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Genetic Variants and Iron Absorption

2014年7月21日更新者：Cornell University

Metabolic Adaptation to Plant-based Diets in Asian Populations

The two specific aims of this study are: 1) to assess the impact of a genetic variant on iron status; 2) to assess the impact of a genetic variant on non-heme absorption among Asian women. The investigators hypothesize that the genetic variant could enhance iron status and iron absorption in Asian women.

研究概览

地位

完全的

条件

铁吸收

详细说明

To determine the HFE genotype of female Asian study volunteers, we collected venous blood samples and extracted DNA from these blood samples. HFE genotype was determined as CC, CT, and TT and used to assess possible differences in iron status as a function of genotype. To measure the impact of genotype on non-heme Fe absorption, a sub-group of women with the CC (n=10) or TT (n=11) genotype were invited to return for an Fe absorption study. Each volunteer consumed stable 57Fe (as ferrous sulfate). Two weeks after ingesting this tracer, a blood sample was collected from each woman and the amount of non-heme (57Fe) iron incorporated into red blood cells was measured with magnetic sector thermal ionization mass spectrometry. Possible associations between iron status and iron absorption as a function of genotypes were explored. Data from this study will provide information that aims to improve human health by better understanding the iron requirements of individuals with different genetic background.

研究类型

观察性的

注册 (实际的)

联系人和位置

本节提供了进行研究的人员的详细联系信息，以及有关进行该研究的地点的信息。

学习地点

美国
- New York
  - Ithaca、New York、美国、14853
    - Human Metabolic Research Unit, Cornell University

参与标准

研究人员寻找符合特定描述的人，称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。

资格标准

适合学习的年龄

18年至 35年 (成人)

接受健康志愿者

是的

有资格学习的性别

女性

取样方法

非概率样本

研究人群

Women were eligible for the study if they met the following criteria: 1) non-pregnant and between the ages of 18~35 y; 2) of East Asian descent with both maternal and paternal grandparents from East Asia, including China, Japan, South Korea, Vietnam, Thailand, Malaysia and Singapore; 3) not taking any vitamin or mineral supplements for at least 1 month before the study and during the 2-week study interval; 4) no pre-existing medical problems including malabsorption, blood disorders, ulcers, joint diseases or asthma that might impact inflammation or Fe status; 5) not taking any prescribed medications known to affect iron homeostasis.

描述

Inclusion Criteria:

non-pregnant and between the ages of 18~35 y
East Asian descent with both maternal and paternal grandparents from East Asia, including China, Japan, South Korea, Vietnam, Thailand, Malaysia and Singapore

Exclusion Criteria:

taking or planing to take any vitamin or mineral supplements during the study period
pre-existing medical problems that might impact inflammation or Fe status, including malabsorption, blood disorders, ulcers, joint diseases and asthma
taking any prescribed medications known to affect iron homeostasis

学习计划

本节提供研究计划的详细信息，包括研究的设计方式和研究的衡量标准。

研究是如何设计的？

设计细节

研究衡量的是什么？

主要结果指标

结果测量	措施说明	大体时间
Genotype at SNP rs9366637 大体时间：2 weeks after the participant's visit to the laboratory	At the participant's visit to the laboratory, a 10 mL blood sample was collected. The blood sample was used for determining genotype.	2 weeks after the participant's visit to the laboratory
Hemoglobin 大体时间：Up to 2 days after the participant's visit to the laboratory	At the participant's visit to the laboratory, a 10 mL blood sample was collected. The blood sample was used for determining the concentration of hemoglobin.	Up to 2 days after the participant's visit to the laboratory
Serum Ferritin 大体时间：Up to 6 months after the participant's visit to the laboratory	At the participant's visit to the laboratory, a 10 mL blood sample was collected. The blood sample was used for determining the concentration of serum ferritin.	Up to 6 months after the participant's visit to the laboratory
Serum transferrin receptor 大体时间：Up to 6 months after the participant's visit to the laboratory	At the participant's visit to the laboratory, a 10 mL blood sample was collected. The blood sample was used for determining the concentration of serum transferrin receptor.	Up to 6 months after the participant's visit to the laboratory
Non-heme Iron absorption in women with 2 HFE genotypes 大体时间：one month for screening with genotype then 2 weeks for iron absorption study	Women donated a blood sample for genotyping. Women with particular HFE genotypes were invited to return for an absorption study. Two weeks after women consume the iron tracer, a blood sample was obtained to measure the amount of iron absorbed.	one month for screening with genotype then 2 weeks for iron absorption study

次要结果测量

结果测量	措施说明	大体时间
Folate 大体时间：Up to 6 months after the participant's visit to the laboratory	At the participant's visit to the laboratory, a 10 mL blood sample was collected. The blood sample was used for determining the concentration of folate.	Up to 6 months after the participant's visit to the laboratory
Vitamin B-12 大体时间：Up to 6 months after the participant's visit to the laboratory	At the participant's visit to the laboratory, a 10 mL blood sample was collected. The blood sample was used for determining the concentration of vitamin B-12.	Up to 6 months after the participant's visit to the laboratory
C-reactive protein 大体时间：Up to 6 months after the participant's visit to the laboratory	At the participant's visit to the laboratory, a 10 mL blood sample was collected. The blood sample was used for determining the concentration of C-reactive protein.	Up to 6 months after the participant's visit to the laboratory

合作者和调查者

在这里您可以找到参与这项研究的人员和组织。

赞助

Cornell University

研究记录日期

这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查，以确保它们在发布到公共网站之前符合特定的质量控制标准。

研究主要日期

学习开始

2012年6月1日

初级完成 (实际的)

2013年4月1日

研究完成 (实际的)

2014年5月1日

研究注册日期

首次提交

2014年7月16日

首先提交符合 QC 标准的

2014年7月21日

首次发布 (估计)

2014年7月23日

研究记录更新

最后更新发布 (估计)

2014年7月23日

上次提交的符合 QC 标准的更新