Effectiveness and Cost-effectiveness of Telephone-delivered Psychotherapy for Depression in Primary Care
Improving Access to Evidence-based Treatment for Depression: Effectiveness and Cost-effectiveness of Telephone-delivered Cognitive Behavioral Therapy (CBT) in Primary Care
Přehled studie
Postavení
Podmínky
Intervence / Léčba
Detailní popis
The overall purpose of the study is to examine the effectiveness of telephone psychotherapy (Tel-PT) for the treatment of mild to moderate depression on different outcome-levels and under clinically representative conditions in Swiss primary health care. The randomized-controlled trial (RCT) will evaluate the primary hypothesis that Tel-PT is more effective than routine primary care (i.e. treatment as usual, TAU), more specifically, that it leads to significant higher reduction in depression severity than TAU at follow-up.
The intervention group (IG) receives a manualized short-term cognitive behavioral treatment, which is the adapted German version of the program "Creating a balance" developed in the USA. The therapy consists of one face-to-face and 8-12 telephone contacts and is carried out by a licensed psychotherapist.
More concrete, recruitment and inclusion of the patients will be carried out by the participating general practitioners (GPs). GPs will be instructed to screen patients at risk for depression, especially those revealing diffuse somatic symptoms and suffering from chronic diseases. If positively screened, patient's depressive symptoms are assessed with Patient Health Questionnaire (PHQ-9) and diagnosed according to ICD-10.
All GPs will receive an initial training prior to their participation, providing them with study information and procedures as well as training in screening procedure, psychodiagnostics and study enrolment.
Eligible patients are provided with detailed study information and asked to participate. Subsequently, patients will give informed consent. Patients will then be included into the study and fill out the baseline questionnaires (t0). After that, randomization will be carried out at the University of Zurich, based on an appropriately created computer algorithm. Both GPs and patients are informed about the results by the study team within two days. Subsequently, patients in control group (CG) will receive regular text messages and patients in the intervention group (IG) will be called by the study therapist to schedule an initial appointment.
In case of positive results, the overarching objective is the optimization of mental health services for depressed patients by implementing an evidence-based, accessible and cost-effective treatment option into primary care.
Typ studie
Zápis (Aktuální)
Fáze
- Nelze použít
Kontakty a umístění
Studijní místa
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Zurich, Švýcarsko, 8050
- University of Zurich
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Kritéria účasti
Kritéria způsobilosti
Věk způsobilý ke studiu
Přijímá zdravé dobrovolníky
Pohlaví způsobilá ke studiu
Popis
Inclusion Criteria:
- PHQ-9 score of > 5 and ≤15.
- Informed Consent as documented by signature (Appendix Informed Consent Form)
- Minimum age of 18 years
- Diagnosis of mild to moderate depression according to ICD-10 (F32.0, F32.1, F33.0, F33.1)
Exclusion Criteria:
- Patients currently being in psychotherapeutic treatment or treatment in past three months
- Suicidal tendencies or suicidality
- Insufficient knowledge of German language
- Health condition that does not allow questionnaire completion
Studijní plán
Jak je studie koncipována?
Detaily designu
- Primární účel: Léčba
- Přidělení: Randomizované
- Intervenční model: Paralelní přiřazení
- Maskování: Žádné (otevřený štítek)
Zbraně a zásahy
Skupina účastníků / Arm |
Intervence / Léčba |
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Experimentální: Tel-PT
Tel-PT receives a manualized short-term CBT.
Treatment consists of one initial face-to-face appointment and 8-12 subsequent telephone sessions between patient and licensed therapist.
Each telephone contact lasts between 20 and 30 minutes and take place on a weekly and later biweekly basis.
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Aktivní komparátor: TAU and text messages
Control Group receives treatment as usual and additionally weekly text messages containing general information about depression.
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Co je měření studie?
Primární výstupní opatření
Měření výsledku |
Popis opatření |
Časové okno |
|---|---|---|
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Change in depressive symptoms
Časové okno: t0 (baseline) and t2 (12 months after baseline)
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The change in depressive symptoms will be assessed with the German version of Patient Health Questionnaire (PHQ-9; Löwe, Spitzer, Zipfel, & Herzog 2002).
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t0 (baseline) and t2 (12 months after baseline)
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Sekundární výstupní opatření
Měření výsledku |
Popis opatření |
Časové okno |
|---|---|---|
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Change in depressive symptoms
Časové okno: t0 (baseline) and t1 (four months after baseline)
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The change in depressive symptoms will be assessed with the German version of Patient Health Questionnaire (PHQ-9; Löwe, Spitzer, Zipfel, & Herzog 2002).
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t0 (baseline) and t1 (four months after baseline)
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Response
Časové okno: t0 (baseline), t1 (four months after baseline), t2 (12 months after baseline)
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Response defined as 50% reduction in the PHQ-9.
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t0 (baseline), t1 (four months after baseline), t2 (12 months after baseline)
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Change in health-related quality of life
Časové okno: t0 (baseline), t1 (four months after baseline), t2 (12 months after baseline)
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Change in health-related quality of life is measured with the 12-Item Short Form Health Survey (SF-12; Bullinger & Kirchberger, 1998).
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t0 (baseline), t1 (four months after baseline), t2 (12 months after baseline)
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Self-efficacy for management and relapse prevention in depression
Časové okno: t0 (baseline), t1 (four months after baseline), t2 (12 months after baseline)
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Depression self-efficacy scale for management and relapse prevention (Bush et al., 2001).
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t0 (baseline), t1 (four months after baseline), t2 (12 months after baseline)
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Cost-effectiveness
Časové okno: t0 (baseline), t1 (four months after baseline), t2 (12 months after baseline)
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Health care utilization and productivity loss will be measured with an adapted version of the Client Sociodemographic and Service Receipt Inventory (CSSRI; Chisholm et al., 2000).
For Switzerland, country-specific unit costs will be employed to calculate direct and indirect costs.
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t0 (baseline), t1 (four months after baseline), t2 (12 months after baseline)
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Cost-effectiveness
Časové okno: t0 (baseline), t1 (four months after baseline), t2 (12 months after baseline)
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Health-related quality of life for the economic analyses will be measured using the EQ-5D-5L (The EuroQuol Group, 1990), Quality-adjusted life years (QALYs) based on the EQ-5D index will be determined and the incremental cost-effectiveness ratio (ICER) will be computed.
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t0 (baseline), t1 (four months after baseline), t2 (12 months after baseline)
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Další výstupní opatření
Měření výsledku |
Popis opatření |
Časové okno |
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Acceptance and satisfaction with the intervention
Časové okno: t1 (four months after baseline)
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Patients' and therapists' acceptance and satisfaction with the intervention will be assessed by a self-constructed questionnaire.
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t1 (four months after baseline)
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Process and structural variable
Časové okno: t1 (four months after baseline), t2 (12 months after baseline)
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Mean duration of telephone contacts
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t1 (four months after baseline), t2 (12 months after baseline)
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Process and structural variable
Časové okno: t1 (four months after baseline), t2 (12 months after baseline)
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Mean number of telephone contacts.
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t1 (four months after baseline), t2 (12 months after baseline)
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Process and structural variable
Časové okno: t1 (four months after baseline), t2 (12 months after baseline)
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Dropout rate
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t1 (four months after baseline), t2 (12 months after baseline)
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Spolupracovníci a vyšetřovatelé
Sponzor
Spolupracovníci
Vyšetřovatelé
- Vrchní vyšetřovatel: Birgit Watzke, Prof, University of Zurich, Department of Clinical Psychology and Psychotherapy Research
Publikace a užitečné odkazy
Obecné publikace
- Simon GE, Ludman EJ, Tutty S, Operskalski B, Von Korff M. Telephone psychotherapy and telephone care management for primary care patients starting antidepressant treatment: a randomized controlled trial. JAMA. 2004 Aug 25;292(8):935-42. doi: 10.1001/jama.292.8.935.
- Löwe, B, Spitzer, RL, Zipfel, S, & Herzog, W. Gesundheitsfragebogen für Patienten (PHQ-D): Manual und Testunterlagen. Pfizer. Karlsruhe: 2002.
- Watzke B, Heddaeus D, Steinmann M, Konig HH, Wegscheider K, Schulz H, Harter M. Effectiveness and cost-effectiveness of a guideline-based stepped care model for patients with depression: study protocol of a cluster-randomized controlled trial in routine care. BMC Psychiatry. 2014 Aug 20;14:230. doi: 10.1186/s12888-014-0230-y.
- Bush, T, Russo, J, Ludman, E, Lin, E, Von Korff, M, Simon, G, Walker, E. Perceived self-efficacy for depression self-management. A reliable and valid self-report measure with predictive validity: Poster presentation at the American Psychological Society Meeting, June 2001. Toronto, Canada.
- Bullinger, M, & Kirchberger, I. Fragebogen zum Gesundheitszustand. Hogrefe. Göttingen: 1998.
- Haller E, Besson N, Watzke B. "Unrigging the support wheels" - A qualitative study on patients' experiences with and perspectives on low-intensity CBT. BMC Health Serv Res. 2019 Oct 9;19(1):686. doi: 10.1186/s12913-019-4495-1.
- Watzke B, Haller E, Steinmann M, Heddaeus D, Harter M, Konig HH, Wegscheider K, Rosemann T. Effectiveness and cost-effectiveness of telephone-based cognitive-behavioural therapy in primary care: study protocol of TIDe - telephone intervention for depression. BMC Psychiatry. 2017 Jul 19;17(1):263. doi: 10.1186/s12888-017-1429-5.
Termíny studijních záznamů
Hlavní termíny studia
Začátek studia
Primární dokončení (Očekávaný)
Dokončení studie (Očekávaný)
Termíny zápisu do studia
První předloženo
První předloženo, které splnilo kritéria kontroly kvality
První zveřejněno (Odhad)
Aktualizace studijních záznamů
Poslední zveřejněná aktualizace (Aktuální)
Odeslaná poslední aktualizace, která splnila kritéria kontroly kvality
Naposledy ověřeno
Více informací
Termíny související s touto studií
Klíčová slova
Další relevantní podmínky MeSH
Další identifikační čísla studie
- BW-0417
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