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The Exercise Capacity and Quality of Life in the Patients With IPAH and Secondary PH

10 juli 2018 uppdaterad av: National Taiwan University Hospital

The Exercise Capacity and Quality of Life in the Patients With Idiopathic Pulmonary Arterial Hypertension and Secondary Pulmonary Hypertension

Pulmonary hypertension (PH) is a progressive disease with high mortality rate, but due to the development of drugs, the prognosis of the disease has improved. However patients still have poor exercise capacity and decrease of the quality of life. Past studies have shown that idiopathic and secondary PH are different in etiology and prognosis. It is necessary to further understand the difference between exercise capacity and quality of life of these two types of patients.

Studieöversikt

Status

Avslutad

Betingelser

Detaljerad beskrivning

Background. Pulmonary hypertension (PH) is a progressive disease with high mortality rate, but due to the development of drugs, the prognosis of the disease has improved. However patients still have poor exercise capacity and decrease of the quality of life. Past studies have shown that idiopathic and secondary PH are different in etiology and prognosis. It is necessary to further understand the difference between exercise capacity and quality of life of these two types of patients.

Purpose. The purpose of this study is the comparison of idiopathic and secondary PH in exercise capacity and quality of life, and analyzed the factors affecting.

Method. The patients recruit from National Taiwan University hospital. Thirty patients who diagnosis with PH and willing to participant our study will recruited. According to the cause of disease patients will divided into two groups, idiopathic group and secondary PH group has fifteen patients. Both of group receive testing, including body composition, exercise capacity (six minutes walk test, cardiopulmonary exercise testing), record their regular physical activity( seven day physical activity recall questionnaire) , fatigue severity(fatigue severity scale), and quality of life (SF-36), monitor cardiac function (non-invasive cardiac output test instrument). Data are analyze using SPSS19.0 version. Data will be presented in mean ± standard deviation and percentage. Using Kolmogorov-Smirmov test to test, whether the data were normal distribution, when P> 0.05 is considered as a normal distribution. Mann-Whitney U test or Chi-square test to processing parameters between two groups. Independent sample t test will be used to compare whether there are between-group differences. Pearson correlation coefficient will be used to test correlations between the parameters. The study defines significant level at α = 0.05, two-tailed.

Studietyp

Observationell

Inskrivning (Faktisk)

26

Kontakter och platser

Det här avsnittet innehåller kontaktuppgifter för dem som genomför studien och information om var denna studie genomförs.

Studieorter

    • Zhongzheng Dist
      • Taipei, Zhongzheng Dist, Taiwan, 10055
        • National Taiwan University Hospital

Deltagandekriterier

Forskare letar efter personer som passar en viss beskrivning, så kallade behörighetskriterier. Några exempel på dessa kriterier är en persons allmänna hälsotillstånd eller tidigare behandlingar.

Urvalskriterier

Åldrar som är berättigade till studier

20 år till 80 år (Vuxen, Äldre vuxen)

Tar emot friska volontärer

Nej

Kön som är behöriga för studier

Allt

Testmetod

Icke-sannolikhetsprov

Studera befolkning

pulmonary hypertension, clinical stable, able to walk and can perform cardiopulmonary exercise testing by bicycle

Beskrivning

inclusion criteria

  1. diagnose as pulmonary hypertension
  2. clinical stable over 3 months
  3. able to walk and can perform cardiopulmonary exercise testing by bicycle

exclusion criteria

  1. acute right heart failure
  2. sever arrythmia
  3. the history of exercise induce syncope

Studieplan

Det här avsnittet ger detaljer om studieplanen, inklusive hur studien är utformad och vad studien mäter.

Hur är studien utformad?

Designdetaljer

Kohorter och interventioner

Grupp / Kohort
idiopathic pulmonary hypertension
  1. diagnose as idiopathic pulmonary arterial hypertension
  2. clinical stable over 3 months
  3. able to walk and can do bicycle cardiopulmonary exercise testing
secondary pulmonary hypertension
  1. diagnose as pulmonary hypertension
  2. clinical stable over 3 months
  3. able to walk and can do bicycle cardiopulmonary exercise testing

Vad mäter studien?

Primära resultatmått

Resultatmått
Åtgärdsbeskrivning
Tidsram
exercise capacity
Tidsram: within 1 months after inclusion
cardiopulmonary exercise testing(using ''MetaMax 3B system, CORTEX Biophysik GmbH'' as the measure system, and the data will present as VO2)
within 1 months after inclusion
quality of life
Tidsram: within 1 months after inclusion
SF-36
within 1 months after inclusion
Functional exercise capacity
Tidsram: within 1 months after inclusion
six minutes walk test
within 1 months after inclusion

Sekundära resultatmått

Resultatmått
Åtgärdsbeskrivning
Tidsram
Cardiac function
Tidsram: within 1 months after inclusion
using non-invasive cardiac output test instrument (Bioelectrical impedance, Physioflow lab1), the data will present as cardiac output(CO)
within 1 months after inclusion
Volume of regular physical activity
Tidsram: within 1 months after inclusion
using "Seven day physical activity recall questionnaire"
within 1 months after inclusion
fatigue severity
Tidsram: within 1 months after inclusion
using "Fatigue severity scale"
within 1 months after inclusion
body composition
Tidsram: within 1 months after inclusion
using bioelectrical impedance (Maltron BioScan BF-920), the data will present as fat percentage
within 1 months after inclusion

Samarbetspartners och utredare

Det är här du hittar personer och organisationer som är involverade i denna studie.

Utredare

  • Studierektor: Chien Meng-Yueh, PhD, School and Graduate Institute of Physical Therapy, National Taiwan University

Studieavstämningsdatum

Dessa datum spårar framstegen för inlämningar av studieposter och sammanfattande resultat till ClinicalTrials.gov. Studieposter och rapporterade resultat granskas av National Library of Medicine (NLM) för att säkerställa att de uppfyller specifika kvalitetskontrollstandarder innan de publiceras på den offentliga webbplatsen.

Studera stora datum

Studiestart (Faktisk)

13 januari 2016

Primärt slutförande (Faktisk)

1 april 2016

Avslutad studie (Faktisk)

19 november 2016

Studieregistreringsdatum

Först inskickad

15 december 2015

Först inskickad som uppfyllde QC-kriterierna

5 januari 2016

Första postat (Uppskatta)

6 januari 2016

Uppdateringar av studier

Senaste uppdatering publicerad (Faktisk)

11 juli 2018

Senaste inskickade uppdateringen som uppfyllde QC-kriterierna

10 juli 2018

Senast verifierad

1 juni 2018

Mer information

Termer relaterade till denna studie

Denna information hämtades direkt från webbplatsen clinicaltrials.gov utan några ändringar. Om du har några önskemål om att ändra, ta bort eller uppdatera dina studieuppgifter, vänligen kontakta register@clinicaltrials.gov. Så snart en ändring har implementerats på clinicaltrials.gov, kommer denna att uppdateras automatiskt även på vår webbplats .

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