Adattamento di molteplici interventi comportamentali che migliorano efficacemente la salute dei sopravvissuti al cancro Salute dei sopravvissuti al cancro (AMPLIFY)

• Mira, pianifica e agisci su LIFestYles: AMPLIFICA la salute dei sopravvissuti

• Mira, pianifica e agisci su LIFestYles: AMPLIFICA la salute dei sopravvissuti

• Mira, pianifica e agisci su LIFestYles: AMPLIFICA la salute dei sopravvissuti

This physical performance test is done as follows:

• Participant sits on the edge of a chair, with one leg is extended straight forward with the heel on the floor and ankle at ~90°.(The other leg remains bent with the foot flat on the floor).
• Participant's hands are placed one on top of the other, and participant slowly reaches forward toward the toes of the extended leg (the test is performed on both legs, and assessor selects the most flexible side)
• The outcome measure is the distance in cm from the closest finger and toe. 0 inches → fingertips touch the toe Negative (-) → Participant cannot reach toes Positive (+) → Participant reaches past toes

This physical performance test of flexibility is done as follows:

- Participant stands upright and reach one hand over the shoulder and the other up the middle of the back, attempting to touch or overlap middle fingers (both sides are tried - right over left, then left over right).

Outcome measure is the distance between the closest fingers (most flexible side is recorded)

Scoring:

0 inches → fingertips just touch Negative (-) → fingers do not touch (gap distance) Positive (+) → fingers overlap (amount of overlap)

This physical activity outcome is measured using the Godin Leisure Time Physical Activity Questionnaire which asks frequency and duration of various levels of physical activity in a week period.

The resulting outcome measure (minutes per week) is the Adjusted Godin Moderate-to-Vigorous Physical Activity (MVPA) score, calculated based on reported frequency and duration of moderate and strenuous (vigorous) leisure-time activities as follows:

Adjusted Godin MVPA= (frequency * duration of moderate activity) + 2 (frequency * duration of vigorous activity)

Quality of life - physical is assessed using the PROMIS global health subscales measuring self-reported overall physical health, including physical functioning, fatigue, pain, and general health perceptions. The outcome measure is the resulting T-scores, standardized to the U.S. general population Range: (0-100) Higher T-scores indicate better global physical health

The Global Physical Health score is calculated by combining responses from survey questionnaire -- raw scores are converted to T-scores via scoring manuals.

Participants complete the 14-item Perceived Stress Scale (PSS-14), a validated self-report instrument that measures the degree to which individuals perceive their lives as unpredictable, uncontrollable, and overloaded over the past month.

Each item is rated on a 5-point scale (0 = never to 4 = very often). Positively stated items are reverse scored, and item responses are summed to generate a raw total score (range: 0 to 56).

The outcome measure is a T-score calculated using standard normalization procedures.

Range = 0 to 100. Higher T-scores indicate greater perceived stress (worse outcome).

Circulating cholesterol levels are assessed using dried blood spot (DBS) samples collected via fingerstick following a 12-hour fast. Blood spots are dried and stored according to standard protocols, and DBS eluents are batch-tested against known standards to determine cholesterol concentrations.

This outcome measure is the measure of mg/dl of total cholesterol

High-density lipoprotein (HDL) cholesterol will be assessed using dried blood spot (DBS) samples collected via fingerstick following a 12-hour fast. Blood spots will be dried and stored according to standard protocols, and DBS eluents will be batch-tested against known standards to determine HDL cholesterol.

Outcome measure is mg/dL of HDL Range (adults): typically, 20 to 100 mg/dL Higher HDL cholesterol indicates a better (protective) cardiovascular outcome.

Triglyceride levels are assessed using dried blood spot (DBS) samples collected via fingerstick following a 12-hour fast. Blood spots are dried and stored according to standard protocols, and DBS eluents will be batch-tested against known standards to determine triglyceride concentrations.

Outcome measure is mg/dL of triglyceride concentration Range:50 to 500 mg/dL (adults) Higher triglyceride levels indicate a worse (higher cardiovascular risk) outcome

Fasting glucose levels will be assessed using dried blood spot (DBS) samples collected via fingerstick following a 12-hour fast. Blood spots will be dried and stored according to standard protocols, and DBS eluents will be batch-tested against known standards to determine glucose concentrations.

Outcome measure is mg/dL of glucose concentration Range:70 to 200 mg/dL (adults) Higher fasting glucose levels indicate a worse metabolic outcome (greater risk of impaired glucose regulation or diabetes).

C-reactive protein (CRP) levels will be assessed using dried blood spot (DBS) samples collected via fingerstick following a 12-hour fast. Blood spots will be dried and stored according to standard protocols, and DBS eluents will be batch-tested against known standards to determine CRP concentrations.

Range: (0.1 to 10 mg/DL) in adults (higher values may occur with acute inflammation) Higher CRP levels indicate greater systemic inflammation and a worse health outcome

Quality of life is assessed using the EuroQol 5-Dimension 5-Level questionnaire (EQ-5D-5L), a standardized instrument that measures health status across five dimensions: mobility, self-care, usual activities, pain/discomfort, and anxiety/depression.

Each dimension is rated on 5 levels: No problems, Slight problems, Moderate problems, Severe problems and Extreme problems Responses are combined into a 5-digit health state, which is converted into a single summary index score.

EQ-5D Index range: 0 to 1. Higher scores indicate better quality of life

Cognitive Function is assessed using the PROMIS Cognitive Function Short Form 4a questionnaire, which evaluates memory, attention span, and concentration

Outcome measure is a T-score, standardized to the U.S. general population:

Range: (0-100) Higher T-scores indicate better cognitive function

Cognitive Ability is measured with PROMIS Cognitive Abilities - Short Form 8a, which evaluates perceived cognitive abilities, including memory, attention, concentration, and mental acuity.

Outcome measure is reported as T-scores, standardized to the U.S. general population:

Range: (0-100) Higher T-scores indicate better cognitive abilities