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Comparison of Leg Elevation and Leg Wrapping in the Prevention of Propofol Induced Hypotension

23. juli 2016 opdateret af: Dr. Sara Jaison, Nitte University

Comparison of Leg Elevation and Leg Wrapping in the Prevention of Propofol Induced Hypotension: A Prospective Randomised Controlled Study

Propofol is an intravenous anaesthetic agent used for both induction and maintenance of anaesthesia. An important adverse effect is the significant fall in blood pressure. The current clinical study will be done to determine the efficacy of leg elevation and wrapping in reducing the incidence and severity of propofol induced hypotension in patients undergoing general anaesthesia.

Studieoversigt

Status

Status

Angiver den aktuelle rekrutteringsstatus eller den udvidede adgangsstatus.
Ukendt

Betingelser

Betingelser

Den sygdom, lidelse, syndrom, sygdom eller skade, der undersøges. På ClinicalTrials.gov kan tilstande også omfatte andre sundhedsrelaterede problemer, såsom levetid, livskvalitet og sundhedsrisici.

Intervention / Behandling

Intervention / Behandling

En proces eller handling, der er i fokus for en klinisk undersøgelse. Interventioner omfatter lægemidler, medicinsk udstyr, procedurer, vacciner og andre produkter, der enten er til undersøgelse eller allerede er tilgængelige. Interventioner kan også omfatte ikke-invasive tilgange, såsom uddannelse eller ændring af kost og motion.

Detaljeret beskrivelse

Propofol is an intravenous anaesthetic agent used for both induction and maintenance of anaesthesia. It is widely employed due to its quick onset of action, short half life and rapid recovery. An important adverse effect is the significant fall in blood pressure. Although the exact mechanism of propofol induced hypotension is not known, venodilation, decreased peripheral resistance and decrease in cardiac output has been suggested.2 Though the hypotension is transient, it can produce devastating effects. Hence there is a need to prevent it. Moreover, several attempts at treating propofol induced hypotension have been met with variable and limited success.

Hypotension following spinal anaesthesia is also a frequent problem. It is generally treated with intravenous fluids and vasopressors. Simple and non pharmacological measures like leg elevation and leg wrapping with Esmarch bandage were reported to be successful.3 These reduce the incidence and severity of hypotension associated with spinal anaesthesia by improving the venous return.

The mechanisms of hypotension following intravenous propofol and spinal anaesthesia are almost similar. Therefore, the investigators hypothesize that leg elevation and wrapping can be attempted to reduce propofol induced hypotension. They are simple and cost effective techniques that will reduce the need for pharmacological measures to control hypotension. As the literature search did not reveal any information regarding the usefulness of these techniques in propofol induced hypotension, the current clinical study will be done to determine the efficacy of leg elevation and wrapping in reducing the incidence and severity of propofol induced hypotension in patients undergoing general anaesthesia.

The current study will compare the efficacy of leg elevation and leg wrapping in reducing the incidence and severity of propofol induced hypotension in terms of incidence of hypotension, magnitude of decrease in systolic, diastolic and mean arterial blood pressures, need for pharmacological measures to treat hypotension, changes in heart rate and adverse clinical outcomes, if any. It will be a prospective randomised controlled open label study from January 2016 to August 2017 involving 150 adult patients undergoing general anaesthesia.

For statistical analysis, descriptive statistics - minimum, maximum, mean and standard deviation will be used. Independent sample t test for data following normal distribution and for data not following normal distribution, Mann-Whitney U test will be used. P value less than 0.05 will be considered statistically significant. To study relationship between hypotension and other variables, Pearson's correlation will be used. Confidence interval will be calculated to 95%.

Undersøgelsestype

Undersøgelsestype

Beskriver karakteren af ​​en klinisk undersøgelse. Undersøgelsestyper omfatter interventionelle undersøgelser (også kaldet kliniske forsøg), observationsundersøgelser (herunder patientregistre) og udvidet adgang.
Interventionel

Tilmelding (Forventet)

Tilmelding

Antallet af deltagere i en klinisk undersøgelse. Den "forventede" tilmelding er det mål for antallet af deltagere, som forskerne skal bruge til undersøgelsen.
150

Fase

Fase

Stadiet af et klinisk forsøg, der studerer et lægemiddel eller et biologisk produkt, baseret på definitioner udviklet af U.S. Food and Drug Administration (FDA). Fasen tager udgangspunkt i undersøgelsens formål, antallet af deltagere og andre karakteristika. Der er fem faser: Tidlig fase 1 (tidligere opført som fase 0), fase 1, fase 2, fase 3 og fase 4. Ikke relevant bruges til at beskrive forsøg uden FDA-definerede faser, herunder forsøg med enheder eller adfærdsmæssige indgreb.
  • Ikke anvendelig

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiekontakt

Studiekontakt

Navn og kontaktoplysninger for den person, der kan besvare spørgsmål om tilmelding til en klinisk undersøgelse. Hvert sted, hvor undersøgelsen udføres, kan også have en specifik kontaktperson, som kan være bedre i stand til at besvare disse spørgsmål.

Undersøgelse Kontakt Backup

Studiesteder

  • Indien
    • Dakshina Kannada
      • Mangalore, Dakshina Kannada, Indien, 575018
        • Rekruttering
        • Justice K. S. Hegde Hospital, K S Hegde Medical Academy, Nitte University
        • Kontakt:
        • Kontakt:
        • Ledende efterforsker:
          • Sara Jaison, MBBS

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Berettigelseskriterier

De nøglekrav, som personer, der ønsker at deltage i et klinisk studie, skal opfylde eller de egenskaber, de skal have. Kvalifikationskriterier består af både inklusionskriterier (som er nødvendige for at en person kan deltage i undersøgelsen) og eksklusionskriterier (som forhindrer en person i at deltage). Typer af berettigelseskriterier omfatter, om en undersøgelse accepterer raske frivillige, har alders- eller aldersgruppekrav eller er begrænset af køn.

Aldre berettiget til at studere

18 år til 60 år (Voksen)

Tager imod sunde frivillige

Ingen

Køn, der er berettiget til at studere

Alle

Beskrivelse

Inclusion Criteria:

  • Patients belonging to ASA physical status I and II undergoing endotracheal general anaesthesia

Exclusion Criteria:

  • Patient refusal
  • Contraindication to application of bandage
  • Partial or complete limb amputation
  • Difficult airway
  • Use of extraglottic airway device
  • Pregnancy
  • On antihypertensive or vasoactive medication
  • Autonomic neuropathy

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

  • Primært formål: Forebyggelse
  • Tildeling: Randomiseret
  • Interventionel model: Parallel tildeling
  • Maskning: Ingen (Åben etiket)

Våben og indgreb

Deltagergruppe / Arm

Deltagergruppe / Arm

En gruppe eller undergruppe af deltagere i et klinisk forsøg, der modtager en specifik intervention/behandling eller ingen intervention i henhold til forsøgets protokol.
Intervention / Behandling

Intervention / Behandling

En proces eller handling, der er i fokus for en klinisk undersøgelse. Interventioner omfatter lægemidler, medicinsk udstyr, procedurer, vacciner og andre produkter, der enten er til undersøgelse eller allerede er tilgængelige. Interventioner kan også omfatte ikke-invasive tilgange, såsom uddannelse eller ændring af kost og motion.
Placebo komparator: Group C Control
Patient will be shifted to operation theatre. Electrocardiography (ECG), pulse oximeter and non-invasive blood pressure (NIBP) monitors will be attached. Baseline vitals will be noted. Intravenous access will be secured and crystalloids at 100ml/hr will be given. Analgesia will be given by inj fentanyl 2µg/kg body weight. Lower limbs will be neither elevated or wrapped. Vitals will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Muscle relaxation will be achieved by inj. vecuronium 0.1mg/kg body weight. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube.
Andet: control
no intervention has been done
Eksperimentel: Group E Leg elevation
Patient will be shifted to operation theatre. Crystalloids at 100ml/hr will be given. Analgesia will be given by inj fentanyl 2µg/kg body weight. Lower limbs are elevated and supported on a stand making an angle of 30 degree to the horizontal. Vitals will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Muscle relaxation will be achieved by inj. vecuronium 0.1mg/kg body weight. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Stand will be removed and legs will be brought to horizontal position 10 minutes after intubation.
Andet: leg elevation
A stand making an angle of 30 degree to the horizontal is used to elevate both the legs
Eksperimentel: Group W Leg wrapping
Patient will be shifted to operation theatre. Crystalloids at 100ml/hr will be given. Analgesia will be given by inj fentanyl. Each lower limb will be elevated alternately and wrapped from toe to mid-thigh with Esmarch bandage. Care will be taken to avoid compressing the legs to greater than arterial pressure by confirming the presence of pulse using a saturation probe. Following wrapping, the lower limbs will be brought to horizontal position. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol injected over 30 seconds. Muscle relaxation by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Esmarch bandage will be removed 10 minutes after intubation.
Andet: leg wrapping
Esmarch bandage is used to wrap each lower limb

Hvad måler undersøgelsen?

Primære resultatmål

Primære resultatmål

I et klinisk studies protokol er det planlagte resultatmål, der er det vigtigste for at evaluere effekten af ​​en intervention/behandling. De fleste kliniske undersøgelser har ét primært resultatmål, men nogle har mere end ét.
Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
incidence of hypotension at baseline
Tidsramme: baseline
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline blood pressure including systolic, diastolic and mean arterial blood pressures will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Blood pressures will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Blood pressures will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Hypotension will be defined as a drop in systolic blood pressure to less than 30% of baseline values or to MAP <60mm Hg. Incidence of hypotension will be noted.
baseline
incidence of hypotension at 0 minutes after leg elevation or wrapping
Tidsramme: 0 minutes after leg elevation or wrapping
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline blood pressure including systolic, diastolic and mean arterial blood pressures will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Blood pressures will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Blood pressures will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Hypotension will be defined as a drop in systolic blood pressure to less than 30% of baseline values or to MAP <60mm Hg. Incidence of hypotension will be noted.
0 minutes after leg elevation or wrapping
incidence of hypotension at 0 minutes after induction with propofol
Tidsramme: 0 minutes after induction with propofol
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline blood pressure including systolic, diastolic and mean arterial blood pressures will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Blood pressures will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Blood pressures will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Hypotension will be defined as a drop in systolic blood pressure to less than 30% of baseline values or to MAP <60mm Hg. Incidence of hypotension will be noted.
0 minutes after induction with propofol
incidence of hypotension at 1 minute after induction
Tidsramme: 1 minute after induction
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline blood pressure including systolic, diastolic and mean arterial blood pressures will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Blood pressures will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Blood pressures will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Hypotension will be defined as a drop in systolic blood pressure to less than 30% of baseline values or to MAP <60mm Hg. Incidence of hypotension will be noted.
1 minute after induction
incidence of hypotension at 2 minutes after induction
Tidsramme: 2 minutes after induction
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline blood pressure including systolic, diastolic and mean arterial blood pressures will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Blood pressures will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Blood pressures will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Hypotension will be defined as a drop in systolic blood pressure to less than 30% of baseline values or to MAP <60mm Hg. Incidence of hypotension will be noted.
2 minutes after induction
incidence of hypotension at 3 minutes after induction
Tidsramme: 3 minutes after induction
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline blood pressure including systolic, diastolic and mean arterial blood pressures will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Blood pressures will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Blood pressures will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Hypotension will be defined as a drop in systolic blood pressure to less than 30% of baseline values or to MAP <60mm Hg. Incidence of hypotension will be noted.
3 minutes after induction
incidence of hypotension at 4 minutes after induction
Tidsramme: 4 minutes after induction
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline blood pressure including systolic, diastolic and mean arterial blood pressures will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Blood pressures will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Blood pressures will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Hypotension will be defined as a drop in systolic blood pressure to less than 30% of baseline values or to MAP <60mm Hg. Incidence of hypotension will be noted.
4 minutes after induction
incidence of hypotension at 5 minutes after induction
Tidsramme: 5 minutes after induction
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline blood pressure including systolic, diastolic and mean arterial blood pressures will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Blood pressures will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Blood pressures will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Hypotension will be defined as a drop in systolic blood pressure to less than 30% of baseline values or to MAP <60mm Hg. Incidence of hypotension will be noted.
5 minutes after induction
incidence of hypotension at 0 minutes after intubation
Tidsramme: 0 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline blood pressure including systolic, diastolic and mean arterial blood pressures will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Blood pressures will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Blood pressures will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Hypotension will be defined as a drop in systolic blood pressure to less than 30% of baseline values or to MAP <60mm Hg. Incidence of hypotension will be noted.
0 minutes after intubation
incidence of hypotension at 1 minute after intubation
Tidsramme: 1 minute after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline blood pressure including systolic, diastolic and mean arterial blood pressures will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Blood pressures will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Blood pressures will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Hypotension will be defined as a drop in systolic blood pressure to less than 30% of baseline values or to MAP <60mm Hg. Incidence of hypotension will be noted.
1 minute after intubation
incidence of hypotension at 2 minutes after intubation
Tidsramme: 2 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline blood pressure including systolic, diastolic and mean arterial blood pressures will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Blood pressures will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Blood pressures will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Hypotension will be defined as a drop in systolic blood pressure to less than 30% of baseline values or to MAP <60mm Hg. Incidence of hypotension will be noted.
2 minutes after intubation
incidence of hypotension at 3 minutes after intubation
Tidsramme: 3 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline blood pressure including systolic, diastolic and mean arterial blood pressures will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Blood pressures will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Blood pressures will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Hypotension will be defined as a drop in systolic blood pressure to less than 30% of baseline values or to MAP <60mm Hg. Incidence of hypotension will be noted.
3 minutes after intubation
incidence of hypotension at 4 minutes after intubation
Tidsramme: 4 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline blood pressure including systolic, diastolic and mean arterial blood pressures will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Blood pressures will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Blood pressures will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Hypotension will be defined as a drop in systolic blood pressure to less than 30% of baseline values or to MAP <60mm Hg. Incidence of hypotension will be noted.
4 minutes after intubation
incidence of hypotension at 5 minutes after intubation
Tidsramme: 5 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline blood pressure including systolic, diastolic and mean arterial blood pressures will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Blood pressures will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Blood pressures will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Hypotension will be defined as a drop in systolic blood pressure to less than 30% of baseline values or to MAP <60mm Hg. Incidence of hypotension will be noted.
5 minutes after intubation
incidence of hypotension at 6 minutes after intubation
Tidsramme: 6 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline blood pressure including systolic, diastolic and mean arterial blood pressures will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Blood pressures will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Blood pressures will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Hypotension will be defined as a drop in systolic blood pressure to less than 30% of baseline values or to MAP <60mm Hg. Incidence of hypotension will be noted.
6 minutes after intubation
incidence of hypotension at 7 minutes after intubation
Tidsramme: 7 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline blood pressure including systolic, diastolic and mean arterial blood pressures will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Blood pressures will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Blood pressures will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Hypotension will be defined as a drop in systolic blood pressure to less than 30% of baseline values or to MAP <60mm Hg. Incidence of hypotension will be noted.
7 minutes after intubation
incidence of hypotension at 8 minutes after intubation
Tidsramme: 8 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline blood pressure including systolic, diastolic and mean arterial blood pressures will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Blood pressures will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Blood pressures will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Hypotension will be defined as a drop in systolic blood pressure to less than 30% of baseline values or to MAP <60mm Hg. Incidence of hypotension will be noted.
8 minutes after intubation
incidence of hypotension at 9 minutes after intubation
Tidsramme: 9 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline blood pressure including systolic, diastolic and mean arterial blood pressures will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Blood pressures will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Blood pressures will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Hypotension will be defined as a drop in systolic blood pressure to less than 30% of baseline values or to MAP <60mm Hg. Incidence of hypotension will be noted.
9 minutes after intubation
incidence of hypotension at 10 minutes after intubation
Tidsramme: 10 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline blood pressure including systolic, diastolic and mean arterial blood pressures will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Blood pressures will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Blood pressures will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Hypotension will be defined as a drop in systolic blood pressure to less than 30% of baseline values or to MAP <60mm Hg. Incidence of hypotension will be noted.
10 minutes after intubation

Sekundære resultatmål

Sekundære resultatmål

I en klinisk undersøgelses protokol er et planlagt resultatmål, der ikke er lige så vigtigt som det primære resultatmål for at evaluere effekten af ​​en intervention, men som stadig er af interesse. De fleste kliniske undersøgelser har mere end ét sekundært resultatmål.
Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Magnitude of change in systolic blood pressure from baseline at 0 minutes after leg leg elevation or wrapping
Tidsramme: baseline, after leg elevation or wrapping
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline systolic blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Systolic blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Systolic blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Systolic blood pressure will be recorded every minute till 10 min post intubation. Magnitude of change in systolic blood pressure from baseline will be noted
baseline, after leg elevation or wrapping
Magnitude of change in systolic blood pressure from baseline at 0 minutes after induction
Tidsramme: baseline, at 0 minutes after induction with propofol
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline systolic blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Systolic blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Systolic blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Systolic blood pressure will be recorded every minute till 10 min post intubation. Magnitude of change in systolic blood pressure from baseline will be noted
baseline, at 0 minutes after induction with propofol
Magnitude of change in systolic blood pressure from baseline at 1 minute after induction
Tidsramme: baseline, at 1 minute after induction with propofol
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline systolic blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Systolic blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Systolic blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Systolic blood pressure will be recorded every minute till 10 min post intubation. Magnitude of change in systolic blood pressure from baseline will be noted
baseline, at 1 minute after induction with propofol
Magnitude of change in systolic blood pressure from baseline at 2 minutes after induction
Tidsramme: baseline, at 2 minutes after induction with propofol
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline systolic blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Systolic blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Systolic blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Systolic blood pressure will be recorded every minute till 10 min post intubation. Magnitude of change in systolic blood pressure from baseline will be noted
baseline, at 2 minutes after induction with propofol
Magnitude of change in systolic blood pressure from baseline at 3 minutes after induction
Tidsramme: baseline, at 3 minutes after induction with propofol
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline systolic blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Systolic blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Systolic blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Systolic blood pressure will be recorded every minute till 10 min post intubation. Magnitude of change in systolic blood pressure from baseline will be noted
baseline, at 3 minutes after induction with propofol
Magnitude of change in systolic blood pressure from baseline at 4 minutes after induction
Tidsramme: baseline, at 4 minutes after induction with propofol
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline systolic blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Systolic blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Systolic blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Systolic blood pressure will be recorded every minute till 10 min post intubation. Magnitude of change in systolic blood pressure from baseline will be noted
baseline, at 4 minutes after induction with propofol
Magnitude of change in systolic blood pressure from baseline at 5 minutes after induction
Tidsramme: baseline, at 5 minutes after induction with propofol
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline systolic blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Systolic blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Systolic blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Systolic blood pressure will be recorded every minute till 10 min post intubation. Magnitude of change in systolic blood pressure from baseline will be noted
baseline, at 5 minutes after induction with propofol
Magnitude of change in systolic blood pressure from baseline at 0 minutes after intubation
Tidsramme: baseline, at 0 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline systolic blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Systolic blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Systolic blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Systolic blood pressure will be recorded every minute till 10 min post intubation. Magnitude of change in systolic blood pressure from baseline will be noted
baseline, at 0 minutes after intubation
Magnitude of change in systolic blood pressure from baseline at 1 minute after intubation
Tidsramme: baseline, at 1 minute after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline systolic blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Systolic blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Systolic blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Systolic blood pressure will be recorded every minute till 10 min post intubation. Magnitude of change in systolic blood pressure from baseline will be noted
baseline, at 1 minute after intubation
Magnitude of change in systolic blood pressure from baseline at 2 minutes after intubation
Tidsramme: baseline, at 2 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline systolic blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Systolic blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Systolic blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Systolic blood pressure will be recorded every minute till 10 min post intubation. Magnitude of change in systolic blood pressure from baseline will be noted
baseline, at 2 minutes after intubation
Magnitude of change in systolic blood pressure from baseline at 3 minutes after intubation
Tidsramme: baseline, at 3 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline systolic blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Systolic blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Systolic blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Systolic blood pressure will be recorded every minute till 10 min post intubation. Magnitude of change in systolic blood pressure from baseline will be noted
baseline, at 3 minutes after intubation
Magnitude of change in systolic blood pressure from baseline at 4 minutes after intubation
Tidsramme: baseline, at 4 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline systolic blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Systolic blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Systolic blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Systolic blood pressure will be recorded every minute till 10 min post intubation. Magnitude of change in systolic blood pressure from baseline will be noted
baseline, at 4 minutes after intubation
Magnitude of change in systolic blood pressure from baseline at 5 minutes after intubation
Tidsramme: baseline, at 5 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline systolic blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Systolic blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Systolic blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Systolic blood pressure will be recorded every minute till 10 min post intubation. Magnitude of change in systolic blood pressure from baseline will be noted
baseline, at 5 minutes after intubation
Magnitude of change in systolic blood pressure from baseline at 6 minutes after intubation
Tidsramme: baseline, at 6 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline systolic blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Systolic blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Systolic blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Systolic blood pressure will be recorded every minute till 10 min post intubation. Magnitude of change in systolic blood pressure from baseline will be noted
baseline, at 6 minutes after intubation
Magnitude of change in systolic blood pressure from baseline at 7 minutes after intubation
Tidsramme: baseline, at 7 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline systolic blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Systolic blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Systolic blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Systolic blood pressure will be recorded every minute till 10 min post intubation. Magnitude of change in systolic blood pressure from baseline will be noted
baseline, at 7 minutes after intubation
Magnitude of change in systolic blood pressure from baseline at 8 minutes after intubation
Tidsramme: baseline, at 8 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline systolic blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Systolic blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Systolic blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Systolic blood pressure will be recorded every minute till 10 min post intubation. Magnitude of change in systolic blood pressure from baseline will be noted
baseline, at 8 minutes after intubation
Magnitude of change in systolic blood pressure from baseline at 9 minutes after intubation
Tidsramme: baseline, at 9 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline systolic blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Systolic blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Systolic blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Systolic blood pressure will be recorded every minute till 10 min post intubation. Magnitude of change in systolic blood pressure from baseline will be noted
baseline, at 9 minutes after intubation
Magnitude of change in systolic blood pressure from baseline at 10 minutes after intubation
Tidsramme: baseline, at 10 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline systolic blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Systolic blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Systolic blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Systolic blood pressure will be recorded every minute till 10 min post intubation. Magnitude of change in systolic blood pressure from baseline will be noted
baseline, at 10 minutes after intubation
Magnitude of change in diastolic blood pressure from baseline at 0 minutes after leg elevation or wrapping
Tidsramme: baseline, at 0 minutes after leg elevation or wrapping, at induction with propofol, every minute till 5 minutes after induction, at intubation and every minute thereafter upto 10 min post intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline diastolic blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Diastolic blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Diastolic blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Magnitude of change in diastolic blood pressure from baseline will be noted.
baseline, at 0 minutes after leg elevation or wrapping, at induction with propofol, every minute till 5 minutes after induction, at intubation and every minute thereafter upto 10 min post intubation
Magnitude of change in diastolic blood pressure from baseline at 0 minutes after induction with propofol
Tidsramme: baseline, at 0 minutes after induction with propofol
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline diastolic blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Diastolic blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Diastolic blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Magnitude of change in diastolic blood pressure from baseline will be noted.
baseline, at 0 minutes after induction with propofol
Magnitude of change in diastolic blood pressure from baseline at 1 minute after induction with propofol
Tidsramme: baseline, at 1 minute after induction with propofol
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline diastolic blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Diastolic blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Diastolic blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Magnitude of change in diastolic blood pressure from baseline will be noted.
baseline, at 1 minute after induction with propofol
Magnitude of change in diastolic blood pressure from baseline at 2 minutes after induction with propofol
Tidsramme: baseline, at 2 minutes after induction with propofol
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline diastolic blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Diastolic blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Diastolic blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Magnitude of change in diastolic blood pressure from baseline will be noted.
baseline, at 2 minutes after induction with propofol
Magnitude of change in diastolic blood pressure from baseline at 3 minutes after induction with propofol
Tidsramme: baseline, at 3 minutes after induction with propofol
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline diastolic blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Diastolic blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Diastolic blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Magnitude of change in diastolic blood pressure from baseline will be noted.
baseline, at 3 minutes after induction with propofol
Magnitude of change in diastolic blood pressure from baseline at 4 minutes after induction with propofol
Tidsramme: baseline, at 4 minutes after induction with propofol
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline diastolic blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Diastolic blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Diastolic blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Magnitude of change in diastolic blood pressure from baseline will be noted.
baseline, at 4 minutes after induction with propofol
Magnitude of change in diastolic blood pressure from baseline at 5 minutes after induction with propofol
Tidsramme: baseline, at 5 minutes after induction with propofol
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline diastolic blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Diastolic blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Diastolic blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Magnitude of change in diastolic blood pressure from baseline will be noted.
baseline, at 5 minutes after induction with propofol
Magnitude of change in diastolic blood pressure from baseline at 0 minutes after intubation
Tidsramme: baseline, at 0 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline diastolic blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Diastolic blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Diastolic blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Magnitude of change in diastolic blood pressure from baseline will be noted.
baseline, at 0 minutes after intubation
Magnitude of change in diastolic blood pressure from baseline at 1 minute after intubation
Tidsramme: baseline, at 1 minute after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline diastolic blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Diastolic blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Diastolic blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Magnitude of change in diastolic blood pressure from baseline will be noted.
baseline, at 1 minute after intubation
Magnitude of change in diastolic blood pressure from baseline at 2 minutes after intubation
Tidsramme: baseline, at 2 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline diastolic blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Diastolic blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Diastolic blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Magnitude of change in diastolic blood pressure from baseline will be noted.
baseline, at 2 minutes after intubation
Magnitude of change in diastolic blood pressure from baseline at 3 minutes after intubation
Tidsramme: baseline, at 3 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline diastolic blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Diastolic blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Diastolic blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Magnitude of change in diastolic blood pressure from baseline will be noted.
baseline, at 3 minutes after intubation
Magnitude of change in diastolic blood pressure from baseline at 4 minutes after intubation
Tidsramme: baseline, at 4 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline diastolic blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Diastolic blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Diastolic blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Magnitude of change in diastolic blood pressure from baseline will be noted.
baseline, at 4 minutes after intubation
Magnitude of change in diastolic blood pressure from baseline at 5 minutes after intubation
Tidsramme: baseline, at 5 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline diastolic blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Diastolic blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Diastolic blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Magnitude of change in diastolic blood pressure from baseline will be noted.
baseline, at 5 minutes after intubation
Magnitude of change in diastolic blood pressure from baseline at 6 minutes after intubation
Tidsramme: baseline, at 6 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline diastolic blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Diastolic blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Diastolic blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Magnitude of change in diastolic blood pressure from baseline will be noted.
baseline, at 6 minutes after intubation
Magnitude of change in diastolic blood pressure from baseline at 7 minutes after intubation
Tidsramme: baseline, at 7 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline diastolic blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Diastolic blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Diastolic blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Magnitude of change in diastolic blood pressure from baseline will be noted.
baseline, at 7 minutes after intubation
Magnitude of change in diastolic blood pressure from baseline at 8 minutes after intubation
Tidsramme: baseline, at 8 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline diastolic blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Diastolic blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Diastolic blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Magnitude of change in diastolic blood pressure from baseline will be noted.
baseline, at 8 minutes after intubation
Magnitude of change in diastolic blood pressure from baseline at 9 minutes after intubation
Tidsramme: baseline, at 9 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline diastolic blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Diastolic blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Diastolic blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Magnitude of change in diastolic blood pressure from baseline will be noted.
baseline, at 9 minutes after intubation
Magnitude of change in diastolic blood pressure from baseline at 10 minutes after intubation
Tidsramme: baseline, at 10 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline diastolic blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Diastolic blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Diastolic blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Magnitude of change in diastolic blood pressure from baseline will be noted.
baseline, at 10 minutes after intubation
Magnitude of change in mean arterial blood pressure from baseline at 0 minutes after leg elevation or wrapping
Tidsramme: baseline, 0 minutes after leg elevation or wrapping
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline mean arterial blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Mean arterial blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Mean arterial blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Magnitude of change in mean arterial blood pressure from baseline will be noted
baseline, 0 minutes after leg elevation or wrapping
Magnitude of change in mean arterial blood pressure from baseline at 1 minute after induction with propofol
Tidsramme: baseline, 0 minute after induction with propofol
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline mean arterial blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Mean arterial blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Mean arterial blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Magnitude of change in mean arterial blood pressure from baseline will be noted
baseline, 0 minute after induction with propofol
Magnitude of change in mean arterial blood pressure from baseline at 2 minutes after induction with propofol
Tidsramme: baseline, 2 minutes after induction with propofol
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline mean arterial blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Mean arterial blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Mean arterial blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Magnitude of change in mean arterial blood pressure from baseline will be noted
baseline, 2 minutes after induction with propofol
Magnitude of change in mean arterial blood pressure from baseline at 3 minutes after induction with propofol
Tidsramme: baseline, 3 minutes after induction with propofol
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline mean arterial blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Mean arterial blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Mean arterial blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Magnitude of change in mean arterial blood pressure from baseline will be noted
baseline, 3 minutes after induction with propofol
Magnitude of change in mean arterial blood pressure from baseline at 4 minutes after induction with propofol
Tidsramme: baseline, 4 minutes after induction with propofol
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline mean arterial blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Mean arterial blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Mean arterial blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Magnitude of change in mean arterial blood pressure from baseline will be noted
baseline, 4 minutes after induction with propofol
Magnitude of change in mean arterial blood pressure from baseline at 5 minutes after induction with propofol
Tidsramme: baseline, 5 minutes after induction with propofol
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline mean arterial blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Mean arterial blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Mean arterial blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Magnitude of change in mean arterial blood pressure from baseline will be noted
baseline, 5 minutes after induction with propofol
Magnitude of change in mean arterial blood pressure from baseline at 0 minute after intubation
Tidsramme: baseline, 0 minute after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline mean arterial blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Mean arterial blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Mean arterial blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Magnitude of change in mean arterial blood pressure from baseline will be noted
baseline, 0 minute after intubation
Magnitude of change in mean arterial blood pressure from baseline at 1 minutes after intubation
Tidsramme: baseline, 1 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline mean arterial blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Mean arterial blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Mean arterial blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Magnitude of change in mean arterial blood pressure from baseline will be noted
baseline, 1 minutes after intubation
Magnitude of change in mean arterial blood pressure from baseline at 2 minutes after intubation
Tidsramme: baseline, 2 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline mean arterial blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Mean arterial blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Mean arterial blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Magnitude of change in mean arterial blood pressure from baseline will be noted
baseline, 2 minutes after intubation
Magnitude of change in mean arterial blood pressure from baseline at 3 minutes after intubation
Tidsramme: baseline, 3 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline mean arterial blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Mean arterial blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Mean arterial blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Magnitude of change in mean arterial blood pressure from baseline will be noted
baseline, 3 minutes after intubation
Magnitude of change in mean arterial blood pressure from baseline at 4 minutes after intubation
Tidsramme: baseline, 4 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline mean arterial blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Mean arterial blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Mean arterial blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Magnitude of change in mean arterial blood pressure from baseline will be noted
baseline, 4 minutes after intubation
Magnitude of change in mean arterial blood pressure from baseline at 5 minutes after intubation
Tidsramme: baseline, 5 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline mean arterial blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Mean arterial blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Mean arterial blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Magnitude of change in mean arterial blood pressure from baseline will be noted
baseline, 5 minutes after intubation
Magnitude of change in mean arterial blood pressure from baseline at 6 minutes after intubation
Tidsramme: baseline, 6 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline mean arterial blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Mean arterial blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Mean arterial blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Magnitude of change in mean arterial blood pressure from baseline will be noted
baseline, 6 minutes after intubation
Magnitude of change in mean arterial blood pressure from baseline at 7 minutes after intubation
Tidsramme: baseline, 7 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline mean arterial blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Mean arterial blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Mean arterial blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Magnitude of change in mean arterial blood pressure from baseline will be noted
baseline, 7 minutes after intubation
Magnitude of change in mean arterial blood pressure from baseline at 8 minutes after intubation
Tidsramme: baseline, 8 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline mean arterial blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Mean arterial blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Mean arterial blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Magnitude of change in mean arterial blood pressure from baseline will be noted
baseline, 8 minutes after intubation
Magnitude of change in mean arterial blood pressure from baseline at 9 minutes after intubation
Tidsramme: baseline, 9 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline mean arterial blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Mean arterial blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Mean arterial blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Magnitude of change in mean arterial blood pressure from baseline will be noted
baseline, 9 minutes after intubation
Magnitude of change in mean arterial blood pressure from baseline at 10 minutes after intubation
Tidsramme: baseline, 10 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline mean arterial blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Mean arterial blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Mean arterial blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Magnitude of change in mean arterial blood pressure from baseline will be noted
baseline, 10 minutes after intubation
changes in heart rate from baseline at 0 minutes after leg elevation or wrapping
Tidsramme: baseline, 0 minutes after leg elevation or wrapping
Patient will be shifted to operation theatre. Baseline heart rate will be noted. Analgesia will be given by inj fentanyl 2µg/kg body weight. Lower limbs will be elevated, wrapped or none according to group allocation. Heart rate will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Heart rate will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Heart rate will be recorded every minute till 10 min post intubation. Changes in heart rate from baseline will be noted
baseline, 0 minutes after leg elevation or wrapping
changes in heart rate from baseline at 0 minutes after induction with propofol
Tidsramme: baseline, 0 minute after induction with propofol
Patient will be shifted to operation theatre. Baseline heart rate will be noted. Analgesia will be given by inj fentanyl 2µg/kg body weight. Lower limbs will be elevated, wrapped or none according to group allocation. Heart rate will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Heart rate will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Heart rate will be recorded every minute till 10 min post intubation. Changes in heart rate from baseline will be noted
baseline, 0 minute after induction with propofol
changes in heart rate from baseline at 1 minutes after induction with propofol
Tidsramme: baseline, 1 minutes after induction with propofol
Patient will be shifted to operation theatre. Baseline heart rate will be noted. Analgesia will be given by inj fentanyl 2µg/kg body weight. Lower limbs will be elevated, wrapped or none according to group allocation. Heart rate will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Heart rate will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Heart rate will be recorded every minute till 10 min post intubation. Changes in heart rate from baseline will be noted
baseline, 1 minutes after induction with propofol
changes in heart rate from baseline at 2 minutes after induction with propofol
Tidsramme: baseline, 2 minutes after induction with propofol
Patient will be shifted to operation theatre. Baseline heart rate will be noted. Analgesia will be given by inj fentanyl 2µg/kg body weight. Lower limbs will be elevated, wrapped or none according to group allocation. Heart rate will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Heart rate will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Heart rate will be recorded every minute till 10 min post intubation. Changes in heart rate from baseline will be noted
baseline, 2 minutes after induction with propofol
changes in heart rate from baseline at 3 minutes after induction with propofol
Tidsramme: baseline, 3 minutes after induction with propofol
Patient will be shifted to operation theatre. Baseline heart rate will be noted. Analgesia will be given by inj fentanyl 2µg/kg body weight. Lower limbs will be elevated, wrapped or none according to group allocation. Heart rate will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Heart rate will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Heart rate will be recorded every minute till 10 min post intubation. Changes in heart rate from baseline will be noted
baseline, 3 minutes after induction with propofol
changes in heart rate from baseline at 4 minutes after induction with propofol
Tidsramme: baseline, 4 minutes after induction with propofol
Patient will be shifted to operation theatre. Baseline heart rate will be noted. Analgesia will be given by inj fentanyl 2µg/kg body weight. Lower limbs will be elevated, wrapped or none according to group allocation. Heart rate will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Heart rate will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Heart rate will be recorded every minute till 10 min post intubation. Changes in heart rate from baseline will be noted
baseline, 4 minutes after induction with propofol
changes in heart rate from baseline at 5 minutes after induction with propofol
Tidsramme: baseline, 5 minutes after induction with propofol
Patient will be shifted to operation theatre. Baseline heart rate will be noted. Analgesia will be given by inj fentanyl 2µg/kg body weight. Lower limbs will be elevated, wrapped or none according to group allocation. Heart rate will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Heart rate will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Heart rate will be recorded every minute till 10 min post intubation. Changes in heart rate from baseline will be noted
baseline, 5 minutes after induction with propofol
changes in heart rate from baseline at 0 minutes after intubation
Tidsramme: baseline, 0 minutes after intubation
Patient will be shifted to operation theatre. Baseline heart rate will be noted. Analgesia will be given by inj fentanyl 2µg/kg body weight. Lower limbs will be elevated, wrapped or none according to group allocation. Heart rate will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Heart rate will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Heart rate will be recorded every minute till 10 min post intubation. Changes in heart rate from baseline will be noted
baseline, 0 minutes after intubation
changes in heart rate from baseline at 1 minute after intubation
Tidsramme: baseline, 1 minute after intubation
Patient will be shifted to operation theatre. Baseline heart rate will be noted. Analgesia will be given by inj fentanyl 2µg/kg body weight. Lower limbs will be elevated, wrapped or none according to group allocation. Heart rate will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Heart rate will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Heart rate will be recorded every minute till 10 min post intubation. Changes in heart rate from baseline will be noted
baseline, 1 minute after intubation
changes in heart rate from baseline at 2 minutes after intubation
Tidsramme: baseline, 2 minutes after intubation
Patient will be shifted to operation theatre. Baseline heart rate will be noted. Analgesia will be given by inj fentanyl 2µg/kg body weight. Lower limbs will be elevated, wrapped or none according to group allocation. Heart rate will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Heart rate will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Heart rate will be recorded every minute till 10 min post intubation. Changes in heart rate from baseline will be noted
baseline, 2 minutes after intubation
changes in heart rate from baseline at 3 minutes after intubation
Tidsramme: baseline, 3 minutes after intubation
Patient will be shifted to operation theatre. Baseline heart rate will be noted. Analgesia will be given by inj fentanyl 2µg/kg body weight. Lower limbs will be elevated, wrapped or none according to group allocation. Heart rate will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Heart rate will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Heart rate will be recorded every minute till 10 min post intubation. Changes in heart rate from baseline will be noted
baseline, 3 minutes after intubation
changes in heart rate from baseline at 4 minutes after intubation
Tidsramme: baseline, 4 minutes after intubation
Patient will be shifted to operation theatre. Baseline heart rate will be noted. Analgesia will be given by inj fentanyl 2µg/kg body weight. Lower limbs will be elevated, wrapped or none according to group allocation. Heart rate will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Heart rate will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Heart rate will be recorded every minute till 10 min post intubation. Changes in heart rate from baseline will be noted
baseline, 4 minutes after intubation
changes in heart rate from baseline at 5 minutes after intubation
Tidsramme: baseline, 5 minutes after intubation
Patient will be shifted to operation theatre. Baseline heart rate will be noted. Analgesia will be given by inj fentanyl 2µg/kg body weight. Lower limbs will be elevated, wrapped or none according to group allocation. Heart rate will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Heart rate will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Heart rate will be recorded every minute till 10 min post intubation. Changes in heart rate from baseline will be noted
baseline, 5 minutes after intubation
changes in heart rate from baseline at 6 minutes after intubation
Tidsramme: baseline, 6 minutes after intubation
Patient will be shifted to operation theatre. Baseline heart rate will be noted. Analgesia will be given by inj fentanyl 2µg/kg body weight. Lower limbs will be elevated, wrapped or none according to group allocation. Heart rate will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Heart rate will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Heart rate will be recorded every minute till 10 min post intubation. Changes in heart rate from baseline will be noted
baseline, 6 minutes after intubation
changes in heart rate from baseline at 7 minutes after intubation
Tidsramme: baseline, 7 minutes after intubation
Patient will be shifted to operation theatre. Baseline heart rate will be noted. Analgesia will be given by inj fentanyl 2µg/kg body weight. Lower limbs will be elevated, wrapped or none according to group allocation. Heart rate will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Heart rate will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Heart rate will be recorded every minute till 10 min post intubation. Changes in heart rate from baseline will be noted
baseline, 7 minutes after intubation
changes in heart rate from baseline at 8 minutes after intubation
Tidsramme: baseline, 8 minutes after intubation
Patient will be shifted to operation theatre. Baseline heart rate will be noted. Analgesia will be given by inj fentanyl 2µg/kg body weight. Lower limbs will be elevated, wrapped or none according to group allocation. Heart rate will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Heart rate will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Heart rate will be recorded every minute till 10 min post intubation. Changes in heart rate from baseline will be noted
baseline, 8 minutes after intubation
changes in heart rate from baseline at 9 minutes after intubation
Tidsramme: baseline, 9 minutes after intubation
Patient will be shifted to operation theatre. Baseline heart rate will be noted. Analgesia will be given by inj fentanyl 2µg/kg body weight. Lower limbs will be elevated, wrapped or none according to group allocation. Heart rate will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Heart rate will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Heart rate will be recorded every minute till 10 min post intubation. Changes in heart rate from baseline will be noted
baseline, 9 minutes after intubation
changes in heart rate from baseline at 10 minutes after intubation
Tidsramme: baseline, 10 minutes after intubation
Patient will be shifted to operation theatre. Baseline heart rate will be noted. Analgesia will be given by inj fentanyl 2µg/kg body weight. Lower limbs will be elevated, wrapped or none according to group allocation. Heart rate will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Heart rate will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Heart rate will be recorded every minute till 10 min post intubation. Changes in heart rate from baseline will be noted
baseline, 10 minutes after intubation

Andre resultatmål

Andre resultatmål

For kliniske forsøg en planlagt måling beskrevet i protokollen, der bruges til at bestemme effekten af ​​en intervention/behandling på deltagerne. Til observationsstudier, en måling eller observation, der bruges til at beskrive mønstre af sygdomme eller egenskaber eller sammenhænge med eksponeringer, risikofaktorer eller behandling. Typer af resultatmål omfatter primært resultatmål og sekundært resultatmål.
Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Need for pharmacological measures to treat hypotension
Tidsramme: baseline, after leg elevation or wrapping, at induction with propofol, every minute till 5 minutes after induction, at intubation and every minute thereafter upto 10 min post intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline mean arterial blood pressure (MAP) will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. MAP will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol. MAP will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed. MAP<55mm Hg will be treated by rapid intravenous fluid administration and by intravenous mephentermine 6mg bolus increments every minute until the systolic pressure rises to greater than 70% of baseline or to above 90mm Hg. Total dose of mephentermine required will be noted.
baseline, after leg elevation or wrapping, at induction with propofol, every minute till 5 minutes after induction, at intubation and every minute thereafter upto 10 min post intubation
Tachycardia
Tidsramme: baseline, after leg elevation or wrapping, at induction with propofol, every minute till 5 minutes after induction, at intubation and every minute thereafter upto 10 min post intubation
Tachycardia will be defined as heart rate more than 100bpm or increase by more than 30% over baseline value. Any incidence of tachycardia during the procedure will be noted
baseline, after leg elevation or wrapping, at induction with propofol, every minute till 5 minutes after induction, at intubation and every minute thereafter upto 10 min post intubation
Bradycardia
Tidsramme: baseline, after leg elevation or wrapping, at induction with propofol, every minute till 5 minutes after induction, at intubation and every minute thereafter upto 10 min post intubation
Bradycardia will be defined as heart rate less than 50bpm or decrease by more than 30% below baseline value. Any incidence of bradycardia during the procedure will be noted
baseline, after leg elevation or wrapping, at induction with propofol, every minute till 5 minutes after induction, at intubation and every minute thereafter upto 10 min post intubation
Arrhythmia
Tidsramme: baseline, after leg elevation or wrapping, at induction with propofol, every minute till 5 minutes after induction, at intubation and every minute thereafter upto 10 min post intubation
any incidence of arrhythmia during the procedure will be noted
baseline, after leg elevation or wrapping, at induction with propofol, every minute till 5 minutes after induction, at intubation and every minute thereafter upto 10 min post intubation

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

Sponsor

Den organisation eller person, der igangsætter undersøgelsen, og som har myndighed og kontrol over undersøgelsen.
Nitte University

Efterforskere

Efterforskere

En forsker involveret i et klinisk studie. Beslægtede termer omfatter stedets principal investigator, site sub-investigator, studieformand, undersøgelsesleder og undersøgelseshovedinvestigator.
  • Studieleder: Sripada G Mehandale, MBBS, MD, Associate professor

Publikationer og nyttige links

Den person, der er ansvarlig for at indtaste oplysninger om undersøgelsen, leverer frivilligt disse publikationer. Disse kan handle om alt relateret til undersøgelsen.

Generelle publikationer

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart

Studiestart

Den faktiske dato, hvor den første deltager blev tilmeldt en klinisk undersøgelse. Den "forventede" undersøgelses startdato er den dato, som forskerne tror vil være undersøgelsens startdato.
1. januar 2016

Primær færdiggørelse (Forventet)

Primær færdiggørelse

Den dato, hvor den sidste deltager i et klinisk studie blev undersøgt eller modtog en intervention for at indsamle endelige data for det primære resultatmål. Hvorvidt det kliniske studie sluttede i henhold til protokollen eller blev afsluttet, påvirker ikke denne dato. For kliniske undersøgelser med mere end ét primært resultatmål med forskellige afslutningsdatoer refererer dette udtryk til den dato, hvor dataindsamlingen er afsluttet for alle de primære resultatmål. Den "forventede" primære afslutningsdato er den dato, som forskerne tror vil være den primære afslutningsdato for undersøgelsen.
1. august 2017

Studieafslutning (Forventet)

Studieafslutning

Den dato, hvor den sidste deltager i et klinisk studie blev undersøgt eller modtog en intervention/behandling for at indsamle endelige data for de primære resultatmål, sekundære udfaldsmål og uønskede hændelser (det vil sige den sidste deltagers sidste besøg). Den "forventede" undersøgelses afslutningsdato er den dato, som forskerne tror vil være undersøgelsens afslutningsdato.
1. december 2017

Datoer for studieregistrering

Først indsendt

Først indsendt

Den dato, hvor undersøgelsens sponsor eller investigator første gang indsendte en undersøgelsespost til ClinicalTrials.gov. Der er typisk en forsinkelse på et par dage mellem den første indsendte dato og postens tilgængelighed på ClinicalTrials.gov (den første offentliggjorte dato).
30. juni 2016

Først indsendt, der opfyldte QC-kriterier

Først indsendt, der opfyldte QC-kriterier

Den dato, hvor undersøgelsens sponsor eller investigator første gang indsender en undersøgelsespost, der er i overensstemmelse med National Library of Medicine (NLM) kvalitetskontrol (QC) gennemgangskriterier. Sponsoren eller investigatoren skal muligvis revidere og indsende en undersøgelsespost en eller flere gange, før NLM's kvalitetskontrolkriterier er opfyldt. Det er sponsorens eller investigatorens ansvar at sikre, at undersøgelsesposten er i overensstemmelse med NLM QC-gennemgangskriterierne.
23. juli 2016

Først opslået (Skøn)

Først opslået

Datoen, hvor undersøgelsesposten først var tilgængelig på ClinicalTrials.gov efter National Library of Medicine (NLM) kvalitetskontrol (QC) gennemgang er afsluttet. Der er typisk en forsinkelse på et par dage mellem den dato, hvor undersøgelsens sponsor eller investigator indsendte undersøgelsesposten, og den første offentliggjorte dato.
27. juli 2016

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Skøn)

Sidste opdatering sendt

Den seneste dato, hvor ændringer i en undersøgelsespost blev gjort tilgængelig på ClinicalTrials.gov. Der kan være en forsinkelse mellem det tidspunkt, hvornår ændringerne blev indsendt til ClinicalTrials.gov af undersøgelsens sponsor eller investigator (datoen for sidste opdatering afsendt) og den sidste opdatering, der blev sendt.
27. juli 2016

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

Den seneste dato, hvor undersøgelsens sponsor eller investigator indsendte ændringer til en undersøgelsespost, der er i overensstemmelse med National Library of Medicine (NLM) kvalitetskontrol (QC) gennemgangskriterier. Det er sponsorens eller investigatorens ansvar at sikre, at undersøgelsesposten er i overensstemmelse med NLM QC-gennemgangskriterierne.
23. juli 2016

Sidst verificeret

Sidst verificeret

Den seneste dato, hvor undersøgelsens sponsor eller investigator bekræftede oplysningerne om en klinisk undersøgelse på ClinicalTrials.gov som nøjagtige og aktuelle. Hvis en undersøgelse med rekrutteringsstatus som rekruttering; rekrutterer endnu ikke; eller aktiv, ikke rekruttering er ikke blevet bekræftet inden for de seneste 2 år, er undersøgelsens rekrutteringsstatus vist som ukendt.
1. juli 2016

Mere information

Begreber relateret til denne undersøgelse

Nøgleord

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

Andre undersøgelses-id-numre

Andre identifikatorer eller ID-numre end NCT-nummeret, der er tildelt til en klinisk undersøgelse af undersøgelsens sponsor, finansieringsgivere eller andre. Disse numre kan omfatte unikke identifikatorer fra andre forsøgsregistre og National Institutes of Health-bevillingsnumre.
  • INST.EC/EC/066/2015-16

Plan for individuelle deltagerdata (IPD)

Planlægger du at dele individuelle deltagerdata (IPD)?

JA

IPD-planbeskrivelse

Age, sex, weight, diagnosis, surgery, asa physical status, heart rate, systolic blood pressure, diastolic blood pressure, mean arterial pressure

Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .

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