Vliv stravy na erektilní funkci (ERECTION)
22. července 2026 aktualizováno: Montefiore Medical Center
Vliv rostlinné stravy versus živočišná strava na erektilní funkci u zdravých mužů s normální erektilní funkcí: studie EREKCE
Cílem této studie je zjistit, zda je erektilní funkce ovlivněna stravovacími návyky u zdravých mužů s normální erektilní funkcí.
Přehled studie
Postavení
Postavení
Nábor
Podmínky
Podmínky
Intervence / Léčba
Intervence / Léčba
Detailní popis
Návštěva 1:
Po kontrole a podpisu souhlasu budou subjekty prověřovány. Promítání se bude skládat z:
Vyplňte IIEF (Mezinárodní index erektilní funkce) a dotazník o frekvenci jídla.
Zaznamenejte si anamnézu, léky Změřte výšku a váhu Vitální funkce Odeberte krev na stanovení celkového testosteronu, globulinu vážícího pohlavní hormony a TSH (hormon stimulující štítnou žlázu) Subjekty budou dotázány na přítomnost genitálních vyrážek nebo lézí
Pokud je skóre IIEF abnormální, bude subjektům doporučeno, aby kontaktovali PCP (poskytovatel primární péče).
Subjekty budou kontaktovány s výsledky laboratorních testů. Pokud je abnormální, bude subjektu doporučeno, aby kontaktoval PCP.
Pokud subjekt nemá žádné PCP, budou uvedeny kontaktní informace pro PCP. Subjekty splňující kritéria pro zařazení a vyloučení budou náhodně rozděleny do sekvence jedna nebo sekvence dvě. Po zařazení do studie nebudou subjekty upravovat stravovací návyky po celou dobu trvání studie kromě dvou večerů a dvou celých dnů, kdy je jim poskytováno jídlo (viz níže).
Sekvence jedna:
Návštěva 2:
Subjekty se vracejí do studijního centra ráno po půstu (kromě konzumace vody) od 23:00 předchozí noci. Subjekty si toho rána nebudou čistit zuby ani používat ústní vodu a/nebo jiné osvěžovače dechu. Budou provedeny antropomorfní záznamy, krevní tlak a srdeční frekvence. Krev bude odebrána a uložena. Moč bude shromažďována a skladována. Účastníci se budou učit, jak používat zařízení Rigiscan™. Subjekty obdrží jednu rostlinnou večeři. Subjekty poté opustí studijní centrum a budou konzumovat obvyklou stravu do 17:00. Po zbytek večera do 23:00 budou subjekty konzumovat pouze poskytnutou večeři. Voda bude jediným povoleným nápojem po 17:00. Večeře by se měla konzumovat ve 20:30, EST (východního standardního času). Subjekty zašlou po 17. hodině textové zprávy s obrázky všeho, co bylo zkonzumováno (jíst nebo pít), PI nebo zástupci studie, který je členem studijního týmu, bude mít alespoň jednou ten večer textový nebo verbální kontakt se subjektem. Subjekty se po 23:00 postí kromě vody. Tu noc budou subjekty provádět hodnocení Rigiscan™ přes noc doma. Měl by být zaznamenán čas, kdy jde subjekt spát a čas, kdy se daný den probudí. Subjekt souhlasí s tím, že bude v posteli se zapnutým Rigiscan™ (kromě naléhavých případů nebo nutných výletů na toaletu) po dobu nejméně sedmi hodin.
Návštěva 3:
Subjekty se vrátí do studijního centra ráno po hodnocení Rigiscan™ a přinesou zařízení Rigiscan™. Subjekty budou od 23:00 předchozí noci držet jiný půst než pití vody. Subjekty si toho rána nebudou čistit zuby ani používat ústní vodu a/nebo jiné osvěžovače dechu. Budou provedeny antropomorfní záznamy, krevní tlak a srdeční frekvence. Krev bude odebrána a uložena. Moč bude shromažďována a skladována. Subjekty pak dostanou jeden celý den rostlinné stravy. Subjekty budou vyzvány, aby snídaly ve studijním centru poté, co byla provedena počáteční antropomorfní opatření, byla odebrána krev a odebrána moč. Subjekty zašlou textové zprávy s obrázky všeho, co bylo během daného dne zkonzumováno, PI a/nebo zástupci studie a člen studijního týmu bude mít textový nebo verbální kontakt se subjektem alespoň dvakrát během daného dne. Večeře by měla být konzumována ve 20:30 EST. Subjekty se po 23:00 postí kromě vody. Tu noc budou subjekty provádět hodnocení Rigiscan™ přes noc doma. Černá káva a/nebo čaj jsou povoleny pouze před polednem. Měl by být zaznamenán čas, kdy jde subjekt spát a čas, kdy se daný den probudí. Subjekt souhlasí s tím, že bude v posteli se zapnutým Rigiscan™ (kromě naléhavých případů nebo nutných výletů na toaletu) po dobu nejméně sedmi hodin.
Návštěva 4:
Subjekty se vrátí do studijního centra ráno po hodnocení Rigiscan™ a přinesou zařízení Rigiscan™. Subjekty si toho rána nebudou čistit zuby ani používat ústní vodu a/nebo jiné osvěžovače dechu. Budou provedeny antropomorfní záznamy, krevní tlak a srdeční frekvence. Krev bude odebrána a uložena. Moč bude shromažďována a skladována. Poté bude následovat vymývací období po dobu 8-12 dnů a subjekty budou instruovány, aby se během tohoto vymývacího období vrátily k obvyklým stravovacím návykům.
Návštěva 5:
Po vymývací periodě se subjekty vracejí do studijního centra ráno po půstu (kromě konzumace vody) od 23 hodin předchozí noci. Subjekty si toho rána nebudou čistit zuby ani používat ústní vodu a/nebo jiné osvěžovače dechu. Budou provedeny antropomorfní záznamy, krevní tlak a srdeční frekvence. Krev bude odebrána a uložena. Moč bude shromažďována a skladována. Subjekty obdrží jednu zvířecí večeři. Subjekty poté opustí studijní centrum a budou konzumovat obvyklou stravu do 17:00. Po zbytek večera do 23:00 budou subjekty konzumovat pouze poskytnutou večeři. Voda bude jediným nápojem konzumovaným po 17:00. Večeře by měla být konzumována ve 20:30 EST. Subjekty po 17. hodině zašlou textové zprávy s obrázky všeho, co bylo zkonzumováno (jíst nebo pít) PI nebo zástupci studie a člen studijního týmu bude mít textový nebo verbální kontakt se subjektem alespoň jednou ten večer. Subjekty se po 23:00 postí kromě vody. Tu noc budou subjekty provádět hodnocení Rigiscan™ přes noc doma. Měl by být zaznamenán čas, kdy jde subjekt spát a čas, kdy se daný den probudí. Subjekt souhlasí s tím, že bude v posteli se zapnutým Rigiscan™ (kromě naléhavých případů nebo nutných výletů na toaletu) po dobu nejméně sedmi hodin.
Návštěva 6:
Subjekty se vrátí do studijního centra ráno po hodnocení Rigiscan™ a přinesou zařízení Rigiscan™. Subjekty si toho rána nebudou čistit zuby ani používat ústní vodu a/nebo jiné osvěžovače dechu. Budou provedeny antropomorfní záznamy, záznamy krevního tlaku a EndoPAT™. Sliny budou uloženy. Krev bude odebrána a uložena. Subjekty pak dostanou jeden celý den jídla na bázi zvířat. Po provedení počátečních antropomorfních opatření, získání slin a odběru krve budou subjekty vyzvány, aby snídaly ve studijním centru. Subjekty zašlou textovou zprávu s obrázky všeho, co bylo během daného dne zkonzumováno, PI a/nebo zástupci studie a studijní tým bude mít textový nebo verbální kontakt se subjektem alespoň dvakrát během daného dne. Večeře by měla být konzumována ve 20:30 EST. Subjekty se po 23:00 postí kromě vody. Tu noc budou subjekty provádět hodnocení Rigiscan™ přes noc doma. Černá káva a/nebo čaj jsou povoleny pouze před polednem. Měl by být zaznamenán čas, kdy jde subjekt spát a čas, kdy se daný den probudí. Subjekt souhlasí s tím, že bude v posteli se zapnutým Rigiscan™ (kromě naléhavých případů nebo nutných výletů na toaletu) po dobu nejméně sedmi hodin.
Návštěva 7 (konec studie):
Subjekty se vrátí do studijního centra ráno po hodnocení Rigiscan™ a přinesou zařízení Rigiscan™. Subjekty si toho rána nebudou čistit zuby ani používat ústní vodu a/nebo jiné osvěžovače dechu. Budou provedeny antropomorfní záznamy, krevní tlak a srdeční frekvence. Krev bude odebrána a uložena. Moč bude shromažďována a skladována.
Sekvence dva:
Sekvence dvě je identická se Sekvencí jedna, s tím rozdílem, že místo rostlinných jídel jsou podávána jídla živočišného původu. Pro subjekty randomizované k živočišným jídlům v Sekvenci jedna a Sekvenci dvě budou identické s tím rozdílem, že budou poskytnuta rostlinná jídla místo živočišných jídel.
Typ studie
Typ studie
Intervenční
Zápis (Odhadovaný)
Zápis
46
Fáze
Fáze
- Nelze použít
Kontakty a umístění
Tato část poskytuje kontaktní údaje pro ty, kteří studii provádějí, a informace o tom, kde se tato studie provádí.
Studijní kontakt
Studijní kontakt
- Jméno: Robert Ostfeld, MD
- Telefonní číslo: 718-920-5197
- E-mail: ROSTFELD@montefiore.org
Studijní místa
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New York
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The Bronx, New York, Spojené státy, 10467
- Nábor
- Montefiore Medical Center, Department of Medicine, Division of Cardiology
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Kontakt:
- Robert J Ostfeld, MD, MS
- Telefonní číslo: 718-920-8011
- E-mail: rostfeld@montefiore.org
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Kritéria účasti
Výzkumníci hledají lidi, kteří odpovídají určitému popisu, kterému se říká kritéria způsobilosti. Některé příklady těchto kritérií jsou celkový zdravotní stav osoby nebo předchozí léčba.
Kritéria způsobilosti
Kritéria způsobilosti
Věk způsobilý ke studiu
14 let až 25 let (Dospělý)
Přijímá zdravé dobrovolníky
Ano
Popis
Kritéria pro zařazení:
- Subjekt poskytuje písemný informovaný souhlas a autorizaci HIPAA v angličtině před provedením jakýchkoli studijních postupů;
- Žádná lékařská terapie (jiná než prn MDI (inhalátory s odměřenou dávkou) a žádná změna doplňků, pokud je to relevantní)
- IIEF skóre větší nebo rovné 22
- Subjekt bude mít penilní-vaginální sex do 4 týdnů od zařazení. Použité skóre IIEF je validováno na základě tohoto časového okna.
- Muž ve věku 18-29 let
- Žije v dojezdové vzdálenosti od Montefiore Health System
- Další významná osoba subjektu (pokud je to relevantní) souhlasí s podporou subjektu během studie
- Subjekt souhlasí s fotografováním a sdílením všech věcí zkonzumovaných/opilých během dietní intervence
- Subjekt souhlasí s tím, že se alespoň dva dny před nahráváním Rigiscan™ a ve dnech a nocích, kdy se nahrávání Rigiscan™ bude vyskytovat, bude vyhýbat všem nelegálním drogám, NSAID a alkoholu.
- Subjekt souhlasí s tím, že se zdrží sexuální aktivity po dobu nejméně 36 hodin před umístěním Rigiscan™ a že nebude mít žádnou sexuální aktivitu ve dnech a nocích záznamu Rigiscan™.
- Subjekt souhlasí s tím, že nebude prohlížet, číst ani jinak konzumovat erotický nebo pornografický materiál po dobu nejméně 36 hodin před dny a nocí záznamu Rigiscan™ a ve dnech a nocích záznamu Rigiscan™
- Subjekt souhlasí s tím, že přijede do Montefiore absolvovat školení Rigiscan™
- Subjekt souhlasí s tím, že bude konzumovat/pít pouze povolené potraviny/nápoje.
- Subjekt souhlasí s tím, že se zúčastní všech osobních návštěv v Montefiore, že zahájí půst v 23 hodin večer před každou návštěvou a podstoupí všechny odběry krve/slin/jiné testy.
- Subjekt souhlasí s tím, že nebude používat ústní vodu nebo ústní vody nebo úmyslně plivat po celou dobu trvání studie. Subjekty budou požádány, aby se zdržely používání ústní vody alespoň 2 dny před zápisem. Subjekt souhlasí s tím, že si nebude čistit zuby ráno v den každé studijní návštěvy. Jinak je čištění zubů přípustné.
- BMI menší než 30, BMI vyšší nebo rovný 18,5, hmotnost vyšší než 110 liber.
- Subjekt souhlasí s dodržováním studijních postupů a návštěv.
- Předmět cvičení po dobu alespoň 15 minut alespoň dvakrát týdně. Subjekt souhlasí s tím, že se bude vyhýbat cvičení den před a v den měření Rigiscan™
Kritéria vyloučení:
- Relevantní dietní alergie
- Vegetariánský nebo veganský dietní vzorec
- Anamnéza poruchy příjmu potravy; důkaz závislosti na jídle
- Hypertenze a nebo anamnéza hypertenze s lékařskou léčbou nebo bez ní
- BMI větší nebo rovné 30, BMI menší než 18,5 nebo hmotnost menší nebo rovna 110 liber
- Známé chronické lékařské onemocnění jiné než nezánětlivé muskuloskeletální onemocnění a astma
- Anamnéza onemocnění ledvin nebo hyperkalémie
- Subjekt obdržel testovaný lék do 30 dnů před podpisem souhlasu
- Erektilní dysfunkce
- Má jakýkoli stav (např. psychiatrické onemocnění) nebo situaci, která podle názoru zkoušejícího může zkreslit výsledky studie nebo může významně narušit pacientovu schopnost dodržovat postupy studie
- V současné době podstupuje léčbu Peyronieho choroby
- Abnormální hladina testosteronu nebo hormonu stimulujícího štítnou žlázu
- Léčený hypogonadismus nebo hypotyreóza
- Plánované cestování během studia
- Anamnéza zneužívání návykových látek v posledních 12 měsících
- Nezákonné užívání drog, kouření nebo vaping do 4 týdnů
- Onemocnění horních cest dýchacích do dvou týdnů na screeningu
- Vyžaduje-li profese pohotovost, žádné povinnosti přes noc nebo pohotovost během studia
- Jakákoli přenosná kožní nebo pohlavní nemoc. Subjekt hlásí vyrážku nebo léze na penisu nebo jeho okolí. Subjekt bude dotázán: "Máte vyrážku nebo léze na penisu nebo v jeho okolí?"
Studijní plán
Tato část poskytuje podrobnosti o studijním plánu, včetně toho, jak je studie navržena a co studie měří.
Jak je studie koncipována?
Detaily designu
- Primární účel: Prevence
- Přidělení: Randomizované
- Intervenční model: Crossover Assignment
- Maskování: Singl
Počet zbraní
2
Zbraně a zásahy
Skupina účastníků / ArmSkupina účastníků / Arm |
Intervence / LéčbaIntervence / Léčba |
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Aktivní komparátor: Rameno na rostlinné bázi
Rostlinné rameno se skládá ze 3 návštěv klinického výzkumného centra, dodržování rostlinné stravy a použití zařízení Rigiscan™ k měření frekvence, rigidity a trvání nočních erekcí.
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Jídlo zajistí Montefiore-Einstein Food Services
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Aktivní komparátor: Rameno na zvířecí bázi
Rameno na zvířatech se skládá ze 3 návštěv klinického výzkumného centra, dodržování diety založené na zvířatech a použití zařízení Rigiscan™ k měření frekvence, rigidity a trvání nočních erekcí.
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Jídlo zajistí Montefiore-Einstein Food Services
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Co je měření studie?
Primární výstupní opatření
Primární výstupní opatření
Měření výsledku |
Popis opatření |
Časové okno |
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Percent of time ≥60% erect during overnight Rigiscan™ use after 4 meals.
Časové okno: During overnight Rigiscan™ use directly after consuming the 4 meals. (The second night of Rigiscan™ use).
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The first 5 minutes of Rigiscan™ recording is discarded.
Erection time is the total time (in minutes) when penile rigidity is ≥ 60% at both the tip and base of the penis with a concurrent increase in penile tumescence at both the tip and base of the penis compared to baseline tumescence as measured by Rigiscan™ during overnight Rigiscan™ use, divided by the total time (in minutes) of overnight Rigiscan™ use.
Overnight Rigiscan™ use time is defined as starting 5 minutes after the start of the Rigiscan™ recording and the end of Rigiscan™ use is defined as the last time the tip or base was >=10% rigid with a corresponding concurrent increase in penile tumescence at the tip or base compared to baseline tumesence.
This total time window from start to end is the Rigiscan™ use time.
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During overnight Rigiscan™ use directly after consuming the 4 meals. (The second night of Rigiscan™ use).
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Sekundární výstupní opatření
Sekundární výstupní opatření
Měření výsledku |
Popis opatření |
Časové okno |
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Percent of time ≥60% erect during overnight Rigiscan™ use after 1 meal.
Časové okno: During overnight Rigiscan™ use directly after consuming 1 meal. (The first night of Rigiscan™ use).
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The first 5 minutes of Rigiscan™ recording is discarded.
Erection time is the total time (in minutes) when penile rigidity is ≥ 60% at both the tip and base of the penis with a concurrent increase in penile tumescence at both the tip and base of the penis compared to baseline tumescence as measured by Rigiscan™ during overnight Rigiscan™ use, divided by the total time (in minutes) of overnight Rigiscan™ use.
Overnight Rigiscan™ use time is defined as starting 5 minutes after the start of the Rigiscan™ recording and the end of Rigiscan™ use is defined as the last time the tip or base was >=10% rigid with a corresponding concurrent increase in penile tumescence at the tip or base compared to baseline tumesence.
This total time window from start to end is the Rigiscan™ use time
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During overnight Rigiscan™ use directly after consuming 1 meal. (The first night of Rigiscan™ use).
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Percent of time ≥60% erect during overnight Rigiscan™ use after 4 meals, where each erection lasts >=5 minutes as measured by Rigiscan™
Časové okno: During overnight Rigiscan™ use directly after consuming 4 meals. (The second night of Rigiscan™ use).
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The first 5 minutes of Rigiscan™ recording is discarded.
Erection time is the total time (in minutes) when penile rigidity is ≥ 60% at both the tip and the base of the penis with a concurrent increase in penile tumescence at both the tip and base of the penis compared to baseline tumescence, and the erection lasts >= 5 minutes, as measured by Rigiscan™ during overnight Rigiscan™ use, divided by the total time (in minutes) of overnight Rigiscan™ use.
Overnight Rigiscan™ use time is defined as starting 5 minutes after the start of the Rigiscan™ recording and the end of Rigiscan™ use is defined as the last time the tip or base was >=10% rigid with a corresponding concurrent increase in penile tumescence at the tip or base compared to baseline tumesence.
This total time window from start to end is the Rigiscan™ use time.
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During overnight Rigiscan™ use directly after consuming 4 meals. (The second night of Rigiscan™ use).
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Percent of time ≥60% erect during overnight Rigiscan™ use after 1 meal, where each erection lasts >=5 minutes as measured by Rigiscan™
Časové okno: During overnight Rigiscan™ use directly after consuming 1 meal. (The first night of Rigiscan™ use).
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The first 5 minutes of Rigiscan™ recording is discarded.
Erection time is the total time (in minutes) when penile rigidity is ≥ 60% at both the tip and the base of the penis with a concurrent increase in penile tumescence at both the tip and base of the penis compared to baseline tumescence, and the erection lasts >= 5 minutes, as measured by Rigiscan™ during overnight Rigiscan™ use, divided by the total time (in minutes) of overnight Rigiscan™ use.
Overnight Rigiscan™ use time is defined as starting 5 minutes after the start of the Rigiscan™ recording and the end of Rigiscan™ use is defined as the last time the tip or base was >=10% rigid with a corresponding concurrent increase in penile tumescence at the tip or base compared to baseline tumesence.
This total time window from start to end is the Rigiscan™ use time.
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During overnight Rigiscan™ use directly after consuming 1 meal. (The first night of Rigiscan™ use).
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Další výstupní opatření
Další výstupní opatření
Měření výsledku |
Popis opatření |
Časové okno |
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Heart rate
Časové okno: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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Comparing heart rate by dietary pattern at both time points (after overnight Rigiscan™ use after consuming the 1 meal and after overnight Rigiscan™ use after consuming the 4 meals) and compared to its respective baseline in beats/minute.
Definition: In regard to the following anthropometric, vital sign, and laboratory data (blood, urine, and saliva) pre-specified outcomes included in this pre-specified outcomes section, at "both time points" is defined as in the sentence above and "respective baseline" refers to either visit 2 or visit 5, as visit 2 is the baseline for one dietary arm (plant or animal) and visit 5 is the baseline for the other dietary arm (plant or animal).
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Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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Blood Pressure
Časové okno: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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Comparing blood pressure by dietary pattern at both time points and compared to its respective baseline in mmHg
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Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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Weight
Časové okno: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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Comparing weight by dietary pattern at both time points and compared to its respective baseline
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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|
Fibrinogen
Časové okno: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in mg/dL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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|
D-dimer
Časové okno: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in ng/mL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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|
Total cholesterol
Časové okno: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in mg/dL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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|
HDL cholesterol
Časové okno: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in mg/dL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
HDL efflux capacity
Časové okno: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline.
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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|
LDL cholesterol
Časové okno: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in mg/dL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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|
Triglyceride
Časové okno: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in mg/dL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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Oxidized LDL cholesterol
Časové okno: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in U/L
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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Free Fatty Acids
Časové okno: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in micromoles
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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|
Myeloperoxidase
Časové okno: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in ug/L
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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|
Factor VII
Časové okno: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in percentage.
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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|
lysolecithin
Časové okno: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in mg/mL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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|
Apolipoprotein B
Časové okno: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in mg/dL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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|
Omega 3 index
Časové okno: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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Comparing it at both time points by dietary pattern and compared to its respective baseline in percentage of erythrocyte fatty acid
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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|
Lipoprotein-associated phospholipase-A2 (Lp PLA2) activity
Časové okno: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in nmol/min/mL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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Lipoprotein (a)
Časové okno: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in nmol/L
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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Homocysteine
Časové okno: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in umol/L
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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|
methylmalonic acid (MMA)
Časové okno: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in umol/L
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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|
Asymmetric Dimethylarginine (ADMA)
Časové okno: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in umol/L
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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|
symmetric dimethylarginine (SDMA)
Časové okno: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in mg/dL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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|
Total testosterone
Časové okno: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in mg/dL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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|
Sex Hormone Binding Globulin
Časové okno: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in nmol/L
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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|
cystatin C
Časové okno: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in mg/dL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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|
remnant cholesterol particles
Časové okno: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in mg/dL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
uric acid
Časové okno: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in mg/dL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
interleukin 1
Časové okno: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in pg/mL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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|
interleukin 6
Časové okno: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in pg/mL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
hsCRP
Časové okno: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in mg/L
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
Blood Urea Nitrogen (BUN)
Časové okno: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in mg/dL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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|
Carbon Dioxide (CO2)
Časové okno: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in mmol/L
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
creatinine
Časové okno: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in mg/dL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
glucose
Časové okno: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in mg/dL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
serum chloride
Časové okno: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in meq/L
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
serum potassium
Časové okno: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in meq/L
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
serum sodium
Časové okno: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in meq/L
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
alanine aminotransferase (ALT)
Časové okno: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in units/L
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
aspartate aminotransferase (AST)
Časové okno: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in units/L
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
estimated glomerular filtration rate (eGFR)
Časové okno: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in mL/min/1.73m2
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
vitamin c
Časové okno: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in mg/dL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
reduced glutathione
Časové okno: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in umol/L
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
superoxide dismutase
Časové okno: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in ng/mL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
vitamin e
Časové okno: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in mg/L
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
selenium
Časové okno: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in ng/mL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
malondialdehyde
Časové okno: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in umol/L
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
non coding RNA
Časové okno: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in copies/mL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
micro RNA
Časové okno: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in copies/mL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
Lnc RNA
Časové okno: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in copies/mL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
trimethylamine-N-oxide (TMAO)
Časové okno: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in umol/L
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
phenylacetylglutamine (PAG)
Časové okno: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in uM (micrometers)
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
Comparing urine albumin-to-creatinine ratio (UACR)
Časové okno: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in mg/g
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
Comparing salivary nitrite level as a correlate of plasma nitric oxide (NO) level
Časové okno: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in micromoles/L
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
Comparing salivary nitrate level in as a correlate of plasma nitric oxide (NO) level
Časové okno: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in micromoles/L
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
Platelets
Časové okno: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in cells/ul.
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
FIB-4 Index
Časové okno: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
Percent of time ≥50% erect during overnight Rigiscan™ use after the 4 meals.
Časové okno: During overnight Rigiscan™ use directly after consuming the 4 meals. (The second night of Rigiscan™ use).
|
The first 5 minutes of Rigiscan™ recording is discarded.
Erection time is the total time (in minutes) when penile rigidity is ≥ 50% at both the tip and base of the penis with a concurrent increase in penile tumescence at both the tip and base of the penis compared to baseline tumescence as measured by Rigiscan™ during overnight Rigiscan™ use, divided by the total time (in minutes) of overnight Rigiscan™ use.
Overnight Rigiscan™ use time is defined as starting 5 minutes after the start of the Rigiscan™ recording and the end of Rigiscan™ use is defined as the last time the tip or base was >=10% rigid with a corresponding concurrent increase in penile tumescence at the tip or base compared to baseline tumesence.
This total time window from start to end is the Rigiscan™ use time.
|
During overnight Rigiscan™ use directly after consuming the 4 meals. (The second night of Rigiscan™ use).
|
|
Percent of time ≥50% erect during overnight Rigiscan™ use after 1 meal.
Časové okno: During overnight Rigiscan™ use directly after consuming 1 meal. (The first night of Rigiscan™ use)
|
The first 5 minutes of Rigiscan™ recording is discarded.
Erection time is the total time (in minutes) when penile rigidity is ≥ 50% at both the tip and base of the penis with a concurrent increase in penile tumescence at both the tip and base of the penis compared to baseline tumescence as measured by Rigiscan™ during overnight Rigiscan™ use, divided by the total time (in minutes) of overnight Rigiscan™ use.
Overnight Rigiscan™ use time is defined as starting 5 minutes after the start of the Rigiscan™ recording and the end of Rigiscan™ use is defined as the last time the tip or base was >=10% rigid with a corresponding concurrent increase in penile tumescence at the tip or base compared to baseline tumesence.
This total time window from start to end is the Rigiscan™ use time
|
During overnight Rigiscan™ use directly after consuming 1 meal. (The first night of Rigiscan™ use)
|
|
Percent of time ≥70% erect during overnight Rigiscan™ use after 4 meals.
Časové okno: During overnight Rigiscan™ use directly after consuming the 4 meals. (The second night of Rigiscan™ use).
|
The first 5 minutes of Rigiscan™ recording is discarded.
Erection time is the total time (in minutes) when penile rigidity is ≥ 70% at both the tip and base of the penis with a concurrent increase in penile tumescence at both the tip and base of the penis compared to baseline tumescence as measured by Rigiscan™ during overnight Rigiscan™ use, divided by the total time (in minutes) of overnight Rigiscan™ use.
Overnight Rigiscan™ use time is defined as starting 5 minutes after the start of the Rigiscan™ recording and the end of Rigiscan™ use is defined as the last time the tip or base was >=10% rigid with a corresponding concurrent increase in penile tumescence at the tip or base compared to baseline tumesence.
This total time window from start to end is the Rigiscan™ use time
|
During overnight Rigiscan™ use directly after consuming the 4 meals. (The second night of Rigiscan™ use).
|
|
Percent of time ≥70% erect during overnight Rigiscan™ use after 1 meal.
Časové okno: During overnight Rigiscan™ use directly after consuming 1 meal. (The first night of Rigiscan™ use).
|
The first 5 minutes of Rigiscan™ recording is discarded.
Erection time is the total time (in minutes) when penile rigidity is ≥ 70% at both the tip and base of the penis with a concurrent increase in penile tumescence at both the tip and base of the penis compared to baseline tumescence as measured by Rigiscan™ during overnight Rigiscan™ use, divided by the total time (in minutes) of overnight Rigiscan™ use.
Overnight Rigiscan™ use time is defined as starting 5 minutes after the start of the Rigiscan™ recording and the end of Rigiscan™ use is defined as the last time the tip or base was >=10% rigid with a corresponding concurrent increase in penile tumescence at the tip or base compared to baseline tumesence.
This total time window from start to end is the Rigiscan™ use time
|
During overnight Rigiscan™ use directly after consuming 1 meal. (The first night of Rigiscan™ use).
|
|
Percent of time ≥70% erect during overnight Rigiscan™ use after 4 meals versus after 1 meal by dietary pattern.
Časové okno: During overnight Rigiscan™ use directly after consuming the 4 meals versus overnight Rigiscan™ use directly after consuming the 1 meal by dietary pattern, for each dietary pattern.
|
The first 5 minutes of Rigiscan™ recording is discarded.
Erection time is the total time (in minutes) when penile rigidity is ≥ 70% at both the tip and base of the penis with a concurrent increase in penile tumescence at both the tip and base of the penis compared to baseline tumescence as measured by Rigiscan™ during overnight Rigiscan™ use, divided by the total time (in minutes) of overnight Rigiscan™ use.
Overnight Rigiscan™ use time is defined as starting 5 minutes after the start of the Rigiscan™ recording and the end of Rigiscan™ use is defined as the last time the tip or base was >=10% rigid with a corresponding concurrent increase in penile tumescence at the tip or base compared to baseline tumesence.
This total time window from start to end is the Rigiscan™ use time.
|
During overnight Rigiscan™ use directly after consuming the 4 meals versus overnight Rigiscan™ use directly after consuming the 1 meal by dietary pattern, for each dietary pattern.
|
|
Percent of time ≥60% erect during overnight Rigiscan™ use after 4 meals versus after 1 meal by dietary pattern.
Časové okno: During overnight Rigiscan™ use directly after consuming the 4 meals versus overnight Rigiscan™ use directly after consuming the 1 meal by dietary pattern, for each dietary pattern.
|
The first 5 minutes of Rigiscan™ recording is discarded.
Erection time is the total time (in minutes) when penile rigidity is ≥ 60% at both the tip and base of the penis with a concurrent increase in penile tumescence at both the tip and base of the penis compared to baseline tumescence as measured by Rigiscan™ during overnight Rigiscan™ use, divided by the total time (in minutes) of overnight Rigiscan™ use.
Overnight Rigiscan™ use time is defined as starting 5 minutes after the start of the Rigiscan™ recording and the end of Rigiscan™ use is defined as the last time the tip or base was >=10% rigid with a corresponding concurrent increase in penile tumescence at the tip or base compared to baseline tumesence.
This total time window from start to end is the Rigiscan™ use time.
|
During overnight Rigiscan™ use directly after consuming the 4 meals versus overnight Rigiscan™ use directly after consuming the 1 meal by dietary pattern, for each dietary pattern.
|
|
Percent of time ≥50% erect during overnight Rigiscan™ use after 4 meals versus after 1 meal by dietary pattern.
Časové okno: During overnight Rigiscan™ use directly after consuming the 4 meals versus overnight Rigiscan™ use directly after consuming the 1 meal by dietary pattern, for each dietary pattern.
|
The first 5 minutes of Rigiscan™ recording is discarded.
Erection time is the total time (in minutes) when penile rigidity is ≥ 50% at both the tip and base of the penis with a concurrent increase in penile tumescence at both the tip and base of the penis compared to baseline tumescence as measured by Rigiscan™ during overnight Rigiscan™ use, divided by the total time (in minutes) of overnight Rigiscan™ use.
Overnight Rigiscan™ use time is defined as starting 5 minutes after the start of the Rigiscan™ recording and the end of Rigiscan™ use is defined as the last time the tip or base was >=10% rigid with a corresponding concurrent increase in penile tumescence at the tip or base compared to baseline tumesence.
This total time window from start to end is the Rigiscan™ use time.
|
During overnight Rigiscan™ use directly after consuming the 4 meals versus overnight Rigiscan™ use directly after consuming the 1 meal by dietary pattern, for each dietary pattern.
|
|
Percent of time ≥70% erect during overnight Rigiscan™ use after 4 meals, where each erection lasts >=5 minutes as measured by Rigiscan™
Časové okno: During overnight Rigiscan™ use directly after consuming 4 meals. (The second night of Rigiscan™ use).
|
The first 5 minutes of Rigiscan™ recording is discarded.
Erection time is the total time (in minutes) when penile rigidity is ≥ 70% at both the tip and the base of the penis with a concurrent increase in penile tumescence at both the tip and base of the penis compared to baseline tumescence, and the erection lasts >= 5 minutes, as measured by Rigiscan™ during overnight Rigiscan™ use, divided by the total time (in minutes) of overnight Rigiscan™ use.
Overnight Rigiscan™ use time is defined as starting 5 minutes after the start of the Rigiscan™ recording and the end of Rigiscan™ use is defined as the last time the tip or base was >=10% rigid with a corresponding concurrent increase in penile tumescence at the tip or base compared to baseline tumesence.
This total time window from start to end is the Rigiscan™ use time.
|
During overnight Rigiscan™ use directly after consuming 4 meals. (The second night of Rigiscan™ use).
|
|
Percent of time ≥70% erect during overnight Rigiscan™ use after 1 meal, where each erection lasts >=5 minutes as measured by Rigiscan™
Časové okno: During overnight Rigiscan™ use directly after consuming 1 meal. (The first night of Rigiscan™ use).
|
The first 5 minutes of Rigiscan™ recording is discarded.
Erection time is the total time (in minutes) when penile rigidity is ≥70% at both the tip and the base of the penis with a concurrent increase in penile tumescence at both the tip and base of the penis compared to baseline tumescence, and the erection lasts >= 5 minutes, as measured by Rigiscan™ during overnight Rigiscan™ use, divided by the total time (in minutes) of overnight Rigiscan™ use.
Overnight Rigiscan™ use time is defined as starting 5 minutes after the start of the Rigiscan™ recording and the end of Rigiscan™ use is defined as the last time the tip or base was >=10% rigid with a corresponding concurrent increase in penile tumescence at the tip or base compared to baseline tumesence.
This total time window from start to end is the Rigiscan™ use time.
|
During overnight Rigiscan™ use directly after consuming 1 meal. (The first night of Rigiscan™ use).
|
|
Percent of time ≥50% erect during overnight Rigiscan™ use after 4 meals, where each erection lasts >=5 minutes as measured by Rigiscan™
Časové okno: During overnight Rigiscan™ use directly after consuming 4 meals. (The second night of Rigiscan™ use).
|
The first 5 minutes of Rigiscan™ recording is discarded.
Erection time is the total time (in minutes) when penile rigidity is ≥ 50% at both the tip and the base of the penis with a concurrent increase in penile tumescence at both the tip and base of the penis compared to baseline tumescence, and the erection lasts >= 5 minutes, as measured by Rigiscan™ during overnight Rigiscan™ use, divided by the total time (in minutes) of overnight Rigiscan™ use.
Overnight Rigiscan™ use time is defined as starting 5 minutes after the start of the Rigiscan™ recording and the end of Rigiscan™ use is defined as the last time the tip or base was >=10% rigid with a corresponding concurrent increase in penile tumescence at the tip or base compared to baseline tumesence.
This total time window from start to end is the Rigiscan™ use time.
|
During overnight Rigiscan™ use directly after consuming 4 meals. (The second night of Rigiscan™ use).
|
|
Percent of time ≥50% erect during overnight Rigiscan™ use after 1 meal, where each erection lasts >=5 minutes as measured by Rigiscan™
Časové okno: During overnight Rigiscan™ use directly after consuming 1 meal. (The first night of Rigiscan™ use).
|
The first 5 minutes of Rigiscan™ recording is discarded.
Erection time is the total time (in minutes) when penile rigidity is ≥ 50% at both the tip and the base of the penis with a concurrent increase in penile tumescence at both the tip and base of the penis compared to baseline tumescence, and the erection lasts >= 5 minutes, as measured by Rigiscan™ during overnight Rigiscan™ use, divided by the total time (in minutes) of overnight Rigiscan™ use.
Overnight Rigiscan™ use time is defined as starting 5 minutes after the start of the Rigiscan™ recording and the end of Rigiscan™ use is defined as the last time the tip or base was >=10% rigid with a corresponding concurrent increase in penile tumescence at the tip or base compared to baseline tumesence.
This total time window from start to end is the Rigiscan™ use time.
|
During overnight Rigiscan™ use directly after consuming 1 meal. (The first night of Rigiscan™ use).
|
Spolupracovníci a vyšetřovatelé
Zde najdete lidi a organizace zapojené do této studie.
Sponzor
Sponzor
Spolupracovníci
Spolupracovníci
Vyšetřovatelé
Vyšetřovatelé
- Vrchní vyšetřovatel: Robert Ostfeld, MD, Montefiore Medical Center
Publikace a užitečné odkazy
Osoba odpovědná za zadávání informací o studiu tyto publikace poskytuje dobrovolně. Mohou se týkat čehokoli, co souvisí se studiem.
Obecné publikace
- Feldman HA, Goldstein I, Hatzichristou DG, Krane RJ, McKinlay JB. Impotence and its medical and psychosocial correlates: results of the Massachusetts Male Aging Study. J Urol. 1994 Jan;151(1):54-61. doi: 10.1016/s0022-5347(17)34871-1.
- Chung F, Abdullah HR, Liao P. STOP-Bang Questionnaire: A Practical Approach to Screen for Obstructive Sleep Apnea. Chest. 2016 Mar;149(3):631-8. doi: 10.1378/chest.15-0903. Epub 2016 Jan 12.
- Gupta BP, Murad MH, Clifton MM, Prokop L, Nehra A, Kopecky SL. The effect of lifestyle modification and cardiovascular risk factor reduction on erectile dysfunction: a systematic review and meta-analysis. Arch Intern Med. 2011 Nov 14;171(20):1797-803. doi: 10.1001/archinternmed.2011.440. Epub 2011 Sep 12.
- Thompson IM, Tangen CM, Goodman PJ, Probstfield JL, Moinpour CM, Coltman CA. Erectile dysfunction and subsequent cardiovascular disease. JAMA. 2005 Dec 21;294(23):2996-3002. doi: 10.1001/jama.294.23.2996.
- Vogel RA, Corretti MC, Plotnick GD. Effect of a single high-fat meal on endothelial function in healthy subjects. Am J Cardiol. 1997 Feb 1;79(3):350-4. doi: 10.1016/s0002-9149(96)00760-6.
- Nehra A. Erectile dysfunction and cardiovascular disease: efficacy and safety of phosphodiesterase type 5 inhibitors in men with both conditions. Mayo Clin Proc. 2009 Feb;84(2):139-48. doi: 10.4065/84.2.139.
- Ong PJ, Dean TS, Hayward CS, Della Monica PL, Sanders TA, Collins P. Effect of fat and carbohydrate consumption on endothelial function. Lancet. 1999 Dec 18-25;354(9196):2134. doi: 10.1016/s0140-6736(99)03374-7.
- Esposito K, Nappo F, Giugliano F, Giugliano G, Marfella R, Giugliano D. Effect of dietary antioxidants on postprandial endothelial dysfunction induced by a high-fat meal in healthy subjects. Am J Clin Nutr. 2003 Jan;77(1):139-43. doi: 10.1093/ajcn/77.1.139.
- Shimabukuro M, Chinen I, Higa N, Takasu N, Yamakawa K, Ueda S. Effects of dietary composition on postprandial endothelial function and adiponectin concentrations in healthy humans: a crossover controlled study. Am J Clin Nutr. 2007 Oct;86(4):923-8. doi: 10.1093/ajcn/86.4.923.
- Sakakibara S, Murakami R, Takahashi M, Fushimi T, Murohara T, Kishi M, Kajimoto Y, Kitakaze M, Kaga T. Vinegar intake enhances flow-mediated vasodilatation via upregulation of endothelial nitric oxide synthase activity. Biosci Biotechnol Biochem. 2010;74(5):1055-61. doi: 10.1271/bbb.90953. Epub 2010 May 7.
- Esposito K, Ciotola M, Giugliano F, De Sio M, Giugliano G, D'armiento M, Giugliano D. Mediterranean diet improves erectile function in subjects with the metabolic syndrome. Int J Impot Res. 2006 Jul-Aug;18(4):405-10. doi: 10.1038/sj.ijir.3901447. Epub 2006 Jan 5.
- Wing RR, Rosen RC, Fava JL, Bahnson J, Brancati F, Gendrano Iii IN, Kitabchi A, Schneider SH, Wadden TA. Effects of weight loss intervention on erectile function in older men with type 2 diabetes in the Look AHEAD trial. J Sex Med. 2010 Jan;7(1 Pt 1):156-65. doi: 10.1111/j.1743-6109.2009.01458.x. Epub 2009 Aug 17.
- Cassidy A, Franz M, Rimm EB. Dietary flavonoid intake and incidence of erectile dysfunction. Am J Clin Nutr. 2016 Feb;103(2):534-41. doi: 10.3945/ajcn.115.122010. Epub 2016 Jan 13.
- Yaman O, Tokath Z, Inal T, Anafarta K. Effect of sildenafil on nocturnal erections of potent men. Int J Impot Res. 2003 Apr;15(2):117-21. doi: 10.1038/sj.ijir.3900978.
- Corbin JD, Francis SH. Cyclic GMP phosphodiesterase-5: target of sildenafil. J Biol Chem. 1999 May 14;274(20):13729-32. doi: 10.1074/jbc.274.20.13729. No abstract available.
- Greenstein A, Chen J, Salonia A, Sofer M, Matzkin H, Montorsi F. Does sildenafil enhance quality of nocturnal erections in healthy young men? A NPT-RigiScan study. J Sex Med. 2004 Nov;1(3):314-7. doi: 10.1111/j.1743-6109.04045.x.
- Burris AS, Banks SM, Sherins RJ. Quantitative assessment of nocturnal penile tumescence and rigidity in normal men using a home monitor. J Androl. 1989 Nov-Dec;10(6):492-7. doi: 10.1002/j.1939-4640.1989.tb00148.x.
Termíny studijních záznamů
Tato data sledují průběh záznamů studie a předkládání souhrnných výsledků na ClinicalTrials.gov. Záznamy ze studií a hlášené výsledky jsou před zveřejněním na veřejné webové stránce přezkoumány Národní lékařskou knihovnou (NLM), aby se ujistily, že splňují specifické standardy kontroly kvality.
Hlavní termíny studia
Začátek studia (Aktuální)
Začátek studia
30. října 2023
Primární dokončení (Odhadovaný)
Primární dokončení
1. prosince 2026
Dokončení studie (Odhadovaný)
Dokončení studie
1. prosince 2026
Termíny zápisu do studia
První předloženo
První předloženo
27. března 2020
První předloženo, které splnilo kritéria kontroly kvality
První předloženo, které splnilo kritéria kontroly kvality
15. dubna 2020
První zveřejněno (Aktuální)
První zveřejněno
16. dubna 2020
Aktualizace studijních záznamů
Poslední zveřejněná aktualizace (Aktuální)
Poslední zveřejněná aktualizace
24. července 2026
Odeslaná poslední aktualizace, která splnila kritéria kontroly kvality
Odeslaná poslední aktualizace, která splnila kritéria kontroly kvality
22. července 2026
Naposledy ověřeno
Naposledy ověřeno
1. července 2026
Více informací
Termíny související s touto studií
Klíčová slova
Další relevantní podmínky MeSH
- Urogenitální onemocnění
- Onemocnění genitálií
- Duševní poruchy
- Onemocnění pohlavních orgánů, muž
- Mužská urogenitální onemocnění
- Sexuální dysfunkce, fyziologické
- Sexuální dysfunkce, psychologické
- Erektilní dysfunkce
- Terapeutika
- Strava, jídlo a výživa
- Fyziologické jevy
- Nutriční fyziologické jevy
- Dietní terapie
- Nutriční terapie
- Strava
- Dieta, rostlinná
Další identifikační čísla studie
Další identifikační čísla studie
- 2019-10465
Plán pro data jednotlivých účastníků (IPD)
Plánujete sdílet data jednotlivých účastníků (IPD)?
NE
Informace o lécích a zařízeních, studijní dokumenty
Studuje lékový produkt regulovaný americkým FDA
Ne
Studuje produkt zařízení regulovaný americkým úřadem FDA
Ne
Tyto informace byly beze změn načteny přímo z webu clinicaltrials.gov. Máte-li jakékoli požadavky na změnu, odstranění nebo aktualizaci podrobností studie, kontaktujte prosím register@clinicaltrials.gov. Jakmile bude změna implementována na clinicaltrials.gov, bude automaticky aktualizována i na našem webu .