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A Retrospective Study on Clinical Characteristics and Outcomes of Patients With Pneumonia

5. maj 2026 opdateret af: Zhonghao Fang
Retrospective Analysis of Clinical Characteristics and Prognostic Factors in Hospitalized Pneumonia Patients from April 2023 to April 2026. Background: Pneumonia remains the leading cause of death from infectious diseases in adults worldwide, with an increasingly severe disease burden exacerbated by population aging and the frequent emergence of drug-resistant bacteria; in China, severe pneumonia accounts for a striking 13.58% to 20.05% of hospitalized cases. In recent years, shifts in the pathogen spectrum (e.g., COVID-19, influenza A) and patient demographic characteristics have posed new challenges for clinical management. However, existing studies mostly focus on single pathogens or specific populations (e.g., ICU patients), lacking systematic analyses of the full-disease course characteristics of general hospitalized pneumonia patients. Furthermore, in the post-pandemic era, the clinical phenotypes, treatment responses, and prognostic factors of pneumonia may have evolved, necessitating evidence-based support from real-world data. This study aims to conduct a retrospective analysis to clarify the epidemiological characteristics, etiological distribution, and prognostic factors influencing current hospitalized pneumonia patients, thereby providing a basis for optimizing diagnosis and treatment strategies.

Studieoversigt

Status

Ikke rekrutterer endnu

Betingelser

Undersøgelsestype

Observationel

Tilmelding (Anslået)

500

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiekontakt

  • Navn: Liang Peng, Doctor
  • Telefonnummer: 86-020-85959142
  • E-mail: pl_206@126.com

Studiesteder

  • Kina
      • Guangzhou, Kina
        • Fifth Affiliated Hospital of Guangzhou Medical University
        • Kontakt:
          • Liang Peng, Doctor
          • Telefonnummer: 86-020-85959142
          • E-mail: pl_206@126.com

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

  • Voksen
  • Ældre voksen

Tager imod sunde frivillige

Ingen

Prøveudtagningsmetode

Ikke-sandsynlighedsprøve

Studiebefolkning

From April 2023 to April 2026, all adult patients who were hospitalized due to pneumonia and met the diagnostic criteria

Beskrivelse

Inclusion Criteria:

  1. Age ≥ 18 years old;
  2. Meet the diagnostic criteria for pneumonia (acute onset + new infiltrates on imaging);
  3. Have a positive result from pathogen testing;
  4. Time from onset to admission ≤ 72 hours (to ensure being in the acute phase of the disease);

  5. Sign a written informed consent form.

    Inclusion criteria for the severe group:

    A diagnosis of "severe pneumonia" can be made if one of the main criteria or ≥ 3 of the secondary criteria are met.

    Main criteria:

    ① Tracheal intubation requiring mechanical ventilation

    ② Need for vasoactive drugs after active fluid resuscitation for septic shock

    Secondary criteria:

    • Respiratory rate ≥ 30 breaths/min

      • PaO₂/FiO₂ ≤ 250 mm Hg

        • Multiple lobe infiltrates

          • Confusion and/or disorientation ⑤ Blood urea nitrogen ≥ 20 mg/dL

            ⑥ Leukopenia (WBC < 4×10⁹/L)

            • Thrombocytopenia (PLT < 100×10⁹/L)

              • Decreased body temperature (central body temperature < 36 ℃) ⑨ Hypotension requiring fluid resuscitation

    Exclusion Criteria:

    • 1) Patients with severely lacking medical records;

2) Those whose main manifestations are other non-infectious diseases (such as pulmonary edema, lung cancer, pulmonary embolism, etc.); 3) Those whose main diagnosis is active pulmonary tuberculosis, non-infectious interstitial lung disease, etc.; 4) Patients considered not applicable by the researchers.

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Kohorter og interventioner

Gruppe / kohorte
pneumonia

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål
Tidsramme
28-day all-cause mortality rate
Tidsramme: 28 days after admission
28 days after admission

Sekundære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Demographic characteristics
Tidsramme: 28 days after admission
Demographic data (age, sex, etc.)
28 days after admission
Comorbidities
Tidsramme: 28 days after admission
Comorbidities, such as chronic obstructive pulmonary disease (COPD), diabetes mellitus, and cardiovascular diseases.
28 days after admission
Symptomatic manifestations
Tidsramme: 28 days after admission
Symptomatic manifestations (e.g., fever, cough, dyspnea)
28 days after admission
Laboratory tests
Tidsramme: 28 days after admission
Laboratory tests (including blood routine, liver and kidney function, etc.)
28 days after admission
Imaging Examination
Tidsramme: 28 days after admission
Imaging Examination: Radiological manifestations and image data from chest X-ray or CT scans
28 days after admission
ICU Length of Stay
Tidsramme: 28 days after admission
28 days after admission
Duration of Mechanical Ventilation
Tidsramme: 28 days after admission
28 days after admission
Length of Hospital Stay
Tidsramme: 28 days after admission
28 days after admission

Andre resultatmål

Resultatmål
Tidsramme
Utilization of Antimicrobial Agents
Tidsramme: 28 days after admission
28 days after admission
Clinical Outcomes (cured, improved, deceased)
Tidsramme: 28 days after admission
28 days after admission

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

Zhonghao Fang

Samarbejdspartnere

Fifth Affiliated Hospital of Guangzhou Medical University

Efterforskere

  • Studieleder: Zifeng Yang, The First Affiliated Hospital of Guangzhou Medical University

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart (Anslået)

1. april 2026

Primær færdiggørelse (Anslået)

1. oktober 2026

Studieafslutning (Anslået)

1. december 2026

Datoer for studieregistrering

Først indsendt

28. april 2026

Først indsendt, der opfyldte QC-kriterier

5. maj 2026

Først opslået (Faktiske)

8. maj 2026

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

8. maj 2026

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

5. maj 2026

Sidst verificeret

1. april 2026

Mere information

Begreber relateret til denne undersøgelse

Nøgleord

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

  • P-2026-003

Plan for individuelle deltagerdata (IPD)

Planlægger du at dele individuelle deltagerdata (IPD)?

INGEN

IPD-planbeskrivelse

Due to concerns over patient privacy and confidentiality issues, the individual patient data (IPD) cannot be shared.

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