
  - Birmingham, Alabama, Stany Zjednoczone, 35233
    - University of Alabama at Birmingham Cancer Center
- Arkansas
  - Jonesboro, Arkansas, Stany Zjednoczone, 72401
    - NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
- California
  - Carmichael, California, Stany Zjednoczone, 95608
    - Mercy San Juan Medical Center
  - Chico, California, Stany Zjednoczone, 95973
    - Adventist Health Cancer Care Center Chico
  - Chico, California, Stany Zjednoczone, 95926
    - Enloe Medical Center
  - Clovis, California, Stany Zjednoczone, 93611
    - Community Cancer Institute
  - Clovis, California, Stany Zjednoczone, 93611
    - University Oncology Associates
  - Rancho Mirage, California, Stany Zjednoczone, 92270
    - Eisenhower Medical Center
  - Sacramento, California, Stany Zjednoczone, 95816
    - Mercy Cancer Center - Sacramento
  - St. Helena, California, Stany Zjednoczone, 94574
    - Saint Helena Hospital
  - Whittier, California, Stany Zjednoczone, 90602
    - Presbyterian Intercommunity Hospital
  - Woodland, California, Stany Zjednoczone, 95695
    - Woodland Memorial Hospital
- Colorado
  - Aurora, Colorado, Stany Zjednoczone, 80012
    - Rocky Mountain Cancer Centers-Aurora
  - Aurora, Colorado, Stany Zjednoczone, 80012
    - The Medical Center of Aurora
  - Boulder, Colorado, Stany Zjednoczone, 80303
    - Boulder Community Foothills Hospital
  - Boulder, Colorado, Stany Zjednoczone, 80304
    - Rocky Mountain Cancer Centers-Boulder
  - Colorado Springs, Colorado, Stany Zjednoczone, 80907
    - Penrose-Saint Francis Healthcare
  - Colorado Springs, Colorado, Stany Zjednoczone, 80909
    - UCHealth Memorial Hospital Central
  - Colorado Springs, Colorado, Stany Zjednoczone, 80907
    - Rocky Mountain Cancer Centers-Penrose
  - Denver, Colorado, Stany Zjednoczone, 80218
    - Presbyterian - Saint Lukes Medical Center - Health One
  - Denver, Colorado, Stany Zjednoczone, 80220
    - Rose Medical Center
  - Denver, Colorado, Stany Zjednoczone, 80218
    - Rocky Mountain Cancer Centers-Midtown
  - Denver, Colorado, Stany Zjednoczone, 80220
    - Rocky Mountain Cancer Centers-Rose
  - Denver, Colorado, Stany Zjednoczone, 80218
    - Colorado Blood Cancer Institute
  - Denver, Colorado, Stany Zjednoczone, 80218
    - Saint Joseph Hospital - Cancer Centers of Colorado
  - Denver, Colorado, Stany Zjednoczone, 80210
    - AdventHealth Porter
  - Durango, Colorado, Stany Zjednoczone, 81301
    - Mercy Medical Center
  - Durango, Colorado, Stany Zjednoczone, 81301
    - CommonSpirit Cancer Center Mercy
  - Englewood, Colorado, Stany Zjednoczone, 80113
    - Mountain Blue Cancer Care Center - Swedish
  - Englewood, Colorado, Stany Zjednoczone, 80113
    - Swedish Medical Center
  - Golden, Colorado, Stany Zjednoczone, 80401
    - Mountain Blue Cancer Care Center
  - Greeley, Colorado, Stany Zjednoczone, 80631
    - Banner North Colorado Medical Center
  - Greenwood Village, Colorado, Stany Zjednoczone, 80111
    - Rocky Mountain Cancer Centers-Greenwood Village
  - Lakewood, Colorado, Stany Zjednoczone, 80228
    - Rocky Mountain Cancer Centers-Lakewood
  - Lakewood, Colorado, Stany Zjednoczone, 80228
    - CommonSpirit Saint Anthony Hospital Cancer Center
  - Littleton, Colorado, Stany Zjednoczone, 80120
    - Rocky Mountain Cancer Centers-Littleton
  - Littleton, Colorado, Stany Zjednoczone, 80122
    - AdventHealth Littleton
  - Lone Tree, Colorado, Stany Zjednoczone, 80124
    - Sky Ridge Medical Center
  - Lone Tree, Colorado, Stany Zjednoczone, 80124
    - Rocky Mountain Cancer Centers-Sky Ridge
  - Longmont, Colorado, Stany Zjednoczone, 80501
    - Longmont United Hospital
  - Longmont, Colorado, Stany Zjednoczone, 80501
    - Rocky Mountain Cancer Centers-Longmont
  - Loveland, Colorado, Stany Zjednoczone, 80539
    - Banner North Colorado Medical Center - Loveland Campus
  - Parker, Colorado, Stany Zjednoczone, 80138
    - Rocky Mountain Cancer Centers-Parker
  - Parker, Colorado, Stany Zjednoczone, 80138
    - AdventHealth Parker
  - Pueblo, Colorado, Stany Zjednoczone, 81004
    - Saint Mary Corwin Medical Center
  - Pueblo, Colorado, Stany Zjednoczone, 81008
    - Rocky Mountain Cancer Centers - Pueblo
  - Thornton, Colorado, Stany Zjednoczone, 80260
    - Rocky Mountain Cancer Centers-Thornton
  - Wheat Ridge, Colorado, Stany Zjednoczone, 80401
    - Intermountain Health Lutheran Hospital
- Connecticut
  - Guilford, Connecticut, Stany Zjednoczone, 06437
    - Smilow Cancer Hospital Care Center - Guilford
  - Hartford, Connecticut, Stany Zjednoczone, 06105
    - Smilow Cancer Hospital Care Center at Saint Francis
  - Manchester, Connecticut, Stany Zjednoczone, 06040
    - Manchester Memorial Hospital
  - Middletown, Connecticut, Stany Zjednoczone, 06457
    - Middlesex Hospital
  - New Britain, Connecticut, Stany Zjednoczone, 06050
    - The Hospital of Central Connecticut
  - New Haven, Connecticut, Stany Zjednoczone, 06520
    - Yale University
  - Orange, Connecticut, Stany Zjednoczone, 06477
    - Smilow Cancer Hospital-Orange Care Center
  - Torrington, Connecticut, Stany Zjednoczone, 06790
    - Smilow Cancer Hospital-Torrington Care Center
  - Waterford, Connecticut, Stany Zjednoczone, 06385
    - Smilow Cancer Hospital Care Center - Waterford
- Delaware
  - Dover, Delaware, Stany Zjednoczone, 19901
    - Bayhealth Hospital Kent Campus
  - Lewes, Delaware, Stany Zjednoczone, 19958
    - Beebe Medical Center
  - Newark, Delaware, Stany Zjednoczone, 19713
    - Helen F Graham Cancer Center
  - Newark, Delaware, Stany Zjednoczone, 19713
    - Medical Oncology Hematology Consultants PA
  - Newark, Delaware, Stany Zjednoczone, 19718
    - Christiana Care Health System-Christiana Hospital
  - Rehoboth Beach, Delaware, Stany Zjednoczone, 19971
    - Beebe Health Campus
  - Seaford, Delaware, Stany Zjednoczone, 19973
    - TidalHealth Nanticoke / Allen Cancer Center
  - Wilmington, Delaware, Stany Zjednoczone, 19801
    - Christiana Care Health System-Wilmington Hospital
- District of Columbia
  - Washington D.C., District of Columbia, Stany Zjednoczone, 20010
    - MedStar Washington Hospital Center
  - Washington D.C., District of Columbia, Stany Zjednoczone, 20007
    - MedStar Georgetown University Hospital
  - Washington D.C., District of Columbia, Stany Zjednoczone, 20016
    - Sibley Memorial Hospital
- Florida
  - Deerfield Beach, Florida, Stany Zjednoczone, 33442
    - UM Sylvester Comprehensive Cancer Center at Deerfield Beach
  - Gainesville, Florida, Stany Zjednoczone, 32610
    - UF Health Cancer Institute - Gainesville
  - Jacksonville, Florida, Stany Zjednoczone, 32207
    - Baptist MD Anderson Cancer Center
  - Lakeland, Florida, Stany Zjednoczone, 33805
    - Lakeland Regional Health Hollis Cancer Center
  - Miami, Florida, Stany Zjednoczone, 33136
    - University of Miami Miller School of Medicine-Sylvester Cancer Center
  - Miami, Florida, Stany Zjednoczone, 33176
    - UM Sylvester Comprehensive Cancer Center at Kendall
  - Plantation, Florida, Stany Zjednoczone, 33324
    - UM Sylvester Comprehensive Cancer Center at Plantation
  - Weston, Florida, Stany Zjednoczone, 33331
    - Cleveland Clinic-Weston
- Georgia
  - Atlanta, Georgia, Stany Zjednoczone, 30308
    - Emory University Hospital Midtown
  - Atlanta, Georgia, Stany Zjednoczone, 30322
    - Emory University Hospital/Winship Cancer Institute
  - Atlanta, Georgia, Stany Zjednoczone, 30342
    - Emory Saint Joseph's Hospital
  - Atlanta, Georgia, Stany Zjednoczone, 30303
    - Grady Health System
  - Columbus, Georgia, Stany Zjednoczone, 31904
    - John B Amos Cancer Center
  - Macon, Georgia, Stany Zjednoczone, 31201
    - Atrium Health Navicent
  - Savannah, Georgia, Stany Zjednoczone, 31405
    - Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
- Hawaii
  - Honolulu, Hawaii, Stany Zjednoczone, 96813
    - Queen's Medical Center
  - Honolulu, Hawaii, Stany Zjednoczone, 96813
    - Hawaii Cancer Care Inc - Waterfront Plaza
  - Honolulu, Hawaii, Stany Zjednoczone, 96813
    - Queen's Cancer Cenrer - POB I
  - Honolulu, Hawaii, Stany Zjednoczone, 96813
    - Straub Clinic and Hospital
  - Honolulu, Hawaii, Stany Zjednoczone, 96813
    - University of Hawaii Cancer Center
  - Honolulu, Hawaii, Stany Zjednoczone, 96817
    - Hawaii Cancer Care Inc-Liliha
  - Honolulu, Hawaii, Stany Zjednoczone, 96817
    - Queen's Cancer Center - Kuakini
  - ‘Aiea, Hawaii, Stany Zjednoczone, 96701
    - Pali Momi Medical Center
  - ‘Aiea, Hawaii, Stany Zjednoczone, 96701
    - Queen's Cancer Center - Pearlridge
- Idaho
  - Boise, Idaho, Stany Zjednoczone, 83706
    - Saint Alphonsus Cancer Care Center-Boise
  - Boise, Idaho, Stany Zjednoczone, 83712
    - Saint Luke's Cancer Institute - Boise
  - Coeur d'Alene, Idaho, Stany Zjednoczone, 83814
    - Kootenai Health - Coeur d'Alene
  - Fruitland, Idaho, Stany Zjednoczone, 83619
    - Saint Luke's Cancer Institute - Fruitland
  - Post Falls, Idaho, Stany Zjednoczone, 83854
    - Kootenai Clinic Cancer Services - Post Falls
  - Sandpoint, Idaho, Stany Zjednoczone, 83864
    - Kootenai Clinic Cancer Services - Sandpoint
  - Twin Falls, Idaho, Stany Zjednoczone, 83301
    - Saint Luke's Cancer Institute - Twin Falls
- Illinois
  - Aurora, Illinois, Stany Zjednoczone, 60504
    - Rush-Copley Medical Center
  - Bloomington, Illinois, Stany Zjednoczone, 61704
    - Illinois CancerCare-Bloomington
  - Bloomington, Illinois, Stany Zjednoczone, 61701
    - OSF Saint Joseph Medical Center
  - Canton, Illinois, Stany Zjednoczone, 61520
    - Illinois CancerCare-Canton
  - Carbondale, Illinois, Stany Zjednoczone, 62902
    - Memorial Hospital of Carbondale
  - Carthage, Illinois, Stany Zjednoczone, 62321
    - Illinois CancerCare-Carthage
  - Centralia, Illinois, Stany Zjednoczone, 62801
    - Centralia Oncology Clinic
  - Chicago, Illinois, Stany Zjednoczone, 60611
    - Northwestern University
  - Chicago, Illinois, Stany Zjednoczone, 60637
    - University of Chicago Comprehensive Cancer Center
  - Chicago, Illinois, Stany Zjednoczone, 60612
    - John H Stroger Jr Hospital of Cook County
  - Chicago, Illinois, Stany Zjednoczone, 60657
    - UChicago Medicine Comprehensive Cancer Center - Saint Joseph Hospital
  - Chicago, Illinois, Stany Zjednoczone, 60625
    - Swedish Covenant Hospital
  - Chicago, Illinois, Stany Zjednoczone, 60640
    - Weiss Memorial Hospital
  - Danville, Illinois, Stany Zjednoczone, 61832
    - Carle at The Riverfront
  - Decatur, Illinois, Stany Zjednoczone, 62526
    - Decatur Memorial Hospital
  - Decatur, Illinois, Stany Zjednoczone, 62526
    - Cancer Care Specialists of Illinois - Decatur
  - Effingham, Illinois, Stany Zjednoczone, 62401
    - Crossroads Cancer Center
  - Effingham, Illinois, Stany Zjednoczone, 62401
    - Carle Physician Group-Effingham
  - Elk Grove Village, Illinois, Stany Zjednoczone, 60007
    - Ascension Alexian Brothers - Elk Grove Village
  - Elmhurst, Illinois, Stany Zjednoczone, 60126
    - Elmhurst Memorial Hospital
  - Eureka, Illinois, Stany Zjednoczone, 61530
    - Illinois CancerCare-Eureka
  - Evanston, Illinois, Stany Zjednoczone, 60202
    - Saint Francis Hospital
  - Freeport, Illinois, Stany Zjednoczone, 61032
    - Freeport Memorial Hospital/Leonard C Ferguson Cancer Center
  - Galesburg, Illinois, Stany Zjednoczone, 61401
    - Western Illinois Cancer Treatment Center
  - Galesburg, Illinois, Stany Zjednoczone, 61401
    - Illinois CancerCare-Galesburg
  - Geneva, Illinois, Stany Zjednoczone, 60134
    - Northwestern Medicine Cancer Center Delnor
  - Harvey, Illinois, Stany Zjednoczone, 60426
    - Ingalls Memorial Hospital
  - Joliet, Illinois, Stany Zjednoczone, 60435
    - Duly Health and Care Joliet
  - Kankakee, Illinois, Stany Zjednoczone, 60901
    - Presence Saint Mary's Hospital
  - Kewanee, Illinois, Stany Zjednoczone, 61443
    - Illinois CancerCare-Kewanee Clinic
  - Macomb, Illinois, Stany Zjednoczone, 61455
    - Illinois CancerCare-Macomb
  - Mattoon, Illinois, Stany Zjednoczone, 61938
    - Carle Physician Group-Mattoon/Charleston
  - Maywood, Illinois, Stany Zjednoczone, 60153
    - Loyola University Medical Center
  - Mount Vernon, Illinois, Stany Zjednoczone, 62864
    - SSM Health Good Samaritan
  - Naperville, Illinois, Stany Zjednoczone, 60540
    - Edward Hospital/Cancer Center
  - Normal, Illinois, Stany Zjednoczone, 61761
    - Carle Cancer Institute Normal
  - Oak Lawn, Illinois, Stany Zjednoczone, 60453-2699
    - Advocate Christ Medical Center
  - Ottawa, Illinois, Stany Zjednoczone, 61350
    - Illinois CancerCare-Ottawa Clinic
  - Ottawa, Illinois, Stany Zjednoczone, 61350
    - Radiation Oncology of Northern Illinois
  - Pekin, Illinois, Stany Zjednoczone, 61554
    - Illinois CancerCare-Pekin
  - Pekin, Illinois, Stany Zjednoczone, 61554
    - OSF Saint Francis Radiation Oncology at Pekin
  - Peoria, Illinois, Stany Zjednoczone, 61636
    - Methodist Medical Center of Illinois
  - Peoria, Illinois, Stany Zjednoczone, 61637
    - OSF Saint Francis Medical Center
  - Peoria, Illinois, Stany Zjednoczone, 61615
    - Illinois CancerCare-Peoria
  - Peoria, Illinois, Stany Zjednoczone, 61615
    - OSF Saint Francis Radiation Oncology at Peoria Cancer Center
  - Peru, Illinois, Stany Zjednoczone, 61354
    - Illinois CancerCare-Peru
  - Peru, Illinois, Stany Zjednoczone, 61354
    - Valley Radiation Oncology
  - Plainfield, Illinois, Stany Zjednoczone, 60585
    - Edward Hospital/Cancer Center?Plainfield
  - Princeton, Illinois, Stany Zjednoczone, 61356
    - Illinois CancerCare-Princeton
  - River Forest, Illinois, Stany Zjednoczone, 60305
    - West Suburban Medical Center
  - Rockford, Illinois, Stany Zjednoczone, 61114
    - UW Health Carbone Cancer Center Rockford
  - Springfield, Illinois, Stany Zjednoczone, 62702
    - Southern Illinois University School of Medicine
  - Springfield, Illinois, Stany Zjednoczone, 62702
    - Springfield Clinic
  - Springfield, Illinois, Stany Zjednoczone, 62702
    - Central Illinois Hematology Oncology Center
  - Springfield, Illinois, Stany Zjednoczone, 62781
    - Springfield Memorial Hospital
  - Urbana, Illinois, Stany Zjednoczone, 61801
    - Carle Cancer Center
  - Urbana, Illinois, Stany Zjednoczone, 61801
    - The Carle Foundation Hospital
  - Warrenville, Illinois, Stany Zjednoczone, 60555
    - Northwestern Medicine Cancer Center Warrenville
  - Yorkville, Illinois, Stany Zjednoczone, 60560
    - Rush-Copley Healthcare Center
- Indiana
  - Carmel, Indiana, Stany Zjednoczone, 46032
    - IU Health North Hospital
  - Fishers, Indiana, Stany Zjednoczone, 46037
    - IU Health Central Indiana Cancer Centers-Fishers
  - Fort Wayne, Indiana, Stany Zjednoczone, 46845
    - Fort Wayne Medical Oncology and Hematology Inc-Parkview
  - Indianapolis, Indiana, Stany Zjednoczone, 46237
    - Franciscan Health Indianapolis
  - Indianapolis, Indiana, Stany Zjednoczone, 46202
    - Indiana University/Melvin and Bren Simon Cancer Center
  - Indianapolis, Indiana, Stany Zjednoczone, 46202
    - Sidney and Lois Eskenazi Hospital
  - Indianapolis, Indiana, Stany Zjednoczone, 46219
    - IU Health Central Indiana Cancer Centers-East
  - Indianapolis, Indiana, Stany Zjednoczone, 46290
    - Springmill Medical Center
  - Indianapolis, Indiana, Stany Zjednoczone, 46202
    - IU Health Methodist Hospital
  - Lafayette, Indiana, Stany Zjednoczone, 47904
    - IU Health Arnett Cancer Care
  - Michigan City, Indiana, Stany Zjednoczone, 46360
    - Woodland Cancer Care Center
  - Mooresville, Indiana, Stany Zjednoczone, 46158
    - Franciscan Health Mooresville
  - Muncie, Indiana, Stany Zjednoczone, 47303
    - IU Health Ball Memorial Hospital
  - Richmond, Indiana, Stany Zjednoczone, 47374
    - Reid Health
  - Terre Haute, Indiana, Stany Zjednoczone, 47804
    - Union Hospital
- Iowa
  - Ames, Iowa, Stany Zjednoczone, 50010
    - Mary Greeley Medical Center
  - Ames, Iowa, Stany Zjednoczone, 50010
    - McFarland Clinic - Ames
  - Bettendorf, Iowa, Stany Zjednoczone, 52722
    - University of Iowa Healthcare Cancer Services Quad Cities
  - Boone, Iowa, Stany Zjednoczone, 50036
    - McFarland Clinic - Boone
  - Cedar Rapids, Iowa, Stany Zjednoczone, 52403
    - Mercy Hospital
  - Cedar Rapids, Iowa, Stany Zjednoczone, 52403
    - Oncology Associates at Mercy Medical Center
  - Clive, Iowa, Stany Zjednoczone, 50325
    - Mercy Cancer Center-West Lakes
  - Clive, Iowa, Stany Zjednoczone, 50325
    - UI Health Care Mission Cancer and Blood - West Des Moines Clinic
  - Council Bluffs, Iowa, Stany Zjednoczone, 51503
    - Alegent Health Mercy Hospital
  - Davenport, Iowa, Stany Zjednoczone, 52803
    - MercyOne Genesis Davenport Medical Center
  - Des Moines, Iowa, Stany Zjednoczone, 50309
    - Iowa Methodist Medical Center
  - Des Moines, Iowa, Stany Zjednoczone, 50314
    - Mercy Medical Center - Des Moines
  - Des Moines, Iowa, Stany Zjednoczone, 50314
    - Broadlawns Medical Center
  - Des Moines, Iowa, Stany Zjednoczone, 50309
    - UI Health Care Mission Cancer and Blood - Des Moines Clinic
  - Des Moines, Iowa, Stany Zjednoczone, 50314
    - UI Health Care Mission Cancer and Blood - Laurel Clinic
  - Fort Dodge, Iowa, Stany Zjednoczone, 50501
    - McFarland Clinic - Trinity Cancer Center
  - Fort Dodge, Iowa, Stany Zjednoczone, 50501
    - UI Healthcare Mission Cancer and Blood - Fort Dodge
  - Iowa City, Iowa, Stany Zjednoczone, 52242
    - University of Iowa/Holden Comprehensive Cancer Center
  - Jefferson, Iowa, Stany Zjednoczone, 50129
    - McFarland Clinic - Jefferson
  - Marshalltown, Iowa, Stany Zjednoczone, 50158
    - McFarland Clinic - Marshalltown
  - Mason City, Iowa, Stany Zjednoczone, 50401
    - Mercy Medical Center - North Iowa
  - Sioux City, Iowa, Stany Zjednoczone, 51101
    - Siouxland Regional Cancer Center
  - West Des Moines, Iowa, Stany Zjednoczone, 50266
    - Mercy Medical Center-West Lakes
- Kansas
  - Chanute, Kansas, Stany Zjednoczone, 66720
    - Cancer Center of Kansas - Chanute
  - Dodge City, Kansas, Stany Zjednoczone, 67801
    - Cancer Center of Kansas - Dodge City
  - El Dorado, Kansas, Stany Zjednoczone, 67042
    - Cancer Center of Kansas - El Dorado
  - Fort Scott, Kansas, Stany Zjednoczone, 66701
    - Cancer Center of Kansas - Fort Scott
  - Garden City, Kansas, Stany Zjednoczone, 67846
    - Saint Catherine Hospital
  - Great Bend, Kansas, Stany Zjednoczone, 67530
    - Central Care Cancer Center - Great Bend
  - Great Bend, Kansas, Stany Zjednoczone, 67530
    - Saint Rose Ambulatory and Surgery Center
  - Hays, Kansas, Stany Zjednoczone, 67601
    - HaysMed
  - Independence, Kansas, Stany Zjednoczone, 67301
    - Cancer Center of Kansas-Independence
  - Kansas City, Kansas, Stany Zjednoczone, 66112
    - University of Kansas Cancer Center-West
  - Kingman, Kansas, Stany Zjednoczone, 67068
    - Cancer Center of Kansas-Kingman
  - Lawrence, Kansas, Stany Zjednoczone, 66044
    - Lawrence Memorial Hospital
  - Lenexa, Kansas, Stany Zjednoczone, 66219
    - Kansas Institute of Medicine Cancer and Blood Center
  - Lenexa, Kansas, Stany Zjednoczone, 66219
    - Minimally Invasive Surgery Hospital
  - Liberal, Kansas, Stany Zjednoczone, 67905
    - Cancer Center of Kansas-Liberal
  - Manhattan, Kansas, Stany Zjednoczone, 66502
    - Cancer Center of Kansas-Manhattan
  - McPherson, Kansas, Stany Zjednoczone, 67460
    - Cancer Center of Kansas - McPherson
  - Newton, Kansas, Stany Zjednoczone, 67114
    - Cancer Center of Kansas - Newton
  - Olathe, Kansas, Stany Zjednoczone, 66061
    - The University of Kansas Cancer Center - Olathe
  - Overland Park, Kansas, Stany Zjednoczone, 66210
    - University of Kansas Cancer Center-Overland Park
  - Overland Park, Kansas, Stany Zjednoczone, 66209
    - Menorah Medical Center
  - Parsons, Kansas, Stany Zjednoczone, 67357
    - Cancer Center of Kansas - Parsons
  - Pratt, Kansas, Stany Zjednoczone, 67124
    - Cancer Center of Kansas - Pratt
  - Salina, Kansas, Stany Zjednoczone, 67401
    - Salina Regional Health Center
  - Salina, Kansas, Stany Zjednoczone, 67401
    - Cancer Center of Kansas - Salina
  - Topeka, Kansas, Stany Zjednoczone, 66606
    - University of Kansas Health System Saint Francis Campus
  - Wellington, Kansas, Stany Zjednoczone, 67152
    - Cancer Center of Kansas - Wellington
  - Wichita, Kansas, Stany Zjednoczone, 67214
    - Ascension Via Christi Hospitals Wichita
  - Wichita, Kansas, Stany Zjednoczone, 67208
    - Cancer Center of Kansas-Wichita Medical Arts Tower
  - Wichita, Kansas, Stany Zjednoczone, 67214
    - Cancer Center of Kansas - Wichita
  - Wichita, Kansas, Stany Zjednoczone, 67208
    - Associates In Womens Health
  - Winfield, Kansas, Stany Zjednoczone, 67156
    - Cancer Center of Kansas - Winfield
- Kentucky
  - Bardstown, Kentucky, Stany Zjednoczone, 40004
    - CommonSpirit Saint Joseph Hospital - Bardstown
  - Corbin, Kentucky, Stany Zjednoczone, 40701
    - Baptist Health Corbin
  - Crestview Hills, Kentucky, Stany Zjednoczone, 41017
    - Oncology Hematology Care Inc-Crestview
  - Edgewood, Kentucky, Stany Zjednoczone, 41017
    - Saint Elizabeth Healthcare Edgewood
  - Elizabethtown, Kentucky, Stany Zjednoczone, 42701
    - Baptist Health Hardin
  - Fort Thomas, Kentucky, Stany Zjednoczone, 41075
    - Saint Elizabeth Healthcare Fort Thomas
  - Lexington, Kentucky, Stany Zjednoczone, 40536
    - University of Kentucky/Markey Cancer Center
  - Lexington, Kentucky, Stany Zjednoczone, 40504
    - Saint Joseph Radiation Oncology Resource Center
  - Lexington, Kentucky, Stany Zjednoczone, 40503
    - Baptist Health Lexington
  - Lexington, Kentucky, Stany Zjednoczone, 40509
    - CommonSpirit Saint Joseph Medical Center - East Lexington
  - Louisville, Kentucky, Stany Zjednoczone, 40202
    - Jewish Hospital
  - Louisville, Kentucky, Stany Zjednoczone, 40245
    - UofL Health Medical Center Northeast
  - Louisville, Kentucky, Stany Zjednoczone, 40207
    - Baptist Health Louisville
  - Madisonville, Kentucky, Stany Zjednoczone, 42431
    - Baptist Health Madisonville/Merle Mahr Cancer Center
  - Paducah, Kentucky, Stany Zjednoczone, 42003
    - Baptist Health Paducah
- Louisiana
  - Baton Rouge, Louisiana, Stany Zjednoczone, 70805
    - LSU Health Baton Rouge-North Clinic
  - Baton Rouge, Louisiana, Stany Zjednoczone, 70809
    - Louisiana Hematology Oncology Associates LLC
  - Baton Rouge, Louisiana, Stany Zjednoczone, 70809
    - Mary Bird Perkins Cancer Center
  - Baton Rouge, Louisiana, Stany Zjednoczone, 70809
    - Ochsner Health Center-Summa
  - Baton Rouge, Louisiana, Stany Zjednoczone, 70816
    - Medical Center of Baton Rouge
  - Baton Rouge, Louisiana, Stany Zjednoczone, 70809
    - Hematology/Oncology Clinic PLLC
  - Baton Rouge, Louisiana, Stany Zjednoczone, 70808
    - Our Lady of the Lake Physician Group
  - Covington, Louisiana, Stany Zjednoczone, 70433
    - Mary Bird Perkins Cancer Center - Covington
  - Covington, Louisiana, Stany Zjednoczone, 70433
    - Northshore Oncology Associates-Covington
  - Houma, Louisiana, Stany Zjednoczone, 70360
    - Mary Bird Perkins Cancer Center - Houma
  - Houma, Louisiana, Stany Zjednoczone, 70360
    - Oncology Center of The South Incorporated
  - New Orleans, Louisiana, Stany Zjednoczone, 70121
    - Ochsner Medical Center Jefferson
  - New Orleans, Louisiana, Stany Zjednoczone, 70112
    - University Medical Center New Orleans
  - New Orleans, Louisiana, Stany Zjednoczone, 70112
    - Louisiana State University Health Science Center
- Maine
  - Augusta, Maine, Stany Zjednoczone, 04330
    - Harold Alfond Center for Cancer Care
  - Bangor, Maine, Stany Zjednoczone, 04401
    - Eastern Maine Medical Center
  - Brewer, Maine, Stany Zjednoczone, 04412
    - Lafayette Family Cancer Center-EMMC
  - Rockport, Maine, Stany Zjednoczone, 04856
    - Penobscot Bay Medical Center
  - York Village, Maine, Stany Zjednoczone, 03909
    - York Hospital
- Maryland
  - Annapolis, Maryland, Stany Zjednoczone, 21401
    - Luminis Health Anne Arundel Medical Center
  - Baltimore, Maryland, Stany Zjednoczone, 21237
    - MedStar Franklin Square Medical Center/Weinberg Cancer Institute
  - Baltimore, Maryland, Stany Zjednoczone, 21287
    - Johns Hopkins University/Sidney Kimmel Cancer Center
  - Baltimore, Maryland, Stany Zjednoczone, 21215
    - Sinai Hospital of Baltimore
  - Baltimore, Maryland, Stany Zjednoczone, 21204
    - Greater Baltimore Medical Center
  - Baltimore, Maryland, Stany Zjednoczone, 21201
    - University of Maryland/Greenebaum Cancer Center
  - Bel Air, Maryland, Stany Zjednoczone, 21014
    - UM Upper Chesapeake Medical Center
  - Cumberland, Maryland, Stany Zjednoczone, 21502
    - UPMC Western Maryland
  - Easton, Maryland, Stany Zjednoczone, 21601
    - University of Maryland Shore Medical Center at Easton
  - Olney, Maryland, Stany Zjednoczone, 20832
    - MedStar Montgomery Medical Center
  - Randallstown, Maryland, Stany Zjednoczone, 21133
    - Northwest Hospital Center
- Massachusetts
  - Beverly, Massachusetts, Stany Zjednoczone, 01915
    - Beverly Hospital
  - Burlington, Massachusetts, Stany Zjednoczone, 01805
    - Lahey Clinic
  - Fall River, Massachusetts, Stany Zjednoczone, 02721
    - Saint Anne's Hospital
  - Gloucester, Massachusetts, Stany Zjednoczone, 01930
    - Addison Gilbert Hospital
  - Newton, Massachusetts, Stany Zjednoczone, 02462
    - Newton-Wellesley Hospital
  - Pittsfield, Massachusetts, Stany Zjednoczone, 01201
    - Berkshire Medical Center - Cancer Center
  - Winchester, Massachusetts, Stany Zjednoczone, 01890
    - Beth Israel Deaconess Medical Center/Winchester Center for Cancer Care
  - Worcester, Massachusetts, Stany Zjednoczone, 01655
    - UMass Memorial Medical Center - University Campus
- Michigan
  - Adrian, Michigan, Stany Zjednoczone, 49221
    - Hickman Cancer Center
  - Ann Arbor, Michigan, Stany Zjednoczone, 48106
    - Trinity Health Saint Joseph Mercy Hospital Ann Arbor
  - Brownstown, Michigan, Stany Zjednoczone, 48183
    - Henry Ford Cancer Institute-Downriver
  - Chelsea, Michigan, Stany Zjednoczone, 48118
    - Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
  - Clinton Township, Michigan, Stany Zjednoczone, 48038
    - Henry Ford Macomb Hospital-Clinton Township
  - Dearborn, Michigan, Stany Zjednoczone, 48126
    - Henry Ford Medical Center-Fairlane
  - Dearborn, Michigan, Stany Zjednoczone, 48124
    - Corewell Health Dearborn Hospital
  - Detroit, Michigan, Stany Zjednoczone, 48202
    - Henry Ford Hospital
  - Detroit, Michigan, Stany Zjednoczone, 48201
    - Wayne State University/Karmanos Cancer Institute
  - Detroit, Michigan, Stany Zjednoczone, 48236
    - Henry Ford Health Saint John Hospital
  - Escanaba, Michigan, Stany Zjednoczone, 49829
    - OSF Saint Francis Hospital and Medical Group
  - Farmington Hills, Michigan, Stany Zjednoczone, 48334
    - Weisberg Cancer Treatment Center
  - Flint, Michigan, Stany Zjednoczone, 48503
    - Hurley Medical Center
  - Flint, Michigan, Stany Zjednoczone, 48503
    - Genesys Hurley Cancer Institute
  - Grand Rapids, Michigan, Stany Zjednoczone, 49503
    - Corewell Health Grand Rapids Hospitals - Butterworth Hospital
  - Grosse Pointe, Michigan, Stany Zjednoczone, 48230
    - William Beaumont Hospital-Grosse Pointe
  - Jackson, Michigan, Stany Zjednoczone, 49201
    - Allegiance Health
  - Kalamazoo, Michigan, Stany Zjednoczone, 49007
    - West Michigan Cancer Center
  - Kalamazoo, Michigan, Stany Zjednoczone, 49048
    - Beacon Kalamazoo
  - Livonia, Michigan, Stany Zjednoczone, 48154
    - Trinity Health Saint Mary Mercy Livonia Hospital
  - Novi, Michigan, Stany Zjednoczone, 48377
    - Henry Ford Medical Center-Columbus
  - Pontiac, Michigan, Stany Zjednoczone, 48341
    - Trinity Health Saint Joseph Mercy Oakland Hospital
  - Port Huron, Michigan, Stany Zjednoczone, 48060
    - Lake Huron Medical Center
  - Royal Oak, Michigan, Stany Zjednoczone, 48073
    - Corewell Health William Beaumont University Hospital
  - Saginaw, Michigan, Stany Zjednoczone, 48601
    - MyMichigan Medical Center Saginaw
  - Troy, Michigan, Stany Zjednoczone, 48085
    - Corewell Health Beaumont Troy Hospital
  - Warren, Michigan, Stany Zjednoczone, 48093
    - Henry Ford Health Warren Hospital
  - West Bloomfield, Michigan, Stany Zjednoczone, 48322
    - Henry Ford West Bloomfield Hospital
- Minnesota
  - Bemidji, Minnesota, Stany Zjednoczone, 56601
    - Sanford Joe Lueken Cancer Center
  - Brainerd, Minnesota, Stany Zjednoczone, 56401
    - Essentia Health Saint Joseph's Medical Center
  - Coon Rapids, Minnesota, Stany Zjednoczone, 55433
    - Mercy Hospital
  - Duluth, Minnesota, Stany Zjednoczone, 55805
    - Essentia Health Cancer Center
  - Fergus Falls, Minnesota, Stany Zjednoczone, 56537
    - Lake Region Healthcare Corporation-Cancer Care
  - Maplewood, Minnesota, Stany Zjednoczone, 55109
    - Saint John's Hospital - Healtheast
  - Maplewood, Minnesota, Stany Zjednoczone, 55109
    - Minnesota Oncology Hematology PA-Maplewood
  - Minneapolis, Minnesota, Stany Zjednoczone, 55407
    - Abbott-Northwestern Hospital
  - Minneapolis, Minnesota, Stany Zjednoczone, 55454
    - Health Partners Inc
  - New Ulm, Minnesota, Stany Zjednoczone, 56073
    - New Ulm Medical Center
  - Saint Cloud, Minnesota, Stany Zjednoczone, 56303
    - Coborn Cancer Center at Saint Cloud Hospital
  - Saint Paul, Minnesota, Stany Zjednoczone, 55101
    - Regions Hospital
  - Stillwater, Minnesota, Stany Zjednoczone, 55082
    - Lakeview Hospital
  - Willmar, Minnesota, Stany Zjednoczone, 56201
    - Rice Memorial Hospital
- Mississippi
  - Columbus, Mississippi, Stany Zjednoczone, 39705
    - Baptist Memorial Hospital and Cancer Center-Golden Triangle
  - Grenada, Mississippi, Stany Zjednoczone, 38901
    - Baptist Cancer Center-Grenada
  - Hattiesburg, Mississippi, Stany Zjednoczone, 39401
    - Hattiesburg Clinic - Hematology/Oncology Clinic
  - Hattiesburg, Mississippi, Stany Zjednoczone, 39404
    - Forrest General Hospital / Cancer Center
  - Jackson, Mississippi, Stany Zjednoczone, 39216
    - University of Mississippi Medical Center
  - New Albany, Mississippi, Stany Zjednoczone, 38652
    - Baptist Memorial Hospital and Cancer Center-Union County
  - Oxford, Mississippi, Stany Zjednoczone, 38655
    - Baptist Memorial Hospital and Cancer Center-Oxford
  - Pascagoula, Mississippi, Stany Zjednoczone, 39581
    - Singing River Hospital
  - Southhaven, Mississippi, Stany Zjednoczone, 38671
    - Baptist Memorial Hospital and Cancer Center-Desoto
- Missouri
  - Ballwin, Missouri, Stany Zjednoczone, 63011
    - Mercy Oncology and Hematology - Clayton-Clarkson
  - Bonne Terre, Missouri, Stany Zjednoczone, 63628
    - Parkland Health Center-Bonne Terre
  - Branson, Missouri, Stany Zjednoczone, 65616
    - Cox Cancer Center Branson
  - Cape Girardeau, Missouri, Stany Zjednoczone, 63703
    - Saint Francis Medical Center
  - Cape Girardeau, Missouri, Stany Zjednoczone, 63703
    - Mercy Cancer Center - Cape Girardeau
  - Chesterfield, Missouri, Stany Zjednoczone, 63017
    - Saint Luke's Hospital
  - City of Saint Peters, Missouri, Stany Zjednoczone, 63376
    - Siteman Cancer Center at Saint Peters Hospital
  - Columbia, Missouri, Stany Zjednoczone, 65212
    - MU Health - University Hospital/Ellis Fischel Cancer Center
  - Creve Coeur, Missouri, Stany Zjednoczone, 63141
    - Siteman Cancer Center at West County Hospital
  - Independence, Missouri, Stany Zjednoczone, 64057
    - Centerpoint Medical Center LLC
  - Jefferson City, Missouri, Stany Zjednoczone, 65109
    - MU Health Care Goldschmidt Cancer Center
  - Kansas City, Missouri, Stany Zjednoczone, 64154
    - University of Kansas Cancer Center - North
  - Kansas City, Missouri, Stany Zjednoczone, 64131
    - The University of Kansas Cancer Center-South
  - Kansas City, Missouri, Stany Zjednoczone, 64132
    - Research Medical Center
  - Kansas City, Missouri, Stany Zjednoczone, 64108
    - University Health Truman Medical Center
  - Lee's Summit, Missouri, Stany Zjednoczone, 64064
    - University of Kansas Cancer Center - Lee's Summit
  - Sainte Genevieve, Missouri, Stany Zjednoczone, 63670
    - Sainte Genevieve County Memorial Hospital
  - Springfield, Missouri, Stany Zjednoczone, 65807
    - CoxHealth South Hospital
  - Springfield, Missouri, Stany Zjednoczone, 65804
    - Mercy Hospital Springfield
  - St Louis, Missouri, Stany Zjednoczone, 63110
    - Washington University School of Medicine
  - St Louis, Missouri, Stany Zjednoczone, 63131
    - Missouri Baptist Medical Center
  - St Louis, Missouri, Stany Zjednoczone, 63109
    - Mercy Infusion Center - Chippewa
  - St Louis, Missouri, Stany Zjednoczone, 63141
    - Mercy Hospital Saint Louis
  - Sullivan, Missouri, Stany Zjednoczone, 63080
    - Missouri Baptist Sullivan Hospital
- Montana
  - Billings, Montana, Stany Zjednoczone, 59101
    - Saint Vincent Healthcare
  - Bozeman, Montana, Stany Zjednoczone, 59715
    - Bozeman Health Deaconess Hospital
  - Butte, Montana, Stany Zjednoczone, 59701
    - Saint James Community Hospital and Cancer Treatment Center
  - Great Falls, Montana, Stany Zjednoczone, 59405
    - Benefis Sletten Cancer Institute
  - Helena, Montana, Stany Zjednoczone, 59601
    - Saint Peter's Community Hospital
  - Kalispell, Montana, Stany Zjednoczone, 59901
    - Logan Health Medical Center
  - Missoula, Montana, Stany Zjednoczone, 59802
    - Saint Patrick Hospital - Community Hospital
- Nebraska
  - Grand Island, Nebraska, Stany Zjednoczone, 68803
    - Nebraska Cancer Specialists/Oncology Hematology West PC
  - Kearney, Nebraska, Stany Zjednoczone, 68847
    - CHI Health Good Samaritan
  - Omaha, Nebraska, Stany Zjednoczone, 68124
    - Alegent Health Bergan Mercy Medical Center
  - Omaha, Nebraska, Stany Zjednoczone, 68122
    - Alegent Health Immanuel Medical Center
  - Omaha, Nebraska, Stany Zjednoczone, 68130
    - Alegent Health Lakeside Hospital
- New Hampshire
  - Dover, New Hampshire, Stany Zjednoczone, 03820
    - Wentworth-Douglass Hospital
  - Keene, New Hampshire, Stany Zjednoczone, 03431
    - Cheshire Medical Center-Dartmouth-Hitchcock Keene
  - Lebanon, New Hampshire, Stany Zjednoczone, 03756
    - Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
  - Manchester, New Hampshire, Stany Zjednoczone, 03104
    - Dartmouth Cancer Center - Manchester/ DCC Manchester
  - Nashua, New Hampshire, Stany Zjednoczone, 03060
    - Saint Joseph Hospital
  - Nashua, New Hampshire, Stany Zjednoczone, 03063
    - Dartmouth Cancer Center - Nashua
- New Jersey
  - Cape May Court House, New Jersey, Stany Zjednoczone, 08210
    - AtlantiCare Health Park-Cape May Court House
  - Egg Harbor, New Jersey, Stany Zjednoczone, 08234
    - AtlantiCare Surgery Center
  - Englewood, New Jersey, Stany Zjednoczone, 07631
    - Englewood Hospital and Medical Center
  - Hackensack, New Jersey, Stany Zjednoczone, 07601
    - Hackensack University Medical Center
  - Hamilton, New Jersey, Stany Zjednoczone, 08690
    - The Cancer Institute of New Jersey Hamilton
  - Long Branch, New Jersey, Stany Zjednoczone, 07740
    - Monmouth Medical Center
  - Mount Holly, New Jersey, Stany Zjednoczone, 08060
    - Virtua Memorial
  - Mullica Hill, New Jersey, Stany Zjednoczone, 08062
    - Inspira Medical Center Mullica Hill
  - Neptune City, New Jersey, Stany Zjednoczone, 07753
    - Jersey Shore Medical Center
  - Somerville, New Jersey, Stany Zjednoczone, 08876
    - Robert Wood Johnson University Hospital Somerset
  - Vineland, New Jersey, Stany Zjednoczone, 08360
    - Inspira Medical Center Vineland
  - Voorhees Township, New Jersey, Stany Zjednoczone, 08043
    - Virtua Voorhees
- New Mexico
  - Albuquerque, New Mexico, Stany Zjednoczone, 87109
    - New Mexico Oncology Hematology Consultants
  - Albuquerque, New Mexico, Stany Zjednoczone, 87106
    - University of New Mexico Cancer Center
  - Albuquerque, New Mexico, Stany Zjednoczone, 87110
    - Presbyterian Kaseman Hospital
  - Las Cruces, New Mexico, Stany Zjednoczone, 88011
    - Memorial Medical Center-Las Cruces
  - Santa Fe, New Mexico, Stany Zjednoczone, 87505
    - Christus Saint Vincent Regional Cancer Center
- New York
  - Auburn, New York, Stany Zjednoczone, 13021
    - Hematology Oncology Associates of Central New York-Auburn
  - Brooklyn, New York, Stany Zjednoczone, 11203
    - Kings County Hospital
  - Brooklyn, New York, Stany Zjednoczone, 11203
    - State University of New York Downstate Medical Center
  - Buffalo, New York, Stany Zjednoczone, 14263
    - Roswell Park Cancer Institute
  - Camillus, New York, Stany Zjednoczone, 13031
    - Hematology Oncology Associates of CNY at Camillus
  - East Syracuse, New York, Stany Zjednoczone, 13057
    - Hematology Oncology Associates of Central New York-East Syracuse
  - Elmira, New York, Stany Zjednoczone, 14905
    - Arnot Ogden Medical Center/Falck Cancer Center
  - New York, New York, Stany Zjednoczone, 10019
    - Mount Sinai West
  - New York, New York, Stany Zjednoczone, 10032
    - NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
  - New York, New York, Stany Zjednoczone, 10065
    - NYP/Weill Cornell Medical Center
  - New York, New York, Stany Zjednoczone, 10003
    - Mount Sinai Union Square
  - Rochester, New York, Stany Zjednoczone, 14642
    - University of Rochester
  - Staten Island, New York, Stany Zjednoczone, 10305
    - Staten Island University Hospital
  - The Bronx, New York, Stany Zjednoczone, 10461
    - Montefiore Medical Center-Einstein Campus
  - The Bronx, New York, Stany Zjednoczone, 10467
    - Montefiore Medical Center - Moses Campus
  - The Bronx, New York, Stany Zjednoczone, 10461
    - Montefiore Medical Center-Weiler Hospital
  - White Plains, New York, Stany Zjednoczone, 10601
    - Dickstein Cancer Treatment Center
- North Carolina
  - Asheboro, North Carolina, Stany Zjednoczone, 27203
    - Randolph Hospital
  - Asheville, North Carolina, Stany Zjednoczone, 28801
    - Mission Hospital
  - Asheville, North Carolina, Stany Zjednoczone, 28816
    - Hope Women's Cancer Centers-Asheville
  - Asheville, North Carolina, Stany Zjednoczone, 28806
    - Messino Cancer Centers
  - Burlington, North Carolina, Stany Zjednoczone, 27215
    - Cone Health Cancer Center at Alamance Regional
  - Chapel Hill, North Carolina, Stany Zjednoczone, 27599
    - UNC Lineberger Comprehensive Cancer Center
  - Clinton, North Carolina, Stany Zjednoczone, 28328
    - Southeastern Medical Oncology Center-Clinton
  - Goldsboro, North Carolina, Stany Zjednoczone, 27534
    - Southeastern Medical Oncology Center-Goldsboro
  - Goldsboro, North Carolina, Stany Zjednoczone, 27534
    - Wayne Memorial Hospital
  - Greensboro, North Carolina, Stany Zjednoczone, 27403
    - Cone Health Cancer Center
  - Hendersonville, North Carolina, Stany Zjednoczone, 28791
    - Margaret R Pardee Memorial Hospital
  - Jacksonville, North Carolina, Stany Zjednoczone, 28546
    - Southeastern Medical Oncology Center-Jacksonville
  - Kinston, North Carolina, Stany Zjednoczone, 28501
    - ECU Health Oncology Kinston
  - Mebane, North Carolina, Stany Zjednoczone, 27302
    - Cone Heath Cancer Center at Mebane
  - Reidsville, North Carolina, Stany Zjednoczone, 27320
    - Annie Penn Memorial Hospital
  - Washington, North Carolina, Stany Zjednoczone, 27889
    - Marion L Shepard Cancer Center - ECU Health Beaufort Hospital
  - Winston-Salem, North Carolina, Stany Zjednoczone, 27157
    - Wake Forest University Health Sciences
- North Dakota
  - Bismarck, North Dakota, Stany Zjednoczone, 58501
    - Sanford Bismarck Medical Center
  - Fargo, North Dakota, Stany Zjednoczone, 58122
    - Sanford Roger Maris Cancer Center
  - Fargo, North Dakota, Stany Zjednoczone, 58103
    - Essentia Health Cancer Center-South University Clinic
  - Fargo, North Dakota, Stany Zjednoczone, 58122
    - Sanford Broadway Medical Center
  - Grand Forks, North Dakota, Stany Zjednoczone, 58201
    - Altru Cancer Center
  - Minot, North Dakota, Stany Zjednoczone, 58701
    - Trinity Cancer Care Center
- Ohio
  - Akron, Ohio, Stany Zjednoczone, 44307
    - Cleveland Clinic Akron General
  - Akron, Ohio, Stany Zjednoczone, 44304
    - Summa Health System - Akron Campus
  - Belpre, Ohio, Stany Zjednoczone, 45714
    - Strecker Cancer Center-Belpre
  - Bowling Green, Ohio, Stany Zjednoczone, 43402
    - Toledo Clinic Cancer Centers-Bowling Green
  - Chillicothe, Ohio, Stany Zjednoczone, 45601
    - Adena Regional Medical Center
  - Cincinnati, Ohio, Stany Zjednoczone, 45220
    - Good Samaritan Hospital - Cincinnati
  - Cincinnati, Ohio, Stany Zjednoczone, 45242
    - Bethesda North Hospital
  - Cincinnati, Ohio, Stany Zjednoczone, 45242
    - Oncology Hematology Care Inc-Blue Ash
  - Cincinnati, Ohio, Stany Zjednoczone, 45202
    - Oncology Hematology Care Inc-Eden Park
  - Cincinnati, Ohio, Stany Zjednoczone, 45211
    - Oncology Hematology Care Inc-Mercy West
  - Cincinnati, Ohio, Stany Zjednoczone, 45230
    - Oncology Hematology Care Inc-Anderson
  - Cincinnati, Ohio, Stany Zjednoczone, 45236
    - Oncology Hematology Care Inc-Kenwood
  - Cincinnati, Ohio, Stany Zjednoczone, 45247
    - TriHealth Cancer Institute-Westside
  - Cincinnati, Ohio, Stany Zjednoczone, 45255
    - TriHealth Cancer Institute-Anderson
  - Cleveland, Ohio, Stany Zjednoczone, 44195
    - Cleveland Clinic Foundation
  - Cleveland, Ohio, Stany Zjednoczone, 44111
    - Cleveland Clinic Cancer Center/Fairview Hospital
  - Columbus, Ohio, Stany Zjednoczone, 43214
    - Riverside Methodist Hospital
  - Columbus, Ohio, Stany Zjednoczone, 43210
    - Ohio State University Comprehensive Cancer Center
  - Columbus, Ohio, Stany Zjednoczone, 43219
    - The Mark H Zangmeister Center
  - Columbus, Ohio, Stany Zjednoczone, 43214
    - Columbus Oncology and Hematology Associates Inc
  - Columbus, Ohio, Stany Zjednoczone, 43228
    - Doctors Hospital
  - Columbus, Ohio, Stany Zjednoczone, 43213
    - Mount Carmel East Hospital
  - Columbus, Ohio, Stany Zjednoczone, 43215
    - Grant Medical Center
  - Columbus, Ohio, Stany Zjednoczone, 43222
    - Mount Carmel Health Center West
  - Delaware, Ohio, Stany Zjednoczone, 43015
    - Delaware Health Center-Grady Cancer Center
  - Delaware, Ohio, Stany Zjednoczone, 43015
    - Delaware Radiation Oncology
  - Delaware, Ohio, Stany Zjednoczone, 43015
    - Grady Memorial Hospital
  - Fairfield, Ohio, Stany Zjednoczone, 45014
    - Oncology Hematology Care Inc-Healthplex
  - Independence, Ohio, Stany Zjednoczone, 44131
    - Cleveland Clinic Cancer Center Independence
  - Lancaster, Ohio, Stany Zjednoczone, 43130
    - Fairfield Medical Center
  - Lima, Ohio, Stany Zjednoczone, 45801
    - Saint Rita's Medical Center
  - Mansfield, Ohio, Stany Zjednoczone, 44906
    - Cleveland Clinic Cancer Center Mansfield
  - Marietta, Ohio, Stany Zjednoczone, 45750
    - Marietta Memorial Hospital
  - Marion, Ohio, Stany Zjednoczone, 43302
    - OhioHealth Marion General Hospital
  - Maumee, Ohio, Stany Zjednoczone, 43537
    - Toledo Clinic Cancer Centers-Maumee
  - Mayfield Heights, Ohio, Stany Zjednoczone, 44124
    - Hillcrest Hospital Cancer Center
  - Mount Vernon, Ohio, Stany Zjednoczone, 43050
    - Knox Community Hospital
  - Newark, Ohio, Stany Zjednoczone, 43055
    - Licking Memorial Hospital
  - Newark, Ohio, Stany Zjednoczone, 43055
    - Newark Radiation Oncology
  - Oregon, Ohio, Stany Zjednoczone, 43616
    - Saint Charles Hospital
  - Oregon, Ohio, Stany Zjednoczone, 43616
    - Toledo Clinic Cancer Centers-Oregon
  - Perrysburg, Ohio, Stany Zjednoczone, 43551
    - Mercy Health - Perrysburg Hospital
  - Portsmouth, Ohio, Stany Zjednoczone, 45662
    - Southern Ohio Medical Center
  - Sandusky, Ohio, Stany Zjednoczone, 44870
    - North Coast Cancer Care
  - Springfield, Ohio, Stany Zjednoczone, 45504
    - Springfield Regional Cancer Center
  - Springfield, Ohio, Stany Zjednoczone, 45504
    - Springfield Regional Medical Center
  - Strongsville, Ohio, Stany Zjednoczone, 44136
    - Cleveland Clinic Cancer Center Strongsville
  - Sylvania, Ohio, Stany Zjednoczone, 43560
    - ProMedica Flower Hospital
  - Toledo, Ohio, Stany Zjednoczone, 43623
    - Mercy Health - Saint Anne Hospital
  - Toledo, Ohio, Stany Zjednoczone, 43623
    - Toledo Clinic Cancer Centers-Toledo
  - Toledo, Ohio, Stany Zjednoczone, 43617
    - Toledo Community Hospital Oncology Program CCOP
  - Troy, Ohio, Stany Zjednoczone, 45373
    - Upper Valley Medical Center
  - Warrensville Heights, Ohio, Stany Zjednoczone, 44122
    - South Pointe Hospital
  - Westerville, Ohio, Stany Zjednoczone, 43081
    - Saint Ann's Hospital
  - Wooster, Ohio, Stany Zjednoczone, 44691
    - Cleveland Clinic Wooster Family Health and Surgery Center
  - Wright-Patterson Air Force Base, Ohio, Stany Zjednoczone, 45433
    - Wright-Patterson Medical Center
  - Zanesville, Ohio, Stany Zjednoczone, 43701
    - Genesis Healthcare System Cancer Care Center
- Oklahoma
  - Lawton, Oklahoma, Stany Zjednoczone, 73505
    - Cancer Centers of Southwest Oklahoma Research
  - Oklahoma City, Oklahoma, Stany Zjednoczone, 73104
    - University of Oklahoma Health Sciences Center
- Oregon
  - Bend, Oregon, Stany Zjednoczone, 97701
    - Saint Charles Health System
  - Clackamas, Oregon, Stany Zjednoczone, 97015
    - Providence Cancer Institute Clackamas Clinic
  - Coos Bay, Oregon, Stany Zjednoczone, 97420
    - Bay Area Hospital
  - Medford, Oregon, Stany Zjednoczone, 97504
    - Asante Rogue Regional Medical Center
  - Newberg, Oregon, Stany Zjednoczone, 97132
    - Providence Newberg Medical Center
  - Oregon City, Oregon, Stany Zjednoczone, 97045
    - Providence Willamette Falls Medical Center
  - Portland, Oregon, Stany Zjednoczone, 97213
    - Providence Portland Medical Center
  - Portland, Oregon, Stany Zjednoczone, 97225
    - Providence Saint Vincent Medical Center
- Pennsylvania
  - Bryn Mawr, Pennsylvania, Stany Zjednoczone, 19010
    - Bryn Mawr Hospital
  - Chadds Ford, Pennsylvania, Stany Zjednoczone, 19317
    - Christiana Care Health System-Concord Health Center
  - Danville, Pennsylvania, Stany Zjednoczone, 17822
    - Geisinger Medical Center
  - Doylestown, Pennsylvania, Stany Zjednoczone, 18901
    - Doylestown Hospital
  - Harrisburg, Pennsylvania, Stany Zjednoczone, 17109
    - UPMC Pinnacle Cancer Center/Community Osteopathic Campus
  - Hazleton, Pennsylvania, Stany Zjednoczone, 18201
    - Geisinger Medical Center-Cancer Center Hazleton
  - Hershey, Pennsylvania, Stany Zjednoczone, 17033-0850
    - Penn State Milton S Hershey Medical Center
  - Jefferson Hills, Pennsylvania, Stany Zjednoczone, 15025
    - Jefferson Hospital
  - Lancaster, Pennsylvania, Stany Zjednoczone, 17602
    - Lancaster General Hospital
  - Lewisburg, Pennsylvania, Stany Zjednoczone, 17837
    - Geisinger Medical Oncology-Lewisburg
  - Lewistown, Pennsylvania, Stany Zjednoczone, 17044
    - Lewistown Hospital
  - Media, Pennsylvania, Stany Zjednoczone, 19063
    - Riddle Memorial Hospital
  - Monroeville, Pennsylvania, Stany Zjednoczone, 15146
    - Forbes Hospital
  - Natrona Heights, Pennsylvania, Stany Zjednoczone, 15065
    - Allegheny Valley Hospital
  - Paoli, Pennsylvania, Stany Zjednoczone, 19301
    - Paoli Memorial Hospital
  - Philadelphia, Pennsylvania, Stany Zjednoczone, 19111
    - Fox Chase Cancer Center
  - Philadelphia, Pennsylvania, Stany Zjednoczone, 19140
    - Temple University Hospital
  - Philadelphia, Pennsylvania, Stany Zjednoczone, 19141
    - Einstein Medical Center Philadelphia
  - Phoenixville, Pennsylvania, Stany Zjednoczone, 19460
    - Reading Hospital McGlinn Cancer Institute at Phoenixville
  - Pittsburgh, Pennsylvania, Stany Zjednoczone, 15212
    - Allegheny General Hospital
  - Pittsburgh, Pennsylvania, Stany Zjednoczone, 15224
    - West Penn Hospital
  - Pittsburgh, Pennsylvania, Stany Zjednoczone, 15232
    - UPMC Hillman Cancer Center
  - Pottsville, Pennsylvania, Stany Zjednoczone, 17901
    - Geisinger Cancer Services-Pottsville
  - Reading, Pennsylvania, Stany Zjednoczone, 19605
    - Penn State Health Saint Joseph Medical Center
  - Sayre, Pennsylvania, Stany Zjednoczone, 18840
    - Guthrie Medical Group PC-Robert Packer Hospital
  - State College, Pennsylvania, Stany Zjednoczone, 16801
    - Geisinger Medical Group
  - State College, Pennsylvania, Stany Zjednoczone, 16803
    - Mount Nittany Medical Center
  - West Chester, Pennsylvania, Stany Zjednoczone, 19380
    - Chester County Hospital
  - West Reading, Pennsylvania, Stany Zjednoczone, 19611
    - Reading Hospital
  - Wexford, Pennsylvania, Stany Zjednoczone, 15090
    - Wexford Health and Wellness Pavilion
  - Wilkes-Barre, Pennsylvania, Stany Zjednoczone, 18711
    - Geisinger Wyoming Valley/Henry Cancer Center
  - Williamsport, Pennsylvania, Stany Zjednoczone, 17701
    - UPMC Susquehanna
  - Wynnewood, Pennsylvania, Stany Zjednoczone, 19096
    - Lankenau Medical Center
- Rhode Island
  - Providence, Rhode Island, Stany Zjednoczone, 02905
    - Women and Infants Hospital
- South Carolina
  - Anderson, South Carolina, Stany Zjednoczone, 29621
    - AnMed Health Cancer Center
  - Boiling Springs, South Carolina, Stany Zjednoczone, 29316
    - Prisma Health Cancer Institute - Spartanburg
  - Charleston, South Carolina, Stany Zjednoczone, 29425
    - Medical University of South Carolina
  - Easley, South Carolina, Stany Zjednoczone, 29640
    - Prisma Health Cancer Institute - Easley
  - Gaffney, South Carolina, Stany Zjednoczone, 29341
    - Gibbs Cancer Center-Gaffney
  - Greenville, South Carolina, Stany Zjednoczone, 29605
    - Prisma Health Cancer Institute - Faris
  - Greenville, South Carolina, Stany Zjednoczone, 29607
    - Saint Francis Cancer Center
  - Greenville, South Carolina, Stany Zjednoczone, 29615
    - Prisma Health Cancer Institute - Eastside
  - Greenville, South Carolina, Stany Zjednoczone, 29605
    - Prisma Health Cancer Institute - Butternut
  - Greenville, South Carolina, Stany Zjednoczone, 29601
    - Saint Francis Hospital
  - Greer, South Carolina, Stany Zjednoczone, 29650
    - Prisma Health Cancer Institute - Greer
  - Greer, South Carolina, Stany Zjednoczone, 29651
    - Gibbs Cancer Center-Pelham
  - Seneca, South Carolina, Stany Zjednoczone, 29672
    - Prisma Health Cancer Institute - Seneca
  - Spartanburg, South Carolina, Stany Zjednoczone, 29303
    - Spartanburg Medical Center
- South Dakota
  - Aberdeen, South Dakota, Stany Zjednoczone, 57401
    - Avera Cancer Institute-Aberdeen
  - Rapid City, South Dakota, Stany Zjednoczone, 57701
    - Rapid City Regional Hospital
  - Sioux Falls, South Dakota, Stany Zjednoczone, 57105
    - Avera Cancer Institute
  - Sioux Falls, South Dakota, Stany Zjednoczone, 57117-5134
    - Sanford USD Medical Center - Sioux Falls
  - Sioux Falls, South Dakota, Stany Zjednoczone, 57104
    - Sanford Cancer Center Oncology Clinic
- Tennessee
  - Jackson, Tennessee, Stany Zjednoczone, 38301
    - Jackson-Madison County General Hospital
  - Kingsport, Tennessee, Stany Zjednoczone, 37660
    - Ballad Health Cancer Care - Kingsport
  - Kingsport, Tennessee, Stany Zjednoczone, 37660
    - Wellmont Holston Valley Hospital and Medical Center
  - Memphis, Tennessee, Stany Zjednoczone, 38120
    - Baptist Memorial Hospital and Cancer Center-Memphis
  - Memphis, Tennessee, Stany Zjednoczone, 38120
    - Baptist Memorial Hospital for Women
  - Memphis, Tennessee, Stany Zjednoczone, 38120
    - Family Cancer Center-Memphis
  - Nashville, Tennessee, Stany Zjednoczone, 37208
    - Meharry Medical College
- Texas
  - Abilene, Texas, Stany Zjednoczone, 79601
    - Hendrick Medical Center
  - Dallas, Texas, Stany Zjednoczone, 75235
    - Parkland Memorial Hospital
  - Dallas, Texas, Stany Zjednoczone, 75390
    - UT Southwestern/Simmons Cancer Center-Dallas
  - El Paso, Texas, Stany Zjednoczone, 79905
    - Texas Tech University Health Sciences Center-El Paso
  - Fort Worth, Texas, Stany Zjednoczone, 76104
    - UT Southwestern/Simmons Cancer Center-Fort Worth
  - Tyler, Texas, Stany Zjednoczone, 75708
    - University of Texas Health Science Center at Tyler
- Vermont
  - Saint Johnsbury, Vermont, Stany Zjednoczone, 05819
    - Dartmouth Cancer Center - North
- Virginia
  - Charlottesville, Virginia, Stany Zjednoczone, 22908
    - University of Virginia Cancer Center
  - Fredericksburg, Virginia, Stany Zjednoczone, 22408
    - Hematology Oncology Associates of Fredericksburg Inc
  - Lynchburg, Virginia, Stany Zjednoczone, 24501
    - Centra Alan B Pearson Regional Cancer Center
  - Martinsville, Virginia, Stany Zjednoczone, 24112
    - Sovah Health Martinsville
  - Mechanicsville, Virginia, Stany Zjednoczone, 23116
    - Bon Secours Memorial Regional Medical Center
  - Midlothian, Virginia, Stany Zjednoczone, 23114
    - Bon Secours Saint Francis Medical Center
  - Norton, Virginia, Stany Zjednoczone, 24273
    - Ballad Health Cancer Care - Norton
  - Richmond, Virginia, Stany Zjednoczone, 23229
    - Virginia Cancer Institute
  - Richmond, Virginia, Stany Zjednoczone, 23226
    - Bon Secours Saint Mary's Hospital
  - Richmond, Virginia, Stany Zjednoczone, 23298
    - VCU Massey Comprehensive Cancer Center
  - South Hill, Virginia, Stany Zjednoczone, 23970
    - VCU Community Memorial Health Center
  - Winchester, Virginia, Stany Zjednoczone, 22601
    - Shenandoah Oncology PC
- Washington
  - Burien, Washington, Stany Zjednoczone, 98166
    - Saint Anne Hospital
  - Edmonds, Washington, Stany Zjednoczone, 98026
    - Swedish Cancer Institute-Edmonds
  - Issaquah, Washington, Stany Zjednoczone, 98029
    - Swedish Cancer Institute-Issaquah
  - Kennewick, Washington, Stany Zjednoczone, 99336
    - Kadlec Clinic Hematology and Oncology
  - Kirkland, Washington, Stany Zjednoczone, 98034
    - FHCC at EvergreenHealth
  - Longview, Washington, Stany Zjednoczone, 98632
    - PeaceHealth Saint John Medical Center
  - Mount Vernon, Washington, Stany Zjednoczone, 98274
    - Skagit Valley Hospital
  - Mount Vernon, Washington, Stany Zjednoczone, 98274
    - Skagit Regional Health Cancer Care Center
  - Poulsbo, Washington, Stany Zjednoczone, 98370
    - Harrison HealthPartners Hematology and Oncology-Poulsbo
  - Seattle, Washington, Stany Zjednoczone, 98107
    - Swedish Medical Center-Ballard Campus
  - Seattle, Washington, Stany Zjednoczone, 98122
    - Swedish Medical Center-First Hill
  - Seattle, Washington, Stany Zjednoczone, 98195
    - University of Washington Medical Center - Montlake
  - Seattle, Washington, Stany Zjednoczone, 98112
    - Kaiser Permanente Washington
  - Seattle, Washington, Stany Zjednoczone, 98104
    - Minor and James Medical PLLC
  - Seattle, Washington, Stany Zjednoczone, 98109
    - Fred Hutchinson Cancer Center
  - Silverdale, Washington, Stany Zjednoczone, 98383
    - Saint Joseph Medical Center Hematology and Oncology - Silverdale
  - Tacoma, Washington, Stany Zjednoczone, 98405
    - Northwest Medical Specialties PLLC
  - Tacoma, Washington, Stany Zjednoczone, 98405
    - Franciscan Research Center-Northwest Medical Plaza
  - Vancouver, Washington, Stany Zjednoczone, 98664
    - PeaceHealth Southwest Medical Center
  - Walla Walla, Washington, Stany Zjednoczone, 99362
    - Providence Saint Mary Regional Cancer Center
  - Yakima, Washington, Stany Zjednoczone, 98902
    - North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
- West Virginia
  - Charleston, West Virginia, Stany Zjednoczone, 25304
    - Vandalia Health/CAMC Institute for Academic Medicine
  - Huntington, West Virginia, Stany Zjednoczone, 25701
    - Edwards Comprehensive Cancer Center
  - Morgantown, West Virginia, Stany Zjednoczone, 26506
    - West Virginia University Healthcare
- Wisconsin
  - Antigo, Wisconsin, Stany Zjednoczone, 54409
    - Aspirus Cancer Care-Antigo-Volm Cancer Center
  - Burlington, Wisconsin, Stany Zjednoczone, 53105
    - Aurora Cancer Care-Southern Lakes VLCC
  - Chippewa Falls, Wisconsin, Stany Zjednoczone, 54729
    - Marshfield Clinic-Chippewa Center
  - Eau Claire, Wisconsin, Stany Zjednoczone, 54701
    - Marshfield Clinic Cancer Center at Sacred Heart
  - Fond du Lac, Wisconsin, Stany Zjednoczone, 54937
    - Aurora Health Center-Fond du Lac
  - Germantown, Wisconsin, Stany Zjednoczone, 53022
    - Aurora Health Care Germantown Health Center
  - Grafton, Wisconsin, Stany Zjednoczone, 53024
    - Aurora Cancer Care-Grafton
  - Green Bay, Wisconsin, Stany Zjednoczone, 54311
    - Aurora BayCare Medical Center
  - Green Bay, Wisconsin, Stany Zjednoczone, 54301
    - Saint Vincent Hospital Cancer Center Green Bay
  - Green Bay, Wisconsin, Stany Zjednoczone, 54303
    - Saint Vincent Hospital Cancer Center at Saint Mary's
  - Green Bay, Wisconsin, Stany Zjednoczone, 54301
    - Bellin Memorial Hospital
  - Janesville, Wisconsin, Stany Zjednoczone, 53548
    - Mercyhealth Hospital and Cancer Center - Janesville
  - Johnson Creek, Wisconsin, Stany Zjednoczone, 53038
    - University of Wisconsin Carbone Cancer Center - Johnson Creek
  - Kenosha, Wisconsin, Stany Zjednoczone, 53142
    - Aurora Cancer Care-Kenosha South
  - La Crosse, Wisconsin, Stany Zjednoczone, 54601
    - Gundersen Lutheran Medical Center
  - Madison, Wisconsin, Stany Zjednoczone, 53792
    - University of Wisconsin Carbone Cancer Center - University Hospital
  - Manitowoc, Wisconsin, Stany Zjednoczone, 54221
    - Holy Family Memorial Hospital
  - Marinette, Wisconsin, Stany Zjednoczone, 54143
    - Aurora Bay Area Medical Group-Marinette
  - Marinette, Wisconsin, Stany Zjednoczone, 54143
    - Saint Vincent Hospital Cancer Center at Marinette
  - Marshfield, Wisconsin, Stany Zjednoczone, 54449
    - Marshfield Medical Center-Marshfield
  - Milwaukee, Wisconsin, Stany Zjednoczone, 53209
    - Aurora Cancer Care-Milwaukee
  - Milwaukee, Wisconsin, Stany Zjednoczone, 53215
    - Aurora Saint Luke's Medical Center
  - Milwaukee, Wisconsin, Stany Zjednoczone, 53233
    - Aurora Sinai Medical Center
  - Minocqua, Wisconsin, Stany Zjednoczone, 54548
    - Marshfield Medical Center - Minocqua
  - Mukwonago, Wisconsin, Stany Zjednoczone, 53149
    - ProHealth D N Greenwald Center
  - New Richmond, Wisconsin, Stany Zjednoczone, 54017
    - Cancer Center of Western Wisconsin
  - Oconomowoc, Wisconsin, Stany Zjednoczone, 53066
    - ProHealth Oconomowoc Memorial Hospital
  - Oconto Falls, Wisconsin, Stany Zjednoczone, 54154
    - Saint Vincent Hospital Cancer Center at Oconto Falls
  - Oshkosh, Wisconsin, Stany Zjednoczone, 54904
    - Vince Lombardi Cancer Clinic - Oshkosh
  - Racine, Wisconsin, Stany Zjednoczone, 53406
    - Aurora Cancer Care-Racine
  - Racine, Wisconsin, Stany Zjednoczone, 53405
    - Ascension All Saints Hospital-Spring Street-Racine
  - Rhinelander, Wisconsin, Stany Zjednoczone, 54501
    - Aspirus Cancer Care-Rhinelander-James Beck Cancer Center
  - Rice Lake, Wisconsin, Stany Zjednoczone, 54868
    - Marshfield Medical Center-Rice Lake
  - Sheboygan, Wisconsin, Stany Zjednoczone, 53081
    - Vince Lombardi Cancer Clinic-Sheboygan
  - Sheboygan, Wisconsin, Stany Zjednoczone, 53081
    - HSHS Saint Nicholas Hospital
  - Stevens Point, Wisconsin, Stany Zjednoczone, 54482
    - Marshfield Medical Center-River Region at Stevens Point
  - Stevens Point, Wisconsin, Stany Zjednoczone, 54481
    - Aspirus Cancer Care - Stevens Point
  - Sturgeon Bay, Wisconsin, Stany Zjednoczone, 54235-1495
    - Saint Vincent Hospital Cancer Center at Sturgeon Bay
  - Summit, Wisconsin, Stany Zjednoczone, 53066
    - Aurora Medical Center in Summit
  - Two Rivers, Wisconsin, Stany Zjednoczone, 54241
    - Vince Lombardi Cancer Clinic-Two Rivers
  - Waukesha, Wisconsin, Stany Zjednoczone, 53188
    - UW Cancer Center at ProHealth Care
  - Waukesha, Wisconsin, Stany Zjednoczone, 53188
    - ProHealth Waukesha Memorial Hospital
  - Waukesha, Wisconsin, Stany Zjednoczone, 53188
    - Aurora Cancer Care-Waukesha
  - Wausau, Wisconsin, Stany Zjednoczone, 54401
    - Marshfield Clinic-Wausau Center
  - Wausau, Wisconsin, Stany Zjednoczone, 54401
    - Aspirus Cancer Care-Wausau
  - Wauwatosa, Wisconsin, Stany Zjednoczone, 53226
    - Aurora Cancer Care-Milwaukee West
  - West Allis, Wisconsin, Stany Zjednoczone, 53227
    - Aurora West Allis Medical Center
  - Weston, Wisconsin, Stany Zjednoczone, 54476
    - Marshfield Medical Center - Weston
  - Wisconsin Rapids, Wisconsin, Stany Zjednoczone, 54494
    - Aspirus Cancer Care - Wisconsin Rapids
  - Wisconsin Rapids, Wisconsin, Stany Zjednoczone, 54494
    - Marshfield Clinic - Wisconsin Rapids Center
- Wyoming
  - Cheyenne, Wyoming, Stany Zjednoczone, 82001
    - Cheyenne Regional Medical Center-West

Kryteria uczestnictwa

Badacze szukają osób, które pasują do określonego opisu, zwanego kryteriami kwalifikacyjnymi. Niektóre przykłady tych kryteriów to ogólny stan zdrowia danej osoby lub wcześniejsze leczenie.

Kryteria kwalifikacji

Wiek uprawniający do nauki

18 lat i starsze (Dorosły, Starszy dorosły)

Akceptuje zdrowych ochotników

Nie

Płeć kwalifikująca się do nauki

Wszystko

Opis

Inclusion Criteria:

Estrogen receptor (ER) and/or progesterone receptor (PR) positive histologically confirmed adenocarcinoma of the breast with staining of >= 1% cells will be considered positive; receptor status may be based on any time during treatment prior to study randomization, and from any site (i.e. primary, recurrent, or metastatic)
Patients whose tumors have HER2 immunohistochemistry (IHC) 3+, in situ hybridization (ISH) >= 2.0, or average HER2 copy number >= 6.0 signals per cell are not eligible; receptor status may be based on any time during treatment prior to study randomization, and from any site (i.e. primary, recurrent, or metastatic)
Patients must have measurable or non-measurable stage III/locally advanced or metastatic carcinoma of the breast where local therapy with curative intent is not possible; lesions must be evaluated =< 4 weeks prior to study randomization; diagnostic-quality computed tomography (CT) scans with both oral and intravenous (IV) contrast are the expected radiologic method, unless an alternative is approved
- NOTE: Where baseline imaging has already been performed =< 6 weeks prior to study randomization, repeat imaging may not be required
- NOTE: As of October 16, 2016, accrual of new patients having non-measurable disease has stopped; the planned accrual for this target population has been reached
Pre/peri- and postmenopausal women and all men are eligible for this trial; postmenopausal is defined as:
- Age >= 55 years and one year or more of amenorrhea
- Age < 55 years and one year or more of amenorrhea, with estradiol < 20 pg/ml
- Age < 55 with prior hysterectomy but intact ovaries, with estradiol < 20 pg/ml
- Prior bilateral oophorectomy
  - NOTE: Women who do not fit the criteria for being postmenopausal as above are deemed pre-or peri-menopausal; pre/perimenopausal women and all men can enroll provided they agree to receive concomitant luteinizing hormone-releasing hormone (LHRH) agonist; pre/perimenopausal women must have commenced treatment with LHRH agonist at least 4 weeks prior to randomization; if patients have received alternative LHRH agonist prior to study entry, they must switch to goserelin for the duration of the trial
Sexually active males and pre/perimenopausal women must agree to use an accepted and effective method of contraception or to abstain from sexual intercourse for the duration of their participation in the study and for 3 months after discontinuation of therapy
Women must not be pregnant or breast-feeding; all females of childbearing potential must have a blood test or urine study =< 2 weeks prior to randomization
- A female of childbearing potential is any woman, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria: 1) has not undergone a hysterectomy or bilateral oophorectomy; or 2) has not been naturally postmenopausal for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months)
Patients must not have known central nervous system metastasis or a history of central nervous system (CNS) metastases; patients with leptomeningeal disease are not eligible
Patients must be disease-free of prior invasive malignancies for > 5 years with the exception of curatively-treated basal cell or squamous cell carcinoma of the skin or carcinoma in situ of the cervix
- NOTE: If there is a history of prior malignancy, patients must not be receiving other specific treatment for that cancer
Patients must meet at least one of the following criteria:
- Disease progression any time after non-steroidal AI use in the advanced disease setting
- Relapse while on or within =< 12 months of end of adjuvant non-steroidal AI therapy with or without prior endocrine therapy for advanced disease
- NOTE: In either setting, treatment with any prior endocrine therapy must be completed >= 2 weeks prior to cycle 1 day 1 (C1D1) of study treatment with the exception of exemestane which is permitted in the advanced disease setting within =< 4 weeks immediately prior to C1D1; prior adjuvant exemestane is allowed if the disease free interval is > 12 months from the discontinuation of exemestane; prior faslodex, everolimus, palbociclib or other cyclin-dependent kinase (CDK) inhibitor (e.g. ribociclib, abemaciclib) use are allowed and must have been completed >= 2 weeks prior to C1D1; failure to adhere to this washout guideline will result in a protocol violation
Patients may have received only one prior chemotherapy regimen for metastatic disease provided treatment was completed >= 3 weeks prior to randomization
Patients may be treated with bone modifying agents such as bisphosphonates or RANK-ligand agents (e.g. denosumab) per American Society of Clinical Oncology (ASCO) guidelines; whenever possible, patients requiring bone modifying agents should start treatment >= 7 days prior to study therapy and should continue the same agent throughout study unless clinically compelled to change
Prior radiotherapy must in general have been completed >= 2 weeks prior to randomization and patients must have recovered from the toxicity of the radiation
- NOTE: Patients may receive concurrent radiation therapy to painful sites of bony disease or areas of impending fracture as long as sites of measurable or non-measurable disease outside the radiation therapy port are available to follow
Patients must NOT receive concurrent anti-cancer therapy or investigational agent unless specified in protocol
Patients must NOT be receiving valproic acid, an histone deacetylase (HDAC) inhibitor, and may not have previously received any HDAC inhibitor prior to enrollment (e.g. valproic acid, entinostat, vorinostat) unless discussed with the study chair; patients must not have received prior HDAC therapy for the treatment of their malignancy
Patients must have no known allergies to exemestane, entinostat, or medications that have a benzamide structure (e.g., tiapride, remoxipride, clebropride)
Patients must NOT suffer from medical or psychiatric conditions that would interfere with protocol compliance, the ability to provide informed consent, or assessment of response or anticipated toxicities; this includes uncontrolled intercurrent illness including, but not limited to ongoing or active infection
Patients must have recovered from all clinically relevant adverse events to grade 1 or baseline due to previous agents administered (except alopecia)
Patients must have adequate hematologic, liver and renal function =< 28 days prior to randomization
- NOTE: It is preferred that laboratory values for eligibility be assessed after the last dose of prior treatment, especially in cases where most-recent treatment prior to study entry is chemotherapy
Hemoglobin (HgB) >= 9.0 g/dL (=< 28 days prior to randomization)
Platelet count >= 100,000/mcL (=< 28 days prior to randomization)
Absolute neutrophil count >= 1,500/mcL (=< 28 days prior to randomization)
Creatinine =< 2.0 mg/dL (=< 28 days prior to randomization)
Total bilirubin < 1.5 x institutional upper limit of normal (=< 3 mg/dL in case of Gilbert's syndrome) (=< 28 days prior to randomization)
Transaminases (alanine aminotransferase [ALT], aspartate aminotransferase [AST]) =< 2.5 x institutional upper limit normal (=< 28 days prior to randomization)
Known human immunodeficiency virus (HIV)-positive patients should have a cluster of differentiation (CD)4 count > 250/mm^3
Patients must have Eastern Cooperative Oncology Group (ECOG) performance status 0-1
Patients must have a life expectancy >= 12 weeks
Patients must be able to swallow tablets

Plan studiów

Ta sekcja zawiera szczegółowe informacje na temat planu badania, w tym sposób zaprojektowania badania i jego pomiary.

Jak projektuje się badanie?

Szczegóły projektu

Główny cel: Leczenie
Przydział: Randomizowane
Model interwencyjny: Przydział równoległy
Maskowanie: Podwójnie

Broń i interwencje

Grupa uczestników / Arm Grupa uczestników / Arm Grupa lub podgrupa uczestników badania klinicznego, którzy zgodnie z protokołem badania otrzymują określoną interwencję/leczenie lub nie otrzymują żadnej interwencji.	Interwencja / Leczenie Interwencja / Leczenie Proces lub działanie będące przedmiotem badania klinicznego. Interwencje obejmują leki, urządzenia medyczne, procedury, szczepionki i inne produkty, które są w fazie badań lub są już dostępne. Interwencje mogą również obejmować podejścia nieinwazyjne, takie jak edukacja lub modyfikacja diety i ćwiczeń.
Eksperymentalny: Arm A (exemestane, entinostat) Patients receive exemestane PO QD on days 1-28 and entinostat PO on days 1, 8, 15, and 22. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients also undergo CT or MRI at baseline, at the end of cycle 3, every 3 cycles, at treatment discontinuation, and during follow-up, collection of blood samples at baseline and day 15 of cycle 1, and collection of archived tissue at baseline. Pre/perimenopausal female patients and all male patients also receive goserelin acetate SC on day 1.	Lek: Exemestane Given PO Inne nazwy: Aromatyna FCE-24304 Inny: Quality-of-Life Assessment Ancillary studies Inne nazwy: Ocena jakości życia Procedura: Computed Tomography Undergo CT Inne nazwy: Tomografia komputerowa KOT Skanowanie CAT Tomografia komputerowa osiowa Komputerowa tomografia osiowa tomografia Komputerowa tomografia osiowa (zabieg) Tomografia komputerowa (CT). Diagnostyczny skan CAT Diagnostyczny typ usługi skanowania CAT Procedura: Magnetic Resonance Imaging Undergo MRI Inne nazwy: MRI Rezonans magnetyczny Skanowanie rezonansu magnetycznego Obrazowanie medyczne, rezonans magnetyczny / jądrowy rezonans magnetyczny PAN Obrazowanie MR Obrazowanie NMR NMRI Obrazowanie magnetycznego rezonansu jądrowego Obrazowanie metodą rezonansu magnetycznego (MRI) sMRI Rezonans magnetyczny (zabieg) Strukturalny MRI Lek: Goserelin Acetate Given SC Inne nazwy: ZDX Zoladeks Procedura: Biospecimen Collection Undergo collection of blood and archived tissue samples Inne nazwy: Pobieranie próbek biologicznych Zebrano próbki biologiczne Kolekcja próbek Lek: Entinostat Given PO Inne nazwy: Inhibitor HDAC SNDX-275 MS 27-275 MS-275 SNDX-275 MS275 MS 275 SNDX275 Lek: Goserelin Given PO Inne nazwy: ICI-118630
Komparator placebo: Arm B (exemestane, placebo) Patients receive exemestane as in Arm A and placebo PO on days 1, 8, 15, and 22. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients also undergo CT or MRI at baseline, at the end of cycle 3, every 3 cycles, at treatment discontinuation, and during follow-up, collection of blood samples at baseline and day 15 of cycle 1, and collection of archived tissue at baseline. Pre/perimenopausal female patients and all male patients also receive goserelin acetate SC on day 1.	Lek: Exemestane Given PO Inne nazwy: Aromatyna FCE-24304 Inny: Quality-of-Life Assessment Ancillary studies Inne nazwy: Ocena jakości życia Procedura: Computed Tomography Undergo CT Inne nazwy: Tomografia komputerowa KOT Skanowanie CAT Tomografia komputerowa osiowa Komputerowa tomografia osiowa tomografia Komputerowa tomografia osiowa (zabieg) Tomografia komputerowa (CT). Diagnostyczny skan CAT Diagnostyczny typ usługi skanowania CAT Procedura: Magnetic Resonance Imaging Undergo MRI Inne nazwy: MRI Rezonans magnetyczny Skanowanie rezonansu magnetycznego Obrazowanie medyczne, rezonans magnetyczny / jądrowy rezonans magnetyczny PAN Obrazowanie MR Obrazowanie NMR NMRI Obrazowanie magnetycznego rezonansu jądrowego Obrazowanie metodą rezonansu magnetycznego (MRI) sMRI Rezonans magnetyczny (zabieg) Strukturalny MRI Inny: Placebo Administration Given PO Lek: Goserelin Acetate Given SC Inne nazwy: ZDX Zoladeks Procedura: Biospecimen Collection Undergo collection of blood and archived tissue samples Inne nazwy: Pobieranie próbek biologicznych Zebrano próbki biologiczne Kolekcja próbek Lek: Goserelin Given PO Inne nazwy: ICI-118630

Grupa uczestników / Arm

Interwencja / Leczenie

Eksperymentalny: Arm A (exemestane, entinostat)

Patients receive exemestane PO QD on days 1-28 and entinostat PO on days 1, 8, 15, and 22. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients also undergo CT or MRI at baseline, at the end of cycle 3, every 3 cycles, at treatment discontinuation, and during follow-up, collection of blood samples at baseline and day 15 of cycle 1, and collection of archived tissue at baseline.

Pre/perimenopausal female patients and all male patients also receive goserelin acetate SC on day 1.

Lek: Exemestane

Given PO

Inne nazwy:

Aromatyna
FCE-24304

Inny: Quality-of-Life Assessment

Ancillary studies

Inne nazwy:

Ocena jakości życia

Procedura: Computed Tomography

Undergo CT

Inne nazwy:

Tomografia komputerowa
KOT
Skanowanie CAT
Tomografia komputerowa osiowa
Komputerowa tomografia osiowa
tomografia
Komputerowa tomografia osiowa (zabieg)
Tomografia komputerowa (CT).
Diagnostyczny skan CAT
Diagnostyczny typ usługi skanowania CAT

Procedura: Magnetic Resonance Imaging

Undergo MRI

Inne nazwy:

MRI
Rezonans magnetyczny
Skanowanie rezonansu magnetycznego
Obrazowanie medyczne, rezonans magnetyczny / jądrowy rezonans magnetyczny
PAN
Obrazowanie MR
Obrazowanie NMR
NMRI
Obrazowanie magnetycznego rezonansu jądrowego
Obrazowanie metodą rezonansu magnetycznego (MRI)
sMRI
Rezonans magnetyczny (zabieg)
Strukturalny MRI

Lek: Goserelin Acetate

Given SC

Inne nazwy:

ZDX
Zoladeks

Procedura: Biospecimen Collection

Undergo collection of blood and archived tissue samples

Inne nazwy:

Pobieranie próbek biologicznych
Zebrano próbki biologiczne
Kolekcja próbek

Lek: Entinostat

Given PO

Inne nazwy:

Inhibitor HDAC SNDX-275
MS 27-275
MS-275
SNDX-275
MS275
MS 275
SNDX275

Lek: Goserelin

Given PO

Inne nazwy:

ICI-118630

Komparator placebo: Arm B (exemestane, placebo)

Patients receive exemestane as in Arm A and placebo PO on days 1, 8, 15, and 22. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients also undergo CT or MRI at baseline, at the end of cycle 3, every 3 cycles, at treatment discontinuation, and during follow-up, collection of blood samples at baseline and day 15 of cycle 1, and collection of archived tissue at baseline.

Pre/perimenopausal female patients and all male patients also receive goserelin acetate SC on day 1.

Lek: Exemestane

Given PO

Inne nazwy:

Aromatyna
FCE-24304

Inny: Quality-of-Life Assessment

Ancillary studies

Inne nazwy:

Ocena jakości życia

Procedura: Computed Tomography

Undergo CT

Inne nazwy:

Tomografia komputerowa
KOT
Skanowanie CAT
Tomografia komputerowa osiowa
Komputerowa tomografia osiowa
tomografia
Komputerowa tomografia osiowa (zabieg)
Tomografia komputerowa (CT).
Diagnostyczny skan CAT
Diagnostyczny typ usługi skanowania CAT

Procedura: Magnetic Resonance Imaging

Undergo MRI

Inne nazwy:

MRI
Rezonans magnetyczny
Skanowanie rezonansu magnetycznego
Obrazowanie medyczne, rezonans magnetyczny / jądrowy rezonans magnetyczny
PAN
Obrazowanie MR
Obrazowanie NMR
NMRI
Obrazowanie magnetycznego rezonansu jądrowego
Obrazowanie metodą rezonansu magnetycznego (MRI)
sMRI
Rezonans magnetyczny (zabieg)
Strukturalny MRI

Inny: Placebo Administration

Given PO

Lek: Goserelin Acetate

Given SC

Inne nazwy:

ZDX
Zoladeks

Procedura: Biospecimen Collection

Undergo collection of blood and archived tissue samples

Inne nazwy:

Pobieranie próbek biologicznych
Zebrano próbki biologiczne
Kolekcja próbek

Lek: Goserelin

Given PO

Inne nazwy:

ICI-118630

Co mierzy badanie?

Podstawowe miary wyniku

Miara wyniku	Opis środka	Ramy czasowe
Progression-free Survival (PFS) Ramy czasowe: Assessed at baseline, then every 12 weeks until treatment discontinuation, then every 3 months within 2 years from study entry, every 6 months between 2-5 years and annually between 6-10 years from study entry, until first disease progression	Progression-free survival (PFS) was defined to be time from randomization to the earliest documented disease progression as defined by the RECIST criteria, new primary breast cancer, or death without progression. Disease assessment was to continue until disease progression, even after non-protocol anti-cancer therapy was started. Cases with incomplete follow up or without adequate disease evaluations were censored at the date last documented to be free of progression, regardless of whether non-protocol anti-cancer therapy was started or not. Disease progression was based on central review, and defined as at least a 20% increase in the sum of the diameters of target lesions, taking as reference the smallest sum on study. In addition to the relative increase of 20%, the sum must also demonstrate an absolute increase of at least 5 mm. In addition, the appearance of one or more new lesions was also considered progression. Kaplan-Meier method was used to estimate PFS rate.	Assessed at baseline, then every 12 weeks until treatment discontinuation, then every 3 months within 2 years from study entry, every 6 months between 2-5 years and annually between 6-10 years from study entry, until first disease progression
Overall Survival (OS) Ramy czasowe: Assessed every 3 months within 2 years from study entry, every 6 months between 2-5 years and annually between 6-10 years from study entry, until death	Overall survival (OS) was defined to be time from randomization to death from any cause. Cases who were still alive were censored at the date last known alive.	Assessed every 3 months within 2 years from study entry, every 6 months between 2-5 years and annually between 6-10 years from study entry, until death

Miary wyników drugorzędnych

Miara wyniku	Opis środka	Ramy czasowe
Objective Response Rate (ORR) Ramy czasowe: Assessed at baseline, then every 12 weeks until treatment discontinuation, then every 3 months within 2 years from study entry, every 6 months between 2-5 years and annually between 6-10 years from study entry, until first disease progression	Objective response rate was defined as number of patients with complete response (CR) or partial response (PR) divided by all randomized patients. Responses were evaluated using the revised Response Evaluation Criteria in Solid Tumors (RECIST) guideline. CR was defined as disappearance of all target and non-target lesions. PR was defined as at least a 30% decrease in the sum of the diameters of target lesions (taking as reference the baseline sum diameters), and/or persistence of one or more non-target lesion(s).	Assessed at baseline, then every 12 weeks until treatment discontinuation, then every 3 months within 2 years from study entry, every 6 months between 2-5 years and annually between 6-10 years from study entry, until first disease progression
Time-to-treatment Deterioration (TTD) Ramy czasowe: Disease assessed at baseline, then every 12 weeks until treatment discontinuation, then every 3 months within 2 years from study entry, every 6 months between 2-5 years and annually between 6-10 years from study entry, until first disease progression	Time-to-treatment deterioration (TTD) was defined as time from randomization to disease progression or death or worsening of symptoms, whichever occurred first. Disease progression was assessed per RECIST v1.1. Symptoms deterioration was measured by 6 items (GP1, GP2, GP4, GF7, B1, P2, scored 0-24) from the 8-item FACT-Breast Symptom Index (FBSI). Symptom deterioration was defined as two consecutive available decreases of at least 3 points from baseline using the 6-item FBSI in this trial, and the second visit time was used as the time of symptom deterioration in this case, unless it was the final score, for which one decrease was sufficient. Kaplan-Meier method was used to estimate the median TTD and TTD rate at a certain time point. Symptoms were assessed every cycle for the first six months after randomization, every two cycles between 6 months and 1 year. It then were assessed based on the same schedule for tumor assessments until disease progression as specified below.	Disease assessed at baseline, then every 12 weeks until treatment discontinuation, then every 3 months within 2 years from study entry, every 6 months between 2-5 years and annually between 6-10 years from study entry, until first disease progression
Lysine Acetylation Change in CD45 Blood Mononuclear Cells Between C1D1 and C1D15 and PFS in Patients on Arm A Ramy czasowe: Disease assessed at baseline, then every 12 weeks until treatment discontinuation, then every 3 months within 2 years from study entry, every 6 months between 2-5 years and annually between 6-10 years from study entry, until first disease progression	Peripheral blood samples (PBMCs) were collected prior to therapy and on Days 8 and 15 of cycle 1, for assessment of lysine acetylation, using an assay developed by the Trepel Laboratory, NCI/NIH. CD45 blood mononuclear cells were measured. Patients with lysine acetylation change of 1.5 folds or higher were compared to patients with lysine acetylation change of less than 1.5 folds.	Disease assessed at baseline, then every 12 weeks until treatment discontinuation, then every 3 months within 2 years from study entry, every 6 months between 2-5 years and annually between 6-10 years from study entry, until first disease progression
Patient-reported Health-related Quality of Life Ramy czasowe: Assessed at baseline and end of cycle 3	Health-related quality of life (HRQL) was measured using Functional Assessment of Cancer Therapy - General (FACT-G). The primary endpoint for HRQL was the FACT-G Trial Outcome Index (TOI) which was an aggregate score of 5 items from the FACT-G-Physical subscale (GP2, GP3, GP4, GP6, and GP7) and 6 items from the FACT-G-Functional subscale (GF1, GF2, GF3, GF4, GF6, and GF7). All items were rated on a 5-point Likert scale from 0 to 4. FACT-G TOI subscale score was calculated based on the scoring manual, subscale score ranges from 0 to 44, and higher scores indicate better quality of life. The primary comparison of HRQL between treatment arms was based on the end of cycle 3 assessment.	Assessed at baseline and end of cycle 3
Patient-reported Diarrhea Ramy czasowe: Assessed at baseline and end of cycle 3	Diarrhea was measured by Functional Assessment of Chronic Illness Therapy for Patients With Diarrhea (FACIT-Diarrhea) subscale form, which had 11 items, all items were rated on a 5-point Likert scale from 0 to 4. FACIT-Diarrhea subscale score was calculated based on the scoring manual, subscale score ranges from 0 to 44, and higher score indicates less diarrhea. The primary comparison of patient-reported diarrhea between treatment arms was based on the end of cycle 3 assessment.	Assessed at baseline and end of cycle 3
Patient-reported Fatigue Ramy czasowe: Assessed at baseline and end of cycle 3	Fatigue was measured by PROMIS Fatigue short form, it had 7 items and all items were rated on a 5-point Likert scale from 1 to 5. The PROMIS Fatigue total score and T score were calculated based on the scoring manual. The total score ranges from 7 to 35, the T score ranges from 29.4 to 83.2, higher scores indicate more fatigue. The PROMIS Fatigue T score was used for arm comparison. The primary comparison of patient-reported fatigue between treatment arms was based on the end of cycle 3 assessment.	Assessed at baseline and end of cycle 3
Patient-reported Nausea and Anorexia Ramy czasowe: Assessed at baseline and end of cycle 3	Nausea and anorexia were measured by The Functional Assessment of Anorexia/Cachexia Treatment (FAACT)-additional concerns, which had 12 items, all items were rated on a 5-point Likert scale from 0 to 4. FAACT-additional concerns subscale score was calculated based on scoring manual. Subscale score ranges from 0 to 48, and higher scores indicate less nausea and anorexia. The primary comparison of patient-reported nausea and anorexia between treatment arms was based on the end of cycle 3 assessment.	Assessed at baseline and end of cycle 3

Współpracownicy i badacze

Tutaj znajdziesz osoby i organizacje zaangażowane w to badanie.

Sponsor

National Cancer Institute (NCI)

Śledczy

Główny śledczy: Roisin M Connolly, ECOG-ACRIN Cancer Research Group

Publikacje i pomocne linki

Osoba odpowiedzialna za wprowadzenie informacji o badaniu dobrowolnie udostępnia te publikacje. Mogą one dotyczyć wszystkiego, co jest związane z badaniem.

Publikacje ogólne

Connolly RM, Zhao F, Miller KD, Lee MJ, Piekarz RL, Smith KL, Brown-Glaberman UA, Winn JS, Faller BA, Onitilo AA, Burkard ME, Budd GT, Levine EG, Royce ME, Kaufman PA, Thomas A, Trepel JB, Wolff AC, Sparano JA. E2112: Randomized Phase III Trial of Endocrine Therapy Plus Entinostat or Placebo in Hormone Receptor-Positive Advanced Breast Cancer. A Trial of the ECOG-ACRIN Cancer Research Group. J Clin Oncol. 2021 Oct 1;39(28):3171-3181. doi: 10.1200/JCO.21.00944. Epub 2021 Aug 6.

Przydatne linki

<p>Data Available: Select individual patient-level data from this trial can be requested from the NCTN/NCORP Data Archive.</p>

Daty zapisu na studia

Daty te śledzą postęp w przesyłaniu rekordów badań i podsumowań wyników do ClinicalTrials.gov. Zapisy badań i zgłoszone wyniki są przeglądane przez National Library of Medicine (NLM), aby upewnić się, że spełniają określone standardy kontroli jakości, zanim zostaną opublikowane na publicznej stronie internetowej.

Główne daty studiów

Rozpoczęcie studiów (Rzeczywisty)

29 marca 2014

Zakończenie podstawowe (Rzeczywisty)

5 maja 2020

Ukończenie studiów (Szacowany)

2 czerwca 2027

Daty rejestracji na studia

Pierwszy przesłany

14 kwietnia 2014

Pierwszy przesłany, który spełnia kryteria kontroli jakości

14 kwietnia 2014

Pierwszy wysłany (Szacowany)

16 kwietnia 2014

Aktualizacje rekordów badań

Ostatnia wysłana aktualizacja (Rzeczywisty)

22 października 2026

Ostatnia przesłana aktualizacja, która spełniała kryteria kontroli jakości

21 października 2026

Ostatnia weryfikacja

1 czerwca 2026

Więcej informacji

Terminy związane z tym badaniem

Dodatkowe istotne warunki MeSH

Inne numery identyfikacyjne badania

NCI-2014-00746
U10CA180820 (Grant/umowa NIH USA)
U24CA196172 (Grant/umowa NIH USA)
U10CA021115 (Grant/umowa NIH USA)
NCI-2014-00746 (Identyfikator rejestru: CTRP (Clinical Trial Reporting Program))
E2112 (Inny identyfikator: CTEP)
ECOG-E2112
E2112 (Inny identyfikator: ECOG-ACRIN Cancer Research Group)

Te informacje zostały pobrane bezpośrednio ze strony internetowej clinicaltrials.gov bez żadnych zmian. Jeśli chcesz zmienić, usunąć lub zaktualizować dane swojego badania, skontaktuj się z register@clinicaltrials.gov. Gdy tylko zmiana zostanie wprowadzona na stronie clinicaltrials.gov, zostanie ona automatycznie zaktualizowana również na naszej stronie internetowej .

Eksemestan z entinostatem lub bez w leczeniu pacjentów z nawracającym rakiem piersi z ekspresją receptorów hormonalnych, miejscowo zaawansowanym lub z przerzutami

Randomizowane badanie fazy III terapii hormonalnej plus entinostat/placebo u pacjentów z zaawansowanym rakiem piersi z ekspresją receptorów hormonalnych

Przegląd badań

Status

Warunki

Interwencja / Leczenie

Szczegółowy opis

Typ studiów

Zapisy (Rzeczywisty)

Faza

Kontakty i lokalizacje

Lokalizacje studiów

Kryteria uczestnictwa

Kryteria kwalifikacji

Wiek uprawniający do nauki

Akceptuje zdrowych ochotników

Płeć kwalifikująca się do nauki

Opis

Plan studiów

Jak projektuje się badanie?

Szczegóły projektu

Liczba ramion

Broń i interwencje

Grupa uczestników / Arm

Interwencja / Leczenie

Co mierzy badanie?

Podstawowe miary wyniku

Miara wyniku

Opis środka

Ramy czasowe

Miary wyników drugorzędnych

Miara wyniku

Opis środka

Ramy czasowe

Współpracownicy i badacze

Sponsor

Śledczy

Publikacje i pomocne linki

Publikacje ogólne

Przydatne linki

Daty zapisu na studia

Główne daty studiów

Rozpoczęcie studiów (Rzeczywisty)

Zakończenie podstawowe (Rzeczywisty)

Ukończenie studiów (Szacowany)

Daty rejestracji na studia

Pierwszy przesłany

Pierwszy przesłany, który spełnia kryteria kontroli jakości

Pierwszy wysłany (Szacowany)

Aktualizacje rekordów badań

Ostatnia wysłana aktualizacja (Rzeczywisty)

Ostatnia przesłana aktualizacja, która spełniała kryteria kontroli jakości

Ostatnia weryfikacja

Więcej informacji

Terminy związane z tym badaniem

Dodatkowe istotne warunki MeSH

Inne numery identyfikacyjne badania