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Magnetic Resonance Imaging of the Brain in Social and Emotional Reasoning

3 maart 2008 bijgewerkt door: National Institute of Neurological Disorders and Stroke (NINDS)

Reasoning About Social and Economic Knowledge: Identifying the Role of the Human Prefrontal Cortex Using Functional Neuroimaging

This study will use magnetic resonance imaging (MRI) to identify brain regions involved in social and emotional reasoning. It will identify differences in brain activity during task performance between people who have a nervous system illness and those who do not. MRI is a diagnostic tool that uses a strong magnetic field and radio waves to produce images of structural and chemical changes in the brain.

Healthy normal volunteers between 21 and 55 years of age who are right-handed and are native English speakers may be eligible for this study. Candidates will be screened with a medical history, including psychiatric and neurological information.

Participants will be asked to perform social and emotional reasoning tasks, such as sorting and judging rules and rule violations, while undergoing MRI scanning. Some tasks may simply involve viewing items on a screen. Others may involve solving complex problems and responding by pressing buttons. During the scan, the subject lies on a table in a narrow cylinder (the scanner) containing a magnetic field. The scan will last about 2 hours, with subjects asked to lie still for up to 10 minutes at a time.

Studie Overzicht

Toestand

Voltooid

Conditie

Gezond

Gedetailleerde beschrijving

The purpose of the protocol is to localize the neural regions and systems mediating the forms of knowledge representations hypothesized by the principal investigator to be stored in the human prefrontal cortex. Utilizing a variety of experimental neuropsychological tasks during functional MRI, we will investigate hypotheses regarding the role of the dorsolateral prefrontal cortex in planning, problem solving, economic exchange and reasoning; and the role of ventromedial prefrontal cortex in social cognition and emotional processing. We will ascertain the relationship between so-called [cold] cognitive processes such as planning and [hot] social processes such as mate choice and specific brain regions within the prefrontal cortex. We will also attempt to determine the relationship between non-frontal neural structures involved in emotional expression, such as the amygdala, and those frontal neural structures involved in executive functions that may modulate emotion. In addition, we will attempt to determine the requirements for frontal-parietal versus frontal-temporal network involvement in spatial landmark tasks. The data that we collect in this protocol will be of value in identifying a set of neural regions and distributed networks mediating the forms of knowledge representation stored in the prefrontal cortex. These questions will be addressed over seven separate studies with healthy, normal adult volunteers. The studies will employ within- and between-subject, event-related fMRI designs. The data collected will consist of behavioral measures of cognitive and emotional performance/judgment and corresponding fMRI images.

Studietype

Observationeel

Inschrijving

330

Contacten en locaties

In dit gedeelte vindt u de contactgegevens van degenen die het onderzoek uitvoeren en informatie over waar dit onderzoek wordt uitgevoerd.

Studie Locaties

Verenigde Staten
- Maryland
  - Bethesda, Maryland, Verenigde Staten, 20892
    - National Institute of Neurological Disorders and Stroke (NINDS)

Deelname Criteria

Onderzoekers zoeken naar mensen die aan een bepaalde beschrijving voldoen, de zogenaamde geschiktheidscriteria. Enkele voorbeelden van deze criteria zijn iemands algemene gezondheidstoestand of eerdere behandelingen.

Geschiktheidscriteria

Leeftijden die in aanmerking komen voor studie

Kind
Volwassen
Oudere volwassene

Accepteert gezonde vrijwilligers

Geslachten die in aanmerking komen voor studie

Allemaal

Beschrijving

INCLUSION CRITERIA:

In all the studies, subjects will consist of healthy, native English-speaking, right-handed volunteers, as measured by the Edinburgh Handedness Inventory. Subjects will range in age from 21 to 55 years old and they will be included regardless of race.

In studies 4 and 5, equal numbers of males and females will be recruited owing to previous findings of significant sex differences on such tests. In all other studies subjects will be recruited indiscriminately on the basis of sex.

EXCLUSION CRITERIA:

Non-native English speakers and non-right handers will be excluded as mentioned above, as will non-neurologically normal volunteers. Subjects younger than 21 and older than 55 will be excluded. A pregnancy test will be employed with all women of childbearing age. The results must be negative in order to proceed with the MRI.

Subjects with any of the following: aneurysm clip; implanted neural stimulator; implanted cardiac pacemaker or auto-defibrillator; cochlear implant; ocular foreign body, e.g. metal shavings; insulin pump; or irremovable body piercing will be excluded from the study due to the possible dangerous effects of the magnet upon metal objects in the body.

Studie plan

Dit gedeelte bevat details van het studieplan, inclusief hoe de studie is opgezet en wat de studie meet.

Hoe is de studie opgezet?

Medewerkers en onderzoekers

Hier vindt u mensen en organisaties die betrokken zijn bij dit onderzoek.

Sponsor

National Institute of Neurological Disorders and Stroke (NINDS)

Publicaties en nuttige links

De persoon die verantwoordelijk is voor het invoeren van informatie over het onderzoek stelt deze publicaties vrijwillig ter beschikking. Dit kan gaan over alles wat met het onderzoek te maken heeft.

Algemene publicaties

Studie record data

Deze datums volgen de voortgang van het onderzoeksdossier en de samenvatting van de ingediende resultaten bij ClinicalTrials.gov. Studieverslagen en gerapporteerde resultaten worden beoordeeld door de National Library of Medicine (NLM) om er zeker van te zijn dat ze voldoen aan specifieke kwaliteitscontrolenormen voordat ze op de openbare website worden geplaatst.

Bestudeer belangrijke data

Studie start

1 mei 2003

Studie voltooiing

1 mei 2005

Studieregistratiedata

Eerst ingediend

14 mei 2003

Eerst ingediend dat voldeed aan de QC-criteria

13 mei 2003

Eerst geplaatst (Schatting)

14 mei 2003

Updates van studierecords

Laatste update geplaatst (Schatting)

4 maart 2008

Laatste update ingediend die voldeed aan QC-criteria

3 maart 2008

Laatst geverifieerd