Could Meditation Modulate the Neurobiology of Learning Not to Fear?
4. maj 2012 opdateret af: Britta Holzel, Massachusetts General Hospital
Effects of Mindfulness Practice on the Neural Circuitry of Conditioned Fear Extinction in Healthy Participants
It is well-established that the practice of mindfulness meditation leads to improvements in mental health and well-being and the cultivation of positive emotions.
However, the neural mechanisms of these improvements are largely unknown.
A few recent studies suggest that mindfulness meditation impacts the structure and function of the ventromedial prefrontal cortex, the hippocampus, and the amygdala.
Interestingly, recent studies have shown that these regions are part of a brain circuit that is critical for the extinction of conditioned fear responses, and for the retention of fear extinction memory.
Building on the overlap of these regions and on conceptual considerations, the project investigates whether mindfulness meditation could influence one's capacity to retain the memory of fear extinction.
Meditation-naïve participants will be randomized to either a mindfulness-meditation based training or an active control training that controls for all mindfulness-unspecific components.
Participants will undergo a fear conditioning, extinction and extinction recall protocol in an MRI scanner before and after the trainings.
We hypothesize that participants who have practiced mindfulness meditation will show greater improvements in fear extinction memory after the course, and that these improvements will be correlated with anatomical and functional changes in the brain regions of interest.
Improvements in fear extinction memory will also be related to improvements in self-reported psychological well-being.
Merging the fields of an ancient spiritual tradition and a fundamental learning mechanism, the project investigates the underlying neural mechanisms of a practice for the enhancement of mental health and well-being.
Studieoversigt
Status
Afsluttet
Betingelser
Intervention / Behandling
Undersøgelsestype
Interventionel
Tilmelding (Faktiske)
85
Fase
- Ikke anvendelig
Kontakter og lokationer
Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.
Studiesteder
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Massachusetts
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Charlestown, Massachusetts, Forenede Stater, 02129
- Massachusetts General Hospital
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Deltagelseskriterier
Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.
Berettigelseskriterier
Aldre berettiget til at studere
18 år til 65 år (Voksen, Ældre voksen)
Tager imod sunde frivillige
Ja
Køn, der er berettiget til at studere
Alle
Beskrivelse
Inclusion Criteria:
18-65 years of age Proficient in English Right-handed Free of medication that affect cerebral metabolism Able to give informed consent High stress level (defined as a score of >= 3 on the 4-item Perceived Stress Scale).
Exclusion Criteria:
More than 10 meditation sessions of any tradition in their lifetime, or more than 5 sessions within the last year.
More than 10 yoga sessions of any tradition in their lifetime, or more than 5 sessions within the last year.
History of neurologic or psychiatric disease, substance abuse or dependence that is current or within the last year.
Major/chronic medical conditions History of head injury resulting in prolonged loss of consciousness and/or neurological sequelae History of seizures History of stroke Prior neurosurgical procedure Metal in the body, metal injury to the eyes Implanted pacemaker, medication pump, vagal stimulator, deep brain stimulator, TENS unit, or ventriculo-peritoneal shunt Pregnancy; breastfeeding or nursing Claustrophobia Weight > 350 lbs.
Studieplan
Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
- Primært formål: Grundvidenskab
- Tildeling: Randomiseret
- Interventionel model: Parallel tildeling
- Maskning: Ingen (Åben etiket)
Våben og indgreb
Deltagergruppe / Arm |
Intervention / Behandling |
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Eksperimentel: Mindfulness-Based Stress Reduction course
an eight week mindfulness-based stress reduction course
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an eight-week mindfulness-based stress reduction course
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Ingen indgriben: Waitlist group
waitlist group
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Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
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change in MRI data
Tidsramme: pre and post intervention or wait period; first set of MRIs within 3 weeks before the course, second set of MRIs within 3 weeks after course; MRIs will take 1.5 hours each and will occur on 2 consecutive days
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We will measure the change in functional MRI during fear conditioning, extinction, and extinction retention memory pre to post intervention.
Furthermore, we will measure changes in structural MRI data, DTI data and resting state fMRI data.
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pre and post intervention or wait period; first set of MRIs within 3 weeks before the course, second set of MRIs within 3 weeks after course; MRIs will take 1.5 hours each and will occur on 2 consecutive days
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Sekundære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
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change in well-being
Tidsramme: pre and post intervention or waitlist period; collected when the MRIs take place; will take about one hour each
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questionnaire data will also be collected pre and post the intervention / wait period; change in the scores will be assessed
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pre and post intervention or waitlist period; collected when the MRIs take place; will take about one hour each
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Samarbejdspartnere og efterforskere
Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.
Sponsor
Samarbejdspartnere
Efterforskere
- Ledende efterforsker: Britta K Holzel, PhD, Massachusetts General Hospital
- Ledende efterforsker: Mohammed R Milad, PhD, Massachusetts General Hospital
Publikationer og nyttige links
Den person, der er ansvarlig for at indtaste oplysninger om undersøgelsen, leverer frivilligt disse publikationer. Disse kan handle om alt relateret til undersøgelsen.
Hjælpsomme links
Datoer for undersøgelser
Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.
Studer store datoer
Studiestart
1. december 2010
Primær færdiggørelse (Faktiske)
1. maj 2012
Studieafslutning (Faktiske)
1. maj 2012
Datoer for studieregistrering
Først indsendt
17. marts 2011
Først indsendt, der opfyldte QC-kriterier
21. marts 2011
Først opslået (Skøn)
23. marts 2011
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Skøn)
7. maj 2012
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
4. maj 2012
Sidst verificeret
1. maj 2012
Mere information
Begreber relateret til denne undersøgelse
Nøgleord
Andre undersøgelses-id-numre
- 2010-P-002025
Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .
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