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The Role of Viral Infection in Acute Exacerbations of Non-cystic Fibrosis Bronchiectasis in Adults

11 mars 2014 uppdaterad av: yonghua gao, The First Affiliated Hospital of Guangzhou Medical University
Bronchiectasis is clinically characterized by irreversible dilation of the bronchi and bronchioles leading to persistent cough, purulent sputum, and airway flow limitation, which may be accompanied by recurrent exacerbations.It has been increasingly recognized that respiratory viruses are mainly responsible for acute exacerbation of chronic pulmonary diseases, i.e. asthma, chronic obstructive pulmonary disease and cystic fibrosis. However,little is known about the roles of viral infection in driving exacerbations of bronchiectasis.This study aims to identify the frequency of common viral infections and determine the roles that viruses play in acute exacerbations of bronchiectasis.

Studieöversikt

Status

Okänd

Betingelser

Detaljerad beskrivning

Bronchiectasis is a chronic airway disease characterised by a vicious cycle of persistent bacterial colonization,inflammation and progressive tissue destruction.Patients with bronchiectasis frequently developed acute exacerbations characterised by acute worsening requiring changes in concomitant use of medication,with attendant adverse effects on their morbidity and health-related quality of life. The detailed pathogenesis of exacerbations of bronchiectasis, however, remains poorly understood.

Recent data suggested that airway infection and inflammation are important drivers of exacerbations,therefore the imbalance between chronic bacterial infection and host immune response may result in bronchiectasis exacerbations. Viral infection may be an important factor that leads to this events.It has been established that respiratory viruses are mainly responsible for the exacerbations of other chronic respiratory diseases, i.e. asthma, COPD and cystic fibosis. However, the data regarding prospective studies that sought to investigate the roles of viruses in acute exacerbation of bronchiectasis are lacking. Furthermore,the associations between viruses and bacteria during exacerbation need to be assessed. This study targets at indentifying the frenquency of common viral infections in adults with non-cystic fibrosis bronchiectasis and may shed light on the effects they have on clinical parameters,i.e. the length of exacerbated symptom to recovery,lung function, pulmonary inflammation, bacterial load and quality of life.

Studietyp

Observationell

Inskrivning (Förväntat)

100

Kontakter och platser

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Studiekontakt

Studera Kontakt Backup

Studieorter

  • Kina
    • Guangdong
      • Guangzhou, Guangdong, Kina, 510000
        • Rekrytering
        • The First Affiliated Hospital of Guangzhou Medical University
        • Kontakt:
        • Kontakt:
        • Underutredare:
          • Yonghua Gao, PHD
        • Underutredare:
          • Gang Xu, PHD
        • Underutredare:
          • Weijie Guan, PHD
        • Underutredare:
          • Zhiya Lin, PHD

Deltagandekriterier

Forskare letar efter personer som passar en viss beskrivning, så kallade behörighetskriterier. Några exempel på dessa kriterier är en persons allmänna hälsotillstånd eller tidigare behandlingar.

Urvalskriterier

Åldrar som är berättigade till studier

18 år till 80 år (Vuxen, Äldre vuxen)

Tar emot friska volontärer

Nej

Kön som är behöriga för studier

Allt

Testmetod

Icke-sannolikhetsprov

Studera befolkning

Adults with non-CF bronchiectasis diagnosed by High Resolution CT(HRCT) attending the out-patient clinics of First Affiliated Hospital of Guangzhou Medical University,Guangzhou,Guangdong,China

Beskrivning

Inclusion Criteria:

  • Age ≥ 18 years
  • HRCT-diagnosed Bronchiectasis
  • Capable of providing written informed consent

Exclusion Criteria:

  • Patient judged to have poor compliance
  • Cystic fibrosis bronchiectasis

Studieplan

Det här avsnittet ger detaljer om studieplanen, inklusive hur studien är utformad och vad studien mäter.

Hur är studien utformad?

Designdetaljer

Kohorter och interventioner

Grupp / Kohort
Bronchiectasis,stable
A patient was defined as stable if there was no exacerbation for the previous 4 wk
Bronchiectasis,exacerbations
Bronchiectasis exacerbations were defined by subjective and persistent(>24 h) deterioration in at least three respiratory symptoms, including cough, dyspnea, hemoptysis, increased sputum purulence or volume, chest pain (with or without fever), radiographic deterioration, systemic disturbances, or changes in chest auscultation

Vad mäter studien?

Primära resultatmått

Resultatmått
Åtgärdsbeskrivning
Tidsram
The prevalence of respiratory virus infection in adults with bronchiectasis during a pulmonary exacerbation and when clinically stable.
Tidsram: 1 year
Respiratory viruses in the nasal swab and sputum will be identified using the polymerase chain reaction(PCR)technique when clinically stable and during exacerbation.The following viruses will be tested for:influenza A,B(including influenza A H1N1),respiratory syncytial virus(RSV),Enterovirus,Parainfluenza 1-4,Rhinovirus,human Coronaviruses(subtypes OC43、229E、HKU1),human metapneumovirus,adenovirus, human bocavirus,chlamydia,mycoplasma.
1 year

Sekundära resultatmått

Resultatmått
Åtgärdsbeskrivning
Tidsram
The effect of respiratory virus infection on systemic and pulmonary inflammatory markers.
Tidsram: 1 year
Systemic and airway inflammatory cytokines including IL-1β、IL-6、IL-8、TNF-a were measured using a commercial multiplex bead-based assay.
1 year
The effect of respiratory virus on lung function
Tidsram: 1 year
Spirometric indices in the present study is referred to as forced expiratory vilume in 1s(FEV1),forced vital capacity(FVC).Spirometry tests are carried out using a spirometer (COSMED, QUARK PFT, Italy). All operation procedures meet the joint recommendation by ATS and ERS. A total of at least 3 (not more than 8) spirometric maneuvers are performed, with the variation between the best two maneuvers of <5% or 200ml in FVC and FEV1. The maximal values of FVC and FEV1 are reported.
1 year
The effect of respiratory virus infection on the bacterial load in bronchiectasis.
Tidsram: 1 year
Type of bacterial infection, also referred to as potentially pathogenic organisms, and bacterial load, as expressed in cfu per mililiter
1 year
Time to recovery of respective symptom
Tidsram: 1 year
The time from exacerbation onset by which a 3-d moving average was equal to or exceeded the baseline value
1 year
The effect of respiratory virus on quality of life in patients with bronchiectasis
Tidsram: 1 year
Quality of life in patients with bronchiectasis were measured by St.George Respiratory Questionnaire、Leicester Cough Questionnaire and COPD assessment test during exacerbations,and then compared between virus-postive and virus-negative patients
1 year
To investigate if upper respiratory tract symptoms are associated with viral infections.
Tidsram: 1 year
1 year

Samarbetspartners och utredare

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Sponsor

The First Affiliated Hospital of Guangzhou Medical University

Utredare

  • Huvudutredare: Nanshan Zhong, MD, The First Affiliated Hospital of Guangzhou Medical University
  • Huvudutredare: Rongchang Chen, MD, The First Affiliated Hospital of Guangzhou Medical University

Publikationer och användbara länkar

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Allmänna publikationer

Studieavstämningsdatum

Dessa datum spårar framstegen för inlämningar av studieposter och sammanfattande resultat till ClinicalTrials.gov. Studieposter och rapporterade resultat granskas av National Library of Medicine (NLM) för att säkerställa att de uppfyller specifika kvalitetskontrollstandarder innan de publiceras på den offentliga webbplatsen.

Studera stora datum

Studiestart

1 februari 2013

Primärt slutförande (Förväntat)

1 april 2014

Avslutad studie (Förväntat)

1 april 2014

Studieregistreringsdatum

Först inskickad

25 februari 2013

Först inskickad som uppfyllde QC-kriterierna

27 februari 2013

Första postat (Uppskatta)

1 mars 2013

Uppdateringar av studier

Senaste uppdatering publicerad (Uppskatta)

12 mars 2014

Senaste inskickade uppdateringen som uppfyllde QC-kriterierna

11 mars 2014

Senast verifierad

1 mars 2014

Mer information

Termer relaterade till denna studie

Nyckelord

Ytterligare relevanta MeSH-villkor

Andra studie-ID-nummer

  • 2009CB522109

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