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Osimertinib med eller uden bevacizumab som indledende behandling for patienter med EGFR-mutant lungekræft

3. november 2026 opdateret af: National Cancer Institute (NCI)

Randomiseret fase III-studie af kombination Osimertinib (AZD9291) og Bevacizumab versus Osimertinib (AZD9291) alene som førstelinjebehandling til patienter med metastatisk EGFR-mutant ikke-småcellet lungekræft (NSCLC)

This phase III trial compares the effect of bevacizumab and osimertinib combination vs. osimertinib alone for the treatment of non-small cell lung cancer that has spread outside of the lungs (stage IIIB-IV) and has a change (mutation) in a gene called EGFR. The EGFR protein is involved in cell signaling pathways that control cell division and survival. Sometimes, mutations in the EGFR gene cause EGFR proteins to be made in higher than normal amounts on some types of cancer cells. This causes cancer cells to divide more rapidly. Osimertinib may stop the growth of tumor cells by blocking EGFR that is needed for cell growth in this type of cancer. Bevacizumab is in a class of medications called antiangiogenic agents. It works by stopping the formation of blood vessels that bring oxygen and nutrients to tumor. This may slow the growth and spread of tumor. Giving osimertinib with bevacizumab may control cancer for longer and help patients live longer as compared to osimertinib alone.

Studieoversigt

Status

Status

Angiver den aktuelle rekrutteringsstatus eller den udvidede adgangsstatus.
Rekruttering

Betingelser

Betingelser

Den sygdom, lidelse, syndrom, sygdom eller skade, der undersøges. På ClinicalTrials.gov kan tilstande også omfatte andre sundhedsrelaterede problemer, såsom levetid, livskvalitet og sundhedsrisici.

Intervention / Behandling

Intervention / Behandling

En proces eller handling, der er i fokus for en klinisk undersøgelse. Interventioner omfatter lægemidler, medicinsk udstyr, procedurer, vacciner og andre produkter, der enten er til undersøgelse eller allerede er tilgængelige. Interventioner kan også omfatte ikke-invasive tilgange, såsom uddannelse eller ændring af kost og motion.

Detaljeret beskrivelse

PRIMARY OBJECTIVE:

I. To evaluate progression-free survival (PFS) of osimertinib (AZD9291) and bevacizumab versus osimertinib (AZD9291) alone as first-line treatment for patients with metastatic EGFR-mutant lung cancers.

SECONDARY OBJECTIVES:

I. To evaluate overall survival (OS). II. To evaluate best objective response rate and duration of objective response.

III. To evaluate time to central nervous system (CNS) progression and CNS PFS. IV. To evaluate toxicity of the combination regimen.

CORRELATIVE OBJECTIVES:

I. To characterize mechanisms of resistance to osimertinib (AZD9291) and osimertinib (AZD9291) with bevacizumab first-line therapy through post-progression circulating tumor-derived deoxyribonucleic acid (ctDNA).

II. To assess for ctDNA clearance on study treatment and associate ctDNA clearance with clinical outcomes.

OUTLINE: Patients are randomized to 1 of 2 arms.

ARM A: Patients receive osimertinib orally (PO) once daily (QD) on days 1-21. Cycles repeat every 21 days in the absence of disease progression or unacceptable toxicity.

ARM B: Patients receive osimertinib PO QD on days 1-21 and bevacizumab intravenously (IV) over 30-90 minutes on day 1. Cycles repeat every 21 days in the absence of disease progression or unacceptable toxicity.

Patients undergo echocardiography (ECHO), multigated acquisition scan (MUGA), computed tomography (CT) and may undergo magnetic resonance imaging (MRI) and blood and urine sample collection on study.

After completion of study treatment, patients are followed up every 3 months for 10 years.

Undersøgelsestype

Undersøgelsestype

Beskriver karakteren af ​​en klinisk undersøgelse. Undersøgelsestyper omfatter interventionelle undersøgelser (også kaldet kliniske forsøg), observationsundersøgelser (herunder patientregistre) og udvidet adgang.
Interventionel

Tilmelding (Anslået)

Tilmelding

Antallet af deltagere i en klinisk undersøgelse. Den "forventede" tilmelding er det mål for antallet af deltagere, som forskerne skal bruge til undersøgelsen.
300

Fase

Fase

Stadiet af et klinisk forsøg, der studerer et lægemiddel eller et biologisk produkt, baseret på definitioner udviklet af U.S. Food and Drug Administration (FDA). Fasen tager udgangspunkt i undersøgelsens formål, antallet af deltagere og andre karakteristika. Der er fem faser: Tidlig fase 1 (tidligere opført som fase 0), fase 1, fase 2, fase 3 og fase 4. Ikke relevant bruges til at beskrive forsøg uden FDA-definerede faser, herunder forsøg med enheder eller adfærdsmæssige indgreb.
  • Fase 3

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

  • Forenede Stater
    • Alaska
      • Anchorage, Alaska, Forenede Stater, 98508
        • Suspenderet
        • Anchorage Associates in Radiation Medicine
      • Anchorage, Alaska, Forenede Stater, 99504
        • Suspenderet
        • Anchorage Radiation Therapy Center
      • Anchorage, Alaska, Forenede Stater, 99508
        • Suspenderet
        • Alaska Breast Care and Surgery LLC
      • Anchorage, Alaska, Forenede Stater, 99508
        • Suspenderet
        • Alaska Oncology and Hematology LLC
      • Anchorage, Alaska, Forenede Stater, 99508
        • Suspenderet
        • Alaska Women's Cancer Care
      • Anchorage, Alaska, Forenede Stater, 99508
        • Suspenderet
        • Anchorage Oncology Centre
      • Anchorage, Alaska, Forenede Stater, 99508
        • Suspenderet
        • Providence Alaska Medical Center
      • Anchorage, Alaska, Forenede Stater, 99508
      • Fairbanks, Alaska, Forenede Stater, 99701
    • Arizona
      • Phoenix, Arizona, Forenede Stater, 85004
    • Arkansas
      • Fort Smith, Arkansas, Forenede Stater, 72903
        • Suspenderet
        • Mercy Hospital Fort Smith
      • Hot Springs, Arkansas, Forenede Stater, 71913
        • Suspenderet
        • CHI Saint Vincent Cancer Center Hot Springs
      • Jonesboro, Arkansas, Forenede Stater, 72401
        • Rekruttering
        • NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
        • Kontakt:
        • Ledende efterforsker:
          • Philip E. Lammers
    • California
      • Antioch, California, Forenede Stater, 94531
        • Rekruttering
        • Kaiser Permanente-Deer Valley Medical Center
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
          • E-mail: Kpoct@kp.org
        • Ledende efterforsker:
          • Jennifer M. Suga
      • Arroyo Grande, California, Forenede Stater, 93420
        • Suspenderet
        • Mission Hope Medical Oncology - Arroyo Grande
      • Burbank, California, Forenede Stater, 91505
        • Suspenderet
        • Providence Saint Joseph Medical Center/Disney Family Cancer Center
      • Burlingame, California, Forenede Stater, 94010
        • Rekruttering
        • UCSF Cancer Center Burlingame
        • Kontakt:
        • Ledende efterforsker:
          • Sirisha Tummala
      • Dublin, California, Forenede Stater, 94568
        • Rekruttering
        • Kaiser Permanente Dublin
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
        • Ledende efterforsker:
          • Jennifer M. Suga
      • Fremont, California, Forenede Stater, 94538
        • Rekruttering
        • Kaiser Permanente-Fremont
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
          • E-mail: Kpoct@kp.org
        • Ledende efterforsker:
          • Jennifer M. Suga
      • Fremont, California, Forenede Stater, 94538
        • Rekruttering
        • Washington Health
        • Ledende efterforsker:
          • Bogdan S. Eftimie
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 510-248-1600
      • Fresno, California, Forenede Stater, 93720
        • Rekruttering
        • Kaiser Permanente-Fresno
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
          • E-mail: Kpoct@kp.org
        • Ledende efterforsker:
          • Jennifer M. Suga
      • Fresno, California, Forenede Stater, 93720
        • Rekruttering
        • Kaiser Permanente Fresno Orchard Plaza
        • Ledende efterforsker:
          • Jennifer M. Suga
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 833-574-2273
      • La Jolla, California, Forenede Stater, 92093
        • Trukket tilbage
        • UC San Diego Moores Cancer Center
      • Modesto, California, Forenede Stater, 95356
        • Rekruttering
        • Kaiser Permanente-Modesto
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
          • E-mail: Kpoct@kp.org
        • Ledende efterforsker:
          • Jennifer M. Suga
      • Modesto, California, Forenede Stater, 95356
        • Rekruttering
        • Kaiser Permanente- Modesto MOB II
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
        • Ledende efterforsker:
          • Jennifer M. Suga
      • Oakland, California, Forenede Stater, 94611
        • Rekruttering
        • Kaiser Permanente-Oakland
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
          • E-mail: Kpoct@kp.org
        • Ledende efterforsker:
          • Jennifer M. Suga
      • Palo Alto, California, Forenede Stater, 94304
        • Rekruttering
        • Stanford Cancer Institute Palo Alto
        • Ledende efterforsker:
          • Joel W. Neal
        • Kontakt:
      • Richmond, California, Forenede Stater, 94801
        • Rekruttering
        • Kaiser Permanente-Richmond
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
          • E-mail: Kpoct@kp.org
        • Ledende efterforsker:
          • Jennifer M. Suga
      • Roseville, California, Forenede Stater, 95661
        • Rekruttering
        • Kaiser Permanente-Roseville
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
          • E-mail: Kpoct@kp.org
        • Ledende efterforsker:
          • Jennifer M. Suga
      • Sacramento, California, Forenede Stater, 95817
        • Rekruttering
        • University of California Davis Comprehensive Cancer Center
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 916-734-3089
        • Ledende efterforsker:
          • Surbhi Singhal
      • Sacramento, California, Forenede Stater, 95814
        • Rekruttering
        • Kaiser Permanente Downtown Commons
        • Ledende efterforsker:
          • Jennifer M. Suga
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
          • E-mail: kpoct@kp.org
      • Sacramento, California, Forenede Stater, 95823
        • Rekruttering
        • Kaiser Permanente-South Sacramento
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
          • E-mail: Kpoct@kp.org
        • Ledende efterforsker:
          • Jennifer M. Suga
      • Salinas, California, Forenede Stater, 93901
        • Aktiv, ikke rekrutterende
        • Salinas Valley Memorial
      • San Francisco, California, Forenede Stater, 94115
        • Rekruttering
        • Kaiser Permanente-San Francisco
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
          • E-mail: Kpoct@kp.org
        • Ledende efterforsker:
          • Jennifer M. Suga
      • San Jose, California, Forenede Stater, 95119
        • Rekruttering
        • Kaiser Permanente-Santa Teresa-San Jose
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
          • E-mail: Kpoct@kp.org
        • Ledende efterforsker:
          • Jennifer M. Suga
      • San Leandro, California, Forenede Stater, 94577
        • Rekruttering
        • Kaiser Permanente San Leandro
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
          • E-mail: Kpoct@kp.org
        • Ledende efterforsker:
          • Jennifer M. Suga
      • San Luis Obispo, California, Forenede Stater, 93401
        • Suspenderet
        • Pacific Central Coast Health Center-San Luis Obispo
      • San Rafael, California, Forenede Stater, 94903
        • Rekruttering
        • Kaiser San Rafael-Gallinas
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
          • E-mail: Kpoct@kp.org
        • Ledende efterforsker:
          • Jennifer M. Suga
      • Santa Clara, California, Forenede Stater, 95051
        • Rekruttering
        • Kaiser Permanente Medical Center - Santa Clara
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
          • E-mail: Kpoct@kp.org
        • Ledende efterforsker:
          • Jennifer M. Suga
      • Santa Maria, California, Forenede Stater, 93444
        • Suspenderet
        • Mission Hope Medical Oncology - Santa Maria
      • Santa Rosa, California, Forenede Stater, 95403
        • Rekruttering
        • Kaiser Permanente-Santa Rosa
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
          • E-mail: Kpoct@kp.org
        • Ledende efterforsker:
          • Jennifer M. Suga
      • South San Francisco, California, Forenede Stater, 94080
        • Rekruttering
        • Kaiser Permanente-South San Francisco
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
          • E-mail: Kpoct@kp.org
        • Ledende efterforsker:
          • Jennifer M. Suga
      • Stockton, California, Forenede Stater, 95210
        • Rekruttering
        • Kaiser Permanente-Stockton
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
          • E-mail: Kpoct@kp.org
        • Ledende efterforsker:
          • Jennifer M. Suga
      • Vacaville, California, Forenede Stater, 95688
        • Rekruttering
        • Kaiser Permanente Medical Center-Vacaville
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
          • E-mail: Kpoct@kp.org
        • Ledende efterforsker:
          • Jennifer M. Suga
      • Vallejo, California, Forenede Stater, 94589
        • Rekruttering
        • Kaiser Permanente-Vallejo
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
          • E-mail: Kpoct@kp.org
        • Ledende efterforsker:
          • Jennifer M. Suga
      • Walnut Creek, California, Forenede Stater, 94596
        • Rekruttering
        • Kaiser Permanente-Walnut Creek
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
          • E-mail: Kpoct@kp.org
        • Ledende efterforsker:
          • Jennifer M. Suga
    • Colorado
      • Aurora, Colorado, Forenede Stater, 80012
        • Suspenderet
        • The Medical Center of Aurora
      • Aurora, Colorado, Forenede Stater, 80012
        • Rekruttering
        • Rocky Mountain Cancer Centers-Aurora
        • Kontakt:
        • Ledende efterforsker:
          • Nicholas J. DiBella
      • Boulder, Colorado, Forenede Stater, 80303
        • Suspenderet
        • Boulder Community Foothills Hospital
      • Boulder, Colorado, Forenede Stater, 80304
        • Rekruttering
        • Rocky Mountain Cancer Centers-Boulder
        • Kontakt:
        • Ledende efterforsker:
          • Nicholas J. DiBella
      • Centennial, Colorado, Forenede Stater, 80112
        • Suspenderet
        • Rocky Mountain Cancer Centers - Centennial
      • Colorado Springs, Colorado, Forenede Stater, 80907
        • Suspenderet
        • Penrose-Saint Francis Healthcare
      • Colorado Springs, Colorado, Forenede Stater, 80907
        • Suspenderet
        • Rocky Mountain Cancer Centers-Penrose
      • Denver, Colorado, Forenede Stater, 80205
        • Rekruttering
        • Kaiser Permanente-Franklin
        • Ledende efterforsker:
          • Matthew J. Eadens
        • Kontakt:
      • Denver, Colorado, Forenede Stater, 80218
        • Suspenderet
        • Presbyterian - Saint Lukes Medical Center - Health One
      • Denver, Colorado, Forenede Stater, 80209
        • Suspenderet
        • The Women's Imaging Center
      • Denver, Colorado, Forenede Stater, 80218
        • Suspenderet
        • Colorado Blood Cancer Institute
      • Denver, Colorado, Forenede Stater, 80220
        • Suspenderet
        • Western Surgical Care
      • Denver, Colorado, Forenede Stater, 80218
        • Suspenderet
        • Rocky Mountain Cancer Centers-Midtown
      • Denver, Colorado, Forenede Stater, 80220
        • Suspenderet
        • Rocky Mountain Cancer Centers-Rose
      • Denver, Colorado, Forenede Stater, 80220
        • Aktiv, ikke rekrutterende
        • Rose Medical Center
      • Denver, Colorado, Forenede Stater, 80210
        • Suspenderet
        • AdventHealth Porter
      • Durango, Colorado, Forenede Stater, 81301
        • Suspenderet
        • Mercy Medical Center
      • Durango, Colorado, Forenede Stater, 81301
        • Suspenderet
        • CommonSpirit Cancer Center Mercy
      • Englewood, Colorado, Forenede Stater, 80113
        • Rekruttering
        • Rocky Mountain Cancer Centers - Swedish
        • Kontakt:
        • Ledende efterforsker:
          • Nicholas J. DiBella
      • Englewood, Colorado, Forenede Stater, 80113
        • Suspenderet
        • The Melanoma and Skin Cancer Institute
      • Englewood, Colorado, Forenede Stater, 80113
        • Suspenderet
        • Swedish Medical Center
      • Englewood, Colorado, Forenede Stater, 80113
        • Suspenderet
        • Mountain Blue Cancer Care Center - Swedish
      • Greeley, Colorado, Forenede Stater, 80631
        • Suspenderet
        • Banner North Colorado Medical Center
      • Lafayette, Colorado, Forenede Stater, 80026
        • Rekruttering
        • Kaiser Permanente-Rock Creek
        • Ledende efterforsker:
          • Matthew J. Eadens
        • Kontakt:
      • Lakewood, Colorado, Forenede Stater, 80228
        • Suspenderet
        • Rocky Mountain Cancer Centers-Lakewood
      • Lakewood, Colorado, Forenede Stater, 80228
        • Suspenderet
        • CommonSpirit Saint Anthony Hospital Cancer Center
      • Littleton, Colorado, Forenede Stater, 80120
        • Suspenderet
        • Rocky Mountain Cancer Centers-Littleton
      • Littleton, Colorado, Forenede Stater, 80122
        • Suspenderet
        • AdventHealth Littleton
      • Lone Tree, Colorado, Forenede Stater, 80124
        • Rekruttering
        • Kaiser Permanente-Lone Tree
        • Ledende efterforsker:
          • Matthew J. Eadens
        • Kontakt:
      • Lone Tree, Colorado, Forenede Stater, 80124
        • Suspenderet
        • Sky Ridge Medical Center
      • Lone Tree, Colorado, Forenede Stater, 80124
        • Suspenderet
        • Rocky Mountain Cancer Centers-Sky Ridge
      • Longmont, Colorado, Forenede Stater, 80501
        • Suspenderet
        • Longmont United Hospital
      • Longmont, Colorado, Forenede Stater, 80501
        • Suspenderet
        • Rocky Mountain Cancer Centers-Longmont
      • Loveland, Colorado, Forenede Stater, 80539
        • Suspenderet
        • Banner North Colorado Medical Center - Loveland Campus
      • Parker, Colorado, Forenede Stater, 80138
        • Suspenderet
        • AdventHealth Parker
      • Pueblo, Colorado, Forenede Stater, 81004
        • Suspenderet
        • Saint Mary Corwin Medical Center
      • Thornton, Colorado, Forenede Stater, 80260
        • Suspenderet
        • Rocky Mountain Cancer Centers-Thornton
    • Connecticut
      • Derby, Connecticut, Forenede Stater, 06418
        • Rekruttering
        • Smilow Cancer Hospital-Derby Care Center
        • Kontakt:
        • Ledende efterforsker:
          • Sarah B. Goldberg
      • Fairfield, Connecticut, Forenede Stater, 06824
        • Rekruttering
        • Smilow Cancer Hospital Care Center-Fairfield
        • Kontakt:
        • Ledende efterforsker:
          • Sarah B. Goldberg
      • Glastonbury, Connecticut, Forenede Stater, 06033
        • Suspenderet
        • Smilow Cancer Hospital Care Center at Glastonbury
      • Greenwich, Connecticut, Forenede Stater, 06830
        • Rekruttering
        • Smilow Cancer Hospital Care Center at Greenwich
        • Kontakt:
        • Ledende efterforsker:
          • Sarah B. Goldberg
      • Guilford, Connecticut, Forenede Stater, 06437
        • Rekruttering
        • Smilow Cancer Hospital Care Center - Guilford
        • Kontakt:
        • Ledende efterforsker:
          • Sarah B. Goldberg
      • Hartford, Connecticut, Forenede Stater, 06105
        • Suspenderet
        • Smilow Cancer Hospital Care Center at Saint Francis
      • Hartford, Connecticut, Forenede Stater, 06102
        • Rekruttering
        • Hartford Hospital
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 860-545-5363
        • Ledende efterforsker:
          • Todd J. Alekshun
      • Meriden, Connecticut, Forenede Stater, 06451
        • Rekruttering
        • Midstate Medical Center
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 866-662-5678
        • Ledende efterforsker:
          • Todd J. Alekshun
      • New Britain, Connecticut, Forenede Stater, 06050
        • Rekruttering
        • The Hospital of Central Connecticut
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 860-224-5660
        • Ledende efterforsker:
          • Todd J. Alekshun
      • New Haven, Connecticut, Forenede Stater, 06520
        • Rekruttering
        • Yale University
        • Kontakt:
        • Ledende efterforsker:
          • Sarah B. Goldberg
      • North Haven, Connecticut, Forenede Stater, 06473
        • Rekruttering
        • Yale-New Haven Hospital North Haven Medical Center
        • Kontakt:
        • Ledende efterforsker:
          • Sarah B. Goldberg
      • Orange, Connecticut, Forenede Stater, 06477
        • Suspenderet
        • Smilow Cancer Hospital-Orange Care Center
      • Stamford, Connecticut, Forenede Stater, 06904
        • Rekruttering
        • Stamford Hospital/Bennett Cancer Center
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 203-323-8944
        • Ledende efterforsker:
          • Salvatore A. Del Prete
      • Stamford, Connecticut, Forenede Stater, 06902
        • Rekruttering
        • Smilow Cancer Hospital Care Center at Long Ridge
        • Kontakt:
        • Ledende efterforsker:
          • Sarah B. Goldberg
      • Torrington, Connecticut, Forenede Stater, 06790
        • Rekruttering
        • Smilow Cancer Hospital-Torrington Care Center
        • Kontakt:
        • Ledende efterforsker:
          • Sarah B. Goldberg
      • Trumbull, Connecticut, Forenede Stater, 06611
        • Rekruttering
        • Smilow Cancer Hospital Care Center-Trumbull
        • Kontakt:
        • Ledende efterforsker:
          • Sarah B. Goldberg
      • Waterbury, Connecticut, Forenede Stater, 06708
        • Rekruttering
        • Smilow Cancer Hospital-Waterbury Care Center
        • Kontakt:
        • Ledende efterforsker:
          • Sarah B. Goldberg
      • Waterford, Connecticut, Forenede Stater, 06385
        • Rekruttering
        • Smilow Cancer Hospital Care Center - Waterford
        • Kontakt:
        • Ledende efterforsker:
          • Sarah B. Goldberg
    • Delaware
      • Lewes, Delaware, Forenede Stater, 19958
        • Aktiv, ikke rekrutterende
        • Beebe Medical Center
      • Millville, Delaware, Forenede Stater, 19967
        • Aktiv, ikke rekrutterende
        • Beebe South Coastal Health Campus
      • Newark, Delaware, Forenede Stater, 19713
        • Aktiv, ikke rekrutterende
        • Helen F Graham Cancer Center
      • Newark, Delaware, Forenede Stater, 19713
        • Aktiv, ikke rekrutterende
        • Medical Oncology Hematology Consultants PA
      • Newark, Delaware, Forenede Stater, 19713
        • Aktiv, ikke rekrutterende
        • Delaware Clinical and Laboratory Physicians PA
      • Newark, Delaware, Forenede Stater, 19718
        • Aktiv, ikke rekrutterende
        • Christiana Care Health System-Christiana Hospital
      • Rehoboth Beach, Delaware, Forenede Stater, 19971
        • Aktiv, ikke rekrutterende
        • Beebe Health Campus
      • Seaford, Delaware, Forenede Stater, 19973
        • Suspenderet
        • TidalHealth Nanticoke / Allen Cancer Center
      • Wilmington, Delaware, Forenede Stater, 19801
        • Aktiv, ikke rekrutterende
        • Christiana Care Health System-Wilmington Hospital
    • District of Columbia
      • Washington D.C., District of Columbia, Forenede Stater, 20037
        • Rekruttering
        • George Washington University Medical Center
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 202-741-2210
        • Ledende efterforsker:
          • Prashanth Ashok Kumar
    • Florida
      • Fort Lauderdale, Florida, Forenede Stater, 33308
    • Georgia
      • Atlanta, Georgia, Forenede Stater, 30322
        • Rekruttering
        • Emory University Hospital/Winship Cancer Institute
        • Ledende efterforsker:
          • Ticiana A. Leal
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 404-778-1868
      • Atlanta, Georgia, Forenede Stater, 30308
        • Rekruttering
        • Emory University Hospital Midtown
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 888-946-7447
        • Ledende efterforsker:
          • Ticiana A. Leal
      • Savannah, Georgia, Forenede Stater, 31405
        • Rekruttering
        • Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
        • Kontakt:
        • Ledende efterforsker:
          • Mark A. Taylor
    • Hawaii
      • Honolulu, Hawaii, Forenede Stater, 96819
        • Rekruttering
        • Kaiser Permanente Moanalua Medical Center
        • Kontakt:
        • Ledende efterforsker:
          • Jennifer M. Suga
      • Honolulu, Hawaii, Forenede Stater, 96813
        • Aktiv, ikke rekrutterende
        • Hawaii Cancer Care Inc - Waterfront Plaza
      • Honolulu, Hawaii, Forenede Stater, 96813
        • Aktiv, ikke rekrutterende
        • Queen's Cancer Cenrer - POB I
      • Honolulu, Hawaii, Forenede Stater, 96813
        • Aktiv, ikke rekrutterende
        • Queen's Medical Center
      • Honolulu, Hawaii, Forenede Stater, 96813
        • Aktiv, ikke rekrutterende
        • Straub Clinic and Hospital
      • Honolulu, Hawaii, Forenede Stater, 96813
        • Aktiv, ikke rekrutterende
        • University of Hawaii Cancer Center
      • Honolulu, Hawaii, Forenede Stater, 96817
        • Aktiv, ikke rekrutterende
        • Kuakini Medical Center
      • Honolulu, Hawaii, Forenede Stater, 96817
        • Aktiv, ikke rekrutterende
        • Queen's Cancer Center - Kuakini
      • Honolulu, Hawaii, Forenede Stater, 96817
        • Aktiv, ikke rekrutterende
        • The Cancer Center of Hawaii-Liliha
      • Honolulu, Hawaii, Forenede Stater, 96826
        • Aktiv, ikke rekrutterende
        • Kapiolani Medical Center for Women and Children
      • Lihue, Hawaii, Forenede Stater, 96766
        • Aktiv, ikke rekrutterende
        • Wilcox Memorial Hospital and Kauai Medical Clinic
      • ‘Aiea, Hawaii, Forenede Stater, 96701
        • Aktiv, ikke rekrutterende
        • Hawaii Cancer Care - Westridge
      • ‘Aiea, Hawaii, Forenede Stater, 96701
        • Aktiv, ikke rekrutterende
        • Pali Momi Medical Center
      • ‘Aiea, Hawaii, Forenede Stater, 96701
        • Aktiv, ikke rekrutterende
        • Queen's Cancer Center - Pearlridge
      • ‘Aiea, Hawaii, Forenede Stater, 96701
        • Aktiv, ikke rekrutterende
        • The Cancer Center of Hawaii-Pali Momi
    • Idaho
      • Boise, Idaho, Forenede Stater, 83712
        • Rekruttering
        • Saint Luke's Cancer Institute - Boise
        • Ledende efterforsker:
          • Alison K. Conlin
        • Kontakt:
      • Boise, Idaho, Forenede Stater, 83706
        • Rekruttering
        • Saint Alphonsus Cancer Care Center-Boise
        • Kontakt:
        • Ledende efterforsker:
          • Elie G. Dib
      • Caldwell, Idaho, Forenede Stater, 83605
        • Rekruttering
        • Saint Alphonsus Cancer Care Center-Caldwell
        • Kontakt:
        • Ledende efterforsker:
          • Elie G. Dib
      • Coeur d'Alene, Idaho, Forenede Stater, 83814
        • Rekruttering
        • Kootenai Health - Coeur d'Alene
        • Ledende efterforsker:
          • John M. Schallenkamp
        • Kontakt:
      • Emmett, Idaho, Forenede Stater, 83617
        • Suspenderet
        • Walter Knox Memorial Hospital
      • Fruitland, Idaho, Forenede Stater, 83619
        • Rekruttering
        • Saint Luke's Cancer Institute - Fruitland
        • Ledende efterforsker:
          • Alison K. Conlin
        • Kontakt:
      • Meridian, Idaho, Forenede Stater, 83642
        • Suspenderet
        • Idaho Urologic Institute-Meridian
      • Meridian, Idaho, Forenede Stater, 83642
        • Rekruttering
        • Saint Luke's Cancer Institute - Meridian
        • Ledende efterforsker:
          • Alison K. Conlin
        • Kontakt:
      • Nampa, Idaho, Forenede Stater, 83687
        • Rekruttering
        • Saint Luke's Cancer Institute - Nampa
        • Ledende efterforsker:
          • Alison K. Conlin
        • Kontakt:
      • Nampa, Idaho, Forenede Stater, 83687
        • Rekruttering
        • Saint Alphonsus Cancer Care Center-Nampa
        • Kontakt:
        • Ledende efterforsker:
          • Elie G. Dib
      • Post Falls, Idaho, Forenede Stater, 83854
        • Rekruttering
        • Kootenai Clinic Cancer Services - Post Falls
        • Ledende efterforsker:
          • John M. Schallenkamp
        • Kontakt:
      • Sandpoint, Idaho, Forenede Stater, 83864
        • Rekruttering
        • Kootenai Clinic Cancer Services - Sandpoint
        • Ledende efterforsker:
          • John M. Schallenkamp
        • Kontakt:
      • Twin Falls, Idaho, Forenede Stater, 83301
        • Rekruttering
        • Saint Luke's Cancer Institute - Twin Falls
        • Ledende efterforsker:
          • Alison K. Conlin
        • Kontakt:
    • Illinois
      • Alton, Illinois, Forenede Stater, 62002
        • Suspenderet
        • OSF Saint Anthony's Health Center
      • Aurora, Illinois, Forenede Stater, 60504
        • Suspenderet
        • Rush-Copley Medical Center
      • Bloomington, Illinois, Forenede Stater, 61704
        • Rekruttering
        • Illinois CancerCare-Bloomington
        • Kontakt:
        • Ledende efterforsker:
          • Bryan A. Faller
      • Canton, Illinois, Forenede Stater, 61520
        • Rekruttering
        • Illinois CancerCare-Canton
        • Kontakt:
        • Ledende efterforsker:
          • Bryan A. Faller
      • Carbondale, Illinois, Forenede Stater, 62902
        • Suspenderet
        • Memorial Hospital of Carbondale
      • Carterville, Illinois, Forenede Stater, 62918
        • Suspenderet
        • SIH Cancer Institute
      • Carthage, Illinois, Forenede Stater, 62321
        • Rekruttering
        • Illinois CancerCare-Carthage
        • Kontakt:
        • Ledende efterforsker:
          • Bryan A. Faller
      • Centralia, Illinois, Forenede Stater, 62801
        • Rekruttering
        • Centralia Oncology Clinic
        • Ledende efterforsker:
          • Bryan A. Faller
        • Kontakt:
      • Chicago, Illinois, Forenede Stater, 60611
        • Rekruttering
        • Northwestern University
        • Kontakt:
        • Ledende efterforsker:
          • Nisha A. Mohindra
      • Chicago, Illinois, Forenede Stater, 60612
        • Rekruttering
        • University of Illinois
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 312-355-3046
        • Ledende efterforsker:
          • Frank Weinberg
      • Chicago, Illinois, Forenede Stater, 60625
        • Suspenderet
        • Swedish Covenant Hospital
      • Chicago, Illinois, Forenede Stater, 60612
        • Aktiv, ikke rekrutterende
        • Jesse Brown Veterans Affairs Medical Center
      • Danville, Illinois, Forenede Stater, 61832
        • Rekruttering
        • Carle at The Riverfront
        • Ledende efterforsker:
          • Vamsi K. Vasireddy
        • Kontakt:
      • DeKalb, Illinois, Forenede Stater, 60115
        • Rekruttering
        • Northwestern Medicine Cancer Center Kishwaukee
        • Ledende efterforsker:
          • Nisha A. Mohindra
        • Kontakt:
      • Decatur, Illinois, Forenede Stater, 62526
        • Rekruttering
        • Cancer Care Specialists of Illinois - Decatur
        • Ledende efterforsker:
          • Bryan A. Faller
        • Kontakt:
      • Decatur, Illinois, Forenede Stater, 62526
        • Suspenderet
        • Decatur Memorial Hospital
      • Dixon, Illinois, Forenede Stater, 61021
        • Rekruttering
        • Illinois CancerCare-Dixon
        • Ledende efterforsker:
          • Bryan A. Faller
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 815-285-7800
      • Effingham, Illinois, Forenede Stater, 62401
        • Rekruttering
        • Carle Physician Group-Effingham
        • Kontakt:
        • Ledende efterforsker:
          • Vamsi K. Vasireddy
      • Effingham, Illinois, Forenede Stater, 62401
        • Rekruttering
        • Crossroads Cancer Center
        • Ledende efterforsker:
          • Bryan A. Faller
        • Kontakt:
      • Eureka, Illinois, Forenede Stater, 61530
        • Rekruttering
        • Illinois CancerCare-Eureka
        • Kontakt:
        • Ledende efterforsker:
          • Bryan A. Faller
      • Galesburg, Illinois, Forenede Stater, 61401
        • Rekruttering
        • Illinois CancerCare-Galesburg
        • Kontakt:
        • Ledende efterforsker:
          • Bryan A. Faller
      • Galesburg, Illinois, Forenede Stater, 61401
        • Suspenderet
        • Western Illinois Cancer Treatment Center
      • Geneva, Illinois, Forenede Stater, 60134
        • Rekruttering
        • Northwestern Medicine Cancer Center Delnor
        • Ledende efterforsker:
          • Nisha A. Mohindra
        • Kontakt:
      • Glenview, Illinois, Forenede Stater, 60026
        • Rekruttering
        • Northwestern Medicine Glenview Outpatient Center
        • Ledende efterforsker:
          • Nisha A. Mohindra
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 312-695-1102
      • Grayslake, Illinois, Forenede Stater, 60030
        • Rekruttering
        • Northwestern Medicine Grayslake Outpatient Center
        • Ledende efterforsker:
          • Nisha A. Mohindra
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 312-695-1102
      • Harvey, Illinois, Forenede Stater, 60426
        • Rekruttering
        • Ingalls Memorial Hospital
        • Ledende efterforsker:
          • James A. Wallace
        • Kontakt:
      • Kewanee, Illinois, Forenede Stater, 61443
        • Rekruttering
        • Illinois CancerCare-Kewanee Clinic
        • Kontakt:
        • Ledende efterforsker:
          • Bryan A. Faller
      • Lake Forest, Illinois, Forenede Stater, 60045
        • Rekruttering
        • Northwestern Medicine Lake Forest Hospital
        • Ledende efterforsker:
          • Nisha A. Mohindra
        • Kontakt:
      • Macomb, Illinois, Forenede Stater, 61455
        • Rekruttering
        • Illinois CancerCare-Macomb
        • Kontakt:
        • Ledende efterforsker:
          • Bryan A. Faller
      • Mattoon, Illinois, Forenede Stater, 61938
        • Rekruttering
        • Carle Physician Group-Mattoon/Charleston
        • Kontakt:
        • Ledende efterforsker:
          • Vamsi K. Vasireddy
      • Mount Vernon, Illinois, Forenede Stater, 62864
        • Rekruttering
        • SSM Health Good Samaritan
        • Ledende efterforsker:
          • Jay W. Carlson
        • Kontakt:
      • O'Fallon, Illinois, Forenede Stater, 62269
        • Rekruttering
        • Cancer Care Center of O'Fallon
        • Ledende efterforsker:
          • Bryan A. Faller
        • Kontakt:
      • Oak Brook, Illinois, Forenede Stater, 60523
      • Orland Park, Illinois, Forenede Stater, 60462
      • Ottawa, Illinois, Forenede Stater, 61350
        • Rekruttering
        • Illinois CancerCare-Ottawa Clinic
        • Kontakt:
        • Ledende efterforsker:
          • Bryan A. Faller
      • Pekin, Illinois, Forenede Stater, 61554
        • Rekruttering
        • Illinois CancerCare-Pekin
        • Kontakt:
        • Ledende efterforsker:
          • Bryan A. Faller
      • Peoria, Illinois, Forenede Stater, 61615
        • Rekruttering
        • Illinois CancerCare-Peoria
        • Kontakt:
        • Ledende efterforsker:
          • Bryan A. Faller
      • Peoria, Illinois, Forenede Stater, 61636
        • Suspenderet
        • Methodist Medical Center of Illinois
      • Peru, Illinois, Forenede Stater, 61354
        • Rekruttering
        • Illinois CancerCare-Peru
        • Kontakt:
        • Ledende efterforsker:
          • Bryan A. Faller
      • Peru, Illinois, Forenede Stater, 61354
        • Suspenderet
        • Valley Radiation Oncology
      • Princeton, Illinois, Forenede Stater, 61356
        • Rekruttering
        • Illinois CancerCare-Princeton
        • Kontakt:
        • Ledende efterforsker:
          • Bryan A. Faller
      • Springfield, Illinois, Forenede Stater, 62702
        • Rekruttering
        • Southern Illinois University School of Medicine
        • Ledende efterforsker:
          • Bryan A. Faller
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 217-545-7929
      • Springfield, Illinois, Forenede Stater, 62702
        • Rekruttering
        • Springfield Clinic
        • Ledende efterforsker:
          • Bryan A. Faller
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 800-444-7541
      • Springfield, Illinois, Forenede Stater, 62781
        • Rekruttering
        • Springfield Memorial Hospital
        • Ledende efterforsker:
          • Bryan A. Faller
        • Kontakt:
      • Swansea, Illinois, Forenede Stater, 62226
        • Suspenderet
        • Southwest Illinois Health Services LLP
      • Urbana, Illinois, Forenede Stater, 61801
        • Rekruttering
        • Carle Cancer Center
        • Kontakt:
        • Ledende efterforsker:
          • Vamsi K. Vasireddy
      • Urbana, Illinois, Forenede Stater, 61801
        • Suspenderet
        • The Carle Foundation Hospital
      • Warrenville, Illinois, Forenede Stater, 60555
        • Rekruttering
        • Northwestern Medicine Cancer Center Warrenville
        • Ledende efterforsker:
          • Nisha A. Mohindra
        • Kontakt:
      • Washington, Illinois, Forenede Stater, 61571
        • Rekruttering
        • Illinois CancerCare - Washington
        • Kontakt:
        • Ledende efterforsker:
          • Bryan A. Faller
      • Yorkville, Illinois, Forenede Stater, 60560
        • Suspenderet
        • Rush-Copley Healthcare Center
    • Indiana
      • Crown Point, Indiana, Forenede Stater, 46307
        • Rekruttering
        • Northwest Cancer Center - Crown Point
        • Ledende efterforsker:
          • Vamsi K. Vasireddy
        • Kontakt:
      • Dyer, Indiana, Forenede Stater, 46311
        • Rekruttering
        • Northwest Oncology LLC
        • Ledende efterforsker:
          • Vamsi K. Vasireddy
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 219-924-8178
      • Hobart, Indiana, Forenede Stater, 46342
        • Rekruttering
        • Northwest Cancer Center - Hobart
        • Ledende efterforsker:
          • Vamsi K. Vasireddy
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 219-947-1795
      • Hobart, Indiana, Forenede Stater, 46342
        • Rekruttering
        • Saint Mary Medical Center
        • Ledende efterforsker:
          • Vamsi K. Vasireddy
        • Kontakt:
      • Indianapolis, Indiana, Forenede Stater, 46312
        • Rekruttering
        • Saint Catherine Hospital
        • Ledende efterforsker:
          • Vamsi K. Vasireddy
        • Kontakt:
      • Munster, Indiana, Forenede Stater, 46321
        • Rekruttering
        • The Community Hospital
        • Ledende efterforsker:
          • Vamsi K. Vasireddy
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 219-836-3349
      • Munster, Indiana, Forenede Stater, 46321
        • Rekruttering
        • Women's Diagnostic Center - Munster
        • Ledende efterforsker:
          • Vamsi K. Vasireddy
        • Kontakt:
      • Richmond, Indiana, Forenede Stater, 47374
        • Suspenderet
        • Reid Health
      • Valparaiso, Indiana, Forenede Stater, 46383
        • Rekruttering
        • Northwest Cancer Center - Valparaiso
        • Ledende efterforsker:
          • Vamsi K. Vasireddy
        • Kontakt:
    • Iowa
      • Ames, Iowa, Forenede Stater, 50010
        • Rekruttering
        • Mary Greeley Medical Center
        • Ledende efterforsker:
          • Joseph J. Merchant
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 515-956-4132
      • Ames, Iowa, Forenede Stater, 50010
        • Rekruttering
        • McFarland Clinic - Ames
        • Ledende efterforsker:
          • Joseph J. Merchant
        • Kontakt:
      • Ankeny, Iowa, Forenede Stater, 50023
        • Rekruttering
        • UI Health Care Mission Cancer and Blood - Ankeny Clinic
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 515-241-3305
        • Ledende efterforsker:
          • Seema Harichand-Herdt
      • Boone, Iowa, Forenede Stater, 50036
        • Suspenderet
        • McFarland Clinic - Boone
      • Carroll, Iowa, Forenede Stater, 51401
        • Rekruttering
        • Saint Anthony Regional Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Seema Harichand-Herdt
      • Clive, Iowa, Forenede Stater, 50325
        • Suspenderet
        • Mercy Cancer Center-West Lakes
      • Clive, Iowa, Forenede Stater, 50325
        • Rekruttering
        • UI Health Care Mission Cancer and Blood - West Des Moines Clinic
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 515-241-3305
        • Ledende efterforsker:
          • Seema Harichand-Herdt
      • Council Bluffs, Iowa, Forenede Stater, 51503
        • Suspenderet
        • Alegent Health Mercy Hospital
      • Creston, Iowa, Forenede Stater, 50801
        • Aktiv, ikke rekrutterende
        • Greater Regional Medical Center
      • Des Moines, Iowa, Forenede Stater, 50314
        • Rekruttering
        • Broadlawns Medical Center
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 515-282-2200
        • Ledende efterforsker:
          • Seema Harichand-Herdt
      • Des Moines, Iowa, Forenede Stater, 50316
        • Suspenderet
        • Iowa Lutheran Hospital
      • Des Moines, Iowa, Forenede Stater, 50309
        • Rekruttering
        • Iowa Methodist Medical Center
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 515-241-6727
        • Ledende efterforsker:
          • Seema Harichand-Herdt
      • Des Moines, Iowa, Forenede Stater, 50314
        • Suspenderet
        • Mercy Medical Center - Des Moines
      • Des Moines, Iowa, Forenede Stater, 50309
        • Rekruttering
        • UI Health Care Mission Cancer and Blood - Des Moines Clinic
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 515-241-3305
        • Ledende efterforsker:
          • Seema Harichand-Herdt
      • Des Moines, Iowa, Forenede Stater, 50314
        • Rekruttering
        • UI Health Care Mission Cancer and Blood - Laurel Clinic
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 515-241-3305
        • Ledende efterforsker:
          • Seema Harichand-Herdt
      • Fort Dodge, Iowa, Forenede Stater, 50501
        • Rekruttering
        • McFarland Clinic - Trinity Cancer Center
        • Ledende efterforsker:
          • Joseph J. Merchant
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 515-956-4132
      • Fort Dodge, Iowa, Forenede Stater, 50501
        • Rekruttering
        • UI Healthcare Mission Cancer and Blood - Fort Dodge
        • Ledende efterforsker:
          • Seema Harichand-Herdt
        • Kontakt:
      • Jefferson, Iowa, Forenede Stater, 50129
        • Suspenderet
        • McFarland Clinic - Jefferson
      • Marshalltown, Iowa, Forenede Stater, 50158
        • Rekruttering
        • McFarland Clinic - Marshalltown
        • Ledende efterforsker:
          • Joseph J. Merchant
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 515-956-4132
      • Waukee, Iowa, Forenede Stater, 50263
        • Rekruttering
        • UI Health Care Mission Cancer and Blood - Waukee Clinic
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 515-241-3305
        • Ledende efterforsker:
          • Seema Harichand-Herdt
      • West Des Moines, Iowa, Forenede Stater, 50266-7700
        • Suspenderet
        • Methodist West Hospital
      • West Des Moines, Iowa, Forenede Stater, 50266
        • Suspenderet
        • Mercy Medical Center-West Lakes
    • Kansas
      • Garden City, Kansas, Forenede Stater, 67846
        • Suspenderet
        • Central Care Cancer Center - Garden City
      • Great Bend, Kansas, Forenede Stater, 67530
        • Suspenderet
        • Central Care Cancer Center - Great Bend
      • Wichita, Kansas, Forenede Stater, 67208
        • Rekruttering
        • Cancer Center of Kansas-Wichita Medical Arts Tower
        • Kontakt:
        • Ledende efterforsker:
          • Dennis F. Moore
      • Wichita, Kansas, Forenede Stater, 67214
        • Rekruttering
        • Ascension Via Christi Hospitals Wichita
        • Kontakt:
        • Ledende efterforsker:
          • Dennis F. Moore
      • Wichita, Kansas, Forenede Stater, 67214
        • Rekruttering
        • Cancer Center of Kansas - Wichita
        • Kontakt:
        • Ledende efterforsker:
          • Dennis F. Moore
    • Kentucky
      • Bardstown, Kentucky, Forenede Stater, 40004
        • Suspenderet
        • CommonSpirit Saint Joseph Hospital - Bardstown
      • Corbin, Kentucky, Forenede Stater, 40701
        • Suspenderet
        • Commonwealth Cancer Center-Corbin
      • Lexington, Kentucky, Forenede Stater, 40504
        • Suspenderet
        • Saint Joseph Radiation Oncology Resource Center
      • Lexington, Kentucky, Forenede Stater, 40509
        • Suspenderet
        • CommonSpirit Saint Joseph Medical Center - East Lexington
      • London, Kentucky, Forenede Stater, 40741
        • Suspenderet
        • CommonSpirit Saint Joseph Hospital London
      • Louisville, Kentucky, Forenede Stater, 40202
        • Suspenderet
        • Jewish Hospital
      • Louisville, Kentucky, Forenede Stater, 40215
        • Suspenderet
        • Saints Mary and Elizabeth Hospital
      • Louisville, Kentucky, Forenede Stater, 40245
        • Suspenderet
        • UofL Health Medical Center Northeast
      • Shepherdsville, Kentucky, Forenede Stater, 40165
        • Suspenderet
        • Jewish Hospital Medical Center South
    • Maryland
      • Bethesda, Maryland, Forenede Stater, 20889-5600
        • Suspenderet
        • Walter Reed National Military Medical Center
    • Massachusetts
      • Beverly, Massachusetts, Forenede Stater, 01915
        • Aktiv, ikke rekrutterende
        • Beverly Hospital
      • Burlington, Massachusetts, Forenede Stater, 01805
        • Aktiv, ikke rekrutterende
        • Lahey Clinic
      • Gloucester, Massachusetts, Forenede Stater, 01930
        • Aktiv, ikke rekrutterende
        • Addison Gilbert Hospital
      • Peabody, Massachusetts, Forenede Stater, 01960
        • Aktiv, ikke rekrutterende
        • Lahey Clinic Peabody
      • Winchester, Massachusetts, Forenede Stater, 01890
        • Aktiv, ikke rekrutterende
        • Beth Israel Deaconess Medical Center/Winchester Center for Cancer Care
      • Worcester, Massachusetts, Forenede Stater, 01655
        • Rekruttering
        • UMass Memorial Medical Center - University Campus
        • Ledende efterforsker:
          • William V. Walsh
        • Kontakt:
    • Michigan
      • Adrian, Michigan, Forenede Stater, 49221
        • Suspenderet
        • Hickman Cancer Center
      • Ann Arbor, Michigan, Forenede Stater, 48106
        • Rekruttering
        • Trinity Health Saint Joseph Mercy Hospital Ann Arbor
        • Kontakt:
        • Ledende efterforsker:
          • Elie G. Dib
      • Brighton, Michigan, Forenede Stater, 48114
        • Rekruttering
        • Trinity Health IHA Medical Group Hematology Oncology - Brighton
        • Kontakt:
        • Ledende efterforsker:
          • Elie G. Dib
      • Brighton, Michigan, Forenede Stater, 48114
      • Canton, Michigan, Forenede Stater, 48188
        • Rekruttering
        • Trinity Health IHA Medical Group Hematology Oncology - Canton
        • Kontakt:
        • Ledende efterforsker:
          • Elie G. Dib
      • Canton, Michigan, Forenede Stater, 48188
      • Caro, Michigan, Forenede Stater, 48723
        • Suspenderet
        • Caro Cancer Center
      • Chelsea, Michigan, Forenede Stater, 48118
        • Rekruttering
        • Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Elie G. Dib
      • Chelsea, Michigan, Forenede Stater, 48118
      • Clarkston, Michigan, Forenede Stater, 48346
        • Rekruttering
        • Hematology Oncology Consultants-Clarkston
        • Kontakt:
        • Ledende efterforsker:
          • Elie G. Dib
      • Clarkston, Michigan, Forenede Stater, 48346
        • Suspenderet
        • Newland Medical Associates-Clarkston
      • Dearborn, Michigan, Forenede Stater, 48124
        • Rekruttering
        • Corewell Health Dearborn Hospital
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 248-551-7695
        • Ledende efterforsker:
          • Andrew A. Muskovitz
      • Detroit, Michigan, Forenede Stater, 48236
        • Rekruttering
        • Henry Ford Health Saint John Hospital
        • Ledende efterforsker:
          • Elie G. Dib
        • Kontakt:
      • East China Township, Michigan, Forenede Stater, 48054
        • Rekruttering
        • Henry Ford River District Hospital
        • Ledende efterforsker:
          • Elie G. Dib
        • Kontakt:
      • Flint, Michigan, Forenede Stater, 48503
        • Rekruttering
        • Genesys Hurley Cancer Institute
        • Kontakt:
        • Ledende efterforsker:
          • Elie G. Dib
      • Flint, Michigan, Forenede Stater, 48503
        • Rekruttering
        • Hurley Medical Center
        • Kontakt:
        • Ledende efterforsker:
          • Elie G. Dib
      • Flint, Michigan, Forenede Stater, 48503
        • Suspenderet
        • Genesee Hematology Oncology PC
      • Flint, Michigan, Forenede Stater, 48503
        • Rekruttering
        • Cancer Hematology Centers - Flint
        • Kontakt:
        • Ledende efterforsker:
          • Elie G. Dib
      • Grosse Pointe Woods, Michigan, Forenede Stater, 48236
        • Suspenderet
        • Henry Ford Saint John Hospital - Breast
      • Grosse Pointe Woods, Michigan, Forenede Stater, 48236
        • Rekruttering
        • Henry Ford Saint John Hospital - Academic
        • Ledende efterforsker:
          • Elie G. Dib
        • Kontakt:
      • Grosse Pointe Woods, Michigan, Forenede Stater, 48236
        • Rekruttering
        • Henry Ford Saint John Hospital - Van Elslander
        • Ledende efterforsker:
          • Elie G. Dib
        • Kontakt:
      • Lansing, Michigan, Forenede Stater, 48912
        • Rekruttering
        • University of Michigan Health - Sparrow Lansing
        • Ledende efterforsker:
          • Elie G. Dib
        • Kontakt:
      • Livonia, Michigan, Forenede Stater, 48154
        • Suspenderet
        • Hope Cancer Clinic
      • Livonia, Michigan, Forenede Stater, 48154
        • Rekruttering
        • Trinity Health Saint Mary Mercy Livonia Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Elie G. Dib
      • Macomb, Michigan, Forenede Stater, 48044
        • Suspenderet
        • Henry Ford Warren Hospital - Breast Macomb
      • Macomb, Michigan, Forenede Stater, 48044
        • Rekruttering
        • Henry Ford Saint John Hospital - Macomb Medical
        • Ledende efterforsker:
          • Elie G. Dib
        • Kontakt:
      • Marlette, Michigan, Forenede Stater, 48453
        • Suspenderet
        • Saint Mary's Oncology/Hematology Associates of Marlette
      • Monroe, Michigan, Forenede Stater, 48162
        • Suspenderet
        • Toledo Clinic Cancer Centers-Monroe
      • Pontiac, Michigan, Forenede Stater, 48341
        • Suspenderet
        • Hope Cancer Center
      • Pontiac, Michigan, Forenede Stater, 48341
        • Rekruttering
        • Trinity Health Saint Joseph Mercy Oakland Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Elie G. Dib
      • Pontiac, Michigan, Forenede Stater, 48341
        • Rekruttering
        • Michigan Healthcare Professionals Pontiac
        • Ledende efterforsker:
          • Elie G. Dib
        • Kontakt:
      • Pontiac, Michigan, Forenede Stater, 48341
        • Rekruttering
        • Trinity Health IHA Medical Group-Alice Gustafson Center
        • Kontakt:
        • Ledende efterforsker:
          • Elie G. Dib
      • Rochester Hills, Michigan, Forenede Stater, 48309
        • Suspenderet
        • Henry Ford Rochester Hospital
      • Royal Oak, Michigan, Forenede Stater, 48073
        • Rekruttering
        • Corewell Health William Beaumont University Hospital
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 248-551-7695
        • Ledende efterforsker:
          • Andrew A. Muskovitz
      • Saginaw, Michigan, Forenede Stater, 48604
        • Suspenderet
        • Oncology Hematology Associates of Saginaw Valley PC
      • Saginaw, Michigan, Forenede Stater, 48601
      • Sterling Heights, Michigan, Forenede Stater, 48312
        • Suspenderet
        • Bhadresh Nayak MD PC-Sterling Heights
      • Tawas City, Michigan, Forenede Stater, 48764
      • Troy, Michigan, Forenede Stater, 48085
        • Rekruttering
        • Corewell Health Beaumont Troy Hospital
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 248-551-7695
        • Ledende efterforsker:
          • Andrew A. Muskovitz
      • Warren, Michigan, Forenede Stater, 48088
        • Suspenderet
        • Advanced Breast Care Center PLLC
      • Warren, Michigan, Forenede Stater, 48093
        • Suspenderet
        • Macomb Hematology Oncology PC
      • Warren, Michigan, Forenede Stater, 48093
        • Suspenderet
        • Henry Ford Madison Heights Hospital - Breast
      • Warren, Michigan, Forenede Stater, 48093
        • Rekruttering
        • Henry Ford Health Warren Hospital
        • Ledende efterforsker:
          • Elie G. Dib
        • Kontakt:
      • Warren, Michigan, Forenede Stater, 48093
        • Rekruttering
        • Henry Ford Warren Hospital - GLCMS
        • Ledende efterforsker:
          • Elie G. Dib
        • Kontakt:
      • West Branch, Michigan, Forenede Stater, 48661
        • Suspenderet
        • Saint Mary's Oncology/Hematology Associates of West Branch
      • Ypsilanti, Michigan, Forenede Stater, 48106
      • Ypsilanti, Michigan, Forenede Stater, 48197
        • Rekruttering
        • Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
        • Kontakt:
        • Ledende efterforsker:
          • Elie G. Dib
    • Minnesota
      • Bemidji, Minnesota, Forenede Stater, 56601
        • Aktiv, ikke rekrutterende
        • Sanford Joe Lueken Cancer Center
      • Burnsville, Minnesota, Forenede Stater, 55337
        • Rekruttering
        • Minnesota Oncology - Burnsville
        • Kontakt:
        • Ledende efterforsker:
          • David M. King
      • Burnsville, Minnesota, Forenede Stater, 55337
        • Suspenderet
        • Fairview Ridges Hospital
      • Cambridge, Minnesota, Forenede Stater, 55008
        • Suspenderet
        • Cambridge Medical Center
      • Coon Rapids, Minnesota, Forenede Stater, 55433
        • Rekruttering
        • Mercy Hospital
        • Kontakt:
        • Ledende efterforsker:
          • David M. King
      • Edina, Minnesota, Forenede Stater, 55435
        • Rekruttering
        • Fairview Southdale Hospital
        • Kontakt:
        • Ledende efterforsker:
          • David M. King
      • Edina, Minnesota, Forenede Stater, 55435
        • Rekruttering
        • Minnesota Oncology - Edina
        • Kontakt:
        • Ledende efterforsker:
          • David M. King
      • Fridley, Minnesota, Forenede Stater, 55432
        • Aktiv, ikke rekrutterende
        • Unity Hospital
      • Maple Grove, Minnesota, Forenede Stater, 55369
        • Rekruttering
        • Fairview Clinics and Surgery Center Maple Grove
        • Kontakt:
        • Ledende efterforsker:
          • David M. King
      • Maplewood, Minnesota, Forenede Stater, 55109
        • Rekruttering
        • Minnesota Oncology Hematology PA-Maplewood
        • Kontakt:
        • Ledende efterforsker:
          • David M. King
      • Maplewood, Minnesota, Forenede Stater, 55109
        • Rekruttering
        • Saint John's Hospital - Healtheast
        • Kontakt:
        • Ledende efterforsker:
          • David M. King
      • Minneapolis, Minnesota, Forenede Stater, 55407
        • Rekruttering
        • Abbott-Northwestern Hospital
        • Kontakt:
        • Ledende efterforsker:
          • David M. King
      • Minneapolis, Minnesota, Forenede Stater, 55415
        • Rekruttering
        • Hennepin County Medical Center
        • Kontakt:
        • Ledende efterforsker:
          • David M. King
      • Minneapolis, Minnesota, Forenede Stater, 55454
        • Suspenderet
        • Health Partners Inc
      • Monticello, Minnesota, Forenede Stater, 55362
        • Suspenderet
        • Monticello Cancer Center
      • New Ulm, Minnesota, Forenede Stater, 56073
        • Suspenderet
        • New Ulm Medical Center
      • Princeton, Minnesota, Forenede Stater, 55371
        • Suspenderet
        • Fairview Northland Medical Center
      • Robbinsdale, Minnesota, Forenede Stater, 55422
        • Suspenderet
        • North Memorial Medical Health Center
      • Saint Louis Park, Minnesota, Forenede Stater, 55416
        • Rekruttering
        • Park Nicollet Clinic - Saint Louis Park
        • Kontakt:
        • Ledende efterforsker:
          • David M. King
      • Saint Paul, Minnesota, Forenede Stater, 55101
        • Rekruttering
        • Regions Hospital
        • Kontakt:
        • Ledende efterforsker:
          • David M. King
      • Saint Paul, Minnesota, Forenede Stater, 55102
        • Rekruttering
        • United Hospital
        • Kontakt:
        • Ledende efterforsker:
          • David M. King
      • Shakopee, Minnesota, Forenede Stater, 55379
        • Rekruttering
        • Saint Francis Regional Medical Center
        • Kontakt:
        • Ledende efterforsker:
          • David M. King
      • Stillwater, Minnesota, Forenede Stater, 55082
        • Suspenderet
        • Lakeview Hospital
      • Thief River Falls, Minnesota, Forenede Stater, 56701
        • Aktiv, ikke rekrutterende
        • Sanford Thief River Falls Medical Center
      • Waconia, Minnesota, Forenede Stater, 55387
        • Rekruttering
        • Ridgeview Medical Center
        • Kontakt:
        • Ledende efterforsker:
          • David M. King
      • Willmar, Minnesota, Forenede Stater, 56201
        • Suspenderet
        • Rice Memorial Hospital
      • Woodbury, Minnesota, Forenede Stater, 55125
        • Suspenderet
        • Minnesota Oncology Hematology PA-Woodbury
      • Worthington, Minnesota, Forenede Stater, 56187
        • Suspenderet
        • Sanford Cancer Center Worthington
      • Wyoming, Minnesota, Forenede Stater, 55092
        • Suspenderet
        • Fairview Lakes Medical Center
    • Mississippi
      • Columbus, Mississippi, Forenede Stater, 39705
        • Rekruttering
        • Baptist Memorial Hospital and Cancer Center-Golden Triangle
        • Kontakt:
        • Ledende efterforsker:
          • Philip E. Lammers
      • Grenada, Mississippi, Forenede Stater, 38901
        • Rekruttering
        • Baptist Cancer Center-Grenada
        • Kontakt:
        • Ledende efterforsker:
          • Philip E. Lammers
      • New Albany, Mississippi, Forenede Stater, 38652
        • Rekruttering
        • Baptist Memorial Hospital and Cancer Center-Union County
        • Kontakt:
        • Ledende efterforsker:
          • Philip E. Lammers
      • Oxford, Mississippi, Forenede Stater, 38655
        • Rekruttering
        • Baptist Memorial Hospital and Cancer Center-Oxford
        • Kontakt:
        • Ledende efterforsker:
          • Philip E. Lammers
      • Southhaven, Mississippi, Forenede Stater, 38671
        • Rekruttering
        • Baptist Memorial Hospital and Cancer Center-Desoto
        • Kontakt:
        • Ledende efterforsker:
          • Philip E. Lammers
    • Missouri
      • Ballwin, Missouri, Forenede Stater, 63011
        • Suspenderet
        • Mercy Oncology and Hematology - Clayton-Clarkson
      • Bolivar, Missouri, Forenede Stater, 65613
        • Suspenderet
        • Central Care Cancer Center - Bolivar
      • Cape Girardeau, Missouri, Forenede Stater, 63703
        • Rekruttering
        • Saint Francis Medical Center
        • Ledende efterforsker:
          • Bryan A. Faller
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 573-334-2230
          • E-mail: sfmc@sfmc.net
      • Cape Girardeau, Missouri, Forenede Stater, 63703
        • Suspenderet
        • Mercy Cancer Center - Cape Girardeau
      • Chesterfield, Missouri, Forenede Stater, 63017
        • Rekruttering
        • Saint Luke's Hospital
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 314-205-6936
        • Ledende efterforsker:
          • Meera Rana
      • Farmington, Missouri, Forenede Stater, 63640
        • Rekruttering
        • Parkland Health Center - Farmington
        • Ledende efterforsker:
          • Bryan A. Faller
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 314-996-5569
      • Jefferson City, Missouri, Forenede Stater, 65109
        • Suspenderet
        • MU Health Care Goldschmidt Cancer Center
      • Joplin, Missouri, Forenede Stater, 64804
        • Suspenderet
        • Freeman Health System
      • Joplin, Missouri, Forenede Stater, 64804
        • Suspenderet
        • Mercy Hospital Joplin
      • Rolla, Missouri, Forenede Stater, 65401
        • Suspenderet
        • Mercy Clinic-Rolla-Cancer and Hematology
      • Rolla, Missouri, Forenede Stater, 65401
        • Suspenderet
        • Phelps Health Delbert Day Cancer Institute
      • Saint Joseph, Missouri, Forenede Stater, 64506
        • Suspenderet
        • Heartland Regional Medical Center
      • Sainte Genevieve, Missouri, Forenede Stater, 63670
        • Rekruttering
        • Sainte Genevieve County Memorial Hospital
        • Ledende efterforsker:
          • Bryan A. Faller
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 314-996-5569
      • Springfield, Missouri, Forenede Stater, 65804
        • Suspenderet
        • Mercy Hospital Springfield
      • Springfield, Missouri, Forenede Stater, 65807
        • Suspenderet
        • CoxHealth South Hospital
      • St Louis, Missouri, Forenede Stater, 63128
        • Rekruttering
        • Mercy Hospital South
        • Ledende efterforsker:
          • Jay W. Carlson
        • Kontakt:
      • St Louis, Missouri, Forenede Stater, 63141
        • Rekruttering
        • Mercy Hospital Saint Louis
        • Ledende efterforsker:
          • Jay W. Carlson
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 314-251-7066
      • St Louis, Missouri, Forenede Stater, 63109
        • Suspenderet
        • Mercy Infusion Center - Chippewa
      • St Louis, Missouri, Forenede Stater, 63131
        • Rekruttering
        • Missouri Baptist Medical Center
        • Ledende efterforsker:
          • Bryan A. Faller
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 314-996-5569
      • Sullivan, Missouri, Forenede Stater, 63080
        • Rekruttering
        • Missouri Baptist Sullivan Hospital
        • Ledende efterforsker:
          • Bryan A. Faller
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 314-996-5569
      • Washington, Missouri, Forenede Stater, 63090
        • Suspenderet
        • Mercy Hospital Washington
    • Montana
      • Anaconda, Montana, Forenede Stater, 59711
        • Rekruttering
        • Community Hospital of Anaconda
        • Ledende efterforsker:
          • John M. Schallenkamp
        • Kontakt:
      • Billings, Montana, Forenede Stater, 59101
        • Rekruttering
        • Billings Clinic Cancer Center
        • Ledende efterforsker:
          • John M. Schallenkamp
        • Kontakt:
      • Bozeman, Montana, Forenede Stater, 59715
        • Rekruttering
        • Bozeman Health Deaconess Hospital
        • Ledende efterforsker:
          • John M. Schallenkamp
        • Kontakt:
      • Great Falls, Montana, Forenede Stater, 59405
        • Suspenderet
        • Great Falls Clinic
      • Great Falls, Montana, Forenede Stater, 59405
        • Rekruttering
        • Benefis Sletten Cancer Institute
        • Ledende efterforsker:
          • John M. Schallenkamp
        • Kontakt:
      • Kalispell, Montana, Forenede Stater, 59901
        • Rekruttering
        • Logan Health Medical Center
        • Ledende efterforsker:
          • John M. Schallenkamp
        • Kontakt:
      • Missoula, Montana, Forenede Stater, 59802
        • Suspenderet
        • Saint Patrick Hospital - Community Hospital
      • Missoula, Montana, Forenede Stater, 59804
        • Rekruttering
        • Community Medical Center
        • Ledende efterforsker:
          • John M. Schallenkamp
        • Kontakt:
    • Nebraska
      • Grand Island, Nebraska, Forenede Stater, 68803
        • Suspenderet
        • Nebraska Cancer Specialists/Oncology Hematology West PC
      • Kearney, Nebraska, Forenede Stater, 68847
        • Suspenderet
        • CHI Health Good Samaritan
      • Lincoln, Nebraska, Forenede Stater, 68510
        • Suspenderet
        • Saint Elizabeth Regional Medical Center
      • Lincoln, Nebraska, Forenede Stater, 68516
        • Rekruttering
        • Cancer Partners of Nebraska
        • Kontakt:
        • Ledende efterforsker:
          • Joni A. Tilford
      • Omaha, Nebraska, Forenede Stater, 68122
        • Suspenderet
        • Alegent Health Immanuel Medical Center
      • Omaha, Nebraska, Forenede Stater, 68124
        • Suspenderet
        • Alegent Health Bergan Mercy Medical Center
      • Omaha, Nebraska, Forenede Stater, 68130
        • Suspenderet
        • Alegent Health Lakeside Hospital
      • Papillion, Nebraska, Forenede Stater, 68046
        • Suspenderet
        • Midlands Community Hospital
    • New Jersey
      • Basking Ridge, New Jersey, Forenede Stater, 07920
        • Rekruttering
        • Memorial Sloan Kettering Basking Ridge
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 212-639-7592
        • Ledende efterforsker:
          • Helena A. Yu
      • Englewood, New Jersey, Forenede Stater, 07631
        • Rekruttering
        • Englewood Hospital and Medical Center
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 201-894-3456
        • Ledende efterforsker:
          • Lewis M. Attas
      • Jersey City, New Jersey, Forenede Stater, 07302
        • Rekruttering
        • Jersey City Medical Center
        • Kontakt:
        • Ledende efterforsker:
          • Missak Haigentz
      • Lakewood, New Jersey, Forenede Stater, 08701
        • Rekruttering
        • Monmouth Medical Center Southern Campus
        • Kontakt:
        • Ledende efterforsker:
          • Missak Haigentz
      • Livingston, New Jersey, Forenede Stater, 07039
        • Suspenderet
        • Cooperman Barnabas Medical Center
      • Long Branch, New Jersey, Forenede Stater, 07740
        • Rekruttering
        • Monmouth Medical Center
        • Kontakt:
        • Ledende efterforsker:
          • Missak Haigentz
      • Middletown, New Jersey, Forenede Stater, 07748
        • Rekruttering
        • Memorial Sloan Kettering Monmouth
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 212-639-7592
        • Ledende efterforsker:
          • Helena A. Yu
      • Montvale, New Jersey, Forenede Stater, 07645
        • Rekruttering
        • Memorial Sloan Kettering Bergen
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 212-639-7592
        • Ledende efterforsker:
          • Helena A. Yu
      • New Brunswick, New Jersey, Forenede Stater, 08903
        • Rekruttering
        • Rutgers Cancer Institute of New Jersey
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 732-235-7356
        • Ledende efterforsker:
          • Missak Haigentz
      • Paramus, New Jersey, Forenede Stater, 07652
        • Rekruttering
        • The Valley Hospital - Luckow Pavilion
        • Ledende efterforsker:
          • Eli D. Kirshner
        • Kontakt:
      • Ridgewood, New Jersey, Forenede Stater, 07450
        • Suspenderet
        • Neurosurgeons of New Jersey-Ridgewood
      • Ridgewood, New Jersey, Forenede Stater, 07450
        • Rekruttering
        • Valley Health System Ridgewood Campus
        • Ledende efterforsker:
          • Eli D. Kirshner
        • Kontakt:
      • Somerville, New Jersey, Forenede Stater, 08876
        • Rekruttering
        • Robert Wood Johnson University Hospital Somerset
        • Ledende efterforsker:
          • Missak Haigentz
        • Kontakt:
      • Westwood, New Jersey, Forenede Stater, 07675
        • Suspenderet
        • Valley Health System-Hematology/Oncology
    • New Mexico
      • Albuquerque, New Mexico, Forenede Stater, 87106
        • Rekruttering
        • University of New Mexico Cancer Center
        • Kontakt:
        • Ledende efterforsker:
          • Martha Mapalo
      • Albuquerque, New Mexico, Forenede Stater, 87109
        • Suspenderet
        • New Mexico Oncology Hematology Consultants
    • New York
      • Buffalo, New York, Forenede Stater, 14263
        • Rekruttering
        • Roswell Park Cancer Institute
        • Kontakt:
        • Ledende efterforsker:
          • Edwin H. Yau
      • Commack, New York, Forenede Stater, 11725
        • Rekruttering
        • Memorial Sloan Kettering Commack
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 212-639-7592
        • Ledende efterforsker:
          • Helena A. Yu
      • East Hills, New York, Forenede Stater, 11548
        • Rekruttering
        • The Cancer Institute at Saint Francis Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Bhoomi Mehrotra
      • Glens Falls, New York, Forenede Stater, 12801
        • Rekruttering
        • Glens Falls Hospital
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 518-926-6700
        • Ledende efterforsker:
          • Aqeel A. Gillani
      • Harrison, New York, Forenede Stater, 10604
        • Rekruttering
        • Memorial Sloan Kettering Westchester
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 212-639-7592
        • Ledende efterforsker:
          • Helena A. Yu
      • New York, New York, Forenede Stater, 10065
        • Rekruttering
        • Memorial Sloan Kettering Cancer Center
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 212-639-7592
        • Ledende efterforsker:
          • Helena A. Yu
      • New York, New York, Forenede Stater, 10011
        • Rekruttering
        • Mount Sinai Chelsea
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 212-824-7309
          • E-mail: CCTO@mssm.edu
        • Ledende efterforsker:
          • Nicholas Rohs
      • New York, New York, Forenede Stater, 10029
        • Rekruttering
        • Mount Sinai Hospital
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 212-824-7309
          • E-mail: CCTO@mssm.edu
        • Ledende efterforsker:
          • Nicholas Rohs
      • Oswego, New York, Forenede Stater, 13126
        • Rekruttering
        • Upstate Cancer Center at Oswego
        • Kontakt:
        • Ledende efterforsker:
          • Komal Akhtar
      • Syracuse, New York, Forenede Stater, 13210
        • Rekruttering
        • State University of New York Upstate Medical University
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 315-464-5476
        • Ledende efterforsker:
          • Komal Akhtar
      • The Bronx, New York, Forenede Stater, 10461
        • Rekruttering
        • Montefiore Medical Center-Einstein Campus
        • Kontakt:
        • Ledende efterforsker:
          • Balazs Halmos
      • The Bronx, New York, Forenede Stater, 10467
        • Rekruttering
        • Montefiore Medical Center - Moses Campus
        • Kontakt:
        • Ledende efterforsker:
          • Balazs Halmos
      • The Bronx, New York, Forenede Stater, 10461
        • Aktiv, ikke rekrutterende
        • Montefiore Medical Center-Weiler Hospital
      • Uniondale, New York, Forenede Stater, 11553
        • Rekruttering
        • Memorial Sloan Kettering Nassau
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 212-639-7592
        • Ledende efterforsker:
          • Helena A. Yu
      • Verona, New York, Forenede Stater, 13478
        • Rekruttering
        • Upstate Cancer Center at Verona
        • Kontakt:
        • Ledende efterforsker:
          • Komal Akhtar
      • West Islip, New York, Forenede Stater, 11795
        • Rekruttering
        • Good Samaritan University Hospital
        • Ledende efterforsker:
          • Ashish Sangal
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 516-326-7514
      • White Plains, New York, Forenede Stater, 10601
        • Rekruttering
        • Dickstein Cancer Treatment Center
        • Kontakt:
        • Ledende efterforsker:
          • Daniel E. Sammartino
    • North Carolina
      • Charlotte, North Carolina, Forenede Stater, 28204
        • Rekruttering
        • Novant Health Presbyterian Medical Center
        • Ledende efterforsker:
          • Alfred J. Newman
        • Kontakt:
      • Clinton, North Carolina, Forenede Stater, 28328
        • Rekruttering
        • Southeastern Medical Oncology Center-Clinton
        • Kontakt:
        • Ledende efterforsker:
          • Samer S. Kasbari
      • Goldsboro, North Carolina, Forenede Stater, 27534
        • Rekruttering
        • Southeastern Medical Oncology Center-Goldsboro
        • Kontakt:
        • Ledende efterforsker:
          • Samer S. Kasbari
      • Huntersville, North Carolina, Forenede Stater, 28078
        • Rekruttering
        • Novant Health Cancer Institute - Huntersville
        • Ledende efterforsker:
          • Alfred J. Newman
        • Kontakt:
      • Jacksonville, North Carolina, Forenede Stater, 28546
        • Rekruttering
        • Southeastern Medical Oncology Center-Jacksonville
        • Ledende efterforsker:
          • Samer S. Kasbari
        • Kontakt:
      • Kenansville, North Carolina, Forenede Stater, 28349
        • Suspenderet
        • ECU Health Oncology Kenansville
      • Kernersville, North Carolina, Forenede Stater, 27284
        • Rekruttering
        • Novant Health Cancer Institute - Kernersville
        • Kontakt:
        • Ledende efterforsker:
          • Garrett B. Sherwood
      • Kinston, North Carolina, Forenede Stater, 28501
        • Suspenderet
        • ECU Health Oncology Kinston
      • Matthews, North Carolina, Forenede Stater, 28105
        • Rekruttering
        • Novant Health Cancer Institute - Matthews
        • Ledende efterforsker:
          • Alfred J. Newman
        • Kontakt:
      • Mooresville, North Carolina, Forenede Stater, 28117
        • Rekruttering
        • Novant Health Cancer Institute - Mooresville
        • Ledende efterforsker:
          • Alfred J. Newman
        • Kontakt:
      • Mount Airy, North Carolina, Forenede Stater, 27030
        • Suspenderet
        • Novant Health Cancer Institute - Mount Airy
      • North Wilkesboro, North Carolina, Forenede Stater, 28659
        • Suspenderet
        • Novant Health Cancer Institute - Wilkesboro
      • Richlands, North Carolina, Forenede Stater, 28574
        • Suspenderet
        • ECU Health Oncology Richlands
      • Statesville, North Carolina, Forenede Stater, 28625
        • Suspenderet
        • Novant Health Cancer Institute - Statesville
      • Thomasville, North Carolina, Forenede Stater, 27360
        • Suspenderet
        • Novant Health Cancer Institute - Thomasville
      • Winston-Salem, North Carolina, Forenede Stater, 27103
        • Rekruttering
        • Novant Health Forsyth Medical Center
        • Ledende efterforsker:
          • Garrett B. Sherwood
        • Kontakt:
    • North Dakota
      • Bismarck, North Dakota, Forenede Stater, 58501
        • Aktiv, ikke rekrutterende
        • Sanford Bismarck Medical Center
      • Fargo, North Dakota, Forenede Stater, 58103
        • Aktiv, ikke rekrutterende
        • Sanford South University Medical Center
      • Fargo, North Dakota, Forenede Stater, 58104
        • Aktiv, ikke rekrutterende
        • Sanford Medical Center Fargo
      • Fargo, North Dakota, Forenede Stater, 58122
        • Aktiv, ikke rekrutterende
        • Sanford Broadway Medical Center
      • Fargo, North Dakota, Forenede Stater, 58122
        • Aktiv, ikke rekrutterende
        • Sanford Roger Maris Cancer Center
      • Fargo, North Dakota, Forenede Stater, 58103
        • Aktiv, ikke rekrutterende
        • Southpointe-Sanford Medical Center Fargo
    • Ohio
      • Avon, Ohio, Forenede Stater, 44011
        • Rekruttering
        • UH Seidman Cancer Center at UH Avon Health Center
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 800-641-2422
        • Ledende efterforsker:
          • Melinda L. Hsu
      • Beachwood, Ohio, Forenede Stater, 44122
        • Rekruttering
        • UHHS-Chagrin Highlands Medical Center
        • Kontakt:
        • Ledende efterforsker:
          • Melinda L. Hsu
      • Beavercreek, Ohio, Forenede Stater, 45431
        • Suspenderet
        • Indu and Raj Soin Medical Center
      • Belpre, Ohio, Forenede Stater, 45714
        • Rekruttering
        • Strecker Cancer Center-Belpre
        • Kontakt:
        • Ledende efterforsker:
          • Aruna C. Gowda
      • Boardman, Ohio, Forenede Stater, 44512
        • Suspenderet
        • Saint Elizabeth Boardman Hospital
      • Centerville, Ohio, Forenede Stater, 45459
        • Rekruttering
        • Miami Valley Hospital South
        • Kontakt:
        • Ledende efterforsker:
          • Tarek M. Sabagh
      • Centerville, Ohio, Forenede Stater, 45459
        • Suspenderet
        • Dayton Physicians LLC-Miami Valley South
      • Chardon, Ohio, Forenede Stater, 44024
        • Aktiv, ikke rekrutterende
        • Geauga Hospital
      • Chillicothe, Ohio, Forenede Stater, 45601
        • Rekruttering
        • Adena Regional Medical Center
        • Kontakt:
        • Ledende efterforsker:
          • Aruna C. Gowda
      • Cincinnati, Ohio, Forenede Stater, 45219
        • Rekruttering
        • University of Cincinnati Cancer Center-UC Medical Center
        • Kontakt:
        • Ledende efterforsker:
          • Kerri McGovern
      • Cincinnati, Ohio, Forenede Stater, 45220
        • Suspenderet
        • Good Samaritan Hospital - Cincinnati
      • Cincinnati, Ohio, Forenede Stater, 45236
        • Suspenderet
        • Oncology Hematology Care Inc-Kenwood
      • Cincinnati, Ohio, Forenede Stater, 45242
        • Suspenderet
        • Bethesda North Hospital
      • Cincinnati, Ohio, Forenede Stater, 45247
        • Suspenderet
        • TriHealth Cancer Institute-Westside
      • Cincinnati, Ohio, Forenede Stater, 45255
        • Suspenderet
        • TriHealth Cancer Institute-Anderson
      • Cleveland, Ohio, Forenede Stater, 44195
        • Rekruttering
        • Cleveland Clinic Foundation
        • Kontakt:
        • Ledende efterforsker:
          • Khaled A. Hassan
      • Cleveland, Ohio, Forenede Stater, 44106
        • Rekruttering
        • Case Western Reserve University
        • Kontakt:
        • Ledende efterforsker:
          • Melinda L. Hsu
      • Columbus, Ohio, Forenede Stater, 43214
        • Rekruttering
        • Columbus Oncology and Hematology Associates Inc
        • Kontakt:
        • Ledende efterforsker:
          • Shakir Sarwar
      • Columbus, Ohio, Forenede Stater, 43215
        • Rekruttering
        • Grant Medical Center
        • Kontakt:
        • Ledende efterforsker:
          • Shakir Sarwar
      • Columbus, Ohio, Forenede Stater, 43219
        • Rekruttering
        • The Mark H Zangmeister Center
        • Kontakt:
        • Ledende efterforsker:
          • Aruna C. Gowda
      • Columbus, Ohio, Forenede Stater, 43228
        • Rekruttering
        • Doctors Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Shakir Sarwar
      • Columbus, Ohio, Forenede Stater, 43213
        • Suspenderet
        • Mount Carmel East Hospital
      • Columbus, Ohio, Forenede Stater, 43214
        • Suspenderet
        • Riverside Methodist Hospital
      • Columbus, Ohio, Forenede Stater, 43222
        • Suspenderet
        • Mount Carmel Health Center West
      • Dayton, Ohio, Forenede Stater, 45409
        • Rekruttering
        • Miami Valley Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Tarek M. Sabagh
      • Dayton, Ohio, Forenede Stater, 45415
        • Rekruttering
        • Miami Valley Hospital North
        • Kontakt:
        • Ledende efterforsker:
          • Tarek M. Sabagh
      • Dayton, Ohio, Forenede Stater, 45409
        • Rekruttering
        • Premier Blood and Cancer Center
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 937-276-8320
        • Ledende efterforsker:
          • Tarek M. Sabagh
      • Dayton, Ohio, Forenede Stater, 45415
        • Suspenderet
        • Dayton Physician LLC - Englewood
      • Delaware, Ohio, Forenede Stater, 43015
        • Rekruttering
        • Delaware Health Center-Grady Cancer Center
        • Kontakt:
        • Ledende efterforsker:
          • Shakir Sarwar
      • Delaware, Ohio, Forenede Stater, 43015
        • Suspenderet
        • Grady Memorial Hospital
      • Dublin, Ohio, Forenede Stater, 43016
        • Suspenderet
        • Dublin Methodist Hospital
      • Findlay, Ohio, Forenede Stater, 45840
        • Suspenderet
        • Blanchard Valley Hospital
      • Findlay, Ohio, Forenede Stater, 45840
        • Suspenderet
        • Orion Cancer Care
      • Findlay, Ohio, Forenede Stater, 45840
        • Suspenderet
        • Armes Family Cancer Center
      • Franklin, Ohio, Forenede Stater, 45005-1066
        • Rekruttering
        • Atrium Medical Center-Middletown Regional Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Tarek M. Sabagh
      • Franklin, Ohio, Forenede Stater, 45005
        • Rekruttering
        • Dayton Physicians LLC-Atrium
        • Kontakt:
        • Ledende efterforsker:
          • Howard M. Gross
      • Gahanna, Ohio, Forenede Stater, 43230
        • Suspenderet
        • Central Ohio Breast and Endocrine Surgery
      • Greenville, Ohio, Forenede Stater, 45331
        • Suspenderet
        • Dayton Physicians LLC-Wayne
      • Greenville, Ohio, Forenede Stater, 45331
        • Suspenderet
        • Wayne Hospital
      • Greenville, Ohio, Forenede Stater, 45331
        • Rekruttering
        • Miami Valley Cancer Care and Infusion
        • Ledende efterforsker:
          • Tarek M. Sabagh
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 937-569-7515
      • Grove City, Ohio, Forenede Stater, 43123
        • Suspenderet
        • Mount Carmel Grove City Hospital
      • Kettering, Ohio, Forenede Stater, 45409
        • Suspenderet
        • Greater Dayton Cancer Center
      • Kettering, Ohio, Forenede Stater, 45429
        • Suspenderet
        • Kettering Medical Center
      • Lancaster, Ohio, Forenede Stater, 43130
        • Suspenderet
        • Fairfield Medical Center
      • Lima, Ohio, Forenede Stater, 45801
        • Suspenderet
        • Saint Rita's Medical Center
      • Mansfield, Ohio, Forenede Stater, 44903
        • Suspenderet
        • OhioHealth Mansfield Hospital
      • Mansfield, Ohio, Forenede Stater, 44906
        • Aktiv, ikke rekrutterende
        • Cleveland Clinic Cancer Center Mansfield
      • Marietta, Ohio, Forenede Stater, 45750
        • Rekruttering
        • Marietta Memorial Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Aruna C. Gowda
      • Marion, Ohio, Forenede Stater, 43302
        • Rekruttering
        • OhioHealth Marion General Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Shakir Sarwar
      • Marysville, Ohio, Forenede Stater, 43040
        • Rekruttering
        • Memorial Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Aruna C. Gowda
      • Mayfield Heights, Ohio, Forenede Stater, 44124
        • Rekruttering
        • Hillcrest Hospital Cancer Center
        • Kontakt:
        • Ledende efterforsker:
          • Khaled A. Hassan
      • Mentor, Ohio, Forenede Stater, 44060
        • Rekruttering
        • UH Seidman Cancer Center at Lake Health Mentor Campus
        • Kontakt:
        • Ledende efterforsker:
          • Melinda L. Hsu
      • Middleburg Heights, Ohio, Forenede Stater, 44130
        • Rekruttering
        • UH Seidman Cancer Center at Southwest General Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Melinda L. Hsu
      • Mount Vernon, Ohio, Forenede Stater, 43050
        • Rekruttering
        • Knox Community Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Aruna C. Gowda
      • Newark, Ohio, Forenede Stater, 43055
        • Rekruttering
        • Licking Memorial Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Aruna C. Gowda
      • Newark, Ohio, Forenede Stater, 43055
        • Suspenderet
        • Newark Radiation Oncology
      • Parma, Ohio, Forenede Stater, 44129
        • Aktiv, ikke rekrutterende
        • University Hospitals Parma Medical Center
      • Portsmouth, Ohio, Forenede Stater, 45662
        • Rekruttering
        • Southern Ohio Medical Center
        • Kontakt:
        • Ledende efterforsker:
          • Aruna C. Gowda
      • Sandusky, Ohio, Forenede Stater, 44870
        • Aktiv, ikke rekrutterende
        • UH Seidman Cancer Center at Firelands Regional Medical Center
      • Springfield, Ohio, Forenede Stater, 45504
        • Rekruttering
        • Springfield Regional Cancer Center
        • Kontakt:
        • Ledende efterforsker:
          • Aruna C. Gowda
      • Springfield, Ohio, Forenede Stater, 45504
        • Suspenderet
        • Springfield Regional Medical Center
      • Toledo, Ohio, Forenede Stater, 43623
        • Suspenderet
        • Mercy Health - Saint Anne Hospital
      • Toledo, Ohio, Forenede Stater, 43623
        • Suspenderet
        • Toledo Clinic Cancer Centers-Toledo
      • Toledo, Ohio, Forenede Stater, 43608
        • Suspenderet
        • Mercy Health - Saint Vincent Hospital
      • Troy, Ohio, Forenede Stater, 45373
        • Rekruttering
        • Upper Valley Medical Center
        • Kontakt:
        • Ledende efterforsker:
          • Tarek M. Sabagh
      • Troy, Ohio, Forenede Stater, 45373
        • Suspenderet
        • Dayton Physicians LLC - Troy
      • Wadsworth, Ohio, Forenede Stater, 44281
        • Aktiv, ikke rekrutterende
        • University Hospitals Sharon Health Center
      • Warren, Ohio, Forenede Stater, 44484
        • Suspenderet
        • Saint Joseph Warren Hospital
      • Warrensville Heights, Ohio, Forenede Stater, 44122
        • Aktiv, ikke rekrutterende
        • South Pointe Hospital
      • West Chester, Ohio, Forenede Stater, 45069
        • Rekruttering
        • University of Cincinnati Cancer Center-West Chester
        • Kontakt:
        • Ledende efterforsker:
          • Kerri McGovern
      • Westerville, Ohio, Forenede Stater, 43081
        • Suspenderet
        • Saint Ann's Hospital
      • Westlake, Ohio, Forenede Stater, 44145
        • Aktiv, ikke rekrutterende
        • UH Seidman Cancer Center at Saint John Medical Center
      • Youngstown, Ohio, Forenede Stater, 44501
        • Suspenderet
        • Saint Elizabeth Youngstown Hospital
      • Zanesville, Ohio, Forenede Stater, 43701
        • Rekruttering
        • Genesis Healthcare System Cancer Care Center
        • Kontakt:
        • Ledende efterforsker:
          • Aruna C. Gowda
    • Oklahoma
      • Oklahoma City, Oklahoma, Forenede Stater, 73104
        • Rekruttering
        • University of Oklahoma Health Sciences Center
        • Kontakt:
        • Ledende efterforsker:
          • Raid Aljumaily
      • Oklahoma City, Oklahoma, Forenede Stater, 73120
        • Suspenderet
        • Mercy Hospital Oklahoma City
      • Oklahoma City, Oklahoma, Forenede Stater, 73109
        • Suspenderet
        • Integris Southwest Medical Center
      • Oklahoma City, Oklahoma, Forenede Stater, 73142
        • Rekruttering
        • Integris Cancer Institute of Oklahoma
        • Ledende efterforsker:
          • Raid Aljumaily
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 405-773-6613
    • Oregon
      • Baker City, Oregon, Forenede Stater, 97814
        • Suspenderet
        • Saint Alphonsus Cancer Care Center-Baker City
      • Bend, Oregon, Forenede Stater, 97701
        • Rekruttering
        • Saint Charles Health System
        • Ledende efterforsker:
          • Alison K. Conlin
        • Kontakt:
      • Clackamas, Oregon, Forenede Stater, 97015
        • Suspenderet
        • Clackamas Radiation Oncology Center
      • Clackamas, Oregon, Forenede Stater, 97015
        • Suspenderet
        • Providence Cancer Institute Clackamas Clinic
      • Coos Bay, Oregon, Forenede Stater, 97420
        • Suspenderet
        • Bay Area Hospital
      • Newberg, Oregon, Forenede Stater, 97132
        • Rekruttering
        • Providence Newberg Medical Center
        • Ledende efterforsker:
          • Alison K. Conlin
        • Kontakt:
      • Ontario, Oregon, Forenede Stater, 97914
        • Rekruttering
        • Saint Alphonsus Cancer Care Center-Ontario
        • Kontakt:
        • Ledende efterforsker:
          • Elie G. Dib
      • Oregon City, Oregon, Forenede Stater, 97045
        • Rekruttering
        • Providence Willamette Falls Medical Center
        • Ledende efterforsker:
          • Alison K. Conlin
        • Kontakt:
      • Portland, Oregon, Forenede Stater, 97213
        • Rekruttering
        • Providence Portland Medical Center
        • Ledende efterforsker:
          • Alison K. Conlin
        • Kontakt:
      • Portland, Oregon, Forenede Stater, 97225
        • Rekruttering
        • Providence Saint Vincent Medical Center
        • Ledende efterforsker:
          • Alison K. Conlin
        • Kontakt:
      • Redmond, Oregon, Forenede Stater, 97756
        • Suspenderet
        • Saint Charles Health System-Redmond
    • Pennsylvania
      • Allentown, Pennsylvania, Forenede Stater, 18103
        • Rekruttering
        • Lehigh Valley Hospital-Cedar Crest
        • Kontakt:
        • Ledende efterforsker:
          • Elie G. Dib
      • Bethlehem, Pennsylvania, Forenede Stater, 18017
        • Rekruttering
        • Lehigh Valley Hospital - Muhlenberg
        • Kontakt:
        • Ledende efterforsker:
          • Elie G. Dib
      • Bryn Mawr, Pennsylvania, Forenede Stater, 19010
        • Rekruttering
        • Bryn Mawr Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Paul B. Gilman
      • Chadds Ford, Pennsylvania, Forenede Stater, 19317
        • Aktiv, ikke rekrutterende
        • Christiana Care Health System-Concord Health Center
      • Chambersburg, Pennsylvania, Forenede Stater, 17201
        • Suspenderet
        • Chambersburg Hospital
      • Chambersburg, Pennsylvania, Forenede Stater, 17201
        • Rekruttering
        • WellSpan Medical Oncology and Hematology
        • Ledende efterforsker:
          • Joseph Kannarkatt
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 717-217-6020
      • Collegeville, Pennsylvania, Forenede Stater, 19426
        • Suspenderet
        • Main Line Health Center-Collegeville
      • East Stroudsburg, Pennsylvania, Forenede Stater, 18301
        • Suspenderet
        • Pocono Medical Center
      • Ephrata, Pennsylvania, Forenede Stater, 17522
        • Rekruttering
        • Ephrata Cancer Center
        • Ledende efterforsker:
          • Joseph Kannarkatt
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 717-721-4840
      • Exton, Pennsylvania, Forenede Stater, 19341
        • Suspenderet
        • Main Line Health Center-Exton
      • Gettysburg, Pennsylvania, Forenede Stater, 17325
        • Rekruttering
        • Adams Cancer Center
        • Ledende efterforsker:
          • Joseph Kannarkatt
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 877-441-7957
      • Hanover, Pennsylvania, Forenede Stater, 17331
        • Rekruttering
        • WellSpan Medical Oncology and Hematology
        • Ledende efterforsker:
          • Joseph Kannarkatt
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 717-632-1559
      • Hazleton, Pennsylvania, Forenede Stater, 18201
        • Suspenderet
        • Lehigh Valley Hospital-Hazleton
      • Lebanon, Pennsylvania, Forenede Stater, 17042
        • Rekruttering
        • Sechler Family Cancer Center
        • Ledende efterforsker:
          • Joseph Kannarkatt
        • Kontakt:
      • Media, Pennsylvania, Forenede Stater, 19063
        • Rekruttering
        • Riddle Memorial Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Paul B. Gilman
      • Paoli, Pennsylvania, Forenede Stater, 19301
        • Rekruttering
        • Paoli Memorial Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Paul B. Gilman
      • Philadelphia, Pennsylvania, Forenede Stater, 19111
        • Rekruttering
        • Fox Chase Cancer Center
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 215-728-4790
        • Ledende efterforsker:
          • Jessica R. Bauman
      • Sayre, Pennsylvania, Forenede Stater, 18840
        • Rekruttering
        • Guthrie Medical Group PC-Robert Packer Hospital
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 800-836-0388
        • Ledende efterforsker:
          • Joyson Poulose
      • Wynnewood, Pennsylvania, Forenede Stater, 19096
        • Rekruttering
        • Lankenau Medical Center
        • Kontakt:
        • Ledende efterforsker:
          • Paul B. Gilman
      • York, Pennsylvania, Forenede Stater, 17403
        • Rekruttering
        • WellSpan Health-York Cancer Center
        • Ledende efterforsker:
          • Joseph Kannarkatt
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 877-441-7957
      • York, Pennsylvania, Forenede Stater, 17403
        • Rekruttering
        • WellSpan Health-York Hospital
        • Ledende efterforsker:
          • Joseph Kannarkatt
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 877-441-7957
      • York, Pennsylvania, Forenede Stater, 17403
        • Suspenderet
        • Cancer Care Associates of York
    • Rhode Island
      • Westerly, Rhode Island, Forenede Stater, 02891
        • Suspenderet
        • Smilow Cancer Hospital Care Center - Westerly
    • South Carolina
      • Charleston, South Carolina, Forenede Stater, 29425
        • Aktiv, ikke rekrutterende
        • Medical University of South Carolina
    • South Dakota
      • Rapid City, South Dakota, Forenede Stater, 57701
        • Aktiv, ikke rekrutterende
        • Rapid City Regional Hospital
      • Sioux Falls, South Dakota, Forenede Stater, 57104
      • Sioux Falls, South Dakota, Forenede Stater, 57117-5134
    • Tennessee
      • Collierville, Tennessee, Forenede Stater, 38017
        • Rekruttering
        • Baptist Memorial Hospital and Cancer Center-Collierville
        • Kontakt:
        • Ledende efterforsker:
          • Philip E. Lammers
      • Memphis, Tennessee, Forenede Stater, 38120
        • Rekruttering
        • Baptist Memorial Hospital and Cancer Center-Memphis
        • Kontakt:
        • Ledende efterforsker:
          • Philip E. Lammers
      • Nashville, Tennessee, Forenede Stater, 37232
        • Aktiv, ikke rekrutterende
        • Vanderbilt University/Ingram Cancer Center
    • Texas
      • Baytown, Texas, Forenede Stater, 77521
        • Rekruttering
        • Houston Methodist San Jacinto Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Jun Zhang
      • Bryan, Texas, Forenede Stater, 77802
        • Suspenderet
        • Saint Joseph Regional Cancer Center
      • Cypress, Texas, Forenede Stater, 77429
        • Rekruttering
        • Houston Methodist Cypress Hospital
        • Ledende efterforsker:
          • Jun Zhang
        • Kontakt:
      • Dallas, Texas, Forenede Stater, 75390
        • Rekruttering
        • UT Southwestern/Simmons Cancer Center-Dallas
        • Kontakt:
        • Ledende efterforsker:
          • Sheena Bhalla
      • Dallas, Texas, Forenede Stater, 75235
        • Rekruttering
        • Parkland Memorial Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Sheena Bhalla
      • Dallas, Texas, Forenede Stater, 75237
        • Rekruttering
        • UT Southwestern Simmons Cancer Center - RedBird
        • Ledende efterforsker:
          • Sheena Bhalla
        • Kontakt:
      • Fort Worth, Texas, Forenede Stater, 76104
        • Rekruttering
        • UT Southwestern/Simmons Cancer Center-Fort Worth
        • Kontakt:
        • Ledende efterforsker:
          • Sheena Bhalla
      • Houston, Texas, Forenede Stater, 77030
        • Rekruttering
        • Houston Methodist Hospital
        • Ledende efterforsker:
          • Jun Zhang
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 713-790-2700
      • Houston, Texas, Forenede Stater, 77070
        • Rekruttering
        • Methodist Willowbrook Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Jun Zhang
      • Houston, Texas, Forenede Stater, 77094
        • Rekruttering
        • Houston Methodist West Hospital
        • Ledende efterforsker:
          • Jun Zhang
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 832-522-2873
      • Nassau Bay, Texas, Forenede Stater, 77058
        • Rekruttering
        • Houston Methodist Saint John Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Jun Zhang
      • Richardson, Texas, Forenede Stater, 75080
        • Rekruttering
        • UT Southwestern Clinical Center at Richardson/Plano
        • Kontakt:
        • Ledende efterforsker:
          • Sheena Bhalla
      • Sugar Land, Texas, Forenede Stater, 77479
        • Rekruttering
        • Houston Methodist Sugar Land Hospital
        • Ledende efterforsker:
          • Jun Zhang
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 281-242-2873
      • The Woodlands, Texas, Forenede Stater, 77385
        • Rekruttering
        • Houston Methodist The Woodlands Hospital
        • Ledende efterforsker:
          • Jun Zhang
        • Kontakt:
    • Virginia
      • Charlottesville, Virginia, Forenede Stater, 22908
    • Washington
      • Aberdeen, Washington, Forenede Stater, 98520
        • Suspenderet
        • Providence Regional Cancer System-Aberdeen
      • Bellingham, Washington, Forenede Stater, 98225
        • Suspenderet
        • PeaceHealth Saint Joseph Medical Center
      • Burien, Washington, Forenede Stater, 98166
        • Suspenderet
        • Saint Anne Hospital
      • Centralia, Washington, Forenede Stater, 98531
        • Suspenderet
        • Providence Regional Cancer System-Centralia
      • Edmonds, Washington, Forenede Stater, 98026
        • Suspenderet
        • Swedish Cancer Institute-Edmonds
      • Enumclaw, Washington, Forenede Stater, 98022
        • Suspenderet
        • Saint Elizabeth Hospital
      • Everett, Washington, Forenede Stater, 98201
        • Suspenderet
        • Providence Regional Cancer Partnership
      • Federal Way, Washington, Forenede Stater, 98003
        • Suspenderet
        • Saint Francis Hospital
      • Issaquah, Washington, Forenede Stater, 98029
        • Suspenderet
        • Swedish Cancer Institute-Issaquah
      • Kennewick, Washington, Forenede Stater, 99336
        • Rekruttering
        • Kadlec Clinic Hematology and Oncology
        • Ledende efterforsker:
          • Alison K. Conlin
        • Kontakt:
      • Lacey, Washington, Forenede Stater, 98503
        • Suspenderet
        • Providence Regional Cancer System-Lacey
      • Lakewood, Washington, Forenede Stater, 98499
        • Suspenderet
        • Saint Clare Hospital
      • Longview, Washington, Forenede Stater, 98632
        • Rekruttering
        • PeaceHealth Saint John Medical Center
        • Ledende efterforsker:
          • Alison K. Conlin
        • Kontakt:
      • Port Townsend, Washington, Forenede Stater, 98368
        • Suspenderet
        • Jefferson Healthcare
      • Poulsbo, Washington, Forenede Stater, 98370
        • Aktiv, ikke rekrutterende
        • Harrison HealthPartners Hematology and Oncology-Poulsbo
      • Seattle, Washington, Forenede Stater, 98104
        • Suspenderet
        • Pacific Gynecology Specialists
      • Seattle, Washington, Forenede Stater, 98107
        • Suspenderet
        • Swedish Medical Center-Ballard Campus
      • Seattle, Washington, Forenede Stater, 98122-5711
        • Suspenderet
        • Swedish Medical Center-Cherry Hill
      • Seattle, Washington, Forenede Stater, 98122
        • Suspenderet
        • Swedish Medical Center-First Hill
      • Sedro-Woolley, Washington, Forenede Stater, 98284
        • Suspenderet
        • PeaceHealth United General Medical Center
      • Shelton, Washington, Forenede Stater, 98584
        • Suspenderet
        • Providence Regional Cancer System-Shelton
      • Silverdale, Washington, Forenede Stater, 98383
        • Suspenderet
        • Saint Joseph Medical Center Hematology and Oncology - Silverdale
      • Tacoma, Washington, Forenede Stater, 98405
        • Suspenderet
        • Franciscan Research Center-Northwest Medical Plaza
      • Tacoma, Washington, Forenede Stater, 98405
        • Suspenderet
        • Northwest Medical Specialties PLLC
      • Vancouver, Washington, Forenede Stater, 98664
        • Suspenderet
        • PeaceHealth Southwest Medical Center
      • Walla Walla, Washington, Forenede Stater, 99362
        • Suspenderet
        • Providence Saint Mary Regional Cancer Center
      • Yelm, Washington, Forenede Stater, 98597
        • Suspenderet
        • Providence Regional Cancer System-Yelm
    • West Virginia
      • Charleston, West Virginia, Forenede Stater, 25304
        • Rekruttering
        • Vandalia Health/CAMC Institute for Academic Medicine
        • Ledende efterforsker:
          • Ahmed A. Khalid
        • Kontakt:
    • Wisconsin
      • Appleton, Wisconsin, Forenede Stater, 54911
        • Rekruttering
        • ThedaCare Regional Cancer Center
        • Kontakt:
        • Ledende efterforsker:
          • Matthias Weiss
      • Berlin, Wisconsin, Forenede Stater, 54923
        • Rekruttering
        • ThedaCare Cancer Care - Berlin
        • Kontakt:
        • Ledende efterforsker:
          • Matthias Weiss
      • Eau Claire, Wisconsin, Forenede Stater, 54701
      • Janesville, Wisconsin, Forenede Stater, 53548
        • Rekruttering
        • Mercyhealth Hospital and Cancer Center - Janesville
        • Kontakt:
        • Ledende efterforsker:
          • Emily G. Robinson
      • La Crosse, Wisconsin, Forenede Stater, 54601
        • Rekruttering
        • Gundersen Lutheran Medical Center
        • Kontakt:
        • Ledende efterforsker:
          • Kurt Oettel
      • Marshfield, Wisconsin, Forenede Stater, 54449
      • Milwaukee, Wisconsin, Forenede Stater, 53226
        • Rekruttering
        • Medical College of Wisconsin
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 414-805-3666
        • Ledende efterforsker:
          • Jonathan R. Thompson
      • Minocqua, Wisconsin, Forenede Stater, 54548
      • Mukwonago, Wisconsin, Forenede Stater, 53149
        • Rekruttering
        • ProHealth D N Greenwald Center
        • Kontakt:
        • Ledende efterforsker:
          • Timothy R. Wassenaar
      • Neenah, Wisconsin, Forenede Stater, 54956
        • Rekruttering
        • ThedaCare Regional Medical Center - Neenah
        • Kontakt:
        • Ledende efterforsker:
          • Matthias Weiss
      • New London, Wisconsin, Forenede Stater, 54961
        • Rekruttering
        • ThedaCare Cancer Care - New London
        • Kontakt:
        • Ledende efterforsker:
          • Matthias Weiss
      • New Richmond, Wisconsin, Forenede Stater, 54017
        • Suspenderet
        • Cancer Center of Western Wisconsin
      • Oconomowoc, Wisconsin, Forenede Stater, 53066
        • Rekruttering
        • ProHealth Oconomowoc Memorial Hospital
        • Ledende efterforsker:
          • Timothy R. Wassenaar
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 262-928-7878
      • Oshkosh, Wisconsin, Forenede Stater, 54904
        • Rekruttering
        • ThedaCare Cancer Care - Oshkosh
        • Kontakt:
        • Ledende efterforsker:
          • Matthias Weiss
      • Rice Lake, Wisconsin, Forenede Stater, 54868
      • Shawano, Wisconsin, Forenede Stater, 54166
        • Rekruttering
        • ThedaCare Cancer Care - Shawano
        • Kontakt:
        • Ledende efterforsker:
          • Matthias Weiss
      • Stevens Point, Wisconsin, Forenede Stater, 54482
      • Waukesha, Wisconsin, Forenede Stater, 53188
        • Rekruttering
        • ProHealth Waukesha Memorial Hospital
        • Ledende efterforsker:
          • Timothy R. Wassenaar
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 262-928-7632
      • Waukesha, Wisconsin, Forenede Stater, 53188
        • Rekruttering
        • UW Cancer Center at ProHealth Care
        • Ledende efterforsker:
          • Timothy R. Wassenaar
        • Kontakt:
      • Waupaca, Wisconsin, Forenede Stater, 54981
        • Rekruttering
        • ThedaCare Cancer Care - Waupaca
        • Kontakt:
        • Ledende efterforsker:
          • Matthias Weiss
      • Weston, Wisconsin, Forenede Stater, 54476
    • Wyoming
      • Cheyenne, Wyoming, Forenede Stater, 82001
        • Suspenderet
        • Cheyenne Regional Medical Center-West
      • Cody, Wyoming, Forenede Stater, 82414
        • Suspenderet
        • Billings Clinic-Cody
      • Sheridan, Wyoming, Forenede Stater, 82801
        • Suspenderet
        • Welch Cancer Center

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Berettigelseskriterier

De nøglekrav, som personer, der ønsker at deltage i et klinisk studie, skal opfylde eller de egenskaber, de skal have. Kvalifikationskriterier består af både inklusionskriterier (som er nødvendige for at en person kan deltage i undersøgelsen) og eksklusionskriterier (som forhindrer en person i at deltage). Typer af berettigelseskriterier omfatter, om en undersøgelse accepterer raske frivillige, har alders- eller aldersgruppekrav eller er begrænset af køn.

Aldre berettiget til at studere

18 år og ældre (Voksen, Ældre voksen)

Tager imod sunde frivillige

Ingen

Køn, der er berettiget til at studere

Alle

Beskrivelse

Inclusion Criteria:

  • Patient must have a pathologically-confirmed diagnosis of non-squamous, non-small cell lung cancer (NSCLC)

  • Patient must have advanced disease, defined as - either stage IV disease, stage IIIB disease not amenable to definitive multi-modality therapy, or recurrent disease after a prior diagnosis of stage I-III disease. All staging is via the American Joint Committee on Cancer (AJCC)/International Association for the Study of Lung Cancer (IASLC) 8th edition staging criteria

  • Patient must have somatic activating sensitizing mutation in EGFR (e.g. but not limited to Exon 19 deletion, L858R, E709X, G719X, exon 19 insertions, L861Q, S768I). Patients with non-sensitizing mutations in EGFR (EGFR exon 20 insertions) are not eligible. Test results originating from a Clinical Laboratory Improvement Act (CLIA)-certified or similarly accredited laboratory are acceptable; no specific assay is mandated. Plasma, cytology, or tumor tissue can be utilized for mutation testing

  • Patient must not have received any prior treatment with an anti-VEGF agent

    • NOTE: Prior treatment with an EGFR TKI is not allowed, however if a candidate for this study has already started osimertinib within 21 days prior to randomization, the exact osimertinib start date is known, and the patient had the required study baseline imaging completed prior to the osimertinib start date, the patient will be eligible

  • Patients that have received prior radiation therapy are eligible. Radiation (limited field stereotactic radiation or conventional radiation) must have been completed at least one week prior to study drug initiation and more extensive field radiation (i.e., whole-brain radiotherapy [WBRT]) must have been completed at least two weeks prior to drug initiation

  • Patient must not have any risk factors for anti-VEGF administration, specifically, hemoptysis, active cardiovascular disease, uncontrolled hypertension, significant proteinuria (screening urinalysis > 300 mg/dl) and tumor invading major blood vessels

  • Patient must have measurable disease. Baseline measurements of sites of disease must be obtained within 4 weeks prior to study randomization. If a potential target lesion is previously irradiated without subsequent growth and/or is radiated after the imaging from which baseline measurements are obtained, they cannot be included as target lesions, and additional target lesions are required to meet criteria for measurable disease

  • Patient must not have had any prior systemic treatment for metastatic disease

  • Patient must be ≥ 18 years of age

  • Patient must have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 2

  • Patient must not be pregnant or breast-feeding due to the potential harm to an unborn fetus and possible risk for adverse events in nursing infants with the treatment regimens being used

  • All females of childbearing potential must have a blood test or urine study within 14 days prior to randomization to rule out pregnancy

  • A female of childbearing potential is defined as any woman, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria: 1) has achieved menarche at some point, 2) has not undergone a hysterectomy or bilateral oophorectomy; or 3) has not been naturally postmenopausal (amenorrhea following cancer therapy does not rule out childbearing potential) for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months)

  • Patient of childbearing potential and sexually active males must not expect to conceive or father children by using accepted and effective method(s) of contraception or by abstaining from sexual intercourse for 2 weeks prior to the start of treatment, while on study treatment, and for

    • 6 weeks after the last dose of protocol treatment for female patients on the osimertinib (AZD9291) alone arm
    • 4 months after the last dose of protocol treatment for male patients on osimertinib (AZD9291) alone arm
    • 6 months after the last dose of protocol treatment for all patients on osimertinib (AZD9291) plus bevacizumab combination arm
    • NOTE: Female patients should also not breastfeed while on treatment and for 6 months after the last dose bevacizumab

  • Leukocytes >= 3,000/mcL (obtained =< 14 days prior to randomization)

  • Absolute neutrophil count >= 1,500/mcL (obtained =< 14 days prior to randomization)

  • Platelets >= 100,000/mcL (obtained =< 14 days prior to randomization)

  • Hemoglobin >= 9 g/dL (obtained =< 14 days prior to randomization)

  • Total bilirubin and creatinine =< 1.5 x institutional upper limit of normal (ULN) (obtained =< 14 days prior to randomization)

  • Aspartate aminotransferase (AST) (serum glutamic-oxaloacetic transaminase [SGOT])/alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase [SGPT]) =< 2.5 x institutional ULN (obtained =< 14 days prior to randomization)

  • Human immunodeficiency virus (HIV)-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months are eligible for this trial

  • For patients with evidence of chronic hepatitis B virus (HBV) infection, the HBV viral load must be undetectable on suppressive therapy, if indicated

  • Patients with a history of hepatitis C virus (HCV) infection must have been treated and cured. For patients with HCV infection who are currently on treatment, they are eligible if they have an undetectable HCV viral load

  • Patients with treated brain metastases are eligible if neurologically stable without glucocorticoid therapy after the stated washout period from radiation therapy (RT) or surgery provided the metastatic lesions are non-hemorrhagic

  • Patients with untreated brain metastases or leptomeningeal disease are eligible if the treating physician determines that immediate CNS specific treatment is not required provided the metastatic lesions are non-hemorrhagic and are neurologically stable without glucocorticoid therapy

  • Patients with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial

  • Patients with known history or current symptoms of cardiac disease, should have a clinical risk assessment of cardiac function using the New York Heart Association Functional Classification. To be eligible for this trial, patients should be class 2B or better

  • Patient must have the ability to understand and the willingness to sign a written informed consent document and comply with study requirements

  • Patient must not have had treatment with any investigational drug within five half-lives or 3 months (whichever is greater), prior to study initiation

  • Patient must not be currently receiving (or unable to stop use prior to receiving the first dose of study treatment) medications or herbal supplements known to be strong inducers of CYP3A4. For any patient currently receiving such inducers of CYP3A4, they must discontinue use prior to first dose of study treatment. All patients must try to avoid concomitant use of any medications, herbal supplements and/or ingestion of foods with known inducer effects on CYP3A4

  • Patient must not have any unresolved toxicities from prior therapy greater than Common Terminology Criteria for Adverse Events (CTCAE) grade 1 at the time of randomization, with the exception of alopecia and grade 2 prior platinum-therapy-related neuropathy

  • Patient must not have any evidence of severe or uncontrolled systemic diseases, including uncontrolled hypertension and active bleeding diatheses, which in the investigator's opinion makes it challenging for the patient to participate in the study. Screening for chronic conditions is not required

  • Patient must not have refractory nausea and vomiting, chronic gastrointestinal diseases, the inability to swallow the osimertinib tablets or previous significant bowel resection that would preclude adequate absorption of osimertinib

  • Patient must not have a medical history of interstitial lung disease, drug-induced interstitial lung disease, radiation pneumonitis which required steroid treatment, or any evidence of clinically active interstitial lung disease

  • Patient must not have a history of hypersensitivity to active or inactive excipients of osimertinib or drugs with a similar chemical structure or class to osimertinib

  • Patient must not have mean resting corrected QT interval (QTc) > 470 msec obtained from 3 electrocardiograms (ECGs), using the screening clinic ECG machine derived QTc value (using Bazett's correction)

  • Patient must not have any clinically important abnormalities in rhythm, conduction or morphology of resting ECG e.g. complete left bundle branch block, third degree heart block and second-degree heart block

  • Patient must not have any factors that increase the risk of QTc prolongation or risk of arrhythmic events such as heart failure, electrolyte abnormalities (including: potassium < lower limit of normal [LLN]; magnesium < LLN; calcium < LLN), congenital long QT syndrome, family history of long QT syndrome or unexplained sudden death under 40 years of age in first degree relatives or any concomitant medication known to prolong the QT interval and cause torsades de pointes

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

  • Primært formål: Behandling
  • Tildeling: Randomiseret
  • Interventionel model: Parallel tildeling
  • Maskning: Ingen (Åben etiket)

Våben og indgreb

Deltagergruppe / Arm

Deltagergruppe / Arm

En gruppe eller undergruppe af deltagere i et klinisk forsøg, der modtager en specifik intervention/behandling eller ingen intervention i henhold til forsøgets protokol.
Intervention / Behandling

Intervention / Behandling

En proces eller handling, der er i fokus for en klinisk undersøgelse. Interventioner omfatter lægemidler, medicinsk udstyr, procedurer, vacciner og andre produkter, der enten er til undersøgelse eller allerede er tilgængelige. Interventioner kan også omfatte ikke-invasive tilgange, såsom uddannelse eller ændring af kost og motion.
Aktiv komparator: Arm A (osimertinib)

Patients receive osimertinib PO QD on days 1-21. Cycles repeat every 21 days in the absence of disease progression or unacceptable toxicity. Patients undergo ECHO, MUGA, CT and may undergo MRI and blood and urine sample collection on study.
Procedure: Computed Tomography

Undergo CT

Andre navne:
  • CT
  • KAT
  • CAT-scanning
  • Beregnet aksial tomografi
  • Computerstyret aksial tomografi
  • Computerstyret tomografi
  • CT-scanning
  • tomografi
  • Computerstyret aksial tomografi (procedure)
  • Computerstyret tomografi (CT) scanning
  • Diagnostisk CAT -scanning
  • Diagnostic CAT Scan Service Type
Procedure: Magnetic Resonance Imaging

Undergo MRI

Andre navne:
  • MR
  • Magnetisk resonans
  • Magnetisk resonansbilledscanning
  • Medicinsk billeddannelse, magnetisk resonans / kernemagnetisk resonans
  • HR
  • MR billeddannelse
  • MR-scanning
  • NMR billeddannelse
  • NMRI
  • Kernemagnetisk resonansbilleddannelse
  • Magnetisk resonansbilleddannelse (MRI)
  • sMRI
  • Magnetisk resonansbilleddannelse (procedure)
  • MRI'er
  • Strukturel MR
Procedure: Echocardiography Test

Undergo ECHO

Andre navne:
  • Ekkokardiografi
  • EC
Procedure: Multigated Acquisition Scan

Undergo MUGA

Andre navne:
  • Blood Pool Scan
  • Ligevægtsradionuklidangiografi
  • Gated Blood Pool Imaging
  • MUGA
  • Radionuklid ventrikulografi
  • RNVG
  • SYMA-scanning
  • Synkroniseret Multigated Acquisition Scanning
  • MUGA Scan
  • Multi-Gated Acquisition Scan
  • Radionuklid Ventrikulogram Scan
  • Gated Heart Pool Scan
  • RNV Scan
Medicin: Osimertinib

Given PO

Andre navne:
  • AZD-9291
  • AZD9291
  • Mereletinib
  • AZD 9291
Procedure: Biospecimen Collection

Undergo blood and urine sample collection

Andre navne:
  • Biologisk prøvesamling
  • Bioprøve indsamlet
  • Prøvesamling
  • Prøvekollektion
Eksperimentel: Arm B (osimertinib, bevacizumab)

Patients receive osimertinib PO QD on days 1-21 and bevacizumab IV over 30-90 minutes on day 1. Cycles repeat every 21 days in the absence of disease progression or unacceptable toxicity. Patients undergo ECHO, MUGA, CT and may undergo MRI and blood and urine sample collection on study.
Biologisk: Bevacizumab

Given IV

Andre navne:
  • Avastin
  • ABP 215
  • Anti-VEGF
  • Anti-VEGF humaniseret monoklonalt antistof
  • Anti-VEGF monoklonalt antistof SIBP04
  • Anti-VEGF rhuMAb
  • Bevacizumab awwb
  • Bevacizumab Biosimilar ABP 215
  • Bevacizumab Biosimilar BEVZ92
  • Bevacizumab Biosimilar BI 695502
  • Bevacizumab Biosimilar CBT 124
  • Bevacizumab Biosimilar CT-P16
  • Bevacizumab Biosimilar FKB238
  • Bevacizumab Biosimilar GB-222
  • Bevacizumab Biosimilar HD204
  • Bevacizumab Biosimilar HLX04
  • Bevacizumab Biosimilar IBI305
  • Bevacizumab Biosimilar LY01008
  • Bevacizumab Biosimilar MIL60
  • Bevacizumab Biosimilar Mvasi
  • Bevacizumab Biosimilar MYL-1402O
  • Bevacizumab Biosimilar QL 1101
  • Bevacizumab Biosimilar RPH-001
  • Bevacizumab Biosimilar SCT501
  • Bevacizumab Biosimilar Zirabev
  • Bevacizumab-awwb
  • Bevacizumab-bvzr
  • BP102
  • BP102 Biosimilar
  • HD204
  • Immunoglobulin G1 (human-mus monoklonal rhuMab-VEGF gammakæde anti-human vaskulær endotelvækstfaktor), disulfid med human-mus monoklonal rhuMab-VEGF let kæde, dimer
  • Mvasi
  • MYL-1402O
  • Rekombinant humaniseret anti-VEGF monoklonalt antistof
  • rhuMab-VEGF
  • SCT501
  • SIBP 04
  • SIBP-04
  • SIBP04
  • Zirabev
  • Avegra
  • QL1101
  • IBI305
  • Byvasda
  • Bevacizumab Biosimilar QL1101
  • BAT1706
  • BAT 1706
  • BAT-1706
  • BAT1706 Biosimilar
  • Bevacizumab Biosimilar BAT1706
  • Bevacizumab-adcd
  • CT-P16
  • Vegzelma
  • Alymsys
  • ABP-215
  • ABP215
  • Aybintio
  • Bevacizumab-aybi
  • Bevacizumab-equi
  • Bevacizumab-maly
  • Bevacizumab-onbe
  • CT P16
  • CTP16
  • Ensartet
  • Onbevzi
  • Avzivi
  • Bevacizumab Biosimilar MB02
  • Bevacizumab-tnjn
  • FKB 238
  • FKB-238
  • FKB238
  • MB 02
  • MB-02
  • MB02
  • Oyavas
  • PF 06439535
  • PF-06439535
  • PF06439535
  • Bevacizumab-aveg
  • Bevacizumab-byva
  • Bevacizumab-nwgd
  • Jobevne
  • IBI 305
  • IBI-305
Procedure: Computed Tomography

Undergo CT

Andre navne:
  • CT
  • KAT
  • CAT-scanning
  • Beregnet aksial tomografi
  • Computerstyret aksial tomografi
  • Computerstyret tomografi
  • CT-scanning
  • tomografi
  • Computerstyret aksial tomografi (procedure)
  • Computerstyret tomografi (CT) scanning
  • Diagnostisk CAT -scanning
  • Diagnostic CAT Scan Service Type
Procedure: Magnetic Resonance Imaging

Undergo MRI

Andre navne:
  • MR
  • Magnetisk resonans
  • Magnetisk resonansbilledscanning
  • Medicinsk billeddannelse, magnetisk resonans / kernemagnetisk resonans
  • HR
  • MR billeddannelse
  • MR-scanning
  • NMR billeddannelse
  • NMRI
  • Kernemagnetisk resonansbilleddannelse
  • Magnetisk resonansbilleddannelse (MRI)
  • sMRI
  • Magnetisk resonansbilleddannelse (procedure)
  • MRI'er
  • Strukturel MR
Procedure: Echocardiography Test

Undergo ECHO

Andre navne:
  • Ekkokardiografi
  • EC
Procedure: Multigated Acquisition Scan

Undergo MUGA

Andre navne:
  • Blood Pool Scan
  • Ligevægtsradionuklidangiografi
  • Gated Blood Pool Imaging
  • MUGA
  • Radionuklid ventrikulografi
  • RNVG
  • SYMA-scanning
  • Synkroniseret Multigated Acquisition Scanning
  • MUGA Scan
  • Multi-Gated Acquisition Scan
  • Radionuklid Ventrikulogram Scan
  • Gated Heart Pool Scan
  • RNV Scan
Medicin: Osimertinib

Given PO

Andre navne:
  • AZD-9291
  • AZD9291
  • Mereletinib
  • AZD 9291
Procedure: Biospecimen Collection

Undergo blood and urine sample collection

Andre navne:
  • Biologisk prøvesamling
  • Bioprøve indsamlet
  • Prøvesamling
  • Prøvekollektion

Hvad måler undersøgelsen?

Primære resultatmål

Primære resultatmål

I et klinisk studies protokol er det planlagte resultatmål, der er det vigtigste for at evaluere effekten af ​​en intervention/behandling. De fleste kliniske undersøgelser har ét primært resultatmål, men nogle har mere end ét.
Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Progression-free survival (PFS)
Tidsramme: From randomization to documented disease progression per Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 or death from any cause, whichever occurs first, assessed up to 10 years

Will be estimated using the Kaplan-Meier method, and Cox proportional hazards models will be used to estimate the treatment hazard ratios. PFS will use a logrank test stratified on the randomization stratification factors with a one-sided type I error rate of 2.5%.
From randomization to documented disease progression per Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 or death from any cause, whichever occurs first, assessed up to 10 years

Sekundære resultatmål

Sekundære resultatmål

I en klinisk undersøgelses protokol er et planlagt resultatmål, der ikke er lige så vigtigt som det primære resultatmål for at evaluere effekten af ​​en intervention, men som stadig er af interesse. De fleste kliniske undersøgelser har mere end ét sekundært resultatmål.
Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Overall survival (OS)
Tidsramme: From randomization to death from any cause, assessed up to 10 years

Will be estimated using the Kaplan-Meier method, and Cox proportional hazards models will be used to estimate the treatment hazard ratios. OS will be tested at the one-sided 10% level.
From randomization to death from any cause, assessed up to 10 years
Best objective response rate
Tidsramme: Up to 10 years

Best objective response will be evaluated via RECIST 1.1 criteria. Will be compared using Fisher's exact tests with a one-sided type I error rate of 2.5%; multivariable logistic regression modeling will be used to adjust for the effect of any covariates that are associated with these categorical outcomes.
Up to 10 years
Time to central nervous system progression
Tidsramme: From study randomization to evidence of central nervous system progressive disease, with death and progression as competing events, assessed up to 10 years

Will be estimated using competing risks methodology, adjusting for death and progression as competing events. Regular central nervous system imaging will occur when patients are on treatment. After they discontinue study treatment, central nervous system imaging will be symptom-prompted during follow up.
From study randomization to evidence of central nervous system progressive disease, with death and progression as competing events, assessed up to 10 years
Central nervous system progression-free survival
Tidsramme: From study randomization to evidence of central nervous system progressive disease or death from any cause, whichever occurs first, assessed up to 10 years

Will be estimated using the Kaplan-Meier method.
From study randomization to evidence of central nervous system progressive disease or death from any cause, whichever occurs first, assessed up to 10 years
Incidence of adverse events
Tidsramme: Up to 30 days after the last administration of investigational agent

Toxicity will be determined using the Common Terminology Criteria for Adverse Events (CTCAE). Will be compared using Fisher's exact tests with a one-sided type I error rate of 2.5%; multivariable logistic regression modeling will be used to adjust for the effect of any covariates that are associated with these categorical outcomes.
Up to 30 days after the last administration of investigational agent

Andre resultatmål

Andre resultatmål

For kliniske forsøg en planlagt måling beskrevet i protokollen, der bruges til at bestemme effekten af ​​en intervention/behandling på deltagerne. Til observationsstudier, en måling eller observation, der bruges til at beskrive mønstre af sygdomme eller egenskaber eller sammenhænge med eksponeringer, risikofaktorer eller behandling. Typer af resultatmål omfatter primært resultatmål og sekundært resultatmål.
Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Mechanisms of resistance to AZD9291 (osimertinib) and AZD9291 (osimertinib) with bevacizumab first-line therapy through post-progression circulating tumor-derived deoxyribonucleic acid (ctDNA)
Tidsramme: Up to 10 years

Preliminary analyses of these data will utilize tests for association comparing the frequency of a particular genomic aberration at baseline and at progression (for example, using McNemar's test) and association between alterations and baseline characteristics (for example, using Fisher's exact test). More sophisticated analyses may include multivariable logistic regression modeling and/or competing risks analysis.
Up to 10 years
Circulating tumor deoxyribonucleic acid (ctDNA) clearance on study treatment
Tidsramme: Up to 10 years

Will assess ctDNA clearance on study treatment and associate ctDNA clearance with clinical outcomes. Cox regression analysis will be used to assess whether EGFR ctDNA clearance is an independent predictor for PFS (and OS), adjusted by treatment effect, the presence of brain metastasis (yes versus [vs.] no), EGFR exon 19 deletion/L858R vs other, Eastern Cooperative Oncology Group (ECOG) performance status (0-1 vs 2) and other possible clinical and biological risk factors.
Up to 10 years

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

Sponsor

Den organisation eller person, der igangsætter undersøgelsen, og som har myndighed og kontrol over undersøgelsen.
National Cancer Institute (NCI)

Efterforskere

Efterforskere

En forsker involveret i et klinisk studie. Beslægtede termer omfatter stedets principal investigator, site sub-investigator, studieformand, undersøgelsesleder og undersøgelseshovedinvestigator.
  • Ledende efterforsker: Helena A Yu, ECOG-ACRIN Cancer Research Group

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart (Faktiske)

Studiestart

Den faktiske dato, hvor den første deltager blev tilmeldt en klinisk undersøgelse. Den "forventede" undersøgelses startdato er den dato, som forskerne tror vil være undersøgelsens startdato.
28. december 2020

Primær færdiggørelse (Anslået)

Primær færdiggørelse

Den dato, hvor den sidste deltager i et klinisk studie blev undersøgt eller modtog en intervention for at indsamle endelige data for det primære resultatmål. Hvorvidt det kliniske studie sluttede i henhold til protokollen eller blev afsluttet, påvirker ikke denne dato. For kliniske undersøgelser med mere end ét primært resultatmål med forskellige afslutningsdatoer refererer dette udtryk til den dato, hvor dataindsamlingen er afsluttet for alle de primære resultatmål. Den "forventede" primære afslutningsdato er den dato, som forskerne tror vil være den primære afslutningsdato for undersøgelsen.
30. juni 2029

Studieafslutning (Anslået)

Studieafslutning

Den dato, hvor den sidste deltager i et klinisk studie blev undersøgt eller modtog en intervention/behandling for at indsamle endelige data for de primære resultatmål, sekundære udfaldsmål og uønskede hændelser (det vil sige den sidste deltagers sidste besøg). Den "forventede" undersøgelses afslutningsdato er den dato, som forskerne tror vil være undersøgelsens afslutningsdato.
30. juni 2029

Datoer for studieregistrering

Først indsendt

Først indsendt

Den dato, hvor undersøgelsens sponsor eller investigator første gang indsendte en undersøgelsespost til ClinicalTrials.gov. Der er typisk en forsinkelse på et par dage mellem den første indsendte dato og postens tilgængelighed på ClinicalTrials.gov (den første offentliggjorte dato).
27. november 2019

Først indsendt, der opfyldte QC-kriterier

Først indsendt, der opfyldte QC-kriterier

Den dato, hvor undersøgelsens sponsor eller investigator første gang indsender en undersøgelsespost, der er i overensstemmelse med National Library of Medicine (NLM) kvalitetskontrol (QC) gennemgangskriterier. Sponsoren eller investigatoren skal muligvis revidere og indsende en undersøgelsespost en eller flere gange, før NLM's kvalitetskontrolkriterier er opfyldt. Det er sponsorens eller investigatorens ansvar at sikre, at undersøgelsesposten er i overensstemmelse med NLM QC-gennemgangskriterierne.
27. november 2019

Først opslået (Faktiske)

Først opslået

Datoen, hvor undersøgelsesposten først var tilgængelig på ClinicalTrials.gov efter National Library of Medicine (NLM) kvalitetskontrol (QC) gennemgang er afsluttet. Der er typisk en forsinkelse på et par dage mellem den dato, hvor undersøgelsens sponsor eller investigator indsendte undersøgelsesposten, og den første offentliggjorte dato.
29. november 2019

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

Sidste opdatering sendt

Den seneste dato, hvor ændringer i en undersøgelsespost blev gjort tilgængelig på ClinicalTrials.gov. Der kan være en forsinkelse mellem det tidspunkt, hvornår ændringerne blev indsendt til ClinicalTrials.gov af undersøgelsens sponsor eller investigator (datoen for sidste opdatering afsendt) og den sidste opdatering, der blev sendt.
4. november 2026

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

Den seneste dato, hvor undersøgelsens sponsor eller investigator indsendte ændringer til en undersøgelsespost, der er i overensstemmelse med National Library of Medicine (NLM) kvalitetskontrol (QC) gennemgangskriterier. Det er sponsorens eller investigatorens ansvar at sikre, at undersøgelsesposten er i overensstemmelse med NLM QC-gennemgangskriterierne.
3. november 2026

Sidst verificeret

Sidst verificeret

Den seneste dato, hvor undersøgelsens sponsor eller investigator bekræftede oplysningerne om en klinisk undersøgelse på ClinicalTrials.gov som nøjagtige og aktuelle. Hvis en undersøgelse med rekrutteringsstatus som rekruttering; rekrutterer endnu ikke; eller aktiv, ikke rekruttering er ikke blevet bekræftet inden for de seneste 2 år, er undersøgelsens rekrutteringsstatus vist som ukendt.
1. september 2026

Mere information

Begreber relateret til denne undersøgelse

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

Andre undersøgelses-id-numre

Andre identifikatorer eller ID-numre end NCT-nummeret, der er tildelt til en klinisk undersøgelse af undersøgelsens sponsor, finansieringsgivere eller andre. Disse numre kan omfatte unikke identifikatorer fra andre forsøgsregistre og National Institutes of Health-bevillingsnumre.
  • NCI-2019-07941
  • U10CA180820 (U.S. NIH-bevilling/kontrakt)
  • NCI-2019-07941 (Registry Identifier: CTRP (Clinical Trial Reporting Program))
  • EA5182 (Anden identifikator: CTEP)
  • EA5182 (Anden identifikator: ECOG-ACRIN Cancer Research Group)

Plan for individuelle deltagerdata (IPD)

Planlægger du at dele individuelle deltagerdata (IPD)?

JA

IPD-planbeskrivelse

NCI is committed to sharing data in accordance with NIH policy. For more details on how clinical trial data is shared, access the link to the NIH data sharing policy page.

Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter

Studerer et amerikansk FDA-reguleret lægemiddelprodukt

Ja

Studerer et amerikansk FDA-reguleret enhedsprodukt

Ingen

Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .

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