- ICH GCP
- US-Register für klinische Studien
- Klinische Studie NCT02208648
Coronary Assessment for Mortality Prediction (CAMP)
The study will investigate whether the presence of coronary artery calcium as demonstrated on pre-operative, thoracic staging Computed Tomography (CT) is an independent risk factor for 90 day mortality in patients undergoing major abdominal surgery.
The study research question: Do higher levels of coronary calcification correlate to an increased risk of post-operative mortality in patients undergoing major abdominal surgery?
Studienübersicht
Status
Bedingungen
Detaillierte Beschreibung
The study uses a retrospective observational study design.
Due to the nature of the subject of the study and its retrospective design no patient contact will be necessary and all imaging reviewed will have been acquired as part of their routine level of care.
Plan for the gathering of study data
A list of patients with the following surgical codes will be identified from the hospital surgical performance database to create retrospective dataset of 5 years' worth of cases (to December 2013). This date range may be extended to ensure an adequate sample size. :
Surgical codes (Healthcare Resource Groups (HRG) codes) to be included:
F31 Large Intestine - Complex Procedures F32 Large Intestine - Very Major Procedures F33 Large Intestine - Major Procedures with complications and comorbidities (w cc) F34 Large Intestine - Major Procedures without complications and comorbidities (w/o cc) F36 Large Intestinal Disorders >69 or w cc F37 Large Intestinal Disorders <70 w/o cc
F41 General Abdominal - Very Major or Major Procedures patients over 69 years of age (>69) or w cc F42 General Abdominal - Very Major or Major Procedures patients under 70 years of age (<70) w/o cc F46 General Abdominal Disorders >69 or w cc F47 General Abdominal Disorders <70 w/o cc
Cross-reference with Somerset Cancer Register and remove any who were not recognised as having bowel cancer.
This patient list will be cross-referenced with records of peri-operative mortality (within 90 days)
Propensity match each deceased patient to a patient who survived beyond 90 days. Our matching rules will be in descending order of importance :
- HRG code
- gender,
- cancer staging
- Age+/-5yrs.
- American Society of Anesthesiologists (ASA) Grade
Where there are multiple potential matches then this will be resolved by consultation between the research team members.
Pairs of CT scans (deceased plus matched control) will be procured from WebPACS (Web Picture Archival Communication System).
Scans will be anonymised and stored on a dedicated secure radiology research server.
Abbreviated Calcium scores will be generated for all patients in the trial by a trained radiologist using the calcium scoring method. Calcium burden will be recorded on a scale of 1-12 . The radiologist will be blinded to the group that the patient belongs to, to minimise bias.
Scans (deceased patients and matched controls) will be analysed in batches of 30 pairs. Radiologist (s) will be blinded to group allocation. Scans will not be "paired" at the time of reading.
Interim statistical analysis (of calcium scores) will be performed after each batch of scans.
Studientyp
Einschreibung (Tatsächlich)
Kontakte und Standorte
Studienorte
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Devon
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Plymouth, Devon, Vereinigtes Königreich, PL6 8DH
- Plymouth Hospitals Nhs Trust
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Teilnahmekriterien
Zulassungskriterien
Studienberechtigtes Alter
Akzeptiert gesunde Freiwillige
Studienberechtigte Geschlechter
Probenahmeverfahren
Studienpopulation
Beschreibung
Inclusion Criteria:
- All adults ≥18yrs old
- Major abdominal surgery (See HRG Codes)
- Bowel Cancer
- Elective admission
Exclusion Criteria:
- <18 yrs old
- No suitable matched patient
- No CT Chest available
- Emergency admission
Studienplan
Wie ist die Studie aufgebaut?
Designdetails
Kohorten und Interventionen
Gruppe / Kohorte |
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Deceased
Peri-operative mortality (within 90 days).
Pairs of CT scans (deceased plus matched control) will be anonymised and stored on a secure server.
Abbreviated Calcium scores will be generated for all patients in the trial by a trained radiologist using a calcium scoring method.
The radiologist will be blinded to the group that the patient belongs to, to minimise bias.
Scans (deceased patients and matched controls) will be analysed in batches of 30 pairs.
Radiologist (s) will be blinded to group allocation.
Scans will not be "paired" at the time of reading.
|
Matched control
Patients who survived beyond 90 days peri-operatively.
Pairs of CT scans (deceased plus matched control) will be anonymised and stored on a secure server.
Abbreviated Calcium scores will be generated for all patients in the trial by a trained radiologist using a calcium scoring method.
The radiologist will be blinded to the group that the patient belongs to, to minimise bias.
Scans (deceased patients and matched controls) will be analysed in batches of 30 pairs.
Radiologist (s) will be blinded to group allocation.
Scans will not be "paired" at the time of reading.
|
Was misst die Studie?
Primäre Ergebnismessungen
Ergebnis Maßnahme |
Maßnahmenbeschreibung |
Zeitfenster |
---|---|---|
The primary outcome measure is an abbreviated calcium score
Zeitfenster: 5 years
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To investigate whether the presence and severity of coronary calcification identified on routine, pre-operative staging CT scans of the chest are an independent risk factor for patients undergoing major surgery.
Techniques have now been validated where calcium scores can be estimated from routine CT scans of the chest (Shemesh et al. 2006).
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5 years
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Sekundäre Ergebnismessungen
Ergebnis Maßnahme |
Zeitfenster |
---|---|
To assess the use of the calcium scoring technique in contrast enhanced studies.
Zeitfenster: 5 years
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5 years
|
Mitarbeiter und Ermittler
Ermittler
- Studienstuhl: Carl Roobottom, MBChB(Hons), Plymouth Hospital NHS Trust
Publikationen und hilfreiche Links
Studienaufzeichnungsdaten
Haupttermine studieren
Studienbeginn (Tatsächlich)
Primärer Abschluss (Tatsächlich)
Studienabschluss (Tatsächlich)
Studienanmeldedaten
Zuerst eingereicht
Zuerst eingereicht, das die QC-Kriterien erfüllt hat
Zuerst gepostet (Schätzen)
Studienaufzeichnungsaktualisierungen
Letztes Update gepostet (Tatsächlich)
Letztes eingereichtes Update, das die QC-Kriterien erfüllt
Zuletzt verifiziert
Mehr Informationen
Begriffe im Zusammenhang mit dieser Studie
Schlüsselwörter
Andere Studien-ID-Nummern
- 14/P/108
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