Effect of Tooth Cleaning in Smokers and Non Smokers With Gum Disease. (ETCSNSGD)
Effects of Nonsurgical Periodontal Therapy on Plasma Hepatocyte Growth Factor Levels in Smokers and Non Smokers With Chronic Periodontitis
調査の概要
詳細な説明
The study was randomised prospective,interventional clinical trial. The sample size for the study was 40 individuals aged between 20 to 60 years,equally divided into two groups.
Group l - smokers with chronic periodontitis (test) group. Group ll - non smokers with chronic periodontitis (controls)
At baseline both the groups were analysed for clinical and biochemical parameters and underwent non surgical periodontal therapy( scaling and root planning). All parameters were reassesed after 3 months.
A total of 40 patients( 20 somkers and 20 non smokers) from the outpatient wing of department of periodontics, Panineeya mahavidyalaya institute of dental sciences and research centre diagnosed with chronic periodontitis and willing to participate in the study.
Clicical parameters included gingival index and periodontal index. Biochmeical parameters included plasma hepatocyte growth factor.
研究の種類
入学 (実際)
段階
- 適用できない
参加基準
適格基準
就学可能な年齢
健康ボランティアの受け入れ
受講資格のある性別
説明
Inclusion Criteria:
- probing depth >4mm
- clinical attachment loss>2mm
Exclusion Criteria:
- patients younger than 20 years and greater than 60 years
- presence of any chronic conditions like diabetes,infections
- antibiotic therapy received preceeding 3 months
- former smokers who had quit the habit of smoking
- patients who already underwent periodontal therapy
研究計画
研究はどのように設計されていますか?
デザインの詳細
- 主な目的:処理
- 割り当て:ランダム化
- 介入モデル:並列代入
- マスキング:なし(オープンラベル)
武器と介入
参加者グループ / アーム |
介入・治療 |
---|---|
実験的:NSPT-Test group
NSPT was done after administration of pre procedural mouth rinse in the test group (20 smokers with chronic periodontitis).Clinical parameters (GI,PI) were assessed at baseline and at the end of 3 months.2
ml blood was drawn to asses the plasma hepatocyte growth factor levels at baseline and at the end of 3 months.
|
NSPT was done by ultrasonic scalers after administration of pre procedural mouth rinse in the test group (20 smokers with chronic periodontitis).Clinical parameters (GI,PI) were assessed at baseline and at the end of 3 months.2
ml blood was drawn to assess the plasma hepatocyte growth factor levels at baseline and at the end of 3 months.
|
実験的:Scaling and root planing-Control group
Scaling and root planing was done after administration of pre procedural mouth rinse in the control group (20 non smokers with chronic periodontitis).Clinical parameters (GI,PI) were assessed at baseline and at the end of 3 months.2
ml blood was drawn to asses the plasma hepatocyte growth factor levels at baseline and at the end of 3 months.
|
Scaling and root planing was done by ultrasonic scalers after administration of pre procedural mouth rinse in the control group (20 non smokers with chronic periodontitis).Clinical parameters (GI,PI) were assessed at baseline and at the end of 3 months.2
ml blood was drawn to assess the plasma hepatocyte growth factor levels at baseline and at the end of 3 months.
|
この研究は何を測定していますか?
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
---|---|---|
Primary outcome of the study was to measure plasma heaptocyte growth factor level
時間枠:baseline, 3 months
|
The change in plasma hepatocyte growth factor level was measured at baseline and at the end of 3 months after scaling and root planing.2
ml blood was drawn from the patient to assess the hepatocyte growth factor levels.biochemical analysis was done by ELISA test i.e., blood samples from both smokers and non smokers with chronic periodontitis were taken at baseline and at the end of 3 monthd
|
baseline, 3 months
|
二次結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
---|---|---|
gingival index
時間枠:baseline and 3 months
|
The secondary outcome of the study is to measure gingival index at baseline and 3 months after scaling and root planing.
gingival index was assesed using williams periodontal probe
|
baseline and 3 months
|
periodontal index
時間枠:baseline and 3 months
|
The secondary outcome of the study is to measure periodontal index at baseline and 3 months after scaling and root planing.
periodontal index was assesed using williams periodontal probe
|
baseline and 3 months
|
協力者と研究者
捜査官
- スタディディレクター:Dr.Veerendranath R Panthula, MDS、Panineeya Mahavidyalaya institute of dental sciences and research centre
出版物と役立つリンク
一般刊行物
- Anil S, Vellappally S, Preethanath RS, Mokeem SA, AlMoharib HS, Patil S, Chalisserry EP, Al Kheraif AA. Hepatocyte growth factor levels in the saliva and gingival crevicular fluid in smokers with periodontitis. Dis Markers. 2014;2014:146974. doi: 10.1155/2014/146974. Epub 2014 Oct 15.
- Rudrakshi C, Srinivas N, Mehta DS. A comparative evaluation of hepatocyte growth factor levels in gingival crevicular fluid and saliva and its correlation with clinical parameters in patients with and without chronic periodontitis: A clinico-biochemical study. J Indian Soc Periodontol. 2011 Apr;15(2):147-51. doi: 10.4103/0972-124X.84384.
研究記録日
主要日程の研究
研究開始
一次修了 (実際)
研究の完了 (実際)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (見積もり)
学習記録の更新
投稿された最後の更新 (見積もり)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
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