A Study of ADH300004 in Surgically Resected Primary or Metastatic Colorectal Cancer and Liver Biopsy, or Planned Hepatic Resection

Inclusion Criteria:

• Signed written informed consent
• > or = 19 years of age

• Patients with histologically confirmed:

  • primary or metastatic (known or suspected) colorectal carcinoma requiring planned surgical resection with hepatic biopsy and systemic chemotherapy , or
  • primary or metastatic neoplastic disease within the liver from any origin requiring planned surgical resection and systemic chemotherapy
• Adequate performance status and organ function, as evidenced by hematological and biochemical blood testing

Exclusion Criteria:

• Lack of known or suspected metastatic disease in the liver
• Known DPD deficiency
• Severe infection
• Inability to take oral medication
• The need for treatment with any fluoropyrimidine within 8 weeks of any ADH300004 dose
• Stroke, major surgery, or other major tissue injury within 30 days before study entry