Understanding New Cachexia Subtypes Through Observational Epidemiological Research (UNCOVER)

Inclusion Criteria:

• Have a primary diagnosis of unresectable or Stage IV 1) non-small cell lung cancer (NSCLC), 2) pancreatic adenocarcinoma, or 3) colorectal cancer (CRC).

Note: Patients do not need to have cachexia to be eligible

• Plan to start first line systemic anti-cancer therapy (chemotherapy, immunotherapy, targeted therapy) in the next 6 weeks or has started first-line systemic therapy in the previous 6 weeks.

Note: Patients who received systemic anti-cancer therapy previously as part of adjuvant or neoadjuvant therapy and have since recurred are still eligible if such treatment was longer than 6 months prior to enrollment.

• Have an an Eastern Cooperative Oncology Group (ECOG) performance status of 0, 1 or 2.
• Be able to understand, speak and read English.
• Be 18 years or older

Exclusion Criteria:

• Have contraindications to physical function assessments (30-second bicep curl, Timed-Up-And-Go test, or 30-Second Sit to Stand test) per the treating provider or their designee.
• Have any planned major surgeries within the next 3 months after enrollment to the best knowledge of the investigator/treating provider or their designee.
• Have received chemotherapy or surgery for separate primary cancer within the past 3 years other than non-melanoma skin cancer.
• Be pregnant or within 6 months postpartum.