The Role of Viral Infection in Acute Exacerbations of Non-cystic Fibrosis Bronchiectasis in Adults
Przegląd badań
Status
Warunki
Szczegółowy opis
Bronchiectasis is a chronic airway disease characterised by a vicious cycle of persistent bacterial colonization,inflammation and progressive tissue destruction.Patients with bronchiectasis frequently developed acute exacerbations characterised by acute worsening requiring changes in concomitant use of medication,with attendant adverse effects on their morbidity and health-related quality of life. The detailed pathogenesis of exacerbations of bronchiectasis, however, remains poorly understood.
Recent data suggested that airway infection and inflammation are important drivers of exacerbations,therefore the imbalance between chronic bacterial infection and host immune response may result in bronchiectasis exacerbations. Viral infection may be an important factor that leads to this events.It has been established that respiratory viruses are mainly responsible for the exacerbations of other chronic respiratory diseases, i.e. asthma, COPD and cystic fibosis. However, the data regarding prospective studies that sought to investigate the roles of viruses in acute exacerbation of bronchiectasis are lacking. Furthermore,the associations between viruses and bacteria during exacerbation need to be assessed. This study targets at indentifying the frenquency of common viral infections in adults with non-cystic fibrosis bronchiectasis and may shed light on the effects they have on clinical parameters,i.e. the length of exacerbated symptom to recovery,lung function, pulmonary inflammation, bacterial load and quality of life.
Typ studiów
Zapisy (Oczekiwany)
Kontakty i lokalizacje
Kontakt w sprawie studiów
- Nazwa: Rongchang Chen, MD
- Numer telefonu: 020-83062718
- E-mail: Chenrc@vip.163.com
Kopia zapasowa kontaktu do badania
- Nazwa: Nanshan Zhong, MD
- Numer telefonu: 020-83062718
- E-mail: nanshan@vip.163.com
Lokalizacje studiów
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Guangdong
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Guangzhou, Guangdong, Chiny, 510000
- Rekrutacyjny
- The First Affiliated Hospital of Guangzhou Medical University
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Kontakt:
- Rongchang Chen, MD
- Numer telefonu: 020-83062718
- E-mail: Chenrc@vip.163.com
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Kontakt:
- Nanshan Zhong, MD
- Numer telefonu: 020-83062718
- E-mail: nanshan@vip.163.com
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Pod-śledczy:
- Yonghua Gao, PHD
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Pod-śledczy:
- Gang Xu, PHD
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Pod-śledczy:
- Weijie Guan, PHD
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Pod-śledczy:
- Zhiya Lin, PHD
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Kryteria uczestnictwa
Kryteria kwalifikacji
Wiek uprawniający do nauki
Akceptuje zdrowych ochotników
Płeć kwalifikująca się do nauki
Metoda próbkowania
Badana populacja
Opis
Inclusion Criteria:
- Age ≥ 18 years
- HRCT-diagnosed Bronchiectasis
- Capable of providing written informed consent
Exclusion Criteria:
- Patient judged to have poor compliance
- Cystic fibrosis bronchiectasis
Plan studiów
Jak projektuje się badanie?
Szczegóły projektu
Kohorty i interwencje
Grupa / Kohorta |
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Bronchiectasis,stable
A patient was defined as stable if there was no exacerbation for the previous 4 wk
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Bronchiectasis,exacerbations
Bronchiectasis exacerbations were defined by subjective and persistent(>24 h) deterioration in at least three respiratory symptoms, including cough, dyspnea, hemoptysis, increased sputum purulence or volume, chest pain (with or without fever), radiographic deterioration, systemic disturbances, or changes in chest auscultation
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Co mierzy badanie?
Podstawowe miary wyniku
Miara wyniku |
Opis środka |
Ramy czasowe |
|---|---|---|
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The prevalence of respiratory virus infection in adults with bronchiectasis during a pulmonary exacerbation and when clinically stable.
Ramy czasowe: 1 year
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Respiratory viruses in the nasal swab and sputum will be identified using the polymerase chain reaction(PCR)technique when clinically stable and during exacerbation.The following viruses will be tested for:influenza A,B(including influenza A H1N1),respiratory syncytial virus(RSV),Enterovirus,Parainfluenza 1-4,Rhinovirus,human Coronaviruses(subtypes OC43、229E、HKU1),human metapneumovirus,adenovirus, human bocavirus,chlamydia,mycoplasma.
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1 year
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Miary wyników drugorzędnych
Miara wyniku |
Opis środka |
Ramy czasowe |
|---|---|---|
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The effect of respiratory virus infection on systemic and pulmonary inflammatory markers.
Ramy czasowe: 1 year
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Systemic and airway inflammatory cytokines including IL-1β、IL-6、IL-8、TNF-a were measured using a commercial multiplex bead-based assay.
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1 year
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The effect of respiratory virus on lung function
Ramy czasowe: 1 year
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Spirometric indices in the present study is referred to as forced expiratory vilume in 1s(FEV1),forced vital capacity(FVC).Spirometry tests are carried out using a spirometer (COSMED, QUARK PFT, Italy).
All operation procedures meet the joint recommendation by ATS and ERS.
A total of at least 3 (not more than 8) spirometric maneuvers are performed, with the variation between the best two maneuvers of <5% or 200ml in FVC and FEV1.
The maximal values of FVC and FEV1 are reported.
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1 year
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The effect of respiratory virus infection on the bacterial load in bronchiectasis.
Ramy czasowe: 1 year
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Type of bacterial infection, also referred to as potentially pathogenic organisms, and bacterial load, as expressed in cfu per mililiter
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1 year
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Time to recovery of respective symptom
Ramy czasowe: 1 year
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The time from exacerbation onset by which a 3-d moving average was equal to or exceeded the baseline value
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1 year
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The effect of respiratory virus on quality of life in patients with bronchiectasis
Ramy czasowe: 1 year
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Quality of life in patients with bronchiectasis were measured by St.George Respiratory Questionnaire、Leicester Cough Questionnaire and COPD assessment test during exacerbations,and then compared between virus-postive and virus-negative patients
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1 year
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To investigate if upper respiratory tract symptoms are associated with viral infections.
Ramy czasowe: 1 year
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1 year
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Współpracownicy i badacze
Śledczy
- Główny śledczy: Nanshan Zhong, MD, The First Affiliated Hospital of Guangzhou Medical University
- Główny śledczy: Rongchang Chen, MD, The First Affiliated Hospital of Guangzhou Medical University
Publikacje i pomocne linki
Daty zapisu na studia
Główne daty studiów
Rozpoczęcie studiów
Zakończenie podstawowe (Oczekiwany)
Ukończenie studiów (Oczekiwany)
Daty rejestracji na studia
Pierwszy przesłany
Pierwszy przesłany, który spełnia kryteria kontroli jakości
Pierwszy wysłany (Oszacować)
Aktualizacje rekordów badań
Ostatnia wysłana aktualizacja (Oszacować)
Ostatnia przesłana aktualizacja, która spełniała kryteria kontroli jakości
Ostatnia weryfikacja
Więcej informacji
Terminy związane z tym badaniem
Słowa kluczowe
Dodatkowe istotne warunki MeSH
Inne numery identyfikacyjne badania
- 2009CB522109
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