The Exercise Capacity and Quality of Life in the Patients With IPAH and Secondary PH
The Exercise Capacity and Quality of Life in the Patients With Idiopathic Pulmonary Arterial Hypertension and Secondary Pulmonary Hypertension
調査の概要
状態
条件
詳細な説明
Background. Pulmonary hypertension (PH) is a progressive disease with high mortality rate, but due to the development of drugs, the prognosis of the disease has improved. However patients still have poor exercise capacity and decrease of the quality of life. Past studies have shown that idiopathic and secondary PH are different in etiology and prognosis. It is necessary to further understand the difference between exercise capacity and quality of life of these two types of patients.
Purpose. The purpose of this study is the comparison of idiopathic and secondary PH in exercise capacity and quality of life, and analyzed the factors affecting.
Method. The patients recruit from National Taiwan University hospital. Thirty patients who diagnosis with PH and willing to participant our study will recruited. According to the cause of disease patients will divided into two groups, idiopathic group and secondary PH group has fifteen patients. Both of group receive testing, including body composition, exercise capacity (six minutes walk test, cardiopulmonary exercise testing), record their regular physical activity( seven day physical activity recall questionnaire) , fatigue severity(fatigue severity scale), and quality of life (SF-36), monitor cardiac function (non-invasive cardiac output test instrument). Data are analyze using SPSS19.0 version. Data will be presented in mean ± standard deviation and percentage. Using Kolmogorov-Smirmov test to test, whether the data were normal distribution, when P> 0.05 is considered as a normal distribution. Mann-Whitney U test or Chi-square test to processing parameters between two groups. Independent sample t test will be used to compare whether there are between-group differences. Pearson correlation coefficient will be used to test correlations between the parameters. The study defines significant level at α = 0.05, two-tailed.
研究の種類
入学 (実際)
連絡先と場所
研究場所
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Zhongzheng Dist
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Taipei、Zhongzheng Dist、台湾、10055
- National Taiwan University Hospital
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参加基準
適格基準
就学可能な年齢
健康ボランティアの受け入れ
受講資格のある性別
サンプリング方法
調査対象母集団
説明
inclusion criteria
- diagnose as pulmonary hypertension
- clinical stable over 3 months
- able to walk and can perform cardiopulmonary exercise testing by bicycle
exclusion criteria
- acute right heart failure
- sever arrythmia
- the history of exercise induce syncope
研究計画
研究はどのように設計されていますか?
デザインの詳細
コホートと介入
グループ/コホート |
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idiopathic pulmonary hypertension
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secondary pulmonary hypertension
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この研究は何を測定していますか?
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
---|---|---|
exercise capacity
時間枠:within 1 months after inclusion
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cardiopulmonary exercise testing(using ''MetaMax 3B system, CORTEX Biophysik GmbH'' as the measure system, and the data will present as VO2)
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within 1 months after inclusion
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quality of life
時間枠:within 1 months after inclusion
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SF-36
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within 1 months after inclusion
|
Functional exercise capacity
時間枠:within 1 months after inclusion
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six minutes walk test
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within 1 months after inclusion
|
二次結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
---|---|---|
Cardiac function
時間枠:within 1 months after inclusion
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using non-invasive cardiac output test instrument (Bioelectrical impedance, Physioflow lab1), the data will present as cardiac output(CO)
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within 1 months after inclusion
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Volume of regular physical activity
時間枠:within 1 months after inclusion
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using "Seven day physical activity recall questionnaire"
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within 1 months after inclusion
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fatigue severity
時間枠:within 1 months after inclusion
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using "Fatigue severity scale"
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within 1 months after inclusion
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body composition
時間枠:within 1 months after inclusion
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using bioelectrical impedance (Maltron BioScan BF-920), the data will present as fat percentage
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within 1 months after inclusion
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協力者と研究者
捜査官
- スタディディレクター:Chien Meng-Yueh, PhD、School and Graduate Institute of Physical Therapy, National Taiwan University
研究記録日
主要日程の研究
研究開始 (実際)
一次修了 (実際)
研究の完了 (実際)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (見積もり)
学習記録の更新
投稿された最後の更新 (実際)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
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