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Menstrual Cycle Hormones and Eating Behavior (FL-84)

1. desember 2017 oppdatert av: USDA, Western Human Nutrition Research Center

Effect of Menstrual Cycle Hormone Changes on Eating Behavior and Nutrient Metabolism

The purpose of this study is to determine if the phase of the menstrual cycle (opposed versus unopposed estrogen phase) affects eating behavior, including types of foods preferred, wanting/desire for specific foods, and perception of hunger.

Studieoversikt

Status

Fullført

Forhold

Detaljert beskrivelse

This is an observational study to investigate the effect of endogenous estrogen (E2) and progesterone (P4) levels on eating behavior and energy-yielding nutrient metabolism. Eating behavior will be assessed during a complete menstrual cycle during the first month of the study. Participants will track the follicular and luteal phases of their menstrual cycle using urinary leuteinizing hormone (LH) kits, they will record information about their food intake, eating behaviors, and appetite in their home environments, and they will complete two laboratory test days: one test day scheduled during their follicular phase, and one test day scheduled during their luteal phase.

Studietype

Observasjonsmessig

Registrering (Faktiske)

Kontakter og plasseringer

Denne delen inneholder kontaktinformasjon for de som utfører studien, og informasjon om hvor denne studien blir utført.

Studiesteder

Forente stater
- California
  - Davis, California, Forente stater, 95616
    - USDA, ARS, Western Human Nutrition Research Center

Deltakelseskriterier

Forskere ser etter personer som passer til en bestemt beskrivelse, kalt kvalifikasjonskriterier. Noen eksempler på disse kriteriene er en persons generelle helsetilstand eller tidligere behandlinger.

Kvalifikasjonskriterier

Alder som er kvalifisert for studier

18 år til 35 år (Voksen)

Tar imot friske frivillige

Kjønn som er kvalifisert for studier

Hunn

Prøvetakingsmetode

Ikke-sannsynlighetsprøve

Studiepopulasjon

Healthy, premenopausal women.

Beskrivelse

Inclusion Criteria:

Body Mass Index between 20-30 Kg/m2
regular menstrual cycles
sedentary lifestyle (physical activity not more than 30 minutes per day three times a week)

Exclusion Criteria:

Fasting blood sugar greater than 110 mg/dL
Systolic Blood Pressure greater than 140 mmHg
Diastolic Blood Pressure greater than 90 mmHg
Fasting triglycerides greater than 120 mg/dL
Documented or self-reported chronic disorders such as arthritis, or other inflammatory diseases
Women who are Post-menopausal or Peri-menopausal
Pre-menopausal women who are pregnant, uni/multiparous, taking oral contraceptives, or who have menstrual cycles lasting less than 20 days or greater than 45 days, polycystic ovary syndrome (PCOS), amenorrhea, eumenorrhoea, or polymenorrhoea.

Studieplan

Denne delen gir detaljer om studieplanen, inkludert hvordan studien er utformet og hva studien måler.

Hvordan er studiet utformet?

Designdetaljer

Hva måler studien?

Primære resultatmål

Resultatmål	Tiltaksbeskrivelse	Tidsramme
Eating behavior Tidsramme: At follicular (day 11) and luteal (day 26) phase of menstrual cycle	Eating behavior, including types of foods preferred, wanting/desire for specific foods, and perception of hunger will be measured using four questionnaires; Eating inventory: to assess dietary restraint, Stanford Brief Physical Activity Questionnaire, Food craving questionnaire, Eating behavior and attitudes questionnaire	At follicular (day 11) and luteal (day 26) phase of menstrual cycle

Sekundære resultatmål

Resultatmål	Tiltaksbeskrivelse	Tidsramme
Insulin sensitivity Tidsramme: At follicular (day 11) and luteal (day 26) phase of menstrual cycle	To determine if the phase of the menstrual cycle affects insulin sensitivity, we will measure plasma insulin, glucose and non-esterified fatty acids (NEFA).	At follicular (day 11) and luteal (day 26) phase of menstrual cycle
Serum lipid profile changes Tidsramme: At follicular (day 11) and luteal (day 26) phase of menstrual cycle	Blood samples will be analyzed for lipids and lipoproteins, including apoproteins A1, B, C-II, C-III, and E.	At follicular (day 11) and luteal (day 26) phase of menstrual cycle
Urinary c-peptide Tidsramme: At follicular (day 11) and luteal (day 26) phase of menstrual cycle	The level of urinary C-peptide and creatinine will be measured in a 24-hour urine collection.	At follicular (day 11) and luteal (day 26) phase of menstrual cycle
Estradiol Tidsramme: At follicular (day 11) and luteal (day 26) phase of menstrual cycle	Estradiol measured in serum in relation to appetite variables	At follicular (day 11) and luteal (day 26) phase of menstrual cycle
progesterone Tidsramme: At follicular (day 11) and luteal (day 26) phase of menstrual cycle	Progesterone measured in serum in relation to appetite variables	At follicular (day 11) and luteal (day 26) phase of menstrual cycle
Dehydroepiandrosterone (DHEA) Tidsramme: At follicular (day 11) and luteal (day 26) phase of menstrual cycle	Dehydroepiandrosterone measured in serum in relation to appetite variables	At follicular (day 11) and luteal (day 26) phase of menstrual cycle
Sex Hormone Binding Globulin (SHBG) Tidsramme: At follicular (day 11) and luteal (day 26) phase of menstrual cycle	SHBG measured in serum in relation to appetite variables	At follicular (day 11) and luteal (day 26) phase of menstrual cycle
Endocannabinoid profile Tidsramme: At follicular (day 11) and luteal (day 26) phase of menstrual cycle	Endocannabinoid profile measured in serum to assess appetite	At follicular (day 11) and luteal (day 26) phase of menstrual cycle
Leptin Tidsramme: At follicular (day 11) and luteal (day 26) phase of menstrual cycle	Leptin measured in serum to assess appetite	At follicular (day 11) and luteal (day 26) phase of menstrual cycle

Samarbeidspartnere og etterforskere

Det er her du vil finne personer og organisasjoner som er involvert i denne studien.

Sponsor

USDA, Western Human Nutrition Research Center

Etterforskere

Hovedetterforsker: Nancy Keim, PhD, USDA, ARS, Western Human Nutrition Research Center

Publikasjoner og nyttige lenker

Den som er ansvarlig for å legge inn informasjon om studien leverer frivillig disse publikasjonene. Disse kan handle om alt relatert til studiet.

Generelle publikasjoner

Hjelpsomme linker

United States Department of Agriculture, ARS, Western Human Nutrition Research Center

Studierekorddatoer

Disse datoene sporer fremdriften for innsending av studieposter og sammendragsresultater til ClinicalTrials.gov. Studieposter og rapporterte resultater gjennomgås av National Library of Medicine (NLM) for å sikre at de oppfyller spesifikke kvalitetskontrollstandarder før de legges ut på det offentlige nettstedet.

Studer hoveddatoer

Studiestart

1. mars 2011

Primær fullføring (Faktiske)

1. desember 2012

Studiet fullført (Faktiske)