The Effects of Exercise and Probiotics on Dysmenorrhea and Microbiome
The Effects of Exercise and Probiotics on the Efficacy and Possible Mechanisms of Dysmenorrhea From the Perspective of Microbiome
調査の概要
詳細な説明
In current study, there were two stages designed for current study. The definition of dysmenorrhea population depended on the Visual Analogue Scale (VAS) of McGill Pain Questionnaire (more than 5) and the VAS score less than 2 was considered as non-dysmenorrhea population.
In the first stage, the 20 subjects were recruit for non-dysmenorrhea group (Control group) and other 60 subjects were randomly allocated into three group with original lifestyle, aerobic, and resistant exercise intervention (Dys-Control, Dys-Aerobic, and Dys-resistant groups). The questionnaires (Premenstrual syndrome, the Menstrual Distress, and McGill Pain), body composition, physical fitness, biochemistries, inflammation, hormones and microbiome analysis (feces and tampon) were evaluated and assessed before and after 10-weeks indicated exercise training.
In the second stage, one hundred subjects (20 non-dysmenorrhea and 80 dysmenorrhea populations) will be recruited and the dysmenorrhea will be randomly allocated into Dys-Control, Dys-probiotics, Dys-exercise and Dys-probiotics and exercise groups. The questionnaires (Premenstrual syndrome, the Menstrual Distress, and McGill Pain), body composition, physical fitness, biochemistries, inflammation, hormones and microbiome analysis (feces and tampon) were evaluated and assessed before and after 10-weeks indicated interventions (probiotics and exercise).
研究の種類
入学 (予想される)
段階
- 適用できない
連絡先と場所
研究連絡先
- 名前:Wen Ching Huang, PhD
- 電話番号:7721 +88628227101
- メール:wenching@ntunhs.edu.tw
研究場所
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Taipei、台湾、112303
- 募集
- National Taipei University of Nursing and Health Sciences
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コンタクト:
- Wen Ching Huang, PhD
- 電話番号:7721 +88628227101
- メール:wenching@ntunhs.edu.tw
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参加基準
適格基準
就学可能な年齢
健康ボランティアの受け入れ
受講資格のある性別
説明
Inclusion Criteria:
- Primary dysmenorrhea
- Visual Analog Score of McGill pain questionnaire (0-2 for non-dysmenorrhea; >5 for dysmenorrhea)
Exclusion Criteria:
- Pregnancy, menstrual disorders, obesity (BMI>30), smoking, and alcohol or drug addiction
- Cardiovascular disease, hypertension, diabetes, asthma, chronic pulmonary obstruction, mental illness
研究計画
研究はどのように設計されていますか?
デザインの詳細
- 主な目的:処理
- 割り当て:ランダム化
- 介入モデル:並列代入
- マスキング:なし(オープンラベル)
武器と介入
参加者グループ / アーム |
介入・治療 |
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介入なし:Control Group
non-dysmenorrhea population with original lifestyle
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介入なし:Dysmenorrhea
dysmenorrhea population without exercise intervention
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実験的:Dysmenorrhea+Aerobic Exercise
dysmenorrhea population with aerobic exercise intervention
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The aerobic exercise :In this study, the exercise intensity is set based on the subject's maximum heart rate, and the target heart rate is adjusted according to the literature to reach 60-90% of the maximum heart rate.
A gradual increase of intermittent exercise will be designed for current exercise prescription.
In terms of exercise frequency and time, there will be two times interventions per week for at least 60 minutes per time (including warm-up and cool down exercises).
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実験的:Dysmenorrhea+Resistant Exercise
dysmenorrhea population with resistant exercise intervention
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The resistant exercise : muscular endurance (15-20RM) and muscular hypertrophy (8-12RM) are applied to main exercise intensity.
The intensity is gradually adjusted according to the state of each subject, and the intervention is performed twice a week (50 minutes per time).The target muscles of resistance training include quadriceps femoris, biceps femoris, calf muscles, core muscles (including pelvic floor muscles), back muscles, pectoralis major, biceps/triceps and other muscle groups.
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この研究は何を測定していますか?
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
---|---|---|
The effects of different types of exercise on premenstrual syndrome questionnaire with dysmenorrhea
時間枠:10 weeks
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The premenstrual syndrome questionnaire is applied for evaluation of premenstrual syndromes before mense.
A higher score indicates severer indicated syndromes.
Changes of the premenstrual syndrome questionnaire measure will be assessed at the 0 week and 10 weeks.
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10 weeks
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The effects of different types of exercise on menstrual distress questionnaire with dysmenorrhea
時間枠:10 weeks
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The menstrual distress questionnaire is applied for evaluation of distress syndromes during mense.
A higher score indicates severer indicated syndromes.
Changes of the menstrual distress questionnaire measure will be assessed at the 0 week and 10 weeks.
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10 weeks
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The effects of different types of exercise on McGill pain questionnaire with dysmenorrhea
時間枠:10 weeks
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The McGill pain questionnaire is applied for evaluation of types and degrees of pain during mense.
A higher score indicates severer indicated syndromes.
Changes of theMcGill pain questionnaire measure will be assessed at the 0 week and 10 weeks.
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10 weeks
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The effects of different types of exercise on cardiovascular capacity
時間枠:10 weeks
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The cardiovascular capacity is evaluated by 3-minute step test.
The higher index of cardiovascular capacity means the higher cardiovascular fitness.
Changes of cardiovascular capacity will be assessed at the 0 week, and 10 weeks.
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10 weeks
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The effects of different types of exercise on muscular strength of upper limbs
時間枠:10 weeks
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The muscular strength of upper limbs is evaluated by grip-strength test.
The higher strength of test means the higher strength fitness in upper limbs.
Changes of muscular strength of upper limbs will be assessed at the 0 week, and 10 weeks.
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10 weeks
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The effects of different types of exercise on power
時間枠:10 weeks
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The power is evaluated by standing long jump.
The higher distance of test means the higher power fitness.
Changes of power will be assessed at the 0 week, and 10 weeks.
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10 weeks
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The effects of different types of exercise on core strength
時間枠:10 weeks
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The core strength endurance is evaluated by 1-minute bent-knee sit-up test.
The higher repetitions mean the higher core strength endurance fitness.
Changes of core strength endurance will be assessed at the 0 week, and 10 weeks.
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10 weeks
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The effects of different types of exercise on body composition
時間枠:10 weeks
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The body composition was simultaneously measured by Inbody 270 (Bioelectrical Impedance Analysis) for outcome measures including body-fat percentage, and muscular percentage in the upper and lower limbs.
The higher muscular percentage and lower body-fat percentage are associated with better fitness.
Changes of body-fat percentage, and muscular percentage in the upper and lower limbs measures will be assessed at the 0 week, and 10 weeks.
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10 weeks
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The microbiome succession of the dysmenorrhea with different types of exercise intervention
時間枠:10 weeks
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Determination of the gut microbiota composition from the feces and tampon samples by 16S metagenomic, data analysis and building of a mathematical model to test the potential modulation of the gut microbiota architecture for primary dysmenorrhea.Changes of microbiota succession in the feces and tampons will be assessed at the 0 week, and 10 weeks.
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10 weeks
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The effects of different types of exercise on cytokines in dysmenorrhea
時間枠:10 weeks
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The cytokines was simultaneously measured by enzyme-linked immunosorbent assay for outcome measures including TNF-α, IL-1β, IL-6, and IL-10.
The higher TNF-α, IL-1β, and IL-6 cytokines mean the higher inflammation and higher IL-10 mean the higher immunosuppression.
Changes of cytokines measures will be assessed at the 0 week, and 10 weeks.
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10 weeks
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The effects of different types of exercise on biochemistries in dysmenorrhea
時間枠:10 weeks
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The biochemical variables were simultaneously measured by automated clinical chemistry analyzer for outcome measures including VEGF, Estrogen, Progesterone, adrenaline, cortisol, serotonin, PEG2, PGF2α, Prostacyclin, and Thromboxane.
The expressive levels of indicated indexes mean different physiological modulations.
Changes of biochemical measures will be assessed at the 0 week, and 10 weeks.
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10 weeks
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協力者と研究者
捜査官
- 主任研究者:Wen Ching Huang, PhD、National Taipei University of Nursing and Health Sciences
研究記録日
主要日程の研究
研究開始 (実際)
一次修了 (予想される)
研究の完了 (予想される)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (実際)
学習記録の更新
投稿された最後の更新 (実際)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
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