Methadone Maintenance Treatment Outcome Study in Taiwan (M0508)
Opioid abuse is a complex problem, which not only impacts on the affected individuals' physical and psychological health, but also threatens public security and the productivity of the society. Further, through needle sharing and sexual contacts, injecting drug users (IDUs) have become laden with HIV and HIV related health problems, representing a serious public health threat all over the world. In Taiwan, since the identification of the first HIV-infected IDU in 1987, the incident cases have continued to increase, reaching a height of 2,461 in 2005. In order to contain the epidemics of HIV among IDUs, and to prevent its spread to the population in general, the Center for Disease Control (CDC) collaborated with the Department of Justice to initiate and implement a number of harm reduction programs in 2005. The fact that opioid addiction is officially treated as a health rather than a legal issue itself represents a remarkable milestone in Taiwan. Among these harm reduction programs, including needle and syringe exchange for IDUs as well as substitution treatment approaches for opioid dependence, methadone maintenance treatment (MMT) perhaps represents the most most important and most crucial component. Remarkably, in a relatively short time span, more than 60 MMT programs were established, which enrolled more than 15,000 heroin addicts. This notwithstanding, the overall and differential effectiveness of these MMT service delivery systems, as well as the characteristics of these programs and the patients that might contribute toward treatment response or failure remain largely unknown. Such knowledge base is crucial for establishing standardized and feasible outcome evaluation processes for opioid addicts receiving MMT programs, as well as for the further improvement of the efficacy and effectiveness of these programs, in Taiwan.
In order to address some of these issues, this study adopts a multi-site, prospective clinical follow-up design. It aims at establishing a research network for examining MMT outcome, developing standardized MMT outcome assessment instruments and procedures, and identifying predictors of MMT outcome. The findings may contribute to the better understanding of the characteristics of opioid addicts, the effectiveness of MMT and remaining service needs for opioid addicts in Taiwan.
Studie Overzicht
Toestand
Conditie
Studietype
Inschrijving (Verwacht)
Contacten en locaties
Studie Locaties
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Miaoli, Taiwan
- Werving
- Departments of Psychiatry, Wei-Gong Memorial Hospital
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Hoofdonderzoeker:
- Ming-Lun Liu, MD
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Contact:
- Ming-Lun Liu, MD
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Taichung, Taiwan
- Werving
- Departments of Psychiatry, China Medical University and Hospital
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Hoofdonderzoeker:
- Chieh-Liang Huang, MD
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Contact:
- Chieh-Liang Huang, MD
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Taipei, Taiwan
- Werving
- Departments of Psychiatry, Taipei City Hospital Song-De Campus
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Hoofdonderzoeker:
- Lien-Wen Su, MD
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Contact:
- Lien-Wen Su, MD
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Taipei, Taiwan
- Werving
- Departments of Psychiatry, Taipei City Hospital Yang-Ming Campus
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Hoofdonderzoeker:
- Yih-Hong Yang, MD
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Onderonderzoeker:
- Yung-Chun Fang, MD
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Contact:
- Yih-Hong Yang, MD
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Taipei, Taiwan
- Werving
- Departments of Psychiatry, Far-Eastern Memorial Hospital
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Hoofdonderzoeker:
- Chi-Shin Wu, MD
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Onderonderzoeker:
- Kai-Chi Fang, MD
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Contact:
- Chi-Shin Wu, MD
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Taipei County, Taiwan
- Werving
- Departments of Psychiatry, En-Chu-Kong Hospital
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Hoofdonderzoeker:
- Li-Nen Lin, MD
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Onderonderzoeker:
- Yen-Feng Lin, MD
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Contact:
- Li-Nen Lin, MD
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Tao-Yuan, Taiwan
- Werving
- Departments of Psychiatry, Tao-yuan Psychiatric Center
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Contact:
- Happy Kuy-Lok Tan, MD, MPH
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Hoofdonderzoeker:
- Happy Kuy-Lok Tan, MD, MPH
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Onderonderzoeker:
- Sun-Yuan Chou, MD
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Onderonderzoeker:
- Kuen-Hong Wu, MD
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Deelname Criteria
Geschiktheidscriteria
Leeftijden die in aanmerking komen voor studie
Accepteert gezonde vrijwilligers
Geslachten die in aanmerking komen voor studie
Bemonsteringsmethode
Studie Bevolking
Beschrijving
Inclusion Criteria:
- Be 18 years or older.
- Be fulfilling the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria of opiate dependence.
- Be agree to and capable of signing informed consent form that has been approved by an Institution Review Board.
Exclusion Criteria:
- Have ever participated in the study at one of the collaborative hospitals/clinics.
- Be expecting to discontinue methadone treatment for any reason (leaving the methadone clinic's geographic area, pending legal action, etc.) in the following 3 months.
Studie plan
Hoe is de studie opgezet?
Ontwerpdetails
Cohorten en interventies
Groep / Cohort |
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Heroin-addicted Patients
Heroin-addicted outpatient department (OPD) patients who seek help for methadone maintenance treatment
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Medewerkers en onderzoekers
Studie record data
Bestudeer belangrijke data
Studie start
Primaire voltooiing (Verwacht)
Studie voltooiing (Verwacht)
Studieregistratiedata
Eerst ingediend
Eerst ingediend dat voldeed aan de QC-criteria
Eerst geplaatst (Schatting)
Updates van studierecords
Laatste update geplaatst (Schatting)
Laatste update ingediend die voldeed aan QC-criteria
Laatst geverifieerd
Meer informatie
Termen gerelateerd aan deze studie
Aanvullende relevante MeSH-voorwaarden
Andere studie-ID-nummers
- 99A1-PHPP39 (Ander subsidie-/financieringsnummer: National Health Research Institutes)
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