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Genetic Variants and Iron Absorption

2014年7月21日更新者：Cornell University

Metabolic Adaptation to Plant-based Diets in Asian Populations

The two specific aims of this study are: 1) to assess the impact of a genetic variant on iron status; 2) to assess the impact of a genetic variant on non-heme absorption among Asian women. The investigators hypothesize that the genetic variant could enhance iron status and iron absorption in Asian women.

調査の概要

状態

完了

条件

鉄の吸収

詳細な説明

To determine the HFE genotype of female Asian study volunteers, we collected venous blood samples and extracted DNA from these blood samples. HFE genotype was determined as CC, CT, and TT and used to assess possible differences in iron status as a function of genotype. To measure the impact of genotype on non-heme Fe absorption, a sub-group of women with the CC (n=10) or TT (n=11) genotype were invited to return for an Fe absorption study. Each volunteer consumed stable 57Fe (as ferrous sulfate). Two weeks after ingesting this tracer, a blood sample was collected from each woman and the amount of non-heme (57Fe) iron incorporated into red blood cells was measured with magnetic sector thermal ionization mass spectrometry. Possible associations between iron status and iron absorption as a function of genotypes were explored. Data from this study will provide information that aims to improve human health by better understanding the iron requirements of individuals with different genetic background.

研究の種類

観察的

入学 (実際)

連絡先と場所

このセクションには、調査を実施する担当者の連絡先の詳細と、この調査が実施されている場所に関する情報が記載されています。

研究場所

アメリカ
- New York
  - Ithaca、New York、アメリカ、14853
    - Human Metabolic Research Unit, Cornell University

参加基準

研究者は、適格基準と呼ばれる特定の説明に適合する人を探します。これらの基準のいくつかの例は、人の一般的な健康状態または以前の治療です。

適格基準

就学可能な年齢

18年～35年 (大人)

健康ボランティアの受け入れ

はい

受講資格のある性別

女性

サンプリング方法

非確率サンプル

調査対象母集団

Women were eligible for the study if they met the following criteria: 1) non-pregnant and between the ages of 18~35 y; 2) of East Asian descent with both maternal and paternal grandparents from East Asia, including China, Japan, South Korea, Vietnam, Thailand, Malaysia and Singapore; 3) not taking any vitamin or mineral supplements for at least 1 month before the study and during the 2-week study interval; 4) no pre-existing medical problems including malabsorption, blood disorders, ulcers, joint diseases or asthma that might impact inflammation or Fe status; 5) not taking any prescribed medications known to affect iron homeostasis.

説明

Inclusion Criteria:

non-pregnant and between the ages of 18~35 y
East Asian descent with both maternal and paternal grandparents from East Asia, including China, Japan, South Korea, Vietnam, Thailand, Malaysia and Singapore

Exclusion Criteria:

taking or planing to take any vitamin or mineral supplements during the study period
pre-existing medical problems that might impact inflammation or Fe status, including malabsorption, blood disorders, ulcers, joint diseases and asthma
taking any prescribed medications known to affect iron homeostasis

研究計画

このセクションでは、研究がどのように設計され、研究が何を測定しているかなど、研究計画の詳細を提供します。

研究はどのように設計されていますか？

デザインの詳細

この研究は何を測定していますか？

主要な結果の測定

結果測定	メジャーの説明	時間枠
Genotype at SNP rs9366637 時間枠：2 weeks after the participant's visit to the laboratory	At the participant's visit to the laboratory, a 10 mL blood sample was collected. The blood sample was used for determining genotype.	2 weeks after the participant's visit to the laboratory
Hemoglobin 時間枠：Up to 2 days after the participant's visit to the laboratory	At the participant's visit to the laboratory, a 10 mL blood sample was collected. The blood sample was used for determining the concentration of hemoglobin.	Up to 2 days after the participant's visit to the laboratory
Serum Ferritin 時間枠：Up to 6 months after the participant's visit to the laboratory	At the participant's visit to the laboratory, a 10 mL blood sample was collected. The blood sample was used for determining the concentration of serum ferritin.	Up to 6 months after the participant's visit to the laboratory
Serum transferrin receptor 時間枠：Up to 6 months after the participant's visit to the laboratory	At the participant's visit to the laboratory, a 10 mL blood sample was collected. The blood sample was used for determining the concentration of serum transferrin receptor.	Up to 6 months after the participant's visit to the laboratory
Non-heme Iron absorption in women with 2 HFE genotypes 時間枠：one month for screening with genotype then 2 weeks for iron absorption study	Women donated a blood sample for genotyping. Women with particular HFE genotypes were invited to return for an absorption study. Two weeks after women consume the iron tracer, a blood sample was obtained to measure the amount of iron absorbed.	one month for screening with genotype then 2 weeks for iron absorption study

二次結果の測定

結果測定	メジャーの説明	時間枠
Folate 時間枠：Up to 6 months after the participant's visit to the laboratory	At the participant's visit to the laboratory, a 10 mL blood sample was collected. The blood sample was used for determining the concentration of folate.	Up to 6 months after the participant's visit to the laboratory
Vitamin B-12 時間枠：Up to 6 months after the participant's visit to the laboratory	At the participant's visit to the laboratory, a 10 mL blood sample was collected. The blood sample was used for determining the concentration of vitamin B-12.	Up to 6 months after the participant's visit to the laboratory
C-reactive protein 時間枠：Up to 6 months after the participant's visit to the laboratory	At the participant's visit to the laboratory, a 10 mL blood sample was collected. The blood sample was used for determining the concentration of C-reactive protein.	Up to 6 months after the participant's visit to the laboratory

協力者と研究者

ここでは、この調査に関係する人々や組織を見つけることができます。

スポンサー

Cornell University

研究記録日

これらの日付は、ClinicalTrials.gov への研究記録と要約結果の提出の進捗状況を追跡します。研究記録と報告された結果は、国立医学図書館 (NLM) によって審査され、公開 Web サイトに掲載される前に、特定の品質管理基準を満たしていることが確認されます。

主要日程の研究

研究開始

2012年6月1日

一次修了 (実際)

2013年4月1日

研究の完了 (実際)

2014年5月1日

試験登録日

最初に提出

2014年7月16日

QC基準を満たした最初の提出物

2014年7月21日

最初の投稿 (見積もり)

2014年7月23日

学習記録の更新

投稿された最後の更新 (見積もり)