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에티오피아의 중증급성영양실조(SAM) 치료 범위 확대 (R-SWITCH)

2026년 9월 21일 업데이트: International Food Policy Research Institute

에티오피아의 중증 급성 영양실조 예방, 선별 및 치료 강화를 위한 지역사회 수준 구조 활용의 효과

The R-SWITCH intervention aims to address the low coverage of treatment for severe wasting (SAM) by leveraging existing community groups to deliver an integrated package focused on prevention, screening, referral, and treatment of SAM. It includes behavior change communication on child nutrition and health, active screening, improved passive screening at health posts, and follow-up of referred cases and those enrolled in outpatient treatment programs (OTP). The primary objectives of the R-SWITCH studies are to assess the intervention's impact on OTP coverage, identify implementation barriers and facilitators, and evaluate its cost-efficiency and cost-effectiveness.

연구 개요

상세 설명

Despite the high mortality risk of severe wasting (also referred to as severe acute malnutrition or SAM), only a small proportion of children with severe wasting are currently identified and admitted to available outpatient treatment programs (OTP). In 2020, an estimated 4.9 million children with severe wasting received treatment, approximately a third of the total burden. Outside of humanitarian settings, this proportion is even lower (estimated to be around 15%). These figures highlight the urgent need to increase treatment coverage to meet the Sustainable Development Goals (SDG), which aim to reduce the prevalence of child wasting to less than 5% by 2025 and less than 3% by 2030. The continuum of care for SAM, from case identification, referral to treatment, and post-treatment follow-up, is hampered by several barriers including caregiver lack of awareness on the risks and treatment services of SAM, stigma related to SAM, poor accessibility to treatment, frequent stockouts of treatment inputs, and the overall workload faced by first-line health workers.

The R-SWITCH intervention will leverage existing community groups to deliver an integrated package aimed at preventing SAM through behavior change communication (BCC) on child nutrition and health, increasing wasting screening coverage through active screening, family-led MUAC and improved passive screening health posts, increasing treatment coverage through follow-up of earlier referred cases, cases enrolled in OTP, and children who completed OTP and recovered.

The primary objectives of the R-SWITCH studies are:

  • To assess the impact of the R-SWITCH intervention on SAM OTP coverage
  • To identify implementation barriers and facilitators
  • To assess the cost-efficiency and cost-effectiveness of the intervention package and services

연구 유형

중재적

등록 (추정된)

1080

단계

  • 해당 없음

연락처 및 위치

이 섹션에서는 연구를 수행하는 사람들의 연락처 정보와 이 연구가 수행되는 장소에 대한 정보를 제공합니다.

연구 연락처

연구 연락처 백업

연구 장소

      • Jimma, 에티오피아
        • 모병
        • Kersa and Jeldessa woredas
        • 수석 연구원:
          • Lieven Huybregts, PhD
        • 수석 연구원:
          • Tefera Belachew, PhD

참여기준

연구원은 적격성 기준이라는 특정 설명에 맞는 사람을 찾습니다. 이러한 기준의 몇 가지 예는 개인의 일반적인 건강 상태 또는 이전 치료입니다.

자격 기준

공부할 수 있는 나이

6개월 (어린이)

건강한 자원 봉사자를 받아들입니다

예

연구 대상 성별

모두

설명

Inclusion Criteria:

  • Child 6-59 months of age
  • Suffering from SAM (defined as MUAC < 115mm or presence of bilateral pitting edema or Weight-for-Length Z-score <-3) OR currently enrolled in SAM OTP

Exclusion Criteria:

- Anthropometric malformation or being handicapped which hampers anthropometric measurements.

공부 계획

이 섹션에서는 연구 설계 방법과 연구가 측정하는 내용을 포함하여 연구 계획에 대한 세부 정보를 제공합니다.

연구는 어떻게 설계됩니까?

디자인 세부사항

  • 주 목적: 건강 서비스 연구
  • 할당: 무작위
  • 중재 모델: 병렬 할당
  • 마스킹: 없음(오픈 라벨)

무기와 개입

참가자 그룹 / 팔
개입 / 치료
간섭 없음: Standard of Care
  • Usual screening of wasting by health extension workers (HEW) using MUAC
  • Previous introduction of Family-led MUAC (not maintained)
  • Behavior Change Communication (BCC) offered by Health extension worker (low intensity)
  • Treatment of SAM at health post or health center
  • Follow-up of SAM OTP defaults through home visits by HEW (very low intensity)
실험적: R-SWITCH integrated intervention package
  1. Monthly group meetings of AFD community groups
  2. Introduction of weight-for-age Z-score <-3 as an additional screening criterion
  3. Promotion of Family-led MUAC screening and SAM awareness to fathers, community and religious leaders
  4. Follow-up and counselling during home visits by AFD leaders
  5. Strengthening communication between HEW and AFDs
  1. Monthly group meetings of Alliance for Development (AFD) community groups) and their members (caregivers of children 0-59 months of age):

    • Introduction and refresher of Family-led MUAC
    • Active screening of wasting by AFD
    • Group SBCC on Infant and Young Child Feeding (IYCF), health and Water, Sanitation and Hygiene (WaSH) with a focus on SAM
    • Promotion of health services such as GMP
  2. Introduction of weight-for-age Z-score <-3 as screening criterion for passive screening by health extension workers at any contact with children (e.g. during GMP)

  3. Promotion of Family-led MUAC screening and SAM awareness to fathers during male agricultural/pastoralist extension activities and by community and religious leaders (creating social support)

  4. Follow-up and counselling during home visits by AFD leaders of i) earlier referred cases of SAM, ii) cases enrolled in SAM OTP, iii) and recovered SAM cases discharged from OTP

  5. Strengthening communication between HEW and AFDs

연구는 무엇을 측정합니까?

주요 결과 측정

결과 측정
측정값 설명
기간
Period prevalence of SAM OTP treatment coverage in children 6-59 months of age
기간: After 24 months of program implementation

Defined as the proportion of children with Severe Acute Malnutrition (SAM) or enrolled in the SAM Outpatient Therapeutic program (OTP) that are "under treatment".

  • SAM is defined as a Mid-Upper Arm Circumference <115mm or a weight-for-height Z-score <-3 (relative to the World Health Organization (WHO) 2006 growth standards) or presence of bilateral pitting edema.

  • "Under treatment" is defined as:

    • the caregiver acknowledging the child is enrolled in a SAM OTP AND
    • the child was fed ready-to-use therapeutic food (RUTF) over the last three days AND
    • the caregiver can either show at least one full RUTF sachet OR more than one empty RUTF sachet.
After 24 months of program implementation

2차 결과 측정

결과 측정
측정값 설명
기간
Point prevalence of SAM OTP treatment coverage in children 6-59 months of age
기간: After 24 months of program implementation

Defined as the proportion of children with SAM at the time of the survey that are under treatment (see definition under primary outcome

After 24 months of program implementation
Period prevalence of SAM OTP treatment coverage in the subgroup of treatment eligible children 6-59 months of age
기간: After 24 months of program implementation

Defined as the proportion of children with Severe Acute Malnutrition (SAM) or Severe underweight (weight-for-age Z-score <-3) or enrolled in the SAM Outpatient Therapeutic program (OTP) that are "under treatment".

  • SAM is defined as a Mid-Upper Arm Circumference <115mm or a weight-for-height Z-score <-3 (relative to the WHO 2006 growth standards) or presence of bilateral pitting edema.

  • "Under treatment" is defined as:

    • the caregiver acknowledging the child is enrolled in a SAM OTP AND
    • the child was fed ready-to-use therapeutic food (RUTF) over the last three days AND
    • the caregiver can either show at least one full RUTF sachet OR more than one empty RUTF sachet.
After 24 months of program implementation
Screening coverage of SAM
기간: After 24 months of program implementation

Defined as the proportion of children aged 6-59 months with SAM screened for wasting over the last 30 days (as reported by the caregiver)

After 24 months of program implementation
Screening coverage of severe underweight
기간: After 24 months of program implementation

Defined as the proportion of children aged 6-59 months with severe underweight (weight-for-age Z-score <-3 relative to WHO 2006 growth standard) screened over the last 30 days (as reported by the caregiver)

After 24 months of program implementation
Platform specific screening coverage of SAM
기간: After 24 months of program implementation

Defined as the proportion of children aged 6-59 months with SAM screened for wasting over the last 30 days (as reported by the caregiver):

  • by Family-led MUAC ( screening by family members using a MUAC tape)
  • during growth monitor promotion (GMP) consultations
  • during Integrated management of childhood illness consultations
After 24 months of program implementation
Growth Monitoring Promotion (GMP) consultation attendance
기간: After 24 months of program implementation

Defined as the proportion of children aged 6-59 months with SAM that attended GMP over the last 30 days (as reported by the caregiver).

After 24 months of program implementation
AFD group meeting attendance
기간: After 24 months of program implementation

Defined as the proportion of of children aged 6-59 months with SAM that attended the monthly AFD group contact over the last 30 days (as reported by the caregiver).

After 24 months of program implementation
AFD home visit coverage
기간: After 24 months of program implementation

Defined as the proportion of children aged 6-59 months with SAM and children enrolled in SAM OTP that received a home visit by an AFD leader/member over the last 30 days (as reported by the caregiver).

After 24 months of program implementation
Prevalence of SAM
기간: After 24 months of program implementation

Defined as the proportion of children aged 6-59 months with SAM (defined as WHZ <-3 or a MUAC < 115 mm or the presence of bilateral pitting edema). To calculate WHZ scores the 2006 WHO growth reference will be used

After 24 months of program implementation
Prevalence of wasting
기간: After 24 months of program implementation

Defined as the proportion of children aged 6-59 months with wasting (defined as WHZ <-2 or a MUAC < 125 mm or the presence of bilateral pitting edema). To calculate WHZ scores the 2006 WHO growth reference will be used

After 24 months of program implementation
Prevalence of stunting
기간: After 24 months of program implementation

Defined as the proportion of children aged 6-59 months with stunting (defined as height-for-age Z-scores (HAZ) <-2 or a MUAC < 125 mm or the presence of bilateral pitting edema). To calculate HAZ scores the 2006 WHO growth reference will be used

After 24 months of program implementation
Prevalence of underweight and severe underweight
기간: After 24 months of program implementation

Defined as the proportion of children aged 6-59 months with underweight (defined as weight-for-age Z-scores (WAZ) <-2 ) and severe underweight (defined as WAZ <-3 ). To calculate WAZ scores the 2006 WHO growth reference will be used

After 24 months of program implementation
Mean height-for-age Z-score (HAZ)
기간: After 24 months of program implementation

In 6-59 months old children. To calculate HAZ scores the 2006 WHO growth reference will be used

After 24 months of program implementation
Mean weight-for-height Z-score (WHZ)
기간: After 24 months of program implementation

In 6-59 months old children.To calculate WHZ scores the 2006 WHO growth reference will be used

After 24 months of program implementation
Mean weight-for-age Z-score (WAZ)
기간: After 24 months of program implementation

In 6-59 months old children.To calculate WAZ scores the 2006 WHO growth reference will be used

After 24 months of program implementation
Mean mid-upper arm circumference (MUAC)
기간: After 24 months of program implementation

In 6-59 months old children.

After 24 months of program implementation
Caregiver's knowledge related to breastfeeding, complementary feeding,child health and hygiene, the condition of severe acute malnutrition, outpatient therapeutic programs, screening of wasting
기간: After 24 months of program implementation

Presented as a total standardized score and by knowledge domain

After 24 months of program implementation
Vaccination coverage
기간: After 24 months of program implementation

Proportion of children aged 6-18 months with SAM or enrolled in SAM OTP who received all age-recommended immunizations

After 24 months of program implementation
Introduction of (semi) solid and soft complementary foods
기간: After 24 months of program implementation

The proportion of children 6-8 months of age who consumed (semi) solid and soft complementary foods during the previous day

After 24 months of program implementation
Minimum dietary diversity in infants and young children (6-23 mo)
기간: After 24 months of program implementation

The proportion of study children aged 6-23 months who consumed at least 5 of the 8 food groups (including breast milk) during the previous day

After 24 months of program implementation
Nr of food groups consumed by infants and young children (6-59 mo)
기간: After 24 months of program implementation

The mean number of food groups consumed during the previous day by study children aged 6-59

After 24 months of program implementation
Minimum meal frequency in infants and young children
기간: After 24 months of program implementation

Defined as the proportion of study children who had eaten during the previous day: 2 meals for breastfed children 6-8 months, 3 meals for breastfed children 9-23 months, or 4 meals for non-breastfed children 6-23 monthsMinimum meal frequency for children, defined as the proportion of children who had eaten the day before the survey: 2 meals for breastfed children 6-8 months, 3 meals for breastfed children 9-23 months, or 4 meals for non-breastfed children 6-23 months.

After 24 months of program implementation
Minimum acceptable diet in infants and young children
기간: After 24 months of program implementation

Defined as the proportion of study children aged 6-23 months with both minimal dietary diversity and minimal meal frequency during the previous day

After 24 months of program implementation
Continuous breastfeeding 12-23 months
기간: After 24 months of program implementation

Defined as the proportion of children aged 12-23 months breastfed during the previous day

After 24 months of program implementation
Egg and/or flesh food consumption
기간: After 24 months of program implementation

Proportion of children 6-23 months of age who consumed egg and/or flesh food during the previous day

After 24 months of program implementation
Sweet beverage consumption
기간: After 24 months of program implementation

Proportion of children 6-23 months of age who consumed a sweet beverage during the previous day

After 24 months of program implementation
Zero vegetable or fruit consumption consumption
기간: After 24 months of program implementation

Proportion of children 6-23 months of age who did not consume any vegetables or fruits during the previous day

After 24 months of program implementation
Minimum milk feeding frequency for non-breastfed children
기간: After 24 months of program implementation

Proportion of non-breastfed children 6-23 months of age who consumed at least two milk feeds during the previous day

After 24 months of program implementation
Weight-for-length Z-score and MUAC at Severe Acute Malnutrition (SAM) Outpatient Therapeutic Feeding program (OTP)
기간: 24 months from baseline until endline of the study

Weight-for-length Z-score (relative to the 2006 WHO reference) and MUAC(mm)

24 months from baseline until endline of the study
SAM OTP adherence
기간: 24 months from baseline until endline of the study

Defined as the proportion of cases enrolled to SAM OTP who received timely treatment from dedicated services (health center or health post) until anthropometric recovery

24 months from baseline until endline of the study
Weight gain rate during SAM OTP
기간: 24 months from baseline until endline of the study

Defined as the weight gain during SAM OTP divided by the length of treatment and divided by the child's weight

24 months from baseline until endline of the study
SAM OTP outcomes (drop-out, death, transfer, non-response rates)
기간: 24 months from baseline until endline of the study

Among cases admitted to SAM OTP

24 months from baseline until endline of the study
SAM OTP duration
기간: 24 months from baseline until endline of the study

Defined as the number of days spent in SAM OTP (from admission to discharge)

24 months from baseline until endline of the study

공동 작업자 및 조사자

여기에서 이 연구와 관련된 사람과 조직을 찾을 수 있습니다.

수사관

  • 수석 연구원: Lieven Huybregts, PhD, International Food Policy Research Institute
  • 수석 연구원: Tefera Belachew, PhD, Ethiopian Public Health Association

간행물 및 유용한 링크

연구에 대한 정보 입력을 담당하는 사람이 자발적으로 이러한 간행물을 제공합니다. 이것은 연구와 관련된 모든 것에 관한 것일 수 있습니다.

연구 기록 날짜

이 날짜는 ClinicalTrials.gov에 대한 연구 기록 및 요약 결과 제출의 진행 상황을 추적합니다. 연구 기록 및 보고된 결과는 공개 웹사이트에 게시되기 전에 특정 품질 관리 기준을 충족하는지 확인하기 위해 국립 의학 도서관(NLM)에서 검토합니다.

연구 주요 날짜

연구 시작 (실제)

2024년 5월 2일

기본 완료 (추정된)

2026년 9월 30일

연구 완료 (추정된)

2027년 6월 30일

연구 등록 날짜

최초 제출

2024년 4월 18일

QC 기준을 충족하는 최초 제출

2024년 4월 23일

처음 게시됨 (실제)

2024년 4월 24일

연구 기록 업데이트

마지막 업데이트 게시됨 (실제)

2026년 9월 24일

QC 기준을 충족하는 마지막 업데이트 제출

2026년 9월 21일

마지막으로 확인됨

2026년 9월 1일

추가 정보

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아니

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