- ICH GCP
- Registre américain des essais cliniques
- Essai clinique NCT00005458
Suppressed Anger, Blood Pressure and Mortality Follow-up
Aperçu de l'étude
Statut
Description détaillée
DESIGN NARRATIVE:
The psychosocial data (e.g. anger-expression, stressful life events) and some medical data (e.g. blood pressure, smoking) were collected in 1971/72, while additional information about other medical risk factors was collected in 1968/69. Mortality ascertainment and cause of death was completed by the end of 1989, through TCHS staff, using the National Death Index (NDI). The estimated cumulative 18-year mortality rate as of 1989 for the Tecumseh cohort of the same age as the LCES sample was 26 percent for males and 16 percent for females. Approximately 144 deaths were expected. Out of the total TCHS cohort deaths, 35 percent were estimated to be due to CHD. Research questions tested included: (1) did suppressed anger predict coronary heart disease mortality as well as all-cause mortality; (2) was the relationship between suppressed anger and mortality modified by other risk factors (e.g. blood pressure, marital stress, gender); (3) were there certain anger-coping strategies among married couples which increased mortality risk for one or both members of the marital pair.
Analyses were done at three levels: for the whole sample, separately for males and females, and for a subgroup of 192 married couples it was done by 'pairs'. To determine univariate association between anger-coping types and all-cause mortality, the percent deceased was compared among persons grouped according to their anger responses. For the situation-specific and total suppressed anger indices, the distribution of scores was divided into thirds. The significance of each association was tested using chi-square statistics. Logistic regression was employed to test for the significance of the association between anger-coping measures and mortality controlling for sex, age, education, marital stress, relative weight, smoking, systolic blood pressure, CHD status, bronchitis, and FEV1 scores. Logistic regression was also used to determine whether any of the risk factors, particularly blood pressure, gender and marital stress, significantly modified the relationship between suppressed anger and mortality. The design and measures of this study had the potential to further identify specific person-situation characteristics associated with higher risks of total as well as cause specific mortality which then could be used to make more knowledgeable recommendations for health behavior interventions.
The study completion date listed in this record was obtained from the "End Date" entered in the Protocol Registration and Results System (PRS) record.
Type d'étude
Critères de participation
Critère d'éligibilité
Âges éligibles pour étudier
Accepte les volontaires sains
Sexes éligibles pour l'étude
La description
Plan d'étude
Comment l'étude est-elle conçue ?
Collaborateurs et enquêteurs
Dates d'enregistrement des études
Dates principales de l'étude
Début de l'étude
Achèvement de l'étude (Réel)
Dates d'inscription aux études
Première soumission
Première soumission répondant aux critères de contrôle qualité
Première publication (Estimation)
Mises à jour des dossiers d'étude
Dernière mise à jour publiée (Estimation)
Dernière mise à jour soumise répondant aux critères de contrôle qualité
Dernière vérification
Plus d'information
Termes liés à cette étude
Termes MeSH pertinents supplémentaires
Autres numéros d'identification d'étude
- 4902
- R01HL041796 (Subvention/contrat des NIH des États-Unis)
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