Monoclonal Antibody ABX-EGF in Treating Patients With Renal (Kidney), Prostate, Pancreatic, Non-Small Cell Lung, Colon or Rectal, Esophageal, or Gastroesophageal Junction Cancer

DISEASE CHARACTERISTICS:

• Histologically confirmed diagnosis of 1 of the following:

  • Renal cell cancer (RCC)

    • Prior nephrectomy required

  • Prostate cancer

    • Failed prior primary therapy (e.g., surgery, radiotherapy, or chemotherapy)
    • Failed prior hormonal therapy (e.g., antiandrogen, luteinizing hormone-releasing hormone inhibitor, or orchiectomy)

  • Pancreatic cancer

    • Failed at least 1 prior standard therapy regimen for unresectable metastatic disease

  • Non-small cell lung cancer

    • Failed at least 1 prior standard therapy regimen for unresectable metastatic disease

  • Colorectal cancer

    • Received 1 or more prior chemotherapy regimen(s) for advanced metastatic disease

  • Esophageal cancer

    • Failed prior primary therapy (e.g., surgery, radiotherapy, or chemotherapy)
  • Gastroesophageal junction cancer
• Evaluable disease

• Epidermal growth factor receptor overexpression

  • Tumor tissue must yield the sum of 1+, 2+, or 3+ staining in at least 10% of evaluated tumor cells
• No uncontrolled brain metastases
• No evidence of disease progression or regression after a 30-day washout period

PATIENT CHARACTERISTICS:

Age:

• 18 and over

Performance status:

• Karnofsky 70-100% OR
• ECOG 0-1

Life expectancy:

• Not specified

Hematopoietic:

• Absolute neutrophil count greater than 1,000/mm^3
• Platelet count greater than 100,000/mm^3

Hepatic:

• AST/ALT no greater than 2 times upper limit of normal (ULN) (3 times ULN for liver metastases)
• Alkaline phosphatase no greater than 2 times ULN (3 times ULN for liver metastases)

Renal:

• Creatinine less than 2.2 mg/dL
• NCI renal toxicity no greater than grade 2
• No hypercalcemia (antihypercalcemic therapy allowed)

Cardiovascular:

• Ejection fraction at least 45% by MUGA
• No abnormal ECG or MUGA
• No myocardial infarction within the past year

Pulmonary:

• No abnormal chest x-ray
• FEV_1 greater than 50% of predicted

Other:

• No known allergy to ingredients of study drug
• No known allergy to Staphylococcus aureus Protein A
• HIV negative
• No chronic medical or psychiatric condition that would preclude study compliance
• Not pregnant or nursing
• Negative pregnancy test
• Fertile patients must use effective contraception during and for 2 months after study participation

PRIOR CONCURRENT THERAPY:

Biologic therapy:

• At least 30 days since prior biologic therapy (e.g., antibodies, cytokines, or co-stimulatory pathway inhibitors)
• No other concurrent biologic therapy

Chemotherapy:

• See Disease Characteristics
• At least 6 weeks since prior chemotherapy and recovered
• No prior chemotherapy for RCC
• No prior anthracyclines
• No concurrent chemotherapy

Endocrine therapy:

• See Disease Characteristics
• Concurrent steroids allowed
• Concurrent hormonal therapy allowed

Radiotherapy:

• See Disease Characteristics
• No prior mediastinal radiotherapy
• No concurrent radiotherapy

Surgery:

• See Disease Characteristics
• Recovered from any recent prior surgery

Other:

• At least 30 days since prior investigational drug or device
• At least 30 days since prior systemic therapy
• No other concurrent investigational drugs
• No other concurrent systemic agents or cancer therapy