- ICH GCP
- Registre américain des essais cliniques
- Essai clinique NCT02208648
Coronary Assessment for Mortality Prediction (CAMP)
The study will investigate whether the presence of coronary artery calcium as demonstrated on pre-operative, thoracic staging Computed Tomography (CT) is an independent risk factor for 90 day mortality in patients undergoing major abdominal surgery.
The study research question: Do higher levels of coronary calcification correlate to an increased risk of post-operative mortality in patients undergoing major abdominal surgery?
Aperçu de l'étude
Statut
Les conditions
Description détaillée
The study uses a retrospective observational study design.
Due to the nature of the subject of the study and its retrospective design no patient contact will be necessary and all imaging reviewed will have been acquired as part of their routine level of care.
Plan for the gathering of study data
A list of patients with the following surgical codes will be identified from the hospital surgical performance database to create retrospective dataset of 5 years' worth of cases (to December 2013). This date range may be extended to ensure an adequate sample size. :
Surgical codes (Healthcare Resource Groups (HRG) codes) to be included:
F31 Large Intestine - Complex Procedures F32 Large Intestine - Very Major Procedures F33 Large Intestine - Major Procedures with complications and comorbidities (w cc) F34 Large Intestine - Major Procedures without complications and comorbidities (w/o cc) F36 Large Intestinal Disorders >69 or w cc F37 Large Intestinal Disorders <70 w/o cc
F41 General Abdominal - Very Major or Major Procedures patients over 69 years of age (>69) or w cc F42 General Abdominal - Very Major or Major Procedures patients under 70 years of age (<70) w/o cc F46 General Abdominal Disorders >69 or w cc F47 General Abdominal Disorders <70 w/o cc
Cross-reference with Somerset Cancer Register and remove any who were not recognised as having bowel cancer.
This patient list will be cross-referenced with records of peri-operative mortality (within 90 days)
Propensity match each deceased patient to a patient who survived beyond 90 days. Our matching rules will be in descending order of importance :
- HRG code
- gender,
- cancer staging
- Age+/-5yrs.
- American Society of Anesthesiologists (ASA) Grade
Where there are multiple potential matches then this will be resolved by consultation between the research team members.
Pairs of CT scans (deceased plus matched control) will be procured from WebPACS (Web Picture Archival Communication System).
Scans will be anonymised and stored on a dedicated secure radiology research server.
Abbreviated Calcium scores will be generated for all patients in the trial by a trained radiologist using the calcium scoring method. Calcium burden will be recorded on a scale of 1-12 . The radiologist will be blinded to the group that the patient belongs to, to minimise bias.
Scans (deceased patients and matched controls) will be analysed in batches of 30 pairs. Radiologist (s) will be blinded to group allocation. Scans will not be "paired" at the time of reading.
Interim statistical analysis (of calcium scores) will be performed after each batch of scans.
Type d'étude
Inscription (Réel)
Contacts et emplacements
Lieux d'étude
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Devon
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Plymouth, Devon, Royaume-Uni, PL6 8DH
- Plymouth Hospitals Nhs Trust
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Critères de participation
Critère d'éligibilité
Âges éligibles pour étudier
Accepte les volontaires sains
Sexes éligibles pour l'étude
Méthode d'échantillonnage
Population étudiée
La description
Inclusion Criteria:
- All adults ≥18yrs old
- Major abdominal surgery (See HRG Codes)
- Bowel Cancer
- Elective admission
Exclusion Criteria:
- <18 yrs old
- No suitable matched patient
- No CT Chest available
- Emergency admission
Plan d'étude
Comment l'étude est-elle conçue ?
Détails de conception
Cohortes et interventions
Groupe / Cohorte |
---|
Deceased
Peri-operative mortality (within 90 days).
Pairs of CT scans (deceased plus matched control) will be anonymised and stored on a secure server.
Abbreviated Calcium scores will be generated for all patients in the trial by a trained radiologist using a calcium scoring method.
The radiologist will be blinded to the group that the patient belongs to, to minimise bias.
Scans (deceased patients and matched controls) will be analysed in batches of 30 pairs.
Radiologist (s) will be blinded to group allocation.
Scans will not be "paired" at the time of reading.
|
Matched control
Patients who survived beyond 90 days peri-operatively.
Pairs of CT scans (deceased plus matched control) will be anonymised and stored on a secure server.
Abbreviated Calcium scores will be generated for all patients in the trial by a trained radiologist using a calcium scoring method.
The radiologist will be blinded to the group that the patient belongs to, to minimise bias.
Scans (deceased patients and matched controls) will be analysed in batches of 30 pairs.
Radiologist (s) will be blinded to group allocation.
Scans will not be "paired" at the time of reading.
|
Que mesure l'étude ?
Principaux critères de jugement
Mesure des résultats |
Description de la mesure |
Délai |
---|---|---|
The primary outcome measure is an abbreviated calcium score
Délai: 5 years
|
To investigate whether the presence and severity of coronary calcification identified on routine, pre-operative staging CT scans of the chest are an independent risk factor for patients undergoing major surgery.
Techniques have now been validated where calcium scores can be estimated from routine CT scans of the chest (Shemesh et al. 2006).
|
5 years
|
Mesures de résultats secondaires
Mesure des résultats |
Délai |
---|---|
To assess the use of the calcium scoring technique in contrast enhanced studies.
Délai: 5 years
|
5 years
|
Collaborateurs et enquêteurs
Parrainer
Les enquêteurs
- Chaise d'étude: Carl Roobottom, MBChB(Hons), Plymouth Hospital NHS Trust
Publications et liens utiles
Dates d'enregistrement des études
Dates principales de l'étude
Début de l'étude (Réel)
Achèvement primaire (Réel)
Achèvement de l'étude (Réel)
Dates d'inscription aux études
Première soumission
Première soumission répondant aux critères de contrôle qualité
Première publication (Estimation)
Mises à jour des dossiers d'étude
Dernière mise à jour publiée (Réel)
Dernière mise à jour soumise répondant aux critères de contrôle qualité
Dernière vérification
Plus d'information
Termes liés à cette étude
Mots clés
Autres numéros d'identification d'étude
- 14/P/108
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