Comparison of the Use of an Outpatient/Mobile MRI Procedure With an Inpatient MRI Procedure in Adult Patients With Known or Suspected Coronary Artery Disease (CAD)

The diagnostic examinations conducted as part of this study will be performed using stress perfusion cardiac magnetic resonance imaging (CMR) with the pharmacologically active agent regadenoson and the contrast agent gadobutrol. A total of 250 patients with a clinical suspicion of hemodynamically significant coronary artery disease (CAD) will undergo stress perfusion CMR using the pharmacologically active vasodilator regadenoson and the contrast agent gadobutrol. Examinations will be performed in either mobile or stationary MRI units. By introducing stress CMR as a mobile diagnostic service, state-of-the-art, highly accurate diagnostic imaging can also be made available in rural areas. This will enable timely diagnostic examinations close to patients' homes, both for patients with abnormal findings and suspected coronary artery disease and for further diagnostic evaluation of patients with already established CAD. Mobile stress CMR diagnostics will provide the treating specialist with additional information to support clinical decision-making regarding the timely initiation of targeted treatment in the cardiac catheterization laboratory, potentially having a positive impact on subsequent treatment and prognosis.

The study aims to achieve the following objectives:

To demonstrate the feasibility of easily performing stress perfusion CMR in a mobile setting using a short, patient- and user-friendly MRI protocol that is identical to the protocol established in clinical routine practice and recommended by professional societies.

Our hypothesis is that there are no differences in the performance of stress CMR examinations in a mobile setting compared with a stationary setting. The primary endpoints are the proportion of successfully completed and evaluable stress CMR examinations with at least adequate image quality.