- ICH GCP
- US Clinical Trials Registry
- Klinisk forsøg NCT01031394
Frequency of Aerobic/Resistance Training in Older Women (SWEET)
Studieoversigt
Status
Betingelser
Intervention / Behandling
Detaljeret beskrivelse
Frequency of aerobic/resistance training in older women
Abstract Combined aerobic and resistance training have unique benefits for maintaining a physical activity (PA). However, the optimal training program for combining these two modes of training in older adults is unknown. This study builds on current and past studies showing that training induced gains in aerobic fitness, muscle strength, and ease of PA are important for maintaining an active lifestyle, a favorable body composition, and high bone density. Traditionally 3 d/wk combined training has been felt to be optimal while recent studies suggest 1 d/wk combined training may create similar adaptations as more frequent training. However, our previous and ongoing studies suggest that 1 d/wk combined aerobic and resistance training (C1) may be insufficient stimulus to induce optimal adaptations and that 3 d/wk combined training (C3) may be too frequent a stimulus for older adults. This study will enable us to compare the effects of C1, 2 d/wk combined training (C2), and C3 on fitness, body composition, ease of PA, PA, and total free-living energy expenditure (TEE). We hypothesize that C2 will result in a larger increase in muscle size, bone density, strength, aerobic capacity, power, ease of PA, PA, and TEE than either C1 or C3. Circulating cytokines and psychological mood states linked to chronic overstress will also be examined. Objectives: We will examine changes in circulating cytokines, mood states, muscle size, bone density, aerobic capacity, strength, power, ease of PA, PA, and TEE following 16 and 32 wks training. Design: We will to evaluate 78 (>60 yrs) Black and White women matched for age, race, and BMI into C1, C2, or C3 groups prior to, after 16, and after 32 wks training. Women will undergo evaluation of metabolic parameters in a General Clinical Research Center. Significance: This study should provide insight into the effects combined training frequency has on improving fitness, ease of PA, and maintenance of a high TEE. Such information is critical to our understanding of ways to improve well being, quality of life, and independence of an aging population.
Undersøgelsestype
Tilmelding (Faktiske)
Fase
- Ikke anvendelig
Kontakter og lokationer
Studiesteder
-
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Alabama
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Birmingham, Alabama, Forenede Stater, 35294
- UAB
-
-
Deltagelseskriterier
Berettigelseskriterier
Aldre berettiget til at studere
Tager imod sunde frivillige
Køn, der er berettiget til at studere
Beskrivelse
Inclusion Criteria:,
- healthy women over 60 years of age,
- Caucasian or African-American.
Exclusion Criteria:
- smoking,
- diabetes,
- osteoporosis,
- inability to coperform weight bearing exercises, currently performing to much exercise.
Studieplan
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
- Primært formål: Behandling
- Tildeling: Randomiseret
- Interventionel model: Parallel tildeling
- Maskning: Enkelt
Våben og indgreb
Deltagergruppe / Arm |
Intervention / Behandling |
---|---|
Aktiv komparator: Group 1
1 aerobic and 1 resistance training per week
|
comparing group results based upon frequency of exercise
Andre navne:
|
Aktiv komparator: Group 2
2 aerobic and 2 resistance training each per week
|
comparing group results based upon frequency of exercise
Andre navne:
|
Aktiv komparator: Group 3
3 aerobic and 3 resistance training per week
|
comparing group results based upon frequency of exercise
Andre navne:
|
Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Tidsramme |
---|---|
Use a repeated measures analysis to compare differences in TEE and other parameters among the 3 intervention groups across time
Tidsramme: over 32 weeks of training
|
over 32 weeks of training
|
Samarbejdspartnere og efterforskere
Samarbejdspartnere
Publikationer og nyttige links
Generelle publikationer
- Martins C, Gower B, Hunter GR. Metabolic adaptation after combined resistance and aerobic exercise training in older women. Obesity (Silver Spring). 2022 Jul;30(7):1453-1461. doi: 10.1002/oby.23450. Epub 2022 Jun 21.
- Carter SJ, Baranauskas MN, Singh H, Martins C, Hunter GR. ARTE index revisited: linking biomarkers of cardiometabolic health with free-living physical activity in postmenopausal women. Am J Physiol Regul Integr Comp Physiol. 2022 Apr 1;322(4):R292-R298. doi: 10.1152/ajpregu.00075.2021. Epub 2022 Jan 26.
Datoer for undersøgelser
Studer store datoer
Studiestart
Primær færdiggørelse (Faktiske)
Studieafslutning (Faktiske)
Datoer for studieregistrering
Først indsendt
Først indsendt, der opfyldte QC-kriterier
Først opslået (Skøn)
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Skøn)
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
Sidst verificeret
Mere information
Begreber relateret til denne undersøgelse
Nøgleord
Andre undersøgelses-id-numre
- F050820002
- R01AG027084 (U.S. NIH-bevilling/kontrakt)
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