Orelabrutinib Combined With Pola-R-CHP as First-Line Treatment for Patients With Intermediate- to High-Risk DLBCL

Inclusion Criteria:

1. Aged ≥ 18 years;
2. Pathologically confirmed diffuse large B-cell lymphoma (DLBCL) by tumor tissue, with at least one measurable lesion, including DLBCL, not otherwise specified (GCB and non-GCB subtypes), DLBCL with MYC and BCL-2 rearrangements, and high-grade B-cell lymphoma;
3. No prior receipt of other anti-tumor treatments;
4. ECOG performance status 0-2;
5. IPI score 2-5, and patients with stage III-IV disease;
6. Life expectancy ≥ 6 months;
7. Voluntarily sign a written informed consent form.

Exclusion Criteria:

1. Lymphoma involving the central nervous system or leptomeningeal metastasis;
2. Transformed lymphoma, i.e., transformed from other types of lymphoma, such as follicular lymphoma, marginal zone lymphoma, chronic lymphocytic leukemia, or small B-cell lymphoma;
3. Primary mediastinal large B-cell lymphoma;
4. Burkitt lymphoma;
5. Left ventricular ejection fraction < 50%;

6. Laboratory test values at screening: (unless caused by lymphoma);

   1. Neutrophils < 1.5×10⁹/L;
   2. Platelets < 75×10⁹/L;
   3. ALT or AST higher than 2 times the upper limit of normal, AKP and bilirubin higher than 1.5 times the upper limit of normal;
   4. Creatinine level higher than 1.5 times the upper limit of normal;
7. Patients with psychiatric disorders or other patients who are known or suspected to be unable to fully comply with the study protocol;
8. Pregnant or lactating women;
9. Known infection with human immunodeficiency virus (HIV), or active hepatitis B or C virus infection (positive result by polymerase chain reaction [PCR]). If a patient has a positive HBsAg test result, HBV DNA testing is required. If HBV DNA < 10³ IU/ml, the patient can be enrolled. If the HBsAg test result is negative, but the HBcAb test is positive (regardless of HBsAb status), HBV DNA testing is also required. If HBV DNA < 10³ IU/ml, the patient can be enrolled. If a patient is HCV antibody positive, HCV RNA is detected by PCR technology, and a positive result meets the exclusion criterion;
10. Need for continuous treatment with strong or moderate CYP3A inhibitors or CYP3A inducers;
11. nability to swallow capsules or presence of diseases that significantly affect gastrointestinal function, such as malabsorption syndrome, bariatric surgery, inflammatory bowel disease, or partial or complete intestinal obstruction;
12. Other concurrent and uncontrolled medical conditions that the investigator deems will affect the patient's participation in the study.