- ICH GCP
- Registr klinických studií v USA
- Klinická studie NCT07665398
Effect of Marjoram, Vetiver, and Lavender Oil in the Treatment of Bruxism
Přehled studie
Postavení
Detailní popis
Bruxism is a repetitive jaw muscle activity characterized by clenching or grinding of the teeth and/or bracing or thrusting of the mandible. Due to increasing evidence suggesting that it may serve a physiological purpose, bruxism has been defined as jaw muscle activity that may occur during sleep and/or wakefulness.
Various methods have been proposed for the treatment of bruxism. These treatment approaches include pharmacological treatments (such as muscle relaxants and clonazepam), orthopedic treatments (such as stabilization splints and rigid stabilization appliances), needling treatments (including acupuncture, botulinum toxin type A, and dry needling), physical and behavioral approaches (such as relaxation training, stress management, biofeedback, and sleep hygiene instructions), manual treatments including exercises (trigger point therapy, soft tissue techniques, exercises, postural corrections, joint mobilizations, and cervical spine treatment), and other physical therapy modalities (including low-level laser therapy, therapeutic ultrasound, and short-wave diathermy).
Manual therapy, therapeutic exercise, and their combination have been shown to effectively reduce pain and improve mandibular function. Massage therapy, which activates the pain-gate mechanism, is an effective treatment option for pain relief. It also stimulates the parasympathetic nervous system and helps restore muscle length and flexibility. In addition, massage therapy improves local blood circulation and promotes the production of endogenous opioids, leading to relaxing effects and reduced pain perception. These effects are of particular interest in the management of bruxism; however, this treatment approach has not been adequately investigated despite its promising results.
Massage therapy can be combined with aromatherapy, one of the most commonly used complementary therapy methods. Its therapeutic effects are based on stimulation of the olfactory system and absorption of active molecules through the skin. Various studies have investigated the analgesic effects of aromatherapy massage using lavender essential oil. Lavandula angustifolia is a well-known medicinal and aromatic plant with anti-inflammatory and analgesic properties. In addition, it has antiseptic, soothing, circulation-stimulating, and cell-regenerating effects. Lavender oil has been reported to reduce pain in patients with various conditions, including neuropathic pain, rheumatoid arthritis, burns, and cancer-related pain. Apart from lavender oil, marjoram oil may contribute to pain control and anxiety reduction, while vetiver oil is known for its sedative effects. However, the effects of aromatherapy massage using these essential oils have not been adequately investigated in patients with bruxism.
The aim of this study is to evaluate the effects of lavender, marjoram, and vetiver essential oils administered through aromatherapy massage in patients with bruxism. Objective outcomes will be assessed through ultrasonographic evaluation of the masseter muscle, while subjective outcomes will be evaluated using patient-reported questionnaires. The findings of this study may contribute to the development of complementary treatment approaches for the management of bruxism.
Typ studie
Zápis (Odhadovaný)
Fáze
- Nelze použít
Kontakty a umístění
Studijní místa
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Merkez
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Bilecik, Merkez, Turecko (Türkiye), 11100
- Bilecik Seyh Edebali University
-
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Kritéria účasti
Kritéria způsobilosti
Věk způsobilý ke studiu
- Dospělý
Přijímá zdravé dobrovolníky
Popis
Inclusion Criteria:
• Patients between 18-25
- Patients with full dentition including 2nd molars
- Patients without facial asymmetry
- Patients without history of sensitivity or allergy to plants
- Patients without olfactory disorders
Exclusion Criteria:
• Patients with systemic (asthma history) and/or neuromuscular disease
- Patients with orofacial pain not caused by bruxism
- Temporomandibular joint (TMJ) surgery or injection history
- Use of any medical drug affecting the muscular system
- Patients with developmental deformity or surgery history in the maxillofacial region (facial trauma history, resection history, etc.)
- TMJ pathologies (major condylar changes seen on panoramic radiograph)
- Radiotherapy and/or chemotherapy history
- Ongoing orthodontic treatment
- Removable prosthesis use
- Inflammatory connective tissue diseases
- Pregnancy
- Obstructive sleep apnea
- Local skin infection over the myofascial area
- Reluctance to take responsibility for the work
Studijní plán
Jak je studie koncipována?
Detaily designu
- Primární účel: Léčba
- Přidělení: Randomizované
- Intervenční model: Paralelní přiřazení
- Maskování: Žádné (otevřený štítek)
Zbraně a zásahy
Skupina účastníků / Arm |
Intervence / Léčba |
|---|---|
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Komparátor placeba: Control Group
Participants receive carrier oil (sesame oil) administered through inhalation and extraoral massage following the same protocol as the intervention group.
Outcomes are evaluated using ultrasonographic measurements and patient-reported questionnaires.
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Participants receive carrier oil (sesame oil) administered through inhalation and extraoral massage according to the same protocol used in the intervention group.
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Experimentální: Aromatherapy Group
Participants receive aromatherapy by inhalation twice daily and extraoral massage once daily throughout the study period.
Outcomes are evaluated using ultrasonographic measurements and patient-reported questionnaires.
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Participants receive aromatherapy using a proprietary essential oil blend (Lavender Lavandula angustifolia, Marjoram Origanum majorana, and Vetiver Vetiveria zizanioides; Art De Huile®, formulated by Hülya Kayhan).
The blend is administered by inhalation twice daily and extraoral massage once daily throughout the study period.
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Co je měření studie?
Primární výstupní opatření
Měření výsledku |
Popis opatření |
Časové okno |
|---|---|---|
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Change in Masseter Muscle Elasticity
Časové okno: Baseline to Week 4
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Assessment of changes in masseter muscle elasticity using shear-wave elastography measured by ultrasonography.
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Baseline to Week 4
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Change in Masseter Muscle Thickness
Časové okno: Baseline to Week 4
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Assessment of changes in masseter muscle thickness measured by ultrasonography.
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Baseline to Week 4
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Sekundární výstupní opatření
Měření výsledku |
Popis opatření |
Časové okno |
|---|---|---|
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Change in Bruxism-Related Symptoms
Časové okno: Baseline to Week 4
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Assessment of changes in bruxism-related symptoms (jaw pain, headache, tooth sensitivity, fatigue, and perceived stress/anxiety) using the Visual Analog Scale (VAS).
Each symptom is rated from 0 (no symptom) to 10 (worst imaginable symptom).
Higher scores indicate more severe symptoms.
A study-specific patient-reported questionnaire is also used to document the presence and characteristics of bruxism-related symptoms.
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Baseline to Week 4
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Patient Satisfaction With Treatment
Časové okno: Week 4
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Assessment of participant satisfaction with the intervention using a study-specific patient-reported questionnaire.
Treatment satisfaction is rated on a 5-point Likert scale ranging from 1 (very dissatisfied) to 5 (very satisfied).
Higher scores indicate greater treatment satisfaction.
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Week 4
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Spolupracovníci a vyšetřovatelé
Sponzor
Publikace a užitečné odkazy
Obecné publikace
- Armijo-Olivo S, Pitance L, Singh V, Neto F, Thie N, Michelotti A. Effectiveness of Manual Therapy and Therapeutic Exercise for Temporomandibular Disorders: Systematic Review and Meta-Analysis. Phys Ther. 2016 Jan;96(1):9-25. doi: 10.2522/ptj.20140548. Epub 2015 Aug 20.
- Medlicott MS, Harris SR. A systematic review of the effectiveness of exercise, manual therapy, electrotherapy, relaxation training, and biofeedback in the management of temporomandibular disorder. Phys Ther. 2006 Jul;86(7):955-73.
- Palinkas M, De Luca Canto G, Rodrigues LA, Bataglion C, Siessere S, Semprini M, Regalo SC. Comparative Capabilities of Clinical Assessment, Diagnostic Criteria, and Polysomnography in Detecting Sleep Bruxism. J Clin Sleep Med. 2015 Nov 15;11(11):1319-25. doi: 10.5664/jcsm.5196.
- Capellini VK, de Souza GS, de Faria CR. Massage therapy in the management of myogenic TMD: a pilot study. J Appl Oral Sci. 2006 Jan;14(1):21-6. doi: 10.1590/s1678-77572006000100005.
- Nasiri A, Mahmodi MA, Nobakht Z. Effect of aromatherapy massage with lavender essential oil on pain in patients with osteoarthritis of the knee: A randomized controlled clinical trial. Complement Ther Clin Pract. 2016 Nov;25:75-80. doi: 10.1016/j.ctcp.2016.08.002. Epub 2016 Aug 3.
- Seifert O, Baerwald C. [Stimulation of the vagus nerve as a therapeutic principle. German Version]. Z Rheumatol. 2023 Aug;82(6):462-471. doi: 10.1007/s00393-023-01390-x. Epub 2023 Jul 25. German.
- Bennett R. Myofascial pain syndromes and their evaluation. Best Pract Res Clin Rheumatol. 2007 Jun;21(3):427-45. doi: 10.1016/j.berh.2007.02.014.
- Johnson JR, Rivard RL, Griffin KH, Kolste AK, Joswiak D, Kinney ME, Dusek JA. The effectiveness of nurse-delivered aromatherapy in an acute care setting. Complement Ther Med. 2016 Apr;25:164-9. doi: 10.1016/j.ctim.2016.03.006. Epub 2016 Mar 7.
- Gok Metin Z, Arikan Donmez A, Izgu N, Ozdemir L, Arslan IE. Aromatherapy Massage for Neuropathic Pain and Quality of Life in Diabetic Patients. J Nurs Scholarsh. 2017 Jul;49(4):379-388. doi: 10.1111/jnu.12300. Epub 2017 Jun 12.
- Ariji Y, Nakayama M, Nishiyama W, Ogi N, Sakuma S, Katsumata A, Kurita K, Ariji E. Potential clinical application of masseter and temporal muscle massage treatment using an oral rehabilitation robot in temporomandibular disorder patients with myofascial pain. Cranio. 2015 Oct;33(4):256-62. doi: 10.1080/08869634.2015.1097303. Epub 2015 Dec 29.
- Pessoa DR, Costa DR, Prianti BM, Costa DR, Delpasso CA, Arisawa EALS, Nicolau RA. Association of facial massage, dry needling, and laser therapy in Temporomandibular Disorder: case report. Codas. 2018 Nov 29;30(6):e20170265. doi: 10.1590/2317-1782/20182017265.
- Fernandez-de-las-Penas C, Svensson P. Myofascial Temporomandibular Disorder. Curr Rheumatol Rev. 2016;12(1):40-54. doi: 10.2174/1573397112666151231110947.
Užitečné odkazy
Termíny studijních záznamů
Hlavní termíny studia
Začátek studia (Aktuální)
Primární dokončení (Odhadovaný)
Dokončení studie (Odhadovaný)
Termíny zápisu do studia
První předloženo
První předloženo, které splnilo kritéria kontroly kvality
První zveřejněno (Aktuální)
Aktualizace studijních záznamů
Poslední zveřejněná aktualizace (Aktuální)
Odeslaná poslední aktualizace, která splnila kritéria kontroly kvality
Naposledy ověřeno
Více informací
Termíny související s touto studií
Klíčová slova
Další relevantní podmínky MeSH
- Stomatognátní onemocnění
- Nemoci nervového systému
- Duševní poruchy
- Nemoci zubů
- Poruchy spánku a bdění
- Parasomnie
- Chování
- Zvyky
- Bruxismus
- Spánkový bruxismus
- Epidemiologické metody
- Terapeutika
- Lipidy
- Veřejné zdraví
- Životní prostředí a veřejné zdraví
- Terapie mysli a těla
- Doplňkové terapie
- Jídlo
- Strava, jídlo a výživa
- Fyziologické jevy
- Jídlo a nápoje
- Psychoterapie
- Disciplíny a činnosti chování
- Přípravky rostlin
- Biologické produkty
- Složité směsi
- Rostlinné oleje
- Oleje
- Dietní tuky
- Tuky
- Dietní tuky, nenasycené
- Smyslové umělecké terapie
- Fytoterapie
- Tuky, nenasycené
- Aromaterapie
- Sezamový olej
- Carrier State
Další identifikační čísla studie
- 2023/346
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Popis plánu IPD
Informace o lécích a zařízeních, studijní dokumenty
Studuje lékový produkt regulovaný americkým FDA
Studuje produkt zařízení regulovaný americkým úřadem FDA
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