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Effect of Marjoram, Vetiver, and Lavender Oil in the Treatment of Bruxism

30 giugno 2026 aggiornato da: SULTAN UZUN, Necmettin Erbakan University
The aim of this study was to investigate the possible effects of the use of lavender, marjoram and vetiver oil via inhalation and/or massage application on the treatment of bruxism.

Panoramica dello studio

Descrizione dettagliata

Bruxism is a repetitive jaw muscle activity characterized by clenching or grinding of the teeth and/or bracing or thrusting of the mandible. Due to increasing evidence suggesting that it may serve a physiological purpose, bruxism has been defined as jaw muscle activity that may occur during sleep and/or wakefulness.

Various methods have been proposed for the treatment of bruxism. These treatment approaches include pharmacological treatments (such as muscle relaxants and clonazepam), orthopedic treatments (such as stabilization splints and rigid stabilization appliances), needling treatments (including acupuncture, botulinum toxin type A, and dry needling), physical and behavioral approaches (such as relaxation training, stress management, biofeedback, and sleep hygiene instructions), manual treatments including exercises (trigger point therapy, soft tissue techniques, exercises, postural corrections, joint mobilizations, and cervical spine treatment), and other physical therapy modalities (including low-level laser therapy, therapeutic ultrasound, and short-wave diathermy).

Manual therapy, therapeutic exercise, and their combination have been shown to effectively reduce pain and improve mandibular function. Massage therapy, which activates the pain-gate mechanism, is an effective treatment option for pain relief. It also stimulates the parasympathetic nervous system and helps restore muscle length and flexibility. In addition, massage therapy improves local blood circulation and promotes the production of endogenous opioids, leading to relaxing effects and reduced pain perception. These effects are of particular interest in the management of bruxism; however, this treatment approach has not been adequately investigated despite its promising results.

Massage therapy can be combined with aromatherapy, one of the most commonly used complementary therapy methods. Its therapeutic effects are based on stimulation of the olfactory system and absorption of active molecules through the skin. Various studies have investigated the analgesic effects of aromatherapy massage using lavender essential oil. Lavandula angustifolia is a well-known medicinal and aromatic plant with anti-inflammatory and analgesic properties. In addition, it has antiseptic, soothing, circulation-stimulating, and cell-regenerating effects. Lavender oil has been reported to reduce pain in patients with various conditions, including neuropathic pain, rheumatoid arthritis, burns, and cancer-related pain. Apart from lavender oil, marjoram oil may contribute to pain control and anxiety reduction, while vetiver oil is known for its sedative effects. However, the effects of aromatherapy massage using these essential oils have not been adequately investigated in patients with bruxism.

The aim of this study is to evaluate the effects of lavender, marjoram, and vetiver essential oils administered through aromatherapy massage in patients with bruxism. Objective outcomes will be assessed through ultrasonographic evaluation of the masseter muscle, while subjective outcomes will be evaluated using patient-reported questionnaires. The findings of this study may contribute to the development of complementary treatment approaches for the management of bruxism.

Tipo di studio

Interventistico

Iscrizione (Stimato)

64

Fase

  • Non applicabile

Contatti e Sedi

Questa sezione fornisce i recapiti di coloro che conducono lo studio e informazioni su dove viene condotto lo studio.

Luoghi di studio

    • Merkez
      • Bilecik, Merkez, Turchia (Türkiye), 11100
        • Bilecik Seyh Edebali University

Criteri di partecipazione

I ricercatori cercano persone che corrispondano a una certa descrizione, chiamata criteri di ammissibilità. Alcuni esempi di questi criteri sono le condizioni generali di salute di una persona o trattamenti precedenti.

Criteri di ammissibilità

Età idonea allo studio

  • Adulto

Accetta volontari sani

Descrizione

Inclusion Criteria:

  • • Patients between 18-25

    • Patients with full dentition including 2nd molars
    • Patients without facial asymmetry
    • Patients without history of sensitivity or allergy to plants
    • Patients without olfactory disorders

Exclusion Criteria:

  • • Patients with systemic (asthma history) and/or neuromuscular disease

    • Patients with orofacial pain not caused by bruxism
    • Temporomandibular joint (TMJ) surgery or injection history
    • Use of any medical drug affecting the muscular system
    • Patients with developmental deformity or surgery history in the maxillofacial region (facial trauma history, resection history, etc.)
    • TMJ pathologies (major condylar changes seen on panoramic radiograph)
    • Radiotherapy and/or chemotherapy history
    • Ongoing orthodontic treatment
    • Removable prosthesis use
    • Inflammatory connective tissue diseases
    • Pregnancy
    • Obstructive sleep apnea
    • Local skin infection over the myofascial area
    • Reluctance to take responsibility for the work

Piano di studio

Questa sezione fornisce i dettagli del piano di studio, compreso il modo in cui lo studio è progettato e ciò che lo studio sta misurando.

Come è strutturato lo studio?

Dettagli di progettazione

  • Scopo principale: Trattamento
  • Assegnazione: Randomizzato
  • Modello interventistico: Assegnazione parallela
  • Mascheramento: Nessuno (etichetta aperta)

Armi e interventi

Gruppo di partecipanti / Arm
Intervento / Trattamento
Comparatore placebo: Control Group
Participants receive carrier oil (sesame oil) administered through inhalation and extraoral massage following the same protocol as the intervention group. Outcomes are evaluated using ultrasonographic measurements and patient-reported questionnaires.
Participants receive carrier oil (sesame oil) administered through inhalation and extraoral massage according to the same protocol used in the intervention group.
Sperimentale: Aromatherapy Group
Participants receive aromatherapy by inhalation twice daily and extraoral massage once daily throughout the study period. Outcomes are evaluated using ultrasonographic measurements and patient-reported questionnaires.
Participants receive aromatherapy using a proprietary essential oil blend (Lavender Lavandula angustifolia, Marjoram Origanum majorana, and Vetiver Vetiveria zizanioides; Art De Huile®, formulated by Hülya Kayhan). The blend is administered by inhalation twice daily and extraoral massage once daily throughout the study period.

Cosa sta misurando lo studio?

Misure di risultato primarie

Misura del risultato
Misura Descrizione
Lasso di tempo
Change in Masseter Muscle Elasticity
Lasso di tempo: Baseline to Week 4
Assessment of changes in masseter muscle elasticity using shear-wave elastography measured by ultrasonography.
Baseline to Week 4
Change in Masseter Muscle Thickness
Lasso di tempo: Baseline to Week 4
Assessment of changes in masseter muscle thickness measured by ultrasonography.
Baseline to Week 4

Misure di risultato secondarie

Misura del risultato
Misura Descrizione
Lasso di tempo
Change in Bruxism-Related Symptoms
Lasso di tempo: Baseline to Week 4
Assessment of changes in bruxism-related symptoms (jaw pain, headache, tooth sensitivity, fatigue, and perceived stress/anxiety) using the Visual Analog Scale (VAS). Each symptom is rated from 0 (no symptom) to 10 (worst imaginable symptom). Higher scores indicate more severe symptoms. A study-specific patient-reported questionnaire is also used to document the presence and characteristics of bruxism-related symptoms.
Baseline to Week 4
Patient Satisfaction With Treatment
Lasso di tempo: Week 4
Assessment of participant satisfaction with the intervention using a study-specific patient-reported questionnaire. Treatment satisfaction is rated on a 5-point Likert scale ranging from 1 (very dissatisfied) to 5 (very satisfied). Higher scores indicate greater treatment satisfaction.
Week 4

Collaboratori e investigatori

Qui è dove troverai le persone e le organizzazioni coinvolte in questo studio.

Pubblicazioni e link utili

La persona responsabile dell'inserimento delle informazioni sullo studio fornisce volontariamente queste pubblicazioni. Questi possono riguardare qualsiasi cosa relativa allo studio.

Pubblicazioni generali

Studiare le date dei record

Queste date tengono traccia dell'avanzamento della registrazione dello studio e dell'invio dei risultati di sintesi a ClinicalTrials.gov. I record degli studi e i risultati riportati vengono esaminati dalla National Library of Medicine (NLM) per assicurarsi che soddisfino specifici standard di controllo della qualità prima di essere pubblicati sul sito Web pubblico.

Studia le date principali

Inizio studio (Effettivo)

2 settembre 2024

Completamento primario (Stimato)

31 dicembre 2026

Completamento dello studio (Stimato)

31 gennaio 2027

Date di iscrizione allo studio

Primo inviato

18 giugno 2026

Primo inviato che soddisfa i criteri di controllo qualità

18 giugno 2026

Primo Inserito (Effettivo)

24 giugno 2026

Aggiornamenti dei record di studio

Ultimo aggiornamento pubblicato (Effettivo)

2 luglio 2026

Ultimo aggiornamento inviato che soddisfa i criteri QC

30 giugno 2026

Ultimo verificato

1 giugno 2026

Maggiori informazioni

Termini relativi a questo studio

Piano per i dati dei singoli partecipanti (IPD)

Hai intenzione di condividere i dati dei singoli partecipanti (IPD)?

NO

Descrizione del piano IPD

Individual participant data (IPD) will not be made publicly available due to participant privacy considerations and institutional data protection policies.

Informazioni su farmaci e dispositivi, documenti di studio

Studia un prodotto farmaceutico regolamentato dalla FDA degli Stati Uniti

No

Studia un dispositivo regolamentato dalla FDA degli Stati Uniti

No

Queste informazioni sono state recuperate direttamente dal sito web clinicaltrials.gov senza alcuna modifica. In caso di richieste di modifica, rimozione o aggiornamento dei dettagli dello studio, contattare register@clinicaltrials.gov. Non appena verrà implementata una modifica su clinicaltrials.gov, questa verrà aggiornata automaticamente anche sul nostro sito web .

Prove cliniche su Bruxismo

Prove cliniche su Carrier Oil (Sesame Oil)

3
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