L'impatto del modello dietetico sulla funzione erettile (ERECTION)
22 luglio 2026 aggiornato da: Montefiore Medical Center
L'impatto di una dieta a base vegetale rispetto a una dieta a base animale sulla funzione erettile in uomini sani con funzione erettile normale: lo studio ERECTION
L'obiettivo di questo studio è determinare se la funzione erettile è influenzata dai modelli dietetici negli uomini sani con normale funzione erettile.
Panoramica dello studio
Stato
Stato
Reclutamento
Condizioni
Condizioni
Intervento / Trattamento
Intervento / Trattamento
Descrizione dettagliata
Visita 1:
Dopo aver esaminato e firmato il consenso, i soggetti verranno sottoposti a screening. Lo screening consisterà in:
Completa IIEF (International Index of Erectile Function) e un questionario sulla frequenza alimentare.
Registrare la storia medica, i farmaci Misurare l'altezza e il peso Vitali Prelevare il sangue per il testosterone totale, la globulina legante gli ormoni sessuali e il TSH (ormone stimolante la tiroide) I soggetti saranno interrogati in merito alla presenza di eruzioni o lesioni genitali
Se il punteggio IIEF è anormale, ai soggetti verrà consigliato di contattare il PCP (fornitore di cure primarie).
I soggetti saranno contattati con i risultati dei test di laboratorio. Se anormale, al soggetto verrà consigliato di contattare il PCP.
Se il soggetto non ha PCP, verranno fornite le informazioni di contatto per un PCP. I soggetti che soddisfano i criteri di inclusione ed esclusione verranno randomizzati nella sequenza uno o nella sequenza due. Una volta arruolati, i soggetti non modificheranno le abitudini alimentari per tutta la durata dello studio se non durante le due sere e i due giorni interi in cui viene fornito il cibo (vedi sotto).
Sequenza uno:
Visita 2:
I soggetti tornano al centro studi la mattina dopo aver digiunato (oltre al consumo di acqua) dalle 23:00 della sera prima. I soggetti non si laveranno i denti né useranno collutori e/o altri rinfrescanti per l'alito quella mattina. Verranno effettuate registrazioni antropomorfiche, della pressione arteriosa e della frequenza cardiaca. Il sangue verrà prelevato e conservato. L'urina sarà raccolta e conservata. Ai soggetti verrà insegnato come utilizzare il dispositivo Rigiscan™. I soggetti riceveranno una cena a base vegetale. I soggetti lasceranno quindi il centro di studio e consumeranno la dieta abituale fino alle 17:00. Per il resto della serata fino alle 23 i soggetti consumeranno solo la cena prevista. L'acqua sarà l'unica bevanda consentita dopo le 17:00. La cena dovrebbe essere consumata alle 20:30, EST (Eastern Standard Time). I soggetti invieranno immagini di tutto ciò che viene consumato (mangiare o bere) dopo le 17:00 al PI oa un rappresentante dello studio un membro del gruppo di studio avrà un contatto testuale o verbale con il soggetto almeno una volta quella sera. I soggetti digiuneranno oltre all'acqua dopo le 23:00. Quella notte, i soggetti eseguiranno una valutazione Rigiscan™ durante la notte a casa. Dovrebbero essere registrate l'ora in cui il soggetto va a letto e l'ora in cui il soggetto si sveglia per la giornata. Il soggetto accetta di stare a letto con Rigiscan™ acceso (tranne che per emergenze o viaggi necessari in bagno) per almeno sette ore.
Visita 3:
I soggetti tornano al centro studi la mattina dopo la valutazione Rigiscan™ e portano il dispositivo Rigiscan™. I soggetti avranno digiunato oltre all'acqua potabile dalle 23:00 della sera prima. I soggetti non si laveranno i denti né useranno collutori e/o altri rinfrescanti per l'alito quella mattina. Verranno effettuate registrazioni antropomorfiche, della pressione arteriosa e della frequenza cardiaca. Il sangue verrà prelevato e conservato. L'urina sarà raccolta e conservata. I soggetti riceveranno quindi un giorno intero di pasti a base vegetale. I soggetti saranno incoraggiati a fare colazione presso il centro studi dopo aver effettuato le misure antropomorfe iniziali, prelevato il sangue e raccolto l'urina. I soggetti invieranno immagini di tutto ciò che viene consumato durante quel giorno al PI e/o a un rappresentante dello studio e un membro del gruppo di studio avrà un contatto testuale o verbale con il soggetto almeno due volte durante quel giorno. La cena dovrebbe essere consumata alle 20:30, EST. I soggetti digiuneranno oltre all'acqua dopo le 23:00. Quella notte, i soggetti eseguiranno una valutazione Rigiscan™ durante la notte a casa. Il caffè nero e/o il tè sono consentiti solo prima di mezzogiorno. Dovrebbero essere registrate l'ora in cui il soggetto va a letto e l'ora in cui il soggetto si sveglia per la giornata. Il soggetto accetta di stare a letto con Rigiscan™ acceso (tranne che per emergenze o viaggi necessari in bagno) per almeno sette ore.
Visita 4:
I soggetti tornano al centro studi la mattina dopo la valutazione Rigiscan™ e portano il dispositivo Rigiscan™. I soggetti non si laveranno i denti né useranno collutori e/o altri rinfrescanti per l'alito quella mattina. Verranno effettuate registrazioni antropomorfiche, della pressione arteriosa e della frequenza cardiaca. Il sangue verrà prelevato e conservato. L'urina sarà raccolta e conservata. Ci sarà quindi un periodo di sospensione per 8-12 giorni e ai soggetti verrà chiesto di tornare alle normali abitudini alimentari durante questo periodo di sospensione.
Visita 5:
Dopo il periodo di washout, i soggetti tornano al centro studi la mattina dopo aver digiunato (oltre al consumo di acqua) dalle 23:00 della sera prima. I soggetti non si laveranno i denti né useranno collutori e/o altri rinfrescanti per l'alito quella mattina. Verranno effettuate registrazioni antropomorfiche, della pressione arteriosa e della frequenza cardiaca. Il sangue verrà prelevato e conservato. L'urina sarà raccolta e conservata. I soggetti riceveranno una cena a base di animali. I soggetti lasceranno quindi il centro di studio e consumeranno la dieta abituale fino alle 17:00. Per il resto della serata fino alle 23 i soggetti consumeranno solo la cena prevista. L'acqua sarà l'unica bevanda consumata dopo le 17:00. La cena dovrebbe essere consumata alle 20:30, EST. I soggetti invieranno immagini di tutto ciò che viene consumato (mangiare o bere) dopo le 17:00 al PI oa un rappresentante dello studio e un membro del gruppo di studio avrà un contatto verbale o testuale con il soggetto almeno una volta quella sera. I soggetti digiuneranno oltre all'acqua dopo le 23:00. Quella notte, i soggetti eseguiranno una valutazione Rigiscan™ durante la notte a casa. Dovrebbero essere registrate l'ora in cui il soggetto va a letto e l'ora in cui il soggetto si sveglia per la giornata. Il soggetto accetta di stare a letto con Rigiscan™ acceso (tranne che per emergenze o viaggi necessari in bagno) per almeno sette ore.
Visita 6:
I soggetti tornano al centro studi la mattina dopo la valutazione Rigiscan™ e portano il dispositivo Rigiscan™. I soggetti non si laveranno i denti né useranno collutori e/o altri rinfrescanti per l'alito quella mattina. Verranno effettuate registrazioni antropomorfiche, della pressione sanguigna e EndoPAT ™. La saliva verrà immagazzinata. Il sangue verrà prelevato e conservato. I soggetti riceveranno quindi un giorno intero di pasti a base di animali. I soggetti saranno incoraggiati a fare colazione presso il centro studi dopo aver effettuato le misure antropomorfe iniziali, aver ottenuto la saliva e prelevato il sangue. I soggetti invieranno immagini di tutto ciò che viene consumato durante quel giorno al PI e/o a un rappresentante dello studio e il team di studio avrà un contatto testuale o verbale con il soggetto almeno due volte durante quel giorno. La cena dovrebbe essere consumata alle 20:30, EST. I soggetti digiuneranno oltre all'acqua dopo le 23:00. Quella notte, i soggetti eseguiranno una valutazione Rigiscan™ durante la notte a casa. Il caffè nero e/o il tè sono consentiti solo prima di mezzogiorno. Dovrebbero essere registrate l'ora in cui il soggetto va a letto e l'ora in cui il soggetto si sveglia per la giornata. Il soggetto accetta di stare a letto con Rigiscan™ acceso (tranne che per emergenze o viaggi necessari in bagno) per almeno sette ore.
Visita 7 (fine studio):
I soggetti tornano al centro studi la mattina dopo la valutazione Rigiscan™ e portano il dispositivo Rigiscan™. I soggetti non si laveranno i denti né useranno collutori e/o altri rinfrescanti per l'alito quella mattina. Verranno effettuate registrazioni antropomorfiche, della pressione arteriosa e della frequenza cardiaca. Il sangue verrà prelevato e conservato. L'urina sarà raccolta e conservata.
Sequenza due:
La Sequenza Due è identica alla Sequenza Uno, tranne per il fatto che vengono forniti pasti a base animale invece di pasti a base vegetale. Per i soggetti randomizzati a pasti a base animale nella Sequenza Uno e nella Sequenza Due saranno identici, tranne per il fatto che verranno forniti pasti a base vegetale invece di pasti a base animale.
Tipo di studio
Tipo di studio
Interventistico
Iscrizione (Stimato)
Iscrizione
46
Fase
Fase
- Non applicabile
Contatti e Sedi
Questa sezione fornisce i recapiti di coloro che conducono lo studio e informazioni su dove viene condotto lo studio.
Contatto studio
Contatto studio
- Nome: Robert Ostfeld, MD
- Numero di telefono: 718-920-5197
- Email: ROSTFELD@montefiore.org
Luoghi di studio
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New York
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The Bronx, New York, Stati Uniti, 10467
- Reclutamento
- Montefiore Medical Center, Department of Medicine, Division of Cardiology
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Contatto:
- Robert J Ostfeld, MD, MS
- Numero di telefono: 718-920-8011
- Email: rostfeld@montefiore.org
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Criteri di partecipazione
I ricercatori cercano persone che corrispondano a una certa descrizione, chiamata criteri di ammissibilità. Alcuni esempi di questi criteri sono le condizioni generali di salute di una persona o trattamenti precedenti.
Criteri di ammissibilità
Criteri di ammissibilità
Età idonea allo studio
Da 14 anni a 25 anni (Adulto)
Accetta volontari sani
Sì
Descrizione
Criterio di inclusione:
- Il soggetto fornisce il consenso informato scritto e l'autorizzazione HIPAA in inglese prima che venga condotta qualsiasi procedura di studio;
- Nessuna terapia medica (diversa dagli MDI prn (inalatori predosati) e nessun cambiamento negli integratori se applicabile)
- Punteggio IIEF maggiore o uguale a 22
- Il soggetto avrà avuto rapporti sessuali pene-vaginali entro 4 settimane dall'arruolamento. Il punteggio IIEF utilizzato viene convalidato in base a questa finestra temporale.
- Maschio di età compresa tra 18 e 29 anni
- Vive a breve distanza dal Sistema Sanitario Montefiore
- L'altro significativo del soggetto (se applicabile) accetta di supportare il soggetto durante lo studio
- Il soggetto accetta di fotografare e condividere tutti gli oggetti consumati/bevuti durante l'intervento dietetico
- Il soggetto accetta di evitare tutte le droghe illecite, i FANS e l'alcool per almeno due giorni prima della registrazione del Rigiscan™ e nei giorni e nelle notti della registrazione del Rigiscan™
- Il soggetto accetta di astenersi dall'attività sessuale per almeno 36 ore prima del posizionamento del Rigiscan™ e di non avere attività sessuale nei giorni e nelle notti della registrazione del Rigiscan™.
- Il soggetto accetta di non visualizzare, leggere o consumare in altro modo materiale erotico o pornografico per almeno 36 ore prima dei giorni e delle notti della registrazione Rigiscan™ e nei giorni e notti della registrazione Rigiscan™
- Il soggetto accetta di venire a Montefiore per sottoporsi all'addestramento Rigiscan™
- Il soggetto accetta di consumare/bere solo cibi/bevande consentiti.
- Il soggetto accetta di partecipare a tutte le visite di persona a Montefiore, di iniziare il digiuno alle 23:00 la sera prima di ogni visita e di sottoporsi a tutti i prelievi di sangue/salivari/altri test.
- Il soggetto accetta di non usare collutori o collutori o sputare intenzionalmente per l'intera durata dello studio. Ai soggetti verrà chiesto di astenersi dall'usare il collutorio per almeno 2 giorni prima dell'arruolamento. Il soggetto accetta di non lavarsi i denti la mattina del giorno di ciascuna visita di studio. La spazzolatura dei denti è altrimenti consentita.
- BMI inferiore a 30, BMI maggiore o uguale a 18,5, peso superiore a 110 libbre.
- Il soggetto accetta di rispettare le procedure e le visite dello studio.
- Il soggetto si esercita per almeno 15 minuti almeno due volte a settimana. Il soggetto accetta di evitare l'esercizio il giorno prima e il giorno delle misurazioni Rigiscan™
Criteri di esclusione:
- Allergia alimentare rilevante
- Modello dietetico vegetariano o vegano
- Storia di un disturbo alimentare; evidenza di dipendenza da cibo
- Ipertensione e/o storia di ipertensione con o senza trattamento medico
- BMI maggiore o uguale a 30, BMI inferiore a 18,5 o peso inferiore o uguale a 110 libbre
- Malattia medica cronica nota diversa dalla malattia muscoloscheletrica non infiammatoria e dall'asma
- Storia di malattia renale o iperkaliemia
- - Il soggetto ha ricevuto un farmaco sperimentale entro 30 giorni prima della firma del consenso
- Disfunzione erettile
- Ha qualsiasi condizione (ad esempio, malattia psichiatrica) o situazione che, secondo l'opinione dello sperimentatore, può confondere i risultati dello studio o può interferire in modo significativo con la capacità del paziente di aderire alle procedure dello studio
- Attualmente in cura per la malattia di Peyronie
- Livello anormale di testosterone o ormone stimolante la tiroide
- Ipogonadismo trattato o ipotiroidismo
- Viaggio programmato durante lo studio
- Storia di abuso di sostanze negli ultimi 12 mesi
- Uso illecito di droghe, fumo o svapo entro 4 settimane
- Malattia delle vie respiratorie superiori entro due settimane dallo screening
- Se la professione richiede di essere di guardia, nessun lavoro notturno o di guardia durante lo studio
- Qualsiasi pelle trasmissibile o malattia venerea. Il soggetto riferisce eruzioni cutanee o lesioni sul pene o nell'area circostante. Al soggetto verrà chiesto: "hai un'eruzione cutanea o una lesione sul tuo pene o nell'area circostante?"
Piano di studio
Questa sezione fornisce i dettagli del piano di studio, compreso il modo in cui lo studio è progettato e ciò che lo studio sta misurando.
Come è strutturato lo studio?
Dettagli di progettazione
- Scopo principale: Prevenzione
- Assegnazione: Randomizzato
- Modello interventistico: Assegnazione incrociata
- Mascheramento: Separare
Numero di armi
2
Armi e interventi
Gruppo di partecipanti / ArmGruppo di partecipanti / Arm |
Intervento / TrattamentoIntervento / Trattamento |
|---|---|
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Comparatore attivo: Braccio vegetale
Il braccio vegetale consiste in 3 visite al centro di ricerca clinica, seguendo una dieta a base vegetale e utilizzando il dispositivo Rigiscan™ per misurare la frequenza, la rigidità e la durata delle erezioni notturne.
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Il cibo sarà fornito da Montefiore-Einstein Food Services
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Comparatore attivo: Braccio animale
Il braccio basato sugli animali consiste in 3 visite al centro di ricerca clinica, seguendo una dieta a base animale e utilizzando il dispositivo Rigiscan™ per misurare la frequenza, la rigidità e la durata delle erezioni notturne.
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Il cibo sarà fornito da Montefiore-Einstein Food Services
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Cosa sta misurando lo studio?
Misure di risultato primarie
Misure di risultato primarie
Misura del risultato |
Misura Descrizione |
Lasso di tempo |
|---|---|---|
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Percent of time ≥60% erect during overnight Rigiscan™ use after 4 meals.
Lasso di tempo: During overnight Rigiscan™ use directly after consuming the 4 meals. (The second night of Rigiscan™ use).
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The first 5 minutes of Rigiscan™ recording is discarded.
Erection time is the total time (in minutes) when penile rigidity is ≥ 60% at both the tip and base of the penis with a concurrent increase in penile tumescence at both the tip and base of the penis compared to baseline tumescence as measured by Rigiscan™ during overnight Rigiscan™ use, divided by the total time (in minutes) of overnight Rigiscan™ use.
Overnight Rigiscan™ use time is defined as starting 5 minutes after the start of the Rigiscan™ recording and the end of Rigiscan™ use is defined as the last time the tip or base was >=10% rigid with a corresponding concurrent increase in penile tumescence at the tip or base compared to baseline tumesence.
This total time window from start to end is the Rigiscan™ use time.
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During overnight Rigiscan™ use directly after consuming the 4 meals. (The second night of Rigiscan™ use).
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Misure di risultato secondarie
Misure di risultato secondarie
Misura del risultato |
Misura Descrizione |
Lasso di tempo |
|---|---|---|
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Percent of time ≥60% erect during overnight Rigiscan™ use after 1 meal.
Lasso di tempo: During overnight Rigiscan™ use directly after consuming 1 meal. (The first night of Rigiscan™ use).
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The first 5 minutes of Rigiscan™ recording is discarded.
Erection time is the total time (in minutes) when penile rigidity is ≥ 60% at both the tip and base of the penis with a concurrent increase in penile tumescence at both the tip and base of the penis compared to baseline tumescence as measured by Rigiscan™ during overnight Rigiscan™ use, divided by the total time (in minutes) of overnight Rigiscan™ use.
Overnight Rigiscan™ use time is defined as starting 5 minutes after the start of the Rigiscan™ recording and the end of Rigiscan™ use is defined as the last time the tip or base was >=10% rigid with a corresponding concurrent increase in penile tumescence at the tip or base compared to baseline tumesence.
This total time window from start to end is the Rigiscan™ use time
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During overnight Rigiscan™ use directly after consuming 1 meal. (The first night of Rigiscan™ use).
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Percent of time ≥60% erect during overnight Rigiscan™ use after 4 meals, where each erection lasts >=5 minutes as measured by Rigiscan™
Lasso di tempo: During overnight Rigiscan™ use directly after consuming 4 meals. (The second night of Rigiscan™ use).
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The first 5 minutes of Rigiscan™ recording is discarded.
Erection time is the total time (in minutes) when penile rigidity is ≥ 60% at both the tip and the base of the penis with a concurrent increase in penile tumescence at both the tip and base of the penis compared to baseline tumescence, and the erection lasts >= 5 minutes, as measured by Rigiscan™ during overnight Rigiscan™ use, divided by the total time (in minutes) of overnight Rigiscan™ use.
Overnight Rigiscan™ use time is defined as starting 5 minutes after the start of the Rigiscan™ recording and the end of Rigiscan™ use is defined as the last time the tip or base was >=10% rigid with a corresponding concurrent increase in penile tumescence at the tip or base compared to baseline tumesence.
This total time window from start to end is the Rigiscan™ use time.
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During overnight Rigiscan™ use directly after consuming 4 meals. (The second night of Rigiscan™ use).
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Percent of time ≥60% erect during overnight Rigiscan™ use after 1 meal, where each erection lasts >=5 minutes as measured by Rigiscan™
Lasso di tempo: During overnight Rigiscan™ use directly after consuming 1 meal. (The first night of Rigiscan™ use).
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The first 5 minutes of Rigiscan™ recording is discarded.
Erection time is the total time (in minutes) when penile rigidity is ≥ 60% at both the tip and the base of the penis with a concurrent increase in penile tumescence at both the tip and base of the penis compared to baseline tumescence, and the erection lasts >= 5 minutes, as measured by Rigiscan™ during overnight Rigiscan™ use, divided by the total time (in minutes) of overnight Rigiscan™ use.
Overnight Rigiscan™ use time is defined as starting 5 minutes after the start of the Rigiscan™ recording and the end of Rigiscan™ use is defined as the last time the tip or base was >=10% rigid with a corresponding concurrent increase in penile tumescence at the tip or base compared to baseline tumesence.
This total time window from start to end is the Rigiscan™ use time.
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During overnight Rigiscan™ use directly after consuming 1 meal. (The first night of Rigiscan™ use).
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Altre misure di risultato
Altre misure di risultato
Misura del risultato |
Misura Descrizione |
Lasso di tempo |
|---|---|---|
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Heart rate
Lasso di tempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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Comparing heart rate by dietary pattern at both time points (after overnight Rigiscan™ use after consuming the 1 meal and after overnight Rigiscan™ use after consuming the 4 meals) and compared to its respective baseline in beats/minute.
Definition: In regard to the following anthropometric, vital sign, and laboratory data (blood, urine, and saliva) pre-specified outcomes included in this pre-specified outcomes section, at "both time points" is defined as in the sentence above and "respective baseline" refers to either visit 2 or visit 5, as visit 2 is the baseline for one dietary arm (plant or animal) and visit 5 is the baseline for the other dietary arm (plant or animal).
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Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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Blood Pressure
Lasso di tempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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Comparing blood pressure by dietary pattern at both time points and compared to its respective baseline in mmHg
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Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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Weight
Lasso di tempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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Comparing weight by dietary pattern at both time points and compared to its respective baseline
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Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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Fibrinogen
Lasso di tempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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Comparing it at both time points by dietary pattern and compared to its respective baseline in mg/dL
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Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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D-dimer
Lasso di tempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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Comparing it at both time points by dietary pattern and compared to its respective baseline in ng/mL
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Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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Total cholesterol
Lasso di tempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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Comparing it at both time points by dietary pattern and compared to its respective baseline in mg/dL
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Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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HDL cholesterol
Lasso di tempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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Comparing it at both time points by dietary pattern and compared to its respective baseline in mg/dL
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Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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HDL efflux capacity
Lasso di tempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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Comparing it at both time points by dietary pattern and compared to its respective baseline.
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Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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|
LDL cholesterol
Lasso di tempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in mg/dL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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Triglyceride
Lasso di tempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in mg/dL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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|
Oxidized LDL cholesterol
Lasso di tempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in U/L
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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Free Fatty Acids
Lasso di tempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in micromoles
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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Myeloperoxidase
Lasso di tempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in ug/L
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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Factor VII
Lasso di tempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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Comparing it at both time points by dietary pattern and compared to its respective baseline in percentage.
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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lysolecithin
Lasso di tempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in mg/mL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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Apolipoprotein B
Lasso di tempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in mg/dL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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Omega 3 index
Lasso di tempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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Comparing it at both time points by dietary pattern and compared to its respective baseline in percentage of erythrocyte fatty acid
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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Lipoprotein-associated phospholipase-A2 (Lp PLA2) activity
Lasso di tempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in nmol/min/mL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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Lipoprotein (a)
Lasso di tempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in nmol/L
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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Homocysteine
Lasso di tempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in umol/L
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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|
methylmalonic acid (MMA)
Lasso di tempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in umol/L
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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Asymmetric Dimethylarginine (ADMA)
Lasso di tempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in umol/L
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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symmetric dimethylarginine (SDMA)
Lasso di tempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in mg/dL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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Total testosterone
Lasso di tempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in mg/dL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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Sex Hormone Binding Globulin
Lasso di tempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in nmol/L
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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cystatin C
Lasso di tempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in mg/dL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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remnant cholesterol particles
Lasso di tempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in mg/dL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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uric acid
Lasso di tempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in mg/dL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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interleukin 1
Lasso di tempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in pg/mL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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interleukin 6
Lasso di tempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in pg/mL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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hsCRP
Lasso di tempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in mg/L
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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Blood Urea Nitrogen (BUN)
Lasso di tempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in mg/dL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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Carbon Dioxide (CO2)
Lasso di tempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in mmol/L
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
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creatinine
Lasso di tempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in mg/dL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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glucose
Lasso di tempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in mg/dL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
serum chloride
Lasso di tempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in meq/L
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
serum potassium
Lasso di tempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in meq/L
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
serum sodium
Lasso di tempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in meq/L
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
alanine aminotransferase (ALT)
Lasso di tempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in units/L
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
aspartate aminotransferase (AST)
Lasso di tempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in units/L
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
estimated glomerular filtration rate (eGFR)
Lasso di tempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in mL/min/1.73m2
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
vitamin c
Lasso di tempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in mg/dL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
reduced glutathione
Lasso di tempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in umol/L
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
superoxide dismutase
Lasso di tempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in ng/mL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
vitamin e
Lasso di tempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in mg/L
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
selenium
Lasso di tempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in ng/mL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
malondialdehyde
Lasso di tempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in umol/L
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
non coding RNA
Lasso di tempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in copies/mL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
micro RNA
Lasso di tempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in copies/mL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
Lnc RNA
Lasso di tempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in copies/mL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
trimethylamine-N-oxide (TMAO)
Lasso di tempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in umol/L
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
phenylacetylglutamine (PAG)
Lasso di tempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in uM (micrometers)
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
Comparing urine albumin-to-creatinine ratio (UACR)
Lasso di tempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in mg/g
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
Comparing salivary nitrite level as a correlate of plasma nitric oxide (NO) level
Lasso di tempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in micromoles/L
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
Comparing salivary nitrate level in as a correlate of plasma nitric oxide (NO) level
Lasso di tempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in micromoles/L
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
Platelets
Lasso di tempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in cells/ul.
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
FIB-4 Index
Lasso di tempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
Percent of time ≥50% erect during overnight Rigiscan™ use after the 4 meals.
Lasso di tempo: During overnight Rigiscan™ use directly after consuming the 4 meals. (The second night of Rigiscan™ use).
|
The first 5 minutes of Rigiscan™ recording is discarded.
Erection time is the total time (in minutes) when penile rigidity is ≥ 50% at both the tip and base of the penis with a concurrent increase in penile tumescence at both the tip and base of the penis compared to baseline tumescence as measured by Rigiscan™ during overnight Rigiscan™ use, divided by the total time (in minutes) of overnight Rigiscan™ use.
Overnight Rigiscan™ use time is defined as starting 5 minutes after the start of the Rigiscan™ recording and the end of Rigiscan™ use is defined as the last time the tip or base was >=10% rigid with a corresponding concurrent increase in penile tumescence at the tip or base compared to baseline tumesence.
This total time window from start to end is the Rigiscan™ use time.
|
During overnight Rigiscan™ use directly after consuming the 4 meals. (The second night of Rigiscan™ use).
|
|
Percent of time ≥50% erect during overnight Rigiscan™ use after 1 meal.
Lasso di tempo: During overnight Rigiscan™ use directly after consuming 1 meal. (The first night of Rigiscan™ use)
|
The first 5 minutes of Rigiscan™ recording is discarded.
Erection time is the total time (in minutes) when penile rigidity is ≥ 50% at both the tip and base of the penis with a concurrent increase in penile tumescence at both the tip and base of the penis compared to baseline tumescence as measured by Rigiscan™ during overnight Rigiscan™ use, divided by the total time (in minutes) of overnight Rigiscan™ use.
Overnight Rigiscan™ use time is defined as starting 5 minutes after the start of the Rigiscan™ recording and the end of Rigiscan™ use is defined as the last time the tip or base was >=10% rigid with a corresponding concurrent increase in penile tumescence at the tip or base compared to baseline tumesence.
This total time window from start to end is the Rigiscan™ use time
|
During overnight Rigiscan™ use directly after consuming 1 meal. (The first night of Rigiscan™ use)
|
|
Percent of time ≥70% erect during overnight Rigiscan™ use after 4 meals.
Lasso di tempo: During overnight Rigiscan™ use directly after consuming the 4 meals. (The second night of Rigiscan™ use).
|
The first 5 minutes of Rigiscan™ recording is discarded.
Erection time is the total time (in minutes) when penile rigidity is ≥ 70% at both the tip and base of the penis with a concurrent increase in penile tumescence at both the tip and base of the penis compared to baseline tumescence as measured by Rigiscan™ during overnight Rigiscan™ use, divided by the total time (in minutes) of overnight Rigiscan™ use.
Overnight Rigiscan™ use time is defined as starting 5 minutes after the start of the Rigiscan™ recording and the end of Rigiscan™ use is defined as the last time the tip or base was >=10% rigid with a corresponding concurrent increase in penile tumescence at the tip or base compared to baseline tumesence.
This total time window from start to end is the Rigiscan™ use time
|
During overnight Rigiscan™ use directly after consuming the 4 meals. (The second night of Rigiscan™ use).
|
|
Percent of time ≥70% erect during overnight Rigiscan™ use after 1 meal.
Lasso di tempo: During overnight Rigiscan™ use directly after consuming 1 meal. (The first night of Rigiscan™ use).
|
The first 5 minutes of Rigiscan™ recording is discarded.
Erection time is the total time (in minutes) when penile rigidity is ≥ 70% at both the tip and base of the penis with a concurrent increase in penile tumescence at both the tip and base of the penis compared to baseline tumescence as measured by Rigiscan™ during overnight Rigiscan™ use, divided by the total time (in minutes) of overnight Rigiscan™ use.
Overnight Rigiscan™ use time is defined as starting 5 minutes after the start of the Rigiscan™ recording and the end of Rigiscan™ use is defined as the last time the tip or base was >=10% rigid with a corresponding concurrent increase in penile tumescence at the tip or base compared to baseline tumesence.
This total time window from start to end is the Rigiscan™ use time
|
During overnight Rigiscan™ use directly after consuming 1 meal. (The first night of Rigiscan™ use).
|
|
Percent of time ≥70% erect during overnight Rigiscan™ use after 4 meals versus after 1 meal by dietary pattern.
Lasso di tempo: During overnight Rigiscan™ use directly after consuming the 4 meals versus overnight Rigiscan™ use directly after consuming the 1 meal by dietary pattern, for each dietary pattern.
|
The first 5 minutes of Rigiscan™ recording is discarded.
Erection time is the total time (in minutes) when penile rigidity is ≥ 70% at both the tip and base of the penis with a concurrent increase in penile tumescence at both the tip and base of the penis compared to baseline tumescence as measured by Rigiscan™ during overnight Rigiscan™ use, divided by the total time (in minutes) of overnight Rigiscan™ use.
Overnight Rigiscan™ use time is defined as starting 5 minutes after the start of the Rigiscan™ recording and the end of Rigiscan™ use is defined as the last time the tip or base was >=10% rigid with a corresponding concurrent increase in penile tumescence at the tip or base compared to baseline tumesence.
This total time window from start to end is the Rigiscan™ use time.
|
During overnight Rigiscan™ use directly after consuming the 4 meals versus overnight Rigiscan™ use directly after consuming the 1 meal by dietary pattern, for each dietary pattern.
|
|
Percent of time ≥60% erect during overnight Rigiscan™ use after 4 meals versus after 1 meal by dietary pattern.
Lasso di tempo: During overnight Rigiscan™ use directly after consuming the 4 meals versus overnight Rigiscan™ use directly after consuming the 1 meal by dietary pattern, for each dietary pattern.
|
The first 5 minutes of Rigiscan™ recording is discarded.
Erection time is the total time (in minutes) when penile rigidity is ≥ 60% at both the tip and base of the penis with a concurrent increase in penile tumescence at both the tip and base of the penis compared to baseline tumescence as measured by Rigiscan™ during overnight Rigiscan™ use, divided by the total time (in minutes) of overnight Rigiscan™ use.
Overnight Rigiscan™ use time is defined as starting 5 minutes after the start of the Rigiscan™ recording and the end of Rigiscan™ use is defined as the last time the tip or base was >=10% rigid with a corresponding concurrent increase in penile tumescence at the tip or base compared to baseline tumesence.
This total time window from start to end is the Rigiscan™ use time.
|
During overnight Rigiscan™ use directly after consuming the 4 meals versus overnight Rigiscan™ use directly after consuming the 1 meal by dietary pattern, for each dietary pattern.
|
|
Percent of time ≥50% erect during overnight Rigiscan™ use after 4 meals versus after 1 meal by dietary pattern.
Lasso di tempo: During overnight Rigiscan™ use directly after consuming the 4 meals versus overnight Rigiscan™ use directly after consuming the 1 meal by dietary pattern, for each dietary pattern.
|
The first 5 minutes of Rigiscan™ recording is discarded.
Erection time is the total time (in minutes) when penile rigidity is ≥ 50% at both the tip and base of the penis with a concurrent increase in penile tumescence at both the tip and base of the penis compared to baseline tumescence as measured by Rigiscan™ during overnight Rigiscan™ use, divided by the total time (in minutes) of overnight Rigiscan™ use.
Overnight Rigiscan™ use time is defined as starting 5 minutes after the start of the Rigiscan™ recording and the end of Rigiscan™ use is defined as the last time the tip or base was >=10% rigid with a corresponding concurrent increase in penile tumescence at the tip or base compared to baseline tumesence.
This total time window from start to end is the Rigiscan™ use time.
|
During overnight Rigiscan™ use directly after consuming the 4 meals versus overnight Rigiscan™ use directly after consuming the 1 meal by dietary pattern, for each dietary pattern.
|
|
Percent of time ≥70% erect during overnight Rigiscan™ use after 4 meals, where each erection lasts >=5 minutes as measured by Rigiscan™
Lasso di tempo: During overnight Rigiscan™ use directly after consuming 4 meals. (The second night of Rigiscan™ use).
|
The first 5 minutes of Rigiscan™ recording is discarded.
Erection time is the total time (in minutes) when penile rigidity is ≥ 70% at both the tip and the base of the penis with a concurrent increase in penile tumescence at both the tip and base of the penis compared to baseline tumescence, and the erection lasts >= 5 minutes, as measured by Rigiscan™ during overnight Rigiscan™ use, divided by the total time (in minutes) of overnight Rigiscan™ use.
Overnight Rigiscan™ use time is defined as starting 5 minutes after the start of the Rigiscan™ recording and the end of Rigiscan™ use is defined as the last time the tip or base was >=10% rigid with a corresponding concurrent increase in penile tumescence at the tip or base compared to baseline tumesence.
This total time window from start to end is the Rigiscan™ use time.
|
During overnight Rigiscan™ use directly after consuming 4 meals. (The second night of Rigiscan™ use).
|
|
Percent of time ≥70% erect during overnight Rigiscan™ use after 1 meal, where each erection lasts >=5 minutes as measured by Rigiscan™
Lasso di tempo: During overnight Rigiscan™ use directly after consuming 1 meal. (The first night of Rigiscan™ use).
|
The first 5 minutes of Rigiscan™ recording is discarded.
Erection time is the total time (in minutes) when penile rigidity is ≥70% at both the tip and the base of the penis with a concurrent increase in penile tumescence at both the tip and base of the penis compared to baseline tumescence, and the erection lasts >= 5 minutes, as measured by Rigiscan™ during overnight Rigiscan™ use, divided by the total time (in minutes) of overnight Rigiscan™ use.
Overnight Rigiscan™ use time is defined as starting 5 minutes after the start of the Rigiscan™ recording and the end of Rigiscan™ use is defined as the last time the tip or base was >=10% rigid with a corresponding concurrent increase in penile tumescence at the tip or base compared to baseline tumesence.
This total time window from start to end is the Rigiscan™ use time.
|
During overnight Rigiscan™ use directly after consuming 1 meal. (The first night of Rigiscan™ use).
|
|
Percent of time ≥50% erect during overnight Rigiscan™ use after 4 meals, where each erection lasts >=5 minutes as measured by Rigiscan™
Lasso di tempo: During overnight Rigiscan™ use directly after consuming 4 meals. (The second night of Rigiscan™ use).
|
The first 5 minutes of Rigiscan™ recording is discarded.
Erection time is the total time (in minutes) when penile rigidity is ≥ 50% at both the tip and the base of the penis with a concurrent increase in penile tumescence at both the tip and base of the penis compared to baseline tumescence, and the erection lasts >= 5 minutes, as measured by Rigiscan™ during overnight Rigiscan™ use, divided by the total time (in minutes) of overnight Rigiscan™ use.
Overnight Rigiscan™ use time is defined as starting 5 minutes after the start of the Rigiscan™ recording and the end of Rigiscan™ use is defined as the last time the tip or base was >=10% rigid with a corresponding concurrent increase in penile tumescence at the tip or base compared to baseline tumesence.
This total time window from start to end is the Rigiscan™ use time.
|
During overnight Rigiscan™ use directly after consuming 4 meals. (The second night of Rigiscan™ use).
|
|
Percent of time ≥50% erect during overnight Rigiscan™ use after 1 meal, where each erection lasts >=5 minutes as measured by Rigiscan™
Lasso di tempo: During overnight Rigiscan™ use directly after consuming 1 meal. (The first night of Rigiscan™ use).
|
The first 5 minutes of Rigiscan™ recording is discarded.
Erection time is the total time (in minutes) when penile rigidity is ≥ 50% at both the tip and the base of the penis with a concurrent increase in penile tumescence at both the tip and base of the penis compared to baseline tumescence, and the erection lasts >= 5 minutes, as measured by Rigiscan™ during overnight Rigiscan™ use, divided by the total time (in minutes) of overnight Rigiscan™ use.
Overnight Rigiscan™ use time is defined as starting 5 minutes after the start of the Rigiscan™ recording and the end of Rigiscan™ use is defined as the last time the tip or base was >=10% rigid with a corresponding concurrent increase in penile tumescence at the tip or base compared to baseline tumesence.
This total time window from start to end is the Rigiscan™ use time.
|
During overnight Rigiscan™ use directly after consuming 1 meal. (The first night of Rigiscan™ use).
|
Collaboratori e investigatori
Qui è dove troverai le persone e le organizzazioni coinvolte in questo studio.
Sponsor
Sponsor
Collaboratori
Collaboratori
Investigatori
Investigatori
- Investigatore principale: Robert Ostfeld, MD, Montefiore Medical Center
Pubblicazioni e link utili
La persona responsabile dell'inserimento delle informazioni sullo studio fornisce volontariamente queste pubblicazioni. Questi possono riguardare qualsiasi cosa relativa allo studio.
Pubblicazioni generali
- Feldman HA, Goldstein I, Hatzichristou DG, Krane RJ, McKinlay JB. Impotence and its medical and psychosocial correlates: results of the Massachusetts Male Aging Study. J Urol. 1994 Jan;151(1):54-61. doi: 10.1016/s0022-5347(17)34871-1.
- Chung F, Abdullah HR, Liao P. STOP-Bang Questionnaire: A Practical Approach to Screen for Obstructive Sleep Apnea. Chest. 2016 Mar;149(3):631-8. doi: 10.1378/chest.15-0903. Epub 2016 Jan 12.
- Gupta BP, Murad MH, Clifton MM, Prokop L, Nehra A, Kopecky SL. The effect of lifestyle modification and cardiovascular risk factor reduction on erectile dysfunction: a systematic review and meta-analysis. Arch Intern Med. 2011 Nov 14;171(20):1797-803. doi: 10.1001/archinternmed.2011.440. Epub 2011 Sep 12.
- Thompson IM, Tangen CM, Goodman PJ, Probstfield JL, Moinpour CM, Coltman CA. Erectile dysfunction and subsequent cardiovascular disease. JAMA. 2005 Dec 21;294(23):2996-3002. doi: 10.1001/jama.294.23.2996.
- Vogel RA, Corretti MC, Plotnick GD. Effect of a single high-fat meal on endothelial function in healthy subjects. Am J Cardiol. 1997 Feb 1;79(3):350-4. doi: 10.1016/s0002-9149(96)00760-6.
- Nehra A. Erectile dysfunction and cardiovascular disease: efficacy and safety of phosphodiesterase type 5 inhibitors in men with both conditions. Mayo Clin Proc. 2009 Feb;84(2):139-48. doi: 10.4065/84.2.139.
- Ong PJ, Dean TS, Hayward CS, Della Monica PL, Sanders TA, Collins P. Effect of fat and carbohydrate consumption on endothelial function. Lancet. 1999 Dec 18-25;354(9196):2134. doi: 10.1016/s0140-6736(99)03374-7.
- Esposito K, Nappo F, Giugliano F, Giugliano G, Marfella R, Giugliano D. Effect of dietary antioxidants on postprandial endothelial dysfunction induced by a high-fat meal in healthy subjects. Am J Clin Nutr. 2003 Jan;77(1):139-43. doi: 10.1093/ajcn/77.1.139.
- Shimabukuro M, Chinen I, Higa N, Takasu N, Yamakawa K, Ueda S. Effects of dietary composition on postprandial endothelial function and adiponectin concentrations in healthy humans: a crossover controlled study. Am J Clin Nutr. 2007 Oct;86(4):923-8. doi: 10.1093/ajcn/86.4.923.
- Sakakibara S, Murakami R, Takahashi M, Fushimi T, Murohara T, Kishi M, Kajimoto Y, Kitakaze M, Kaga T. Vinegar intake enhances flow-mediated vasodilatation via upregulation of endothelial nitric oxide synthase activity. Biosci Biotechnol Biochem. 2010;74(5):1055-61. doi: 10.1271/bbb.90953. Epub 2010 May 7.
- Esposito K, Ciotola M, Giugliano F, De Sio M, Giugliano G, D'armiento M, Giugliano D. Mediterranean diet improves erectile function in subjects with the metabolic syndrome. Int J Impot Res. 2006 Jul-Aug;18(4):405-10. doi: 10.1038/sj.ijir.3901447. Epub 2006 Jan 5.
- Wing RR, Rosen RC, Fava JL, Bahnson J, Brancati F, Gendrano Iii IN, Kitabchi A, Schneider SH, Wadden TA. Effects of weight loss intervention on erectile function in older men with type 2 diabetes in the Look AHEAD trial. J Sex Med. 2010 Jan;7(1 Pt 1):156-65. doi: 10.1111/j.1743-6109.2009.01458.x. Epub 2009 Aug 17.
- Cassidy A, Franz M, Rimm EB. Dietary flavonoid intake and incidence of erectile dysfunction. Am J Clin Nutr. 2016 Feb;103(2):534-41. doi: 10.3945/ajcn.115.122010. Epub 2016 Jan 13.
- Yaman O, Tokath Z, Inal T, Anafarta K. Effect of sildenafil on nocturnal erections of potent men. Int J Impot Res. 2003 Apr;15(2):117-21. doi: 10.1038/sj.ijir.3900978.
- Corbin JD, Francis SH. Cyclic GMP phosphodiesterase-5: target of sildenafil. J Biol Chem. 1999 May 14;274(20):13729-32. doi: 10.1074/jbc.274.20.13729. No abstract available.
- Greenstein A, Chen J, Salonia A, Sofer M, Matzkin H, Montorsi F. Does sildenafil enhance quality of nocturnal erections in healthy young men? A NPT-RigiScan study. J Sex Med. 2004 Nov;1(3):314-7. doi: 10.1111/j.1743-6109.04045.x.
- Burris AS, Banks SM, Sherins RJ. Quantitative assessment of nocturnal penile tumescence and rigidity in normal men using a home monitor. J Androl. 1989 Nov-Dec;10(6):492-7. doi: 10.1002/j.1939-4640.1989.tb00148.x.
Studiare le date dei record
Queste date tengono traccia dell'avanzamento della registrazione dello studio e dell'invio dei risultati di sintesi a ClinicalTrials.gov. I record degli studi e i risultati riportati vengono esaminati dalla National Library of Medicine (NLM) per assicurarsi che soddisfino specifici standard di controllo della qualità prima di essere pubblicati sul sito Web pubblico.
Studia le date principali
Inizio studio (Effettivo)
Inizio studio
30 ottobre 2023
Completamento primario (Stimato)
Completamento primario
1 dicembre 2026
Completamento dello studio (Stimato)
Completamento dello studio
1 dicembre 2026
Date di iscrizione allo studio
Primo inviato
Primo inviato
27 marzo 2020
Primo inviato che soddisfa i criteri di controllo qualità
Primo inviato che soddisfa i criteri di controllo qualità
15 aprile 2020
Primo Inserito (Effettivo)
Primo Inserito
16 aprile 2020
Aggiornamenti dei record di studio
Ultimo aggiornamento pubblicato (Effettivo)
Ultimo aggiornamento pubblicato
24 luglio 2026
Ultimo aggiornamento inviato che soddisfa i criteri QC
Ultimo aggiornamento inviato che soddisfa i criteri QC
22 luglio 2026
Ultimo verificato
Ultimo verificato
1 luglio 2026
Maggiori informazioni
Termini relativi a questo studio
Parole chiave
Termini MeSH pertinenti aggiuntivi
- Malattie urogenitali
- Malattie genitali
- Disordini mentali
- Malattie genitali, maschio
- Malattie urogenitali maschili
- Disfunzione sessuale, fisiologica
- Disfunzioni sessuali, psicologiche
- Disfunzione erettile
- Terapie
- Dieta, cibo e nutrizione
- Fenomeni fisiologici
- Fenomeni fisiologici nutrizionali
- Terapia dietetica
- Terapia nutrizionale
- Dieta
- Dieta, a base vegetale
Altri numeri di identificazione dello studio
Altri numeri di identificazione dello studio
- 2019-10465
Piano per i dati dei singoli partecipanti (IPD)
Hai intenzione di condividere i dati dei singoli partecipanti (IPD)?
NO
Informazioni su farmaci e dispositivi, documenti di studio
Studia un prodotto farmaceutico regolamentato dalla FDA degli Stati Uniti
No
Studia un dispositivo regolamentato dalla FDA degli Stati Uniti
No
Queste informazioni sono state recuperate direttamente dal sito web clinicaltrials.gov senza alcuna modifica. In caso di richieste di modifica, rimozione o aggiornamento dei dettagli dello studio, contattare register@clinicaltrials.gov. Non appena verrà implementata una modifica su clinicaltrials.gov, questa verrà aggiornata automaticamente anche sul nostro sito web .