The Role of Viral Infection in Acute Exacerbations of Non-cystic Fibrosis Bronchiectasis in Adults
調査の概要
状態
条件
詳細な説明
Bronchiectasis is a chronic airway disease characterised by a vicious cycle of persistent bacterial colonization,inflammation and progressive tissue destruction.Patients with bronchiectasis frequently developed acute exacerbations characterised by acute worsening requiring changes in concomitant use of medication,with attendant adverse effects on their morbidity and health-related quality of life. The detailed pathogenesis of exacerbations of bronchiectasis, however, remains poorly understood.
Recent data suggested that airway infection and inflammation are important drivers of exacerbations,therefore the imbalance between chronic bacterial infection and host immune response may result in bronchiectasis exacerbations. Viral infection may be an important factor that leads to this events.It has been established that respiratory viruses are mainly responsible for the exacerbations of other chronic respiratory diseases, i.e. asthma, COPD and cystic fibosis. However, the data regarding prospective studies that sought to investigate the roles of viruses in acute exacerbation of bronchiectasis are lacking. Furthermore,the associations between viruses and bacteria during exacerbation need to be assessed. This study targets at indentifying the frenquency of common viral infections in adults with non-cystic fibrosis bronchiectasis and may shed light on the effects they have on clinical parameters,i.e. the length of exacerbated symptom to recovery,lung function, pulmonary inflammation, bacterial load and quality of life.
研究の種類
入学 (予想される)
連絡先と場所
研究場所
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Guangdong
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Guangzhou、Guangdong、中国、510000
- 募集
- The First Affiliated Hospital of Guangzhou Medical University
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コンタクト：
- Rongchang Chen, MD
- 電話番号：020-83062718
- メール：Chenrc@vip.163.com
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コンタクト：
- Nanshan Zhong, MD
- 電話番号：020-83062718
- メール：nanshan@vip.163.com
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副調査官：
- Yonghua Gao, PHD
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副調査官：
- Gang Xu, PHD
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副調査官：
- Weijie Guan, PHD
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副調査官：
- Zhiya Lin, PHD
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参加基準
適格基準
就学可能な年齢
健康ボランティアの受け入れ
受講資格のある性別
サンプリング方法
調査対象母集団
説明
Inclusion Criteria:
- Age ≥ 18 years
- HRCT-diagnosed Bronchiectasis
- Capable of providing written informed consent
Exclusion Criteria:
- Patient judged to have poor compliance
- Cystic fibrosis bronchiectasis
研究計画
研究はどのように設計されていますか？
デザインの詳細
コホートと介入
グループ/コホート |
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Bronchiectasis,stable
A patient was defined as stable if there was no exacerbation for the previous 4 wk
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Bronchiectasis,exacerbations
Bronchiectasis exacerbations were defined by subjective and persistent(>24 h) deterioration in at least three respiratory symptoms, including cough, dyspnea, hemoptysis, increased sputum purulence or volume, chest pain (with or without fever), radiographic deterioration, systemic disturbances, or changes in chest auscultation
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この研究は何を測定していますか？
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
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The prevalence of respiratory virus infection in adults with bronchiectasis during a pulmonary exacerbation and when clinically stable.
時間枠：1 year
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Respiratory viruses in the nasal swab and sputum will be identified using the polymerase chain reaction(PCR)technique when clinically stable and during exacerbation.The following viruses will be tested for:influenza A,B(including influenza A H1N1),respiratory syncytial virus(RSV),Enterovirus,Parainfluenza 1-4,Rhinovirus,human Coronaviruses(subtypes OC43、229E、HKU1),human metapneumovirus,adenovirus, human bocavirus,chlamydia,mycoplasma.
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1 year
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二次結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
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The effect of respiratory virus infection on systemic and pulmonary inflammatory markers.
時間枠：1 year
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Systemic and airway inflammatory cytokines including IL-1β、IL-6、IL-8、TNF-a were measured using a commercial multiplex bead-based assay.
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1 year
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The effect of respiratory virus on lung function
時間枠：1 year
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Spirometric indices in the present study is referred to as forced expiratory vilume in 1s(FEV1),forced vital capacity(FVC).Spirometry tests are carried out using a spirometer (COSMED, QUARK PFT, Italy).
All operation procedures meet the joint recommendation by ATS and ERS.
A total of at least 3 (not more than 8) spirometric maneuvers are performed, with the variation between the best two maneuvers of <5% or 200ml in FVC and FEV1.
The maximal values of FVC and FEV1 are reported.
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1 year
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The effect of respiratory virus infection on the bacterial load in bronchiectasis.
時間枠：1 year
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Type of bacterial infection, also referred to as potentially pathogenic organisms, and bacterial load, as expressed in cfu per mililiter
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1 year
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Time to recovery of respective symptom
時間枠：1 year
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The time from exacerbation onset by which a 3-d moving average was equal to or exceeded the baseline value
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1 year
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The effect of respiratory virus on quality of life in patients with bronchiectasis
時間枠：1 year
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Quality of life in patients with bronchiectasis were measured by St.George Respiratory Questionnaire、Leicester Cough Questionnaire and COPD assessment test during exacerbations,and then compared between virus-postive and virus-negative patients
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1 year
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To investigate if upper respiratory tract symptoms are associated with viral infections.
時間枠：1 year
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1 year
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協力者と研究者
捜査官
- 主任研究者：Nanshan Zhong, MD、The First Affiliated Hospital of Guangzhou Medical University
- 主任研究者：Rongchang Chen, MD、The First Affiliated Hospital of Guangzhou Medical University
出版物と役立つリンク
研究記録日
主要日程の研究
研究開始
一次修了 (予想される)
研究の完了 (予想される)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (見積もり)
学習記録の更新
投稿された最後の更新 (見積もり)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
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