Drug Resistance Spread in 6 Metropolitan Regions, Germany, 2001-20181
Melanie Stecher, Antoine Chaillon, Christoph Stephan, Elena Knops, Niko Kohmer, Clara Lehmann, Josef Eberle, Johannes Bogner, Christoph D Spinner, Anna Maria Eis-Hübinger, Jan-Christian Wasmuth, Guido Schäfer, Georg Behrens, Sanjay R Mehta, Jörg Janne Vehreschild, Martin Hoenigl, Melanie Stecher, Antoine Chaillon, Christoph Stephan, Elena Knops, Niko Kohmer, Clara Lehmann, Josef Eberle, Johannes Bogner, Christoph D Spinner, Anna Maria Eis-Hübinger, Jan-Christian Wasmuth, Guido Schäfer, Georg Behrens, Sanjay R Mehta, Jörg Janne Vehreschild, Martin Hoenigl
Abstract
We analyzed 1,397 HIV-1 pol sequences of antiretroviral therapy-naive patients in a total of 7 university hospitals in Bonn, Cologne, Frankfurt, Hamburg, Hannover, and Munich, Germany. Phylogenetic and network analysis elucidated numerous cases of shared drug resistance mutations among genetically linked patients; K103N was the most frequently shared mutation.
Trial registration: ClinicalTrials.gov NCT02149004.
Keywords: ART; Germany; HIV transmission; antimicrobial resistance; antiretroviral therapy; mutations; phylogenetic analysis; public health.
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Source: PubMed