Quality of life in the trastuzumab for gastric cancer trial
Taroh Satoh, Yung-Jue Bang, Evgeny A Gotovkin, Yasuo Hamamoto, Yoon-Koo Kang, Vladimir M Moiseyenko, Atsushi Ohtsu, Eric Van Cutsem, Nedal Al-Sakaff, Alexa Urspruch, Julie Hill, Harald A Weber, Hyun-Cheol Chung, ToGA Trial Investigators, Taroh Satoh, Yung-Jue Bang, Evgeny A Gotovkin, Yasuo Hamamoto, Yoon-Koo Kang, Vladimir M Moiseyenko, Atsushi Ohtsu, Eric Van Cutsem, Nedal Al-Sakaff, Alexa Urspruch, Julie Hill, Harald A Weber, Hyun-Cheol Chung, ToGA Trial Investigators
Abstract
Background: The Trastuzumab for Gastric Cancer phase III trial demonstrated that combining trastuzumab with chemotherapy significantly improved overall survival compared with chemotherapy alone in HER2-positive advanced gastric or gastroesophageal junction cancer. We report health-related quality of life (HRQoL) and quality-adjusted time without symptoms of disease or toxicity (Q-TWiST) results from this trial.
Patients and methods: Patients were randomized to receive six cycles of chemotherapy given every 3 weeks (capecitabine or fluorouracil, plus cisplatin) either alone or combined with administration of trastuzumab every 3 weeks until disease progression. At each clinical visit, HRQoL was assessed using two European Organization for Research and Treatment of Cancer quality of life questionnaires, QLQ-C30 and QLQ-STO22. Q-TWiST methodology was applied retrospectively using the clinical data and utility coefficients.
Results: Trastuzumab plus chemotherapy prolonged time to 10% definitive deterioration in all QLQ-C30 and QLQ-STO22 scores, including QLQ-C30 global health status versus chemotherapy alone, from 6.4 months to 10.2 months. In addition, trastuzumab plus chemotherapy extended Q-TWiST by 2.42 months compared with chemotherapy alone.
Conclusion: Compared with chemotherapy alone, trastuzumab plus chemotherapy prolongs time to deterioration of HRQoL and increases quality-adjusted survival in patients with HER2-positive gastric or gastroesophageal junction cancer.
Trial registration: ClinicalTrials.gov NCT01041404.
Keywords: Chemotherapy; Gastric cancer; HER2; Quality of life; Trastuzumab.
Conflict of interest statement
Disclosures of potential conflicts of interest may be found at the end of this article.
©AlphaMed Press.
Figures
Source: PubMed