A Comparison of Diagnostic Approaches for Malaria and Pneumonia
Malaria and Pneumonia in Children Under the Age of Five Years Old Presenting to Primary Healthcare Centres in Benin City, Nigeria: a Comparison of Early Diagnostic Approaches
調査の概要
詳細な説明
Of the preventable and treatable diseases, both malaria and pneumonia are significant contributors to under-five mortality in Nigeria. To reduce the burden of these diseases, the Integrated Management of Childhood Illness (IMCI) guidelines were developed by the World Health Organisation (WHO) to be used at first point of contact (e.g., primary healthcare centres) with children under the age of five years old. Preliminary literature review suggests that although interventions based on numerous diagnostic approaches have been trialed, burden from malaria and pneumonia remains unacceptably high in Nigeria, suggesting limited effectiveness of existing approaches. Therefore, this study aims to compare the accuracy of different early diagnostic approaches used in the community(for e.g. the WHO Integrated Management of Childhood Illness (IMCI) guidelines versus the gold standard diagnostic tests comprising microscopy in malaria and chest radiography in pneumonia) in children under the age of five years presenting with suspected malaria and pneumonia to primary healthcare centres in Benin City, Edo State of Nigeria.
The research will compare the accuracy of these various diagnostic approaches using measures such as sensitivity, specificity, positive predictive value, negative predictive value, and area under the receiver operating characteristic curve. The research will also assess patient outcomes like complications, hospitalisation and death following a diagnosis of either pneumonia or malaria in all study participants as well as costs associated with malaria and pneumonia.
研究の種類
入学 (実際)
連絡先と場所
研究場所
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Edo State
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Benin City、Edo State、ナイジェリア
- Health Services Department, University of Benin
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参加基準
適格基準
就学可能な年齢
健康ボランティアの受け入れ
受講資格のある性別
サンプリング方法
調査対象母集団
説明
Inclusion Criteria:
- Suspected malaria (symptoms reported by caregiver that are consistent with malaria: high temperature, chills and no other probable diagnosis)
- Suspected pneumonia (fever, cough, shortness of breath/difficulty in breathing, with or without chills and no other probable diagnosis)
- Willingness of caregiver to provide written or verbal consent in the presence of a witness.
Exclusion Criteria:
None
研究計画
研究はどのように設計されていますか?
デザインの詳細
- 観測モデル:コホート
- 時間の展望:見込みのある
この研究は何を測定していますか?
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
---|---|---|
Malaria confirmed by microscopy (yes/no)
時間枠:Participants will be assessed within an average period of 24 hours of presenting to study primary healthcare centres
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This is the gold standard diagnosis for malaria and will be used to assess the accuracy of other diagnostic approaches
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Participants will be assessed within an average period of 24 hours of presenting to study primary healthcare centres
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Pneumonia confirmed by chest x-ray (yes/no)
時間枠:Participants will be assessed within an average period of 48 hours of presenting to study primary healthcare centres
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This is the gold standard test for pneumonia and will be used to assess the accuracy of other diagnostic approaches
|
Participants will be assessed within an average period of 48 hours of presenting to study primary healthcare centres
|
二次結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
---|---|---|
Hospitalisation (yes/no)
時間枠:Within 30 days of first consultation
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This will be assessed for all study participants with either a malaria or pneumonia diagnosis as part of an epidemiological study
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Within 30 days of first consultation
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Death (yes/no)
時間枠:Within 30 days of first consultation
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This will be assessed for all study participants with either a malaria or pneumonia diagnosis as part of an epidemiological study
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Within 30 days of first consultation
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協力者と研究者
スポンサー
捜査官
- 主任研究者:Kelly O Elimian, MSc、University of Nottingham & University of Benin
- スタディディレクター:Puja R Myles, PhD、University of Nottingham
- スタディディレクター:Catherine Pritchard, PhD、University of Nottingham
- スタディディレクター:Ayebo Sadoh, PhD、University of Benin
研究記録日
主要日程の研究
研究開始
一次修了 (予想される)
研究の完了 (予想される)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (見積もり)
学習記録の更新
投稿された最後の更新 (見積もり)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
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