- ICH GCP
- 미국 임상 시험 레지스트리
- 임상시험 NCT03185507
The Effect of Cryotherapy on Cerebral Hemodynamics Within Healthy Subjects
연구 개요
상세 설명
The prevalence of concussion has been estimated to be between 4,380 and 10,403 concussions per day in the United States annually with over an estimated 3 million visits to emergency departments each year.1 Symptoms following a concussion last up to 10 days for 90% of cases2; however, the reduction of symptoms in this time frame does not indicate full neurometabolic recovery.
Following concussion, a neurometabolic cascade of events immediately occurs following initial impact with return to normative values around 30 days post-injury. In an attempt to maintain homeostasis in the brain following impact, glucose and oxygen demand increases temporarily and are coupled with periods of increased hyperperfusion and decreased cerebral blood flow (CBF). Although the neurometabolic timeline immediately following impact is only generally understood, there is consensus upon acute increases in CBF and metabolic activity followed by decreased CBF until return to normative values.
Cryotherapy has been studied extensively for its' effects throughout the musculoskeletal system. Cryotherapy in the musculoskeletal system has been shown to decrease tissue temperature and blood flow, as well as decrease oxygen and energy demands.12-19 Cryotherapy has also been applied in cases of moderate or severe traumatic brain injury and has demonstrated to decrease intracranial metabolic processes and oxygenation consumption. Although the potential benefits of cryotherapy have been established in cases of moderate to severe traumatic brain injury (TBI), there is no current research examining cryotherapy in the treatment of concussion.
A convenience sample of 34 healthy, recreationally active individuals between the ages of 18-25 years will be recruited for participation in this study. The independent variable in this study will be group (cryotherapy, control). The primary outcome measures of interest are cognitive functioning measured using the Stroop Test and cerebral blood hemodynamics and hemoglobin saturation measured using near infrared spectroscopy. The pain visual analog scale (VAS) will be used to quantify tolerance to the intervention.
The following study will address the following objectives and related hypotheses:
Objective 1: To determine if the application of cryotherapy influences intracranial hemodynamics within healthy recreationally active young adults.
Hypothesis 1: Cryotherapy will cause a decrease in intracranial hemodynamics; specifically, the CO2 saturation and deoxygenated hemoglobin causing a decrease in intracranial metabolic activity.
Objective 2: To determine if the application of cryotherapy decreases cerebral blood flow within healthy recreationally active individuals.
Hypothesis 2: The application of cryotherapy will not cause a change in cerebral blood flow due to the highly regulated central nervous system.
연구 유형
등록 (실제)
단계
- 1단계
연락처 및 위치
연구 장소
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Virginia
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Charlottesville, Virginia, 미국, 22904
- University of Virginia Memorial Gymnasium
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참여기준
자격 기준
공부할 수 있는 나이
건강한 자원 봉사자를 받아들입니다
연구 대상 성별
설명
Inclusion Criteria:
- Between 18 and 25 years of age
- Recreationally active (exercise at least 30 minutes, 3 times weekly)
Exclusion Criteria:
- Contraindications for cryotherapy (eg. Raynaud's phenomenon, cold urticaria)
- Any documented learning difficulty or disability
- Any known neurological or psychiatric disorder
- History of migraines
- History of a concussion or traumatic brain injury in past 6 months
- Currently taking psychotropic medications
- Any known metabolism diseases
- Any known hematological diseases
- Any recreational drug use in past month
- Any known cardiopulmonary impairments or pathologies
공부 계획
연구는 어떻게 설계됩니까?
디자인 세부사항
- 주 목적: 치료
- 할당: 무작위
- 중재 모델: 병렬 할당
- 마스킹: 하나의
무기와 개입
참가자 그룹 / 팔 |
개입 / 치료 |
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실험적: Cryotherapy
Participants received superficial cryotherapy using the Cryohelmet(TM)
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Cryotherapy was administered using the Catalyst CryoHelmet™ (All-Star Sporting Goods®, Shirley, Massachusetts, USA).
The CyroHelmet is a flexible helmet equipped with gel ice packs meant to cool the head and neck.
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간섭 없음: Control
Participants sat quietly for 20 minutes
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연구는 무엇을 측정합니까?
주요 결과 측정
결과 측정 |
측정값 설명 |
기간 |
---|---|---|
Oxygenated blood
기간: Oxygenated blood was collected throughout the data collection period (45 minutes)
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Oxygenated blood based on functional near-infrared spectroscopy (fNIRS) data output
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Oxygenated blood was collected throughout the data collection period (45 minutes)
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Deoxygenated blood
기간: Dexoygenated blood was collected throughout the data collection period (45 minutes)
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Deoxygenated blood based on functional near-infrared spectroscopy (fNIRS)
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Dexoygenated blood was collected throughout the data collection period (45 minutes)
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Stroop Task reaction time
기간: Stroop Task reaction time was collected prior to and following the intervention. Each test took approximately 5 minutes to complete.
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Reaction time measured in milliseconds while completing the Stroop Task
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Stroop Task reaction time was collected prior to and following the intervention. Each test took approximately 5 minutes to complete.
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공동 작업자 및 조사자
간행물 및 유용한 링크
연구 기록 날짜
연구 주요 날짜
연구 시작 (실제)
기본 완료 (실제)
연구 완료 (실제)
연구 등록 날짜
최초 제출
QC 기준을 충족하는 최초 제출
처음 게시됨 (실제)
연구 기록 업데이트
마지막 업데이트 게시됨 (실제)
QC 기준을 충족하는 마지막 업데이트 제출
마지막으로 확인됨
추가 정보
이 연구와 관련된 용어
추가 관련 MeSH 약관
기타 연구 ID 번호
- 19706
개별 참가자 데이터(IPD) 계획
개별 참가자 데이터(IPD)를 공유할 계획입니까?
약물 및 장치 정보, 연구 문서
미국 FDA 규제 의약품 연구
미국 FDA 규제 기기 제품 연구
이 정보는 변경 없이 clinicaltrials.gov 웹사이트에서 직접 가져온 것입니다. 귀하의 연구 세부 정보를 변경, 제거 또는 업데이트하도록 요청하는 경우 register@clinicaltrials.gov. 문의하십시오. 변경 사항이 clinicaltrials.gov에 구현되는 즉시 저희 웹사이트에도 자동으로 업데이트됩니다. .
산소 결핍에 대한 임상 시험
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Jerry Vockley, MD, PhDUltragenyx Pharmaceutical Inc더 이상 사용할 수 없음바르트 증후군 | 미토콘드리아 삼중기능 단백질 결핍 | 초장쇄 acylCoA 탈수소효소(VLCAD) 결핍증 | 카르니틴 팔미토일전이효소 결핍(CPT1, CPT2) | 장쇄 하이드록시아실-CoA 탈수소효소 결핍증 | 글리코겐 저장 장애 | 피루브산 카르복실라제 결핍증 | ACYL-CoA DEHYDROGENASE FAMILY, MEMBER 9, DEFICIENCY of미국