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Ocena upośledzonej mobilności w konstytucji przewlekłej choroby kohorty (EVALMOB)

2 listopada 2026 zaktualizowane przez: University Hospital, Clermont-Ferrand

Chronic illness is a public health issue and mobility loss is frequent in this population. Among its' multiple physical and psychological consequences, increased mortality and cardiovascular morbidity seem the main concern. Therefore, the exploration of locomotor deficiencies, physical capacities and metabolism of patients with chronic illnesses constitutes a major challenge both for the treatment of causal pathologies, as well as for evaluating the impact of therapeutic interventions, the benefit of which will be an improvement in physical capacities and ultimately mobility. In view of the hypothesis of an increase in the prevalence of mobility disorders in this population, this approach is part of a logic of screening and improving the effectiveness of the care of these patients with a multidisciplinary evaluation of individual risks. The EVALMOB protocol was designed in order to try to determine a standard profile of "dysmobility" in patients with chronic illness

Przegląd badań

Status

Status

Wskazuje aktualny stan rekrutacji lub stan rozszerzonego dostępu.
Rekrutacyjny

Warunki

Warunki

Badana choroba, zaburzenie, zespół, choroba lub uraz. Na stronie ClinicalTrials.gov warunki mogą również obejmować inne kwestie związane ze zdrowiem, takie jak długość życia, jakość życia i zagrożenia dla zdrowia.

Interwencja / Leczenie

Interwencja / Leczenie

Proces lub działanie będące przedmiotem badania klinicznego. Interwencje obejmują leki, urządzenia medyczne, procedury, szczepionki i inne produkty, które są w fazie badań lub są już dostępne. Interwencje mogą również obejmować podejścia nieinwazyjne, takie jak edukacja lub modyfikacja diety i ćwiczeń.

Szczegółowy opis

We propose to constitute a prospective cohort of subjects carrying chronic disease. The objective is to explore all the different components of mobility (balance, muscle force, body composition, walking ability, metabolism, etc.), to assess their impact on the functional capacity of individuals and to identify their potential interactions. Processing this data could ultimately allow the development of a model to determine a composite standard profile of "dysmobility" in patients with chronic disease.

In the present protocol, parameters will be measured on five occasions (at inclusion, at 6 months from the inclusion day, at 1,2 and 5 year(s) from the inclusion day). All tests will be performed on the same day. New assessments will be done on the same principle as the initial evaluation.

Statistical analyses will be carried out using Stata software (version 13, StataCorp, College Station, USA). Data will be described by frequencies and percentages for categorical variables and by means and standard deviation (or median and interquartile range if data are not normally distributed) for continuous variables. The normality of continuous data will be assessed graphically and using the Shapiro-Wilk test. The main analysis will consist in determining patient profiles regarding their mobility. Clustering-type approaches (supervised or not) will be proposed: k-means, vector machine support, machine learning, factor analysis. For example, factor analyses on mixed data will allow the main components of mobility to be characterized. They can be followed by an ascending hierarchical classification in order to determine homogeneous groups of patients.

These groups will be described and compared on the main criteria evaluated using standard statistical tests: chi2 test (or Fisher's exact test if applicable) for the categorical criteria and using an analysis of variance (or Kruskal-Wallis if data are not normally distributed) for continuous criteria. The main analysis will be broken down more specifically for each of the pathologies considered. In addition, the sensitivity to change will be assessed in each pathology and for each assessment criterion. The search for factors related to the evolution of the different criteria will be carried out using usual tests and mixed multivariate models (logistics for categorical / linear criteria for continuous criteria) considering the subject as a random effect, and adjusting on the time criteria (inclusion / follow-up) and the criteria highlighted in the univariate analyses and in light of the elements reported in the literature. A sensitivity analysis will be proposed in order to study the statistical nature of the missing data and to propose, if necessary, the most suitable method of imputing the data: multiple imputation, maximum bias or LOCF in the case of longitudinal data.

Typ studiów

Typ studiów

Opisuje charakter badania klinicznego. Rodzaje badań obejmują badania interwencyjne (zwane także badaniami klinicznymi), badania obserwacyjne (w tym rejestry pacjentów) i rozszerzony dostęp.
Interwencyjne

Zapisy (Szacowany)

Zapisy

Liczba uczestników badania klinicznego. „Przewidywana” rekrutacja to docelowa liczba uczestników, których naukowcy potrzebują do badania.
5000

Faza

Faza

Etap badania klinicznego badającego lek lub produkt biologiczny w oparciu o definicje opracowane przez amerykańską Agencję ds. Żywności i Leków (FDA). Faza opiera się na celu badania, liczbie uczestników i innych cechach. Istnieje pięć faz: wczesna faza 1 (wcześniej wymieniona jako faza 0), faza 1, faza 2, faza 3 i faza 4. Nie dotyczy jest używany do opisania badań bez faz zdefiniowanych przez FDA, w tym prób urządzeń lub interwencji behawioralnych.
  • Nie dotyczy

Kontakty i lokalizacje

Ta sekcja zawiera dane kontaktowe osób prowadzących badanie oraz informacje o tym, gdzie badanie jest przeprowadzane.

Kontakt w sprawie studiów

Kontakt w sprawie studiów

Imię i nazwisko oraz dane kontaktowe osoby, która może odpowiedzieć na pytania dotyczące rejestracji do badania klinicznego. Każda lokalizacja, w której prowadzone jest badanie, może mieć również określoną osobę kontaktową, która może lepiej odpowiedzieć na te pytania.

Lokalizacje studiów

Kryteria uczestnictwa

Badacze szukają osób, które pasują do określonego opisu, zwanego kryteriami kwalifikacyjnymi. Niektóre przykłady tych kryteriów to ogólny stan zdrowia danej osoby lub wcześniejsze leczenie.

Kryteria kwalifikacji

Kryteria kwalifikacji

Kluczowe wymagania, które muszą spełniać osoby chcące wziąć udział w badaniu klinicznym lub cechy, które muszą posiadać. Kryteria kwalifikowalności obejmują zarówno kryteria włączenia (które są wymagane, aby dana osoba mogła uczestniczyć w badaniu), jak i kryteria wykluczenia (które uniemożliwiają osobie udział). Rodzaje kryteriów kwalifikowalności obejmują to, czy badanie akceptuje zdrowych ochotników, ma wymagania dotyczące wieku lub grupy wiekowej lub jest ograniczone ze względu na płeć.

Wiek uprawniający do nauki

18 lat do 90 lat (Dorosły, Starszy dorosły)

Akceptuje zdrowych ochotników

Nie

Płeć kwalifikująca się do nauki

Wszystko

Opis

Inclusion Criteria:

  • Man or woman aged 18 to 90.
  • Patients with chronic pathology contributing to impaired mobility.
  • Volunteers who have given their written consent.
  • Affiliated to French health care system (for France)

Exclusion Criteria:

  • Patients suffering from progressive psychiatric pathologies (active psychosis, hallucinations, etc.) or the presence of another serious unstabilized pathology (decompensated heart failure, progressive terminal cancer, etc.).
  • People with poorly controlled or unstable cardiovascular disease.
  • Major osteoarticular or neurological problems completely preventing the proper performance of the various tests.
  • Non-autonomous patient
  • Persons under guardianship, curatorship, deprived of liberty or safeguarding justice.
  • People excluded from another study.
  • Pregnant or lactating women.

Plan studiów

Ta sekcja zawiera szczegółowe informacje na temat planu badania, w tym sposób zaprojektowania badania i jego pomiary.

Jak projektuje się badanie?

Szczegóły projektu

  • Główny cel: Diagnostyczny
  • Przydział: Nie dotyczy
  • Model interwencyjny: Zadanie dla jednej grupy
  • Maskowanie: Brak (otwarta etykieta)

Broń i interwencje

Grupa uczestników / Arm

Grupa uczestników / Arm

Grupa lub podgrupa uczestników badania klinicznego, którzy zgodnie z protokołem badania otrzymują określoną interwencję/leczenie lub nie otrzymują żadnej interwencji.
Interwencja / Leczenie

Interwencja / Leczenie

Proces lub działanie będące przedmiotem badania klinicznego. Interwencje obejmują leki, urządzenia medyczne, procedury, szczepionki i inne produkty, które są w fazie badań lub są już dostępne. Interwencje mogą również obejmować podejścia nieinwazyjne, takie jak edukacja lub modyfikacja diety i ćwiczeń.
Eksperymentalny: Cohort 1

Participants will be involved in a long-term evaluation program combining, body composition measures, physical tests as well as self-administered questionnaires. Participants will be followed for 5 years with evaluations taking place at inclusion, 6 months, at 1, 2 and 5 years
Inny: Development of a screening algorithm designed to determine a "dysmobility" profile in patients with chronic illness.

Firstly, volunteers will be invited to complete online questionnaires on a secure platform. The mobility assessment will be carried out initially (t1) and up to a maximum of 4 times (t1 to t4) as part of a day hospitalization. Questionnaires will be diverse (SF36, KOOS, HOOS, BROCKER, MNA, TAMPA, etc.) in order to assess several aspects that compose mobility.

Physical evaluations will include various validated tests (isokinetic strength measure, TUG, 6MWT, Berg Balance Scale, etc.)

Co mierzy badanie?

Podstawowe miary wyniku

Podstawowe miary wyniku

W protokole badania klinicznego planowana miara wyniku, która jest najważniejsza dla oceny efektu interwencji/leczenia. Większość badań klinicznych ma jedną główną miarę wyniku, ale niektóre mają więcej niż jedną.
Miara wyniku
Opis środka
Ramy czasowe
dismobility score calculated from the results reported in secondary outcomes
Ramy czasowe: Day 0

The main objective being to determine patient profiles with regard to "dysmobility", all the criteria detailed as secondary outcomes will be considered for the definition of the profiles
Day 0
dismobility score calculated from the results reported in secondary outcomes
Ramy czasowe: Month 6

The main objective being to determine patient profiles with regard to "dysmobility", all the criteria detailed as secondary outcomes will be considered for the definition of the profiles
Month 6
dismobility score calculated from the results reported in secondary outcomes
Ramy czasowe: Year 1

The main objective being to determine patient profiles with regard to "dysmobility", all the criteria detailed as secondary outcomes will be considered for the definition of the profiles
Year 1
dismobility score calculated from the results reported in secondary outcomes
Ramy czasowe: Year 2

The main objective being to determine patient profiles with regard to "dysmobility", all the criteria detailed as secondary outcomes will be considered for the definition of the profiles
Year 2
dismobility score calculated from the results reported in secondary outcomes
Ramy czasowe: Year 5

The main objective being to determine patient profiles with regard to "dysmobility", all the criteria detailed as secondary outcomes will be considered for the definition of the profiles
Year 5

Miary wyników drugorzędnych

Miary wyników drugorzędnych

W protokole badania klinicznego planowana miara wyniku, która nie jest tak ważna jak główna miara wyniku w ocenie efektu interwencji, ale nadal jest interesująca. Większość badań klinicznych ma więcej niż jedną drugorzędową miarę wyniku.
Miara wyniku
Opis środka
Ramy czasowe
The main objective being to determine patient profiles with regard to "dysmobility", all the criteria detailed as secondary outcomes will be considered for the definition of the profiles
Ramy czasowe: Day 0

Demographics information will be obtained using a single questionnaire including questions on age, gender, qualification, personal work status, ethnicity, life and occupational events.
Day 0
Weight (Kg).
Ramy czasowe: Day 0

Weight will be measured with the medical body weight scale SECA® and according to the ISAK recommendations.
Day 0
Weight (Kg).
Ramy czasowe: Month 6

Weight will be measured with the medical body weight scale SECA® and according to the ISAK recommendations.
Month 6
Weight (Kg).
Ramy czasowe: Year 1

Weight will be measured with the medical body weight scale SECA® and according to the ISAK recommendations.
Year 1
Weight (Kg).
Ramy czasowe: Year 2

Weight will be measured with the medical body weight scale SECA® and according to the ISAK recommendations.
Year 2
Weight (Kg).
Ramy czasowe: Year 5

Weight will be measured with the medical body weight scale SECA® and according to the ISAK recommendations.
Year 5
Height (cm).
Ramy czasowe: Day 0

Height will be measured with a wall mounted tape measure and according to the ISAK recommendations
Day 0
Height (cm).
Ramy czasowe: Month 6

Height will be measured with a wall mounted tape measure and according to the ISAK recommendations
Month 6
Height (cm).
Ramy czasowe: Year 1

Height will be measured with a wall mounted tape measure and according to the ISAK recommendations
Year 1
Height (cm).
Ramy czasowe: Year 2

Height will be measured with a wall mounted tape measure and according to the ISAK recommendations
Year 2
Height (cm).
Ramy czasowe: Year 5

Height will be measured with a wall mounted tape measure and according to the ISAK recommendations
Year 5
Body fat percentage (%).
Ramy czasowe: Day 0

Body fat percentage will be measured with the Harpenden skinfold caliper by measuring skinfold thickness in four different sites (triceps; biceps, suprailiac, subscapular).
Day 0
Body fat percentage (%).
Ramy czasowe: Month 6

Body fat percentage will be measured with the Harpenden skinfold caliper by measuring skinfold thickness in four different sites (triceps; biceps, suprailiac, subscapular).
Month 6
Body fat percentage (%).
Ramy czasowe: Year 1

Body fat percentage will be measured with the Harpenden skinfold caliper by measuring skinfold thickness in four different sites (triceps; biceps, suprailiac, subscapular).
Year 1
Body fat percentage (%).
Ramy czasowe: Year 2

Body fat percentage will be measured with the Harpenden skinfold caliper by measuring skinfold thickness in four different sites (triceps; biceps, suprailiac, subscapular).
Year 2
Body fat percentage (%).
Ramy czasowe: Year 5

Body fat percentage will be measured with the Harpenden skinfold caliper by measuring skinfold thickness in four different sites (triceps; biceps, suprailiac, subscapular).
Year 5
Waist circumference (cm).
Ramy czasowe: Day 0

Waist circumference will be measured with a medical body tape measure and according to the ISAK recommendations
Day 0
Waist circumference (cm).
Ramy czasowe: Month 5

Waist circumference will be measured with a medical body tape measure and according to the ISAK recommendations
Month 5
Waist circumference (cm).
Ramy czasowe: Year 1

Waist circumference will be measured with a medical body tape measure and according to the ISAK recommendations
Year 1
Waist circumference (cm).
Ramy czasowe: Year 2

Waist circumference will be measured with a medical body tape measure and according to the ISAK recommendations
Year 2
Waist circumference (cm).
Ramy czasowe: Year 5

Waist circumference will be measured with a medical body tape measure and according to the ISAK recommendations
Year 5
Hip circumference (cm).
Ramy czasowe: Day 0

Hip circumference will be measured with a medical body tape measure and according to the ISAK recommendations.
Day 0
Hip circumference (cm).
Ramy czasowe: Month 6

Hip circumference will be measured with a medical body tape measure and according to the ISAK recommendations.
Month 6
Hip circumference (cm).
Ramy czasowe: Year 1

Hip circumference will be measured with a medical body tape measure and according to the ISAK recommendations.
Year 1
Hip circumference (cm).
Ramy czasowe: Year 2

Hip circumference will be measured with a medical body tape measure and according to the ISAK recommendations.
Year 2
Hip circumference (cm).
Ramy czasowe: Year 5

Hip circumference will be measured with a medical body tape measure and according to the ISAK recommendations.
Year 5
Brachial circumference (cm).
Ramy czasowe: Day 0

Brachial circumference will be measured with a medical body tape measure and according to the ISAK recommendations.
Day 0
Brachial circumference (cm).
Ramy czasowe: Month 6

Brachial circumference will be measured with a medical body tape measure and according to the ISAK recommendations.
Month 6
Brachial circumference (cm).
Ramy czasowe: Year 1

Brachial circumference will be measured with a medical body tape measure and according to the ISAK recommendations.
Year 1
Brachial circumference (cm).
Ramy czasowe: Year 2

Brachial circumference will be measured with a medical body tape measure and according to the ISAK recommendations.
Year 2
Brachial circumference (cm).
Ramy czasowe: Year 5

Brachial circumference will be measured with a medical body tape measure and according to the ISAK recommendations.
Year 5
Calf circumference (cm).
Ramy czasowe: Day 0

Calf circumference will be measured with a medical body tape measure and according to the ISAK recommendations
Day 0
Calf circumference (cm).
Ramy czasowe: Month 6

Calf circumference will be measured with a medical body tape measure and according to the ISAK recommendations
Month 6
Calf circumference (cm).
Ramy czasowe: Year 1

Calf circumference will be measured with a medical body tape measure and according to the ISAK recommendations
Year 1
Calf circumference (cm).
Ramy czasowe: Year 2

Calf circumference will be measured with a medical body tape measure and according to the ISAK recommendations
Year 2
Calf circumference (cm).
Ramy czasowe: Year 5

Calf circumference will be measured with a medical body tape measure and according to the ISAK recommendations
Year 5
Body Mass Index (Kg/m²).
Ramy czasowe: Day 0

BMI will be calculated (weight in kilograms divided by height in meters squared).
Day 0
Body Mass Index (Kg/m²).
Ramy czasowe: Month 6

BMI will be calculated (weight in kilograms divided by height in meters squared).
Month 6
Body Mass Index (Kg/m²).
Ramy czasowe: Year 1

BMI will be calculated (weight in kilograms divided by height in meters squared).
Year 1
Body Mass Index (Kg/m²).
Ramy czasowe: Year 2

BMI will be calculated (weight in kilograms divided by height in meters squared).
Year 2
Body Mass Index (Kg/m²).
Ramy czasowe: Year 5

BMI will be calculated (weight in kilograms divided by height in meters squared).
Year 5
Body composition
Ramy czasowe: Day 0

Body composition (muscle and fat) will be measured using he Bodystat® Impedance-meter.
Day 0
Body composition
Ramy czasowe: Month 6

Body composition (muscle and fat) will be measured using he Bodystat® Impedance-meter.
Month 6
Body composition
Ramy czasowe: Year 1

Body composition (muscle and fat) will be measured using he Bodystat® Impedance-meter.
Year 1
Body composition
Ramy czasowe: Year 2

Body composition (muscle and fat) will be measured using he Bodystat® Impedance-meter.
Year 2
Body composition
Ramy czasowe: Year 5

Body composition (muscle and fat) will be measured using he Bodystat® Impedance-meter.
Year 5
T-score (DS).
Ramy czasowe: DAy 0

- Description: T-score will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
DAy 0
T-score (DS).
Ramy czasowe: Month 6

- Description: T-score will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Month 6
T-score (DS).
Ramy czasowe: Year 1

- Description: T-score will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 1
T-score (DS).
Ramy czasowe: Year 2

- Description: T-score will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 2
T-score (DS).
Ramy czasowe: Year 5

- Description: T-score will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 5
Z-score (DS).
Ramy czasowe: Day 0

Z-score will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer
Day 0
Z-score (DS).
Ramy czasowe: Month 6

Z-score will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer
Month 6
Z-score (DS).
Ramy czasowe: Year 1

Z-score will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer
Year 1
Z-score (DS).
Ramy czasowe: Year 2

Z-score will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer
Year 2
Z-score (DS).
Ramy czasowe: Year 5

Z-score will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer
Year 5
Fat mass
Ramy czasowe: Day 0

Fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Day 0
Fat mass
Ramy czasowe: Month 6

Fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Month 6
Fat mass
Ramy czasowe: Year 1

Fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 1
Fat mass
Ramy czasowe: Year 2

Fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 2
Fat mass
Ramy czasowe: Year 5

Fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 5
Fat-free mass (%).
Ramy czasowe: Day 0

: Fat free mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Day 0
Fat-free mass (%).
Ramy czasowe: Month 6

: Fat free mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Month 6
Fat-free mass (%).
Ramy czasowe: Year 1

: Fat free mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 1
Fat-free mass (%).
Ramy czasowe: Year 2

: Fat free mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 2
Fat-free mass (%).
Ramy czasowe: Year 5

: Fat free mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 5
Fat mas index (Kg/m²).
Ramy czasowe: Day 0

Fat mas index will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Day 0
Fat mas index (Kg/m²).
Ramy czasowe: Month 6

Fat mas index will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Month 6
Fat mas index (Kg/m²).
Ramy czasowe: Year 1

Fat mas index will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 1
Fat mas index (Kg/m²).
Ramy czasowe: Year 2

Fat mas index will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 2
Fat mas index (Kg/m²).
Ramy czasowe: Year 5

Fat mas index will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 5
Ratio of android to gynoid fat mass.
Ramy czasowe: Day 0

Ratio of android to gynoid fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer
Day 0
Ratio of android to gynoid fat mass.
Ramy czasowe: Month 6

Ratio of android to gynoid fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer
Month 6
Ratio of android to gynoid fat mass.
Ramy czasowe: Year 1

Ratio of android to gynoid fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer
Year 1
Ratio of android to gynoid fat mass.
Ramy czasowe: Year 2

Ratio of android to gynoid fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer
Year 2
Ratio of android to gynoid fat mass.
Ramy czasowe: Year 5

Ratio of android to gynoid fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer
Year 5
Visceral adipose tissue (Kg).
Ramy czasowe: Day 0

Visceral fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Day 0
Visceral adipose tissue (Kg).
Ramy czasowe: Month 6

Visceral fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Month 6
Visceral adipose tissue (Kg).
Ramy czasowe: Year 1

Visceral fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 1
Visceral adipose tissue (Kg).
Ramy czasowe: Year 2

Visceral fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 2
Visceral adipose tissue (Kg).
Ramy czasowe: Year 5

Visceral fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 5
Fat-free mass index (kg/m²).
Ramy czasowe: Day 0

: Fat-free mass index will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Day 0
Fat-free mass index (kg/m²).
Ramy czasowe: Month 6

: Fat-free mass index will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Month 6
Fat-free mass index (kg/m²).
Ramy czasowe: Year 1

: Fat-free mass index will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 1
Fat-free mass index (kg/m²).
Ramy czasowe: Year 2

: Fat-free mass index will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 2
Fat-free mass index (kg/m²).
Ramy czasowe: Year 5

: Fat-free mass index will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 5
Appendicular fat-free mass index (Kg/m²).
Ramy czasowe: Day 0

Appendicular fat-free mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Day 0
Appendicular fat-free mass index (Kg/m²).
Ramy czasowe: Month 6

Appendicular fat-free mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Month 6
Appendicular fat-free mass index (Kg/m²).
Ramy czasowe: Year 1

Appendicular fat-free mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 1
Appendicular fat-free mass index (Kg/m²).
Ramy czasowe: Year 2

Appendicular fat-free mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 2
Appendicular fat-free mass index (Kg/m²).
Ramy czasowe: Year 5

Appendicular fat-free mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 5
Bone mass (Kg)
Ramy czasowe: Day 0

- Description: Bone mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Day 0
Bone mass (Kg)
Ramy czasowe: Month 6

- Description: Bone mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Month 6
Bone mass (Kg)
Ramy czasowe: Year 1

- Description: Bone mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 1
Bone mass (Kg)
Ramy czasowe: Year 2

- Description: Bone mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 2
Bone mass (Kg)
Ramy czasowe: Year 5

- Description: Bone mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 5
Daily caloric intake (Kcal/24h).
Ramy czasowe: Day 0

Daily caloric intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Day 0
Daily caloric intake (Kcal/24h).
Ramy czasowe: Month 6

Daily caloric intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Month 6
Daily caloric intake (Kcal/24h).
Ramy czasowe: Year 1

Daily caloric intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Year 1
Daily caloric intake (Kcal/24h).
Ramy czasowe: Year 2

Daily caloric intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Year 2
Daily caloric intake (Kcal/24h).
Ramy czasowe: Year 5

Daily caloric intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Year 5
Daily protein intake (in g and as a percentage of total caloric intake).
Ramy czasowe: Day 0

Daily protein intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Day 0
Daily protein intake (in g and as a percentage of total caloric intake).
Ramy czasowe: Month 6

Daily protein intake (in g and as a percentage of total caloric intake).
Month 6
Daily protein intake (in g and as a percentage of total caloric intake).
Ramy czasowe: Year 1

Daily protein intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Year 1
Daily protein intake (in g and as a percentage of total caloric intake).
Ramy czasowe: Year 2

Daily protein intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Year 2
Daily protein intake (in g and as a percentage of total caloric intake).
Ramy czasowe: Year 5

Daily protein intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Year 5
Daily carbohydrate intake (in g and as a percentage of total caloric intake).
Ramy czasowe: Day 0

Daily carbohydrate intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Day 0
Daily carbohydrate intake (in g and as a percentage of total caloric intake).
Ramy czasowe: Month 6

Daily carbohydrate intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Month 6
Daily carbohydrate intake (in g and as a percentage of total caloric intake).
Ramy czasowe: Year 1

Daily carbohydrate intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Year 1
Daily carbohydrate intake (in g and as a percentage of total caloric intake).
Ramy czasowe: Year 2

Daily carbohydrate intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Year 2
Daily carbohydrate intake (in g and as a percentage of total caloric intake).
Ramy czasowe: Year 5

Daily carbohydrate intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Year 5
Daily fat intake (in g and as a percentage of total caloric intake).
Ramy czasowe: Day 0

Daily fat intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Day 0
Daily fat intake (in g and as a percentage of total caloric intake).
Ramy czasowe: Month 6

Daily fat intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Month 6
Daily fat intake (in g and as a percentage of total caloric intake).
Ramy czasowe: Year 1

Daily fat intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Year 1
Daily fat intake (in g and as a percentage of total caloric intake).
Ramy czasowe: Year 2

Daily fat intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Year 2
Daily fat intake (in g and as a percentage of total caloric intake).
Ramy czasowe: Year 5

Daily fat intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Year 5
Nutritional status assessment
Ramy czasowe: Day 0

Nutritional status assessment will be assessed with the Mini Nutritional Assessment Questionnaire.
Day 0
Nutritional status assessment
Ramy czasowe: Month 6

Nutritional status assessment will be assessed with the Mini Nutritional Assessment Questionnaire.
Month 6
Nutritional status assessment
Ramy czasowe: Year 1

Nutritional status assessment will be assessed with the Mini Nutritional Assessment Questionnaire.
Year 1
Nutritional status assessment
Ramy czasowe: Year 2

Nutritional status assessment will be assessed with the Mini Nutritional Assessment Questionnaire.
Year 2
Nutritional status assessment
Ramy czasowe: Year 5

Nutritional status assessment will be assessed with the Mini Nutritional Assessment Questionnaire.
Year 5
Risk of undernutrition.
Ramy czasowe: Day 0

Risk of undernutrition will be assessed with the Brocker Questionnaire
Day 0
Risk of undernutrition.
Ramy czasowe: Month 6

Risk of undernutrition will be assessed with the Brocker Questionnaire
Month 6
Risk of undernutrition.
Ramy czasowe: Year 1

Risk of undernutrition will be assessed with the Brocker Questionnaire
Year 1
Risk of undernutrition.
Ramy czasowe: Year 2

Risk of undernutrition will be assessed with the Brocker Questionnaire
Year 2
Risk of undernutrition.
Ramy czasowe: Year 5

Risk of undernutrition will be assessed with the Brocker Questionnaire
Year 5
Basic biology.
Ramy czasowe: Day 0

: Basic biology will be measured using endocrine assays (fasting blood glucose, HbA1c, HDL-c and LDL-c, TG, CPK)
Day 0
Basic biology.
Ramy czasowe: Month 6

: Basic biology will be measured using endocrine assays (fasting blood glucose, HbA1c, HDL-c and LDL-c, TG, CPK)
Month 6
Basic biology.
Ramy czasowe: Year 1

: Basic biology will be measured using endocrine assays (fasting blood glucose, HbA1c, HDL-c and LDL-c, TG, CPK)
Year 1
Basic biology.
Ramy czasowe: Year 2

: Basic biology will be measured using endocrine assays (fasting blood glucose, HbA1c, HDL-c and LDL-c, TG, CPK)
Year 2
Basic biology.
Ramy czasowe: Year 5

: Basic biology will be measured using endocrine assays (fasting blood glucose, HbA1c, HDL-c and LDL-c, TG, CPK)
Year 5
Maximum voluntary isometric strength of the quadriceps muscles at 45° (Nm).
Ramy czasowe: Day 0

: Maximum voluntary isometric strength of the quadriceps muscles will be measured with the HUMA® /NORM™ device.
Day 0
Maximum voluntary isometric strength of the quadriceps muscles at 45° (Nm).
Ramy czasowe: Month 6

: Maximum voluntary isometric strength of the quadriceps muscles will be measured with the HUMA® /NORM™ device.
Month 6
Maximum voluntary isometric strength of the quadriceps muscles at 45° (Nm).
Ramy czasowe: Year 1

: Maximum voluntary isometric strength of the quadriceps muscles will be measured with the HUMA® /NORM™ device.
Year 1
Maximum voluntary isometric strength of the quadriceps muscles at 45° (Nm).
Ramy czasowe: Year 2

: Maximum voluntary isometric strength of the quadriceps muscles will be measured with the HUMA® /NORM™ device.
Year 2
Maximum voluntary isometric strength of the quadriceps muscles at 45° (Nm).
Ramy czasowe: Year 5

: Maximum voluntary isometric strength of the quadriceps muscles will be measured with the HUMA® /NORM™ device.
Year 5
Maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s (Nm).
Ramy czasowe: Day 0

- Description: Maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s will be measured with the HUMA® /NORM™ device.
Day 0
Maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s (Nm).
Ramy czasowe: Month 6

- Description: Maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s will be measured with the HUMA® /NORM™ device.
Month 6
Maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s (Nm).
Ramy czasowe: Year 1

- Description: Maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s will be measured with the HUMA® /NORM™ device.
Year 1
Maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s (Nm).
Ramy czasowe: Year 2

- Description: Maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s will be measured with the HUMA® /NORM™ device.
Year 2
Maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s (Nm).
Ramy czasowe: Year 5

- Description: Maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s will be measured with the HUMA® /NORM™ device.
Year 5
Maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s (Nm).
Ramy czasowe: Day 0

Maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s will be measured with the HUMA® /NORM™ device.
Day 0
Maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s (Nm).
Ramy czasowe: Month 6

Maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s will be measured with the HUMA® /NORM™ device.
Month 6
Maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s (Nm).
Ramy czasowe: Year 1

Maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s will be measured with the HUMA® /NORM™ device.
Year 1
Maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s (Nm).
Ramy czasowe: Year 2

Maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s will be measured with the HUMA® /NORM™ device.
Year 2
Maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s (Nm).
Ramy czasowe: Year 5

Maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s will be measured with the HUMA® /NORM™ device.
Year 5
Maximum voluntary isokinetic strength of the quadriceps muscles at 30°/s (eccentric contraction) (Nm).
Ramy czasowe: Day 0

Maximum voluntary isokinetic strength of the quadriceps muscles at 30°/s will be measured with the HUMA® /NORM™ device.
Day 0
Maximum voluntary isokinetic strength of the quadriceps muscles at 30°/s (eccentric contraction) (Nm).
Ramy czasowe: Month 6

Maximum voluntary isokinetic strength of the quadriceps muscles at 30°/s will be measured with the HUMA® /NORM™ device.
Month 6
Maximum voluntary isokinetic strength of the quadriceps muscles at 30°/s (eccentric contraction) (Nm).
Ramy czasowe: Year 1

Maximum voluntary isokinetic strength of the quadriceps muscles at 30°/s will be measured with the HUMA® /NORM™ device.
Year 1
Maximum voluntary isokinetic strength of the quadriceps muscles at 30°/s (eccentric contraction) (Nm).
Ramy czasowe: Year 2

Maximum voluntary isokinetic strength of the quadriceps muscles at 30°/s will be measured with the HUMA® /NORM™ device.
Year 2
Maximum voluntary isokinetic strength of the quadriceps muscles at 30°/s (eccentric contraction) (Nm).
Ramy czasowe: Year 5

Maximum voluntary isokinetic strength of the quadriceps muscles at 30°/s will be measured with the HUMA® /NORM™ device.
Year 5
Maximum voluntary isokinetic strength of the hamstring muscles at 60°/s (Nm).
Ramy czasowe: Day 0

Maximum voluntary isokinetic strength of the hamstring muscles at 60°/s will be measured with the HUMA® /NORM™ device.
Day 0
Maximum voluntary isokinetic strength of the hamstring muscles at 60°/s (Nm).
Ramy czasowe: Month 6

Maximum voluntary isokinetic strength of the hamstring muscles at 60°/s will be measured with the HUMA® /NORM™ device.
Month 6
Maximum voluntary isokinetic strength of the hamstring muscles at 60°/s (Nm).
Ramy czasowe: Year 1

Maximum voluntary isokinetic strength of the hamstring muscles at 60°/s will be measured with the HUMA® /NORM™ device.
Year 1
Maximum voluntary isokinetic strength of the hamstring muscles at 60°/s (Nm).
Ramy czasowe: Year 2

Maximum voluntary isokinetic strength of the hamstring muscles at 60°/s will be measured with the HUMA® /NORM™ device.
Year 2
Maximum voluntary isokinetic strength of the hamstring muscles at 60°/s (Nm).
Ramy czasowe: Year 5

Maximum voluntary isokinetic strength of the hamstring muscles at 60°/s will be measured with the HUMA® /NORM™ device.
Year 5
Maximum voluntary isokinetic strength of the hamstring muscles at 240°/s (Nm).
Ramy czasowe: Day 0

- Description: Maximum voluntary isokinetic strength of the hamstring muscles at 240°/s will be measured with the HUMA® /NORM™ device.
Day 0
Maximum voluntary isokinetic strength of the hamstring muscles at 240°/s (Nm).
Ramy czasowe: Month 6

- Description: Maximum voluntary isokinetic strength of the hamstring muscles at 240°/s will be measured with the HUMA® /NORM™ device.
Month 6
Maximum voluntary isokinetic strength of the hamstring muscles at 240°/s (Nm).
Ramy czasowe: Year 1

- Description: Maximum voluntary isokinetic strength of the hamstring muscles at 240°/s will be measured with the HUMA® /NORM™ device.
Year 1
Maximum voluntary isokinetic strength of the hamstring muscles at 240°/s (Nm).
Ramy czasowe: Year 2

- Description: Maximum voluntary isokinetic strength of the hamstring muscles at 240°/s will be measured with the HUMA® /NORM™ device.
Year 2
Maximum voluntary isokinetic strength of the hamstring muscles at 240°/s (Nm).
Ramy czasowe: Year 5

- Description: Maximum voluntary isokinetic strength of the hamstring muscles at 240°/s will be measured with the HUMA® /NORM™ device.
Year 5
Maximum voluntary isokinetic strength of the hamstring muscles at 30°/s (eccentric contraction) (Nm).
Ramy czasowe: Day 0

Maximum voluntary isokinetic strength of the hamstring muscles at 30°/s will be measured with the HUMA® /NORM™ device.
Day 0
Maximum voluntary isokinetic strength of the hamstring muscles at 30°/s (eccentric contraction) (Nm).
Ramy czasowe: Month 6

Maximum voluntary isokinetic strength of the hamstring muscles at 30°/s will be measured with the HUMA® /NORM™ device.
Month 6
Maximum voluntary isokinetic strength of the hamstring muscles at 30°/s (eccentric contraction) (Nm).
Ramy czasowe: Year 1

Maximum voluntary isokinetic strength of the hamstring muscles at 30°/s will be measured with the HUMA® /NORM™ device.
Year 1
Maximum voluntary isokinetic strength of the hamstring muscles at 30°/s (eccentric contraction) (Nm).
Ramy czasowe: Year 2

Maximum voluntary isokinetic strength of the hamstring muscles at 30°/s will be measured with the HUMA® /NORM™ device.
Year 2
Maximum voluntary isokinetic strength of the hamstring muscles at 30°/s (eccentric contraction) (Nm).
Ramy czasowe: Year 5

Maximum voluntary isokinetic strength of the hamstring muscles at 30°/s will be measured with the HUMA® /NORM™ device.
Year 5
Endurance coefficient of the quadriceps muscles at 180°/s.
Ramy czasowe: Day 0

Endurance coefficient will be estimated as a Σ Peak torque ratio of the last 3 contractions on the first 3 at 180°/s with the HUMA® /NORM™ device.
Day 0
Endurance coefficient of the quadriceps muscles at 180°/s.
Ramy czasowe: Month 6

Endurance coefficient will be estimated as a Σ Peak torque ratio of the last 3 contractions on the first 3 at 180°/s with the HUMA® /NORM™ device.
Month 6
Endurance coefficient of the quadriceps muscles at 180°/s.
Ramy czasowe: Year 1

Endurance coefficient will be estimated as a Σ Peak torque ratio of the last 3 contractions on the first 3 at 180°/s with the HUMA® /NORM™ device.
Year 1
Endurance coefficient of the quadriceps muscles at 180°/s.
Ramy czasowe: Year 2

Endurance coefficient will be estimated as a Σ Peak torque ratio of the last 3 contractions on the first 3 at 180°/s with the HUMA® /NORM™ device.
Year 2
Endurance coefficient of the quadriceps muscles at 180°/s.
Ramy czasowe: Year 5

Endurance coefficient will be estimated as a Σ Peak torque ratio of the last 3 contractions on the first 3 at 180°/s with the HUMA® /NORM™ device.
Year 5
Endurance coefficient of the hamstring muscles at 180°/s.
Ramy czasowe: Day 0

Endurance coefficient will be estimated as a Σ Peak torque ratio of the last 3 contractions on the first 3 at 180°/s with the HUMA® /NORM™ device..
Day 0
Endurance coefficient of the hamstring muscles at 180°/s.
Ramy czasowe: Month 6

Endurance coefficient will be estimated as a Σ Peak torque ratio of the last 3 contractions on the first 3 at 180°/s with the HUMA® /NORM™ device..
Month 6
Endurance coefficient of the hamstring muscles at 180°/s.
Ramy czasowe: Year 1

Endurance coefficient will be estimated as a Σ Peak torque ratio of the last 3 contractions on the first 3 at 180°/s with the HUMA® /NORM™ device..
Year 1
Endurance coefficient of the hamstring muscles at 180°/s.
Ramy czasowe: Year 2

Endurance coefficient will be estimated as a Σ Peak torque ratio of the last 3 contractions on the first 3 at 180°/s with the HUMA® /NORM™ device..
Year 2
Endurance coefficient of the hamstring muscles at 180°/s.
Ramy czasowe: Year 5

Endurance coefficient will be estimated as a Σ Peak torque ratio of the last 3 contractions on the first 3 at 180°/s with the HUMA® /NORM™ device..
Year 5
Functional ratio
Ramy czasowe: Day 0

Functional ratio will be estimated by dividing the maximum voluntary isokinetic strength of the hamstring muscles at 60°/s with the maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s.
Day 0
Functional ratio
Ramy czasowe: Month 6

Functional ratio will be estimated by dividing the maximum voluntary isokinetic strength of the hamstring muscles at 60°/s with the maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s.
Month 6
Functional ratio
Ramy czasowe: Year 1

Functional ratio will be estimated by dividing the maximum voluntary isokinetic strength of the hamstring muscles at 60°/s with the maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s.
Year 1
Functional ratio
Ramy czasowe: Year 2

Functional ratio will be estimated by dividing the maximum voluntary isokinetic strength of the hamstring muscles at 60°/s with the maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s.
Year 2
Functional ratio
Ramy czasowe: Year 5

Functional ratio will be estimated by dividing the maximum voluntary isokinetic strength of the hamstring muscles at 60°/s with the maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s.
Year 5
Mixed ratio
Ramy czasowe: Day 0

- Mixed ratio will be estimated by dividing the maximum voluntary isokinetic strength of the hamstring muscles at 30°/s (eccentric contraction) with the maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s Title: Maximum voluntary strength of the quadriceps muscles at 60°/s.
Day 0
Mixed ratio
Ramy czasowe: Month 6

- Mixed ratio will be estimated by dividing the maximum voluntary isokinetic strength of the hamstring muscles at 30°/s (eccentric contraction) with the maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s Title: Maximum voluntary strength of the quadriceps muscles at 60°/s.
Month 6
Mixed ratio
Ramy czasowe: Year 1

- Mixed ratio will be estimated by dividing the maximum voluntary isokinetic strength of the hamstring muscles at 30°/s (eccentric contraction) with the maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s Title: Maximum voluntary strength of the quadriceps muscles at 60°/s.
Year 1
Mixed ratio
Ramy czasowe: Year 2

- Mixed ratio will be estimated by dividing the maximum voluntary isokinetic strength of the hamstring muscles at 30°/s (eccentric contraction) with the maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s Title: Maximum voluntary strength of the quadriceps muscles at 60°/s.
Year 2
Mixed ratio
Ramy czasowe: Year 5

- Mixed ratio will be estimated by dividing the maximum voluntary isokinetic strength of the hamstring muscles at 30°/s (eccentric contraction) with the maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s Title: Maximum voluntary strength of the quadriceps muscles at 60°/s.
Year 5
Maximum voluntary hand grip strength (Kg).
Ramy czasowe: Day 0

Maximum voluntary hand grip strength will be measured with the Jamar® hydraulic dynamometer and with the Baseline® pneumatic dynamometer.
Day 0
Maximum voluntary hand grip strength (Kg).
Ramy czasowe: Month 6

Maximum voluntary hand grip strength will be measured with the Jamar® hydraulic dynamometer and with the Baseline® pneumatic dynamometer.
Month 6
Maximum voluntary hand grip strength (Kg).
Ramy czasowe: Year 1

Maximum voluntary hand grip strength will be measured with the Jamar® hydraulic dynamometer and with the Baseline® pneumatic dynamometer.
Year 1
Maximum voluntary hand grip strength (Kg).
Ramy czasowe: Year 2

Maximum voluntary hand grip strength will be measured with the Jamar® hydraulic dynamometer and with the Baseline® pneumatic dynamometer.
Year 2
Maximum voluntary hand grip strength (Kg).
Ramy czasowe: Year 5

Maximum voluntary hand grip strength will be measured with the Jamar® hydraulic dynamometer and with the Baseline® pneumatic dynamometer.
Year 5
Maximum voluntary pinch strength (Kg).
Ramy czasowe: Day 0

Maximum voluntary pinch strength will be measured with the Baseline® pinch gauche test mechanical dynamometer.
Day 0
Maximum voluntary pinch strength (Kg).
Ramy czasowe: Month 6

Maximum voluntary pinch strength will be measured with the Baseline® pinch gauche test mechanical dynamometer.
Month 6
Maximum voluntary pinch strength (Kg).
Ramy czasowe: Year 1

Maximum voluntary pinch strength will be measured with the Baseline® pinch gauche test mechanical dynamometer.
Year 1
Maximum voluntary pinch strength (Kg).
Ramy czasowe: Year 2

Maximum voluntary pinch strength will be measured with the Baseline® pinch gauche test mechanical dynamometer.
Year 2
Maximum voluntary pinch strength (Kg).
Ramy czasowe: Year 5

Maximum voluntary pinch strength will be measured with the Baseline® pinch gauche test mechanical dynamometer.
Year 5
Hip passive joint range
Ramy czasowe: Day 0

Hip joint range will be measured with a medical goniometer.
Day 0
Hip passive joint range
Ramy czasowe: Month 6

Hip joint range will be measured with a medical goniometer.
Month 6
Hip passive joint range
Ramy czasowe: Year 1

Hip joint range will be measured with a medical goniometer.
Year 1
Hip passive joint range
Ramy czasowe: Year 2

Hip joint range will be measured with a medical goniometer.
Year 2
Hip passive joint range
Ramy czasowe: Year 5

Hip joint range will be measured with a medical goniometer.
Year 5
Knee passive joint range.
Ramy czasowe: Day 0

Knee joint range will be measured with a medical goniometer.
Day 0
Knee passive joint range.
Ramy czasowe: Month 6

Knee joint range will be measured with a medical goniometer.
Month 6
Knee passive joint range.
Ramy czasowe: Year 1

Knee joint range will be measured with a medical goniometer.
Year 1
Knee passive joint range.
Ramy czasowe: Year 2

Knee joint range will be measured with a medical goniometer.
Year 2
Knee passive joint range.
Ramy czasowe: Year 5

Knee joint range will be measured with a medical goniometer.
Year 5
Ankle passive joint range
Ramy czasowe: Day 0

Ankle joint range will be measured with a medical goniometer.
Day 0
Ankle passive joint range
Ramy czasowe: Month 6

Ankle joint range will be measured with a medical goniometer.
Month 6
Ankle passive joint range
Ramy czasowe: Year 1

Ankle joint range will be measured with a medical goniometer.
Year 1
Ankle passive joint range
Ramy czasowe: Year 2

Ankle joint range will be measured with a medical goniometer.
Year 2
Ankle passive joint range
Ramy czasowe: Year 5

Ankle joint range will be measured with a medical goniometer.
Year 5
Lower and upper limb muscle power assessment (MRC)
Ramy czasowe: Day 0

Lower and upper limb muscle power assessment will be performed by an experienced physician.
Day 0
Lower and upper limb muscle power assessment (MRC)
Ramy czasowe: Month 6

Lower and upper limb muscle power assessment will be performed by an experienced physician.
Month 6
Lower and upper limb muscle power assessment (MRC)
Ramy czasowe: Year 1

Lower and upper limb muscle power assessment will be performed by an experienced physician.
Year 1
Lower and upper limb muscle power assessment (MRC)
Ramy czasowe: Year 2

Lower and upper limb muscle power assessment will be performed by an experienced physician.
Year 2
Lower and upper limb muscle power assessment (MRC)
Ramy czasowe: Year 5

Lower and upper limb muscle power assessment will be performed by an experienced physician.
Year 5
Statokinesigram surface area (mm²)
Ramy czasowe: Day 0

Statokinesigram surface area will be measured with the STATIPRO® static posturography platform.
Day 0
Statokinesigram surface area (mm²)
Ramy czasowe: Month 6

Statokinesigram surface area will be measured with the STATIPRO® static posturography platform.
Month 6
Statokinesigram surface area (mm²)
Ramy czasowe: Year 1

Statokinesigram surface area will be measured with the STATIPRO® static posturography platform.
Year 1
Statokinesigram surface area (mm²)
Ramy czasowe: Year 2

Statokinesigram surface area will be measured with the STATIPRO® static posturography platform.
Year 2
Statokinesigram surface area (mm²)
Ramy czasowe: Year 5

Statokinesigram surface area will be measured with the STATIPRO® static posturography platform.
Year 5
Stabilogram length (mm).
Ramy czasowe: Day 0

Stabilogram length will be measured with the STATIPRO® static posturography platform
Day 0
Stabilogram length (mm).
Ramy czasowe: Month 6

Stabilogram length will be measured with the STATIPRO® static posturography platform
Month 6
Stabilogram length (mm).
Ramy czasowe: Year 1

Stabilogram length will be measured with the STATIPRO® static posturography platform
Year 1
Stabilogram length (mm).
Ramy czasowe: Year 2

Stabilogram length will be measured with the STATIPRO® static posturography platform
Year 2
Stabilogram length (mm).
Ramy czasowe: Year 5

Stabilogram length will be measured with the STATIPRO® static posturography platform
Year 5
Maximal deflection (forward, backward left and right).
Ramy czasowe: Day 0

Maximal deflection will be measured with the STATIPRO® static posturography platform.
Day 0
Maximal deflection (forward, backward left and right).
Ramy czasowe: Month 6

Maximal deflection will be measured with the STATIPRO® static posturography platform.
Month 6
Maximal deflection (forward, backward left and right).
Ramy czasowe: Year 1

Maximal deflection will be measured with the STATIPRO® static posturography platform.
Year 1
Maximal deflection (forward, backward left and right).
Ramy czasowe: Year 2

Maximal deflection will be measured with the STATIPRO® static posturography platform.
Year 2
Maximal deflection (forward, backward left and right).
Ramy czasowe: Year 5

Maximal deflection will be measured with the STATIPRO® static posturography platform.
Year 5
Velocity variations (mm/s).
Ramy czasowe: Day 0

: Velocity variations will be measured with the STATIPRO® static posturography platform.
Day 0
Velocity variations (mm/s).
Ramy czasowe: Month 6

: Velocity variations will be measured with the STATIPRO® static posturography platform.
Month 6
Velocity variations (mm/s).
Ramy czasowe: Year 1

: Velocity variations will be measured with the STATIPRO® static posturography platform.
Year 1
Velocity variations (mm/s).
Ramy czasowe: Year 2

: Velocity variations will be measured with the STATIPRO® static posturography platform.
Year 2
Velocity variations (mm/s).
Ramy czasowe: Year 5

: Velocity variations will be measured with the STATIPRO® static posturography platform.
Year 5
: Romberg ratio according to sway area
Ramy czasowe: Day 0

Romberg ratio will be measured with the STATIPRO® static posturography platform.
Day 0
: Romberg ratio according to sway area
Ramy czasowe: Month 6

Romberg ratio will be measured with the STATIPRO® static posturography platform.
Month 6
: Romberg ratio according to sway area
Ramy czasowe: Year 1

Romberg ratio will be measured with the STATIPRO® static posturography platform.
Year 1
: Romberg ratio according to sway area
Ramy czasowe: Year 2

Romberg ratio will be measured with the STATIPRO® static posturography platform.
Year 2
: Romberg ratio according to sway area
Ramy czasowe: Year 5

Romberg ratio will be measured with the STATIPRO® static posturography platform.
Year 5
Romberg ratio according to center of pressure path length
Ramy czasowe: Day 0

Romberg ratio will be measured with the STATIPRO® static posturography platform.
Day 0
Romberg ratio according to center of pressure path length
Ramy czasowe: Month 6

Romberg ratio will be measured with the STATIPRO® static posturography platform.
Month 6
Romberg ratio according to center of pressure path length
Ramy czasowe: Year 1

Romberg ratio will be measured with the STATIPRO® static posturography platform.
Year 1
Romberg ratio according to center of pressure path length
Ramy czasowe: Year 2

Romberg ratio will be measured with the STATIPRO® static posturography platform.
Year 2
Romberg ratio according to center of pressure path length
Ramy czasowe: Year 5

Romberg ratio will be measured with the STATIPRO® static posturography platform.
Year 5
: Plantar pressure ratio sway area.
Ramy czasowe: Day 0

Plantar pressure ratio sway area will be measured with the STATIPRO® static posturography platform.
Day 0
: Plantar pressure ratio sway area.
Ramy czasowe: Month 6

Plantar pressure ratio sway area will be measured with the STATIPRO® static posturography platform.
Month 6
: Plantar pressure ratio sway area.
Ramy czasowe: Year 1

Plantar pressure ratio sway area will be measured with the STATIPRO® static posturography platform.
Year 1
: Plantar pressure ratio sway area.
Ramy czasowe: Year 2

Plantar pressure ratio sway area will be measured with the STATIPRO® static posturography platform.
Year 2
: Plantar pressure ratio sway area.
Ramy czasowe: Year 5

Plantar pressure ratio sway area will be measured with the STATIPRO® static posturography platform.
Year 5
Plantar pressure ratio length.
Ramy czasowe: Day 0

Plantar pressure ratio length will be measured with the STATIPRO® static posturography platform.
Day 0
Plantar pressure ratio length.
Ramy czasowe: Month 6

Plantar pressure ratio length will be measured with the STATIPRO® static posturography platform.
Month 6
Plantar pressure ratio length.
Ramy czasowe: Year 1

Plantar pressure ratio length will be measured with the STATIPRO® static posturography platform.
Year 1
Plantar pressure ratio length.
Ramy czasowe: Year 2

Plantar pressure ratio length will be measured with the STATIPRO® static posturography platform.
Year 2
Plantar pressure ratio length.
Ramy czasowe: Year 5

Plantar pressure ratio length will be measured with the STATIPRO® static posturography platform.
Year 5
Walking velocity (cm/s).
Ramy czasowe: Day 0

Walking velocity will be measured with the GAITRite® Electronic Walkway.
Day 0
Walking velocity (cm/s).
Ramy czasowe: Month 6

Walking velocity will be measured with the GAITRite® Electronic Walkway.
Month 6
Walking velocity (cm/s).
Ramy czasowe: Year 1

Walking velocity will be measured with the GAITRite® Electronic Walkway.
Year 1
Walking velocity (cm/s).
Ramy czasowe: Year 2

Walking velocity will be measured with the GAITRite® Electronic Walkway.
Year 2
Walking velocity (cm/s).
Ramy czasowe: Year 5

Walking velocity will be measured with the GAITRite® Electronic Walkway.
Year 5
Cadence (steps/min).
Ramy czasowe: Day 0

: Cadence will be measured with the GAITRite® Electronic Walkway.
Day 0
Cadence (steps/min).
Ramy czasowe: Month 6

: Cadence will be measured with the GAITRite® Electronic Walkway.
Month 6
Cadence (steps/min).
Ramy czasowe: Year 1

: Cadence will be measured with the GAITRite® Electronic Walkway.
Year 1
Cadence (steps/min).
Ramy czasowe: Year 2

: Cadence will be measured with the GAITRite® Electronic Walkway.
Year 2
Cadence (steps/min).
Ramy czasowe: Year 5

: Cadence will be measured with the GAITRite® Electronic Walkway.
Year 5
Step length (left and right foot) (cm)
Ramy czasowe: DAy 0

Step length will be measured with the GAITRite® Electronic Walkway.
DAy 0
Step length (left and right foot) (cm)
Ramy czasowe: Month 6

Step length will be measured with the GAITRite® Electronic Walkway.
Month 6
Step length (left and right foot) (cm)
Ramy czasowe: Year 1

Step length will be measured with the GAITRite® Electronic Walkway.
Year 1
Step length (left and right foot) (cm)
Ramy czasowe: Year 2

Step length will be measured with the GAITRite® Electronic Walkway.
Year 2
Step length (left and right foot) (cm)
Ramy czasowe: Year 5

Step length will be measured with the GAITRite® Electronic Walkway.
Year 5
Stride length (cm).
Ramy czasowe: Day 0

Stride length will be measured with the GAITRite® Electronic Walkway.
Day 0
Stride length (cm).
Ramy czasowe: month 6

Stride length will be measured with the GAITRite® Electronic Walkway.
month 6
Stride length (cm).
Ramy czasowe: year 1

Stride length will be measured with the GAITRite® Electronic Walkway.
year 1
Stride length (cm).
Ramy czasowe: year 2

Stride length will be measured with the GAITRite® Electronic Walkway.
year 2
Stride length (cm).
Ramy czasowe: year 5

Stride length will be measured with the GAITRite® Electronic Walkway.
year 5
Single support time left and right foot (s).
Ramy czasowe: Day 0

Single support time will be measured with the GAITRite® Electronic Walkway.
Day 0
Single support time left and right foot (s).
Ramy czasowe: Month 6

Single support time will be measured with the GAITRite® Electronic Walkway.
Month 6
Single support time left and right foot (s).
Ramy czasowe: Year 1

Single support time will be measured with the GAITRite® Electronic Walkway.
Year 1
Single support time left and right foot (s).
Ramy czasowe: Year 2

Single support time will be measured with the GAITRite® Electronic Walkway.
Year 2
Single support time left and right foot (s).
Ramy czasowe: Year 5

Single support time will be measured with the GAITRite® Electronic Walkway.
Year 5
Double support time (s).
Ramy czasowe: Day 0

: Double support time will be measured with the GAITRite® Electronic Walkway.
Day 0
Double support time (s).
Ramy czasowe: Month 6

: Double support time will be measured with the GAITRite® Electronic Walkway.
Month 6
Double support time (s).
Ramy czasowe: YEar 1

: Double support time will be measured with the GAITRite® Electronic Walkway.
YEar 1
Double support time (s).
Ramy czasowe: Year 2

: Double support time will be measured with the GAITRite® Electronic Walkway.
Year 2
Double support time (s).
Ramy czasowe: Year 5

: Double support time will be measured with the GAITRite® Electronic Walkway.
Year 5
Swing time (s).
Ramy czasowe: Day 0

: Swing time will be measured with the GAITRite® Electronic Walkway.
Day 0
Swing time (s).
Ramy czasowe: Month 6

: Swing time will be measured with the GAITRite® Electronic Walkway.
Month 6
Swing time (s).
Ramy czasowe: Year 1

: Swing time will be measured with the GAITRite® Electronic Walkway.
Year 1
Swing time (s).
Ramy czasowe: Year 2

: Swing time will be measured with the GAITRite® Electronic Walkway.
Year 2
Swing time (s).
Ramy czasowe: Year 5

: Swing time will be measured with the GAITRite® Electronic Walkway.
Year 5
Swing phase (as a % of walking cycle).
Ramy czasowe: DAy 0

: Swing phase will be measured with the GAITRite® Electronic Walkway.
DAy 0
Swing phase (as a % of walking cycle).
Ramy czasowe: Month 6

: Swing phase will be measured with the GAITRite® Electronic Walkway.
Month 6
Swing phase (as a % of walking cycle).
Ramy czasowe: Year 1

: Swing phase will be measured with the GAITRite® Electronic Walkway.
Year 1
Swing phase (as a % of walking cycle).
Ramy czasowe: Year 2

: Swing phase will be measured with the GAITRite® Electronic Walkway.
Year 2
Swing phase (as a % of walking cycle).
Ramy czasowe: Year 5

: Swing phase will be measured with the GAITRite® Electronic Walkway.
Year 5
Stance phase (as a % of walking cycle).
Ramy czasowe: Day 0

Stance phase will be measured with the GAITRite® Electronic Walkway.
Day 0
Stance phase (as a % of walking cycle).
Ramy czasowe: Month 6

Stance phase will be measured with the GAITRite® Electronic Walkway.
Month 6
Stance phase (as a % of walking cycle).
Ramy czasowe: Year 1

Stance phase will be measured with the GAITRite® Electronic Walkway.
Year 1
Stance phase (as a % of walking cycle).
Ramy czasowe: Year 2

Stance phase will be measured with the GAITRite® Electronic Walkway.
Year 2
Stance phase (as a % of walking cycle).
Ramy czasowe: Year 5

Stance phase will be measured with the GAITRite® Electronic Walkway.
Year 5
Vo2max (maximal oxygen consumption) (mL/Kg/min).
Ramy czasowe: Day 0

: Vo2max will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Day 0
Vo2max (maximal oxygen consumption) (mL/Kg/min).
Ramy czasowe: Month 6

: Vo2max will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Month 6
Vo2max (maximal oxygen consumption) (mL/Kg/min).
Ramy czasowe: Year 1

: Vo2max will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 1
Vo2max (maximal oxygen consumption) (mL/Kg/min).
Ramy czasowe: Year 2

: Vo2max will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 2
Vo2max (maximal oxygen consumption) (mL/Kg/min).
Ramy czasowe: Year 5

: Vo2max will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 5
Maximum heart rate (bpm).
Ramy czasowe: Day 0

Maximum heart rate will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Day 0
Maximum heart rate (bpm).
Ramy czasowe: Month 6

Maximum heart rate will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Month 6
Maximum heart rate (bpm).
Ramy czasowe: Year 1

Maximum heart rate will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 1
Maximum heart rate (bpm).
Ramy czasowe: Year 2

Maximum heart rate will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 2
Maximum heart rate (bpm).
Ramy czasowe: Year 5

Maximum heart rate will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 5
Maximum power (Watts).
Ramy czasowe: Day 0

Maximum power will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Day 0
Maximum power (Watts).
Ramy czasowe: Month 6

Maximum power will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Month 6
Maximum power (Watts).
Ramy czasowe: Year 1

Maximum power will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 1
Maximum power (Watts).
Ramy czasowe: Year 2

Maximum power will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 2
Maximum power (Watts).
Ramy czasowe: Year 5

Maximum power will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 5
Threshold power (Watts).
Ramy czasowe: Day 0

Threshold power will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Day 0
Threshold power (Watts).
Ramy czasowe: Month 6

Threshold power will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Month 6
Threshold power (Watts).
Ramy czasowe: Year 1

Threshold power will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 1
Threshold power (Watts).
Ramy czasowe: Year 2

Threshold power will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 2
Threshold power (Watts).
Ramy czasowe: Year 5

Threshold power will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 5
Threshold heart rate (bpm).
Ramy czasowe: DAy 0

Threshold heart will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
DAy 0
Threshold heart rate (bpm).
Ramy czasowe: Month 6

Threshold heart will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Month 6
Threshold heart rate (bpm).
Ramy czasowe: Year 1

Threshold heart will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 1
Threshold heart rate (bpm).
Ramy czasowe: Year 2

Threshold heart will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 2
Threshold heart rate (bpm).
Ramy czasowe: Year 5

Threshold heart will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 5
Forced vital Capacity (L).
Ramy czasowe: Day 0

: Forced vital Capacity will be measured with a spirometry test.
Day 0
Forced vital Capacity (L).
Ramy czasowe: Month 6

: Forced vital Capacity will be measured with a spirometry test.
Month 6
Forced vital Capacity (L).
Ramy czasowe: Year 1

: Forced vital Capacity will be measured with a spirometry test.
Year 1
Forced vital Capacity (L).
Ramy czasowe: Year 2

: Forced vital Capacity will be measured with a spirometry test.
Year 2
Forced vital Capacity (L).
Ramy czasowe: Year 5

: Forced vital Capacity will be measured with a spirometry test.
Year 5
Forced Expiratory volume (L)
Ramy czasowe: Day 0

Forced Expiratory volume will be measured with a spirometry test.
Day 0
Forced Expiratory volume (L)
Ramy czasowe: Month 6

Forced Expiratory volume will be measured with a spirometry test.
Month 6
Forced Expiratory volume (L)
Ramy czasowe: Year 1

Forced Expiratory volume will be measured with a spirometry test.
Year 1
Forced Expiratory volume (L)
Ramy czasowe: Year 2

Forced Expiratory volume will be measured with a spirometry test.
Year 2
Forced Expiratory volume (L)
Ramy czasowe: Year 5

Forced Expiratory volume will be measured with a spirometry test.
Year 5
Tiffeneau ratio (%).
Ramy czasowe: Day 0

Tiffeneau ratio will be calculated by dividing the Forced Expiratory volume to the Forced vital Capacity.
Day 0
Tiffeneau ratio (%).
Ramy czasowe: Month 6

Tiffeneau ratio will be calculated by dividing the Forced Expiratory volume to the Forced vital Capacity.
Month 6
Tiffeneau ratio (%).
Ramy czasowe: Year 1

Tiffeneau ratio will be calculated by dividing the Forced Expiratory volume to the Forced vital Capacity.
Year 1
Tiffeneau ratio (%).
Ramy czasowe: Year 2

Tiffeneau ratio will be calculated by dividing the Forced Expiratory volume to the Forced vital Capacity.
Year 2
Tiffeneau ratio (%).
Ramy czasowe: Year 5

Tiffeneau ratio will be calculated by dividing the Forced Expiratory volume to the Forced vital Capacity.
Year 5
Ventilatory reserve (%).
Ramy czasowe: Day 0

Ventilatory reserve will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Day 0
Ventilatory reserve (%).
Ramy czasowe: Month 6

Ventilatory reserve will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Month 6
Ventilatory reserve (%).
Ramy czasowe: Year 1

Ventilatory reserve will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 1
Ventilatory reserve (%).
Ramy czasowe: Year 2

Ventilatory reserve will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 2
Ventilatory reserve (%).
Ramy czasowe: Year 5

Ventilatory reserve will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 5
Physical activity
Ramy czasowe: Day 0

Physical activity will be measured using the Global Physical Activity Questionnaire (GPAQ)
Day 0
Physical activity
Ramy czasowe: Month 6

Physical activity will be measured using the Global Physical Activity Questionnaire (GPAQ)
Month 6
Physical activity
Ramy czasowe: Year 1

Physical activity will be measured using the Global Physical Activity Questionnaire (GPAQ)
Year 1
Physical activity
Ramy czasowe: Year 2

Physical activity will be measured using the Global Physical Activity Questionnaire (GPAQ)
Year 2
Physical activity
Ramy czasowe: Year 5

Physical activity will be measured using the Global Physical Activity Questionnaire (GPAQ)
Year 5
Functional capacity timed-up and go
Ramy czasowe: Day 0

Functional capacity will be evaluated using the Timed-Up and Go test.
Day 0
Functional capacity timed-up and go
Ramy czasowe: Month 6

Functional capacity will be evaluated using the Timed-Up and Go test.
Month 6
Functional capacity timed-up and go
Ramy czasowe: Year 1

Functional capacity will be evaluated using the Timed-Up and Go test.
Year 1
Functional capacity timed-up and go
Ramy czasowe: Year 2

Functional capacity will be evaluated using the Timed-Up and Go test.
Year 2
Functional capacity timed-up and go
Ramy czasowe: Year 5

Functional capacity will be evaluated using the Timed-Up and Go test.
Year 5
Functional capacity TDM6
Ramy czasowe: Day 0

Functional capacity will be evaluated using the 6-minute walk test.
Day 0
Functional capacity TDM6
Ramy czasowe: Month 6

Functional capacity will be evaluated using the 6-minute walk test.
Month 6
Functional capacity TDM6
Ramy czasowe: Year 1

Functional capacity will be evaluated using the 6-minute walk test.
Year 1
Functional capacity TDM6
Ramy czasowe: Year 2

Functional capacity will be evaluated using the 6-minute walk test.
Year 2
Functional capacity TDM6
Ramy czasowe: Year 5

Functional capacity will be evaluated using the 6-minute walk test.
Year 5
Functional capacity Five Times Sit to Stand test.
Ramy czasowe: Day 0

Functional capacity will be evaluated using the Five Times Sit to Stand test.
Day 0
Functional capacity Five Times Sit to Stand test.
Ramy czasowe: Month 6

Functional capacity will be evaluated using the Five Times Sit to Stand test.
Month 6
Functional capacity Five Times Sit to Stand test.
Ramy czasowe: Year 1

Functional capacity will be evaluated using the Five Times Sit to Stand test.
Year 1
Functional capacity Five Times Sit to Stand test.
Ramy czasowe: Year 2

Functional capacity will be evaluated using the Five Times Sit to Stand test.
Year 2
Functional capacity Five Times Sit to Stand test.
Ramy czasowe: Year 5

Functional capacity will be evaluated using the Five Times Sit to Stand test.
Year 5
Functional capacity SPPB
Ramy czasowe: Day 0

Functional capacity will be evaluated using the Five Times Sit to Stand test.Functional capacity will be evaluated using the Short Physical Performance Battery test.
Day 0
Functional capacity SPPB
Ramy czasowe: Month 6

Functional capacity will be evaluated using the Five Times Sit to Stand test.Functional capacity will be evaluated using the Short Physical Performance Battery test.
Month 6
Functional capacity SPPB
Ramy czasowe: Year 1

Functional capacity will be evaluated using the Five Times Sit to Stand test.Functional capacity will be evaluated using the Short Physical Performance Battery test.
Year 1
Functional capacity SPPB
Ramy czasowe: Year 2

Functional capacity will be evaluated using the Five Times Sit to Stand test.Functional capacity will be evaluated using the Short Physical Performance Battery test.
Year 2
Functional capacity SPPB
Ramy czasowe: Year 5

Functional capacity will be evaluated using the Five Times Sit to Stand test.Functional capacity will be evaluated using the Short Physical Performance Battery test.
Year 5
Functional capacity the mini-BESTest.
Ramy czasowe: Day 0

Functional capacity will be evaluated using the mini-BESTest.
Day 0
Functional capacity the mini-BESTest.
Ramy czasowe: Month 6

Functional capacity will be evaluated using the mini-BESTest.
Month 6
Functional capacity the mini-BESTest.
Ramy czasowe: Year 1

Functional capacity will be evaluated using the mini-BESTest.
Year 1
Functional capacity the mini-BESTest.
Ramy czasowe: Year 2

Functional capacity will be evaluated using the mini-BESTest.
Year 2
Functional capacity the mini-BESTest.
Ramy czasowe: Year 5

Functional capacity will be evaluated using the mini-BESTest.
Year 5
Functional capacity Berg Balance Scale.
Ramy czasowe: Day 0

Functional capacity will be evaluated using the Berg Balance Scale.
Day 0
Functional capacity Berg Balance Scale.
Ramy czasowe: Month 6

Functional capacity will be evaluated using the Berg Balance Scale.
Month 6
Functional capacity Berg Balance Scale.
Ramy czasowe: Year 1

Functional capacity will be evaluated using the Berg Balance Scale.
Year 1
Functional capacity Berg Balance Scale.
Ramy czasowe: Year 2

Functional capacity will be evaluated using the Berg Balance Scale.
Year 2
Functional capacity Berg Balance Scale.
Ramy czasowe: Year 5

Functional capacity will be evaluated using the Berg Balance Scale.
Year 5
Functional capacity 10-meter walk test
Ramy czasowe: Day 0

Functional capacity will be evaluated using the 10-meter walk test (at usual and maximal pace).
Day 0
Functional capacity 10-meter walk test
Ramy czasowe: Month 6

Functional capacity will be evaluated using the 10-meter walk test (at usual and maximal pace).
Month 6
Functional capacity 10-meter walk test
Ramy czasowe: Year 1

Functional capacity will be evaluated using the 10-meter walk test (at usual and maximal pace).
Year 1
Functional capacity 10-meter walk test
Ramy czasowe: Year 2

Functional capacity will be evaluated using the 10-meter walk test (at usual and maximal pace).
Year 2
Functional capacity 10-meter walk test
Ramy czasowe: Year 5

Functional capacity will be evaluated using the 10-meter walk test (at usual and maximal pace).
Year 5
Dyspnea
Ramy czasowe: Day 0

Dyspnea will be evaluated by a Numeric Rating scale ranging from 0 to 10.
Day 0
Dyspnea
Ramy czasowe: Month 6

Dyspnea will be evaluated by a Numeric Rating scale ranging from 0 to 10.
Month 6
Dyspnea
Ramy czasowe: Year 1

Dyspnea will be evaluated by a Numeric Rating scale ranging from 0 to 10.
Year 1
Dyspnea
Ramy czasowe: Year 2

Dyspnea will be evaluated by a Numeric Rating scale ranging from 0 to 10.
Year 2
Dyspnea
Ramy czasowe: Year 5

Dyspnea will be evaluated by a Numeric Rating scale ranging from 0 to 10.
Year 5
Perceived exertion before, during and after effort
Ramy czasowe: DAy 0

Perceived exertion will be evaluated by a Numeric Rating scale ranging from 0 to 10.
DAy 0
Perceived exertion before, during and after effort
Ramy czasowe: Month 6

Perceived exertion will be evaluated by a Numeric Rating scale ranging from 0 to 10.
Month 6
Perceived exertion before, during and after effort
Ramy czasowe: Year 1

Perceived exertion will be evaluated by a Numeric Rating scale ranging from 0 to 10.
Year 1
Perceived exertion before, during and after effort
Ramy czasowe: Year 2

Perceived exertion will be evaluated by a Numeric Rating scale ranging from 0 to 10.
Year 2
Perceived exertion before, during and after effort
Ramy czasowe: Year 5

Perceived exertion will be evaluated by a Numeric Rating scale ranging from 0 to 10.
Year 5
Musculoskeletal Pain
Ramy czasowe: Day 0

: Pain will be measured by a visual analogue scale (VAS) ranging from 0 to 10 and possibly as appropriate by other questionnaires or specific scales.
Day 0
Musculoskeletal Pain
Ramy czasowe: Month 6

: Pain will be measured by a visual analogue scale (VAS) ranging from 0 to 10 and possibly as appropriate by other questionnaires or specific scales.
Month 6
Musculoskeletal Pain
Ramy czasowe: Year 1

: Pain will be measured by a visual analogue scale (VAS) ranging from 0 to 10 and possibly as appropriate by other questionnaires or specific scales.
Year 1
Musculoskeletal Pain
Ramy czasowe: Year 2

: Pain will be measured by a visual analogue scale (VAS) ranging from 0 to 10 and possibly as appropriate by other questionnaires or specific scales.
Year 2
Musculoskeletal Pain
Ramy czasowe: Year 5

: Pain will be measured by a visual analogue scale (VAS) ranging from 0 to 10 and possibly as appropriate by other questionnaires or specific scales.
Year 5
Sarcopenia risk
Ramy czasowe: Day 0

Sarcopenia risk will be evaluated with the SARC-F Questionnaire.
Day 0
Sarcopenia risk
Ramy czasowe: Month 6

Sarcopenia risk will be evaluated with the SARC-F Questionnaire.
Month 6
Sarcopenia risk
Ramy czasowe: Year 1

Sarcopenia risk will be evaluated with the SARC-F Questionnaire.
Year 1
Sarcopenia risk
Ramy czasowe: Year 2

Sarcopenia risk will be evaluated with the SARC-F Questionnaire.
Year 2
Sarcopenia risk
Ramy czasowe: Year 5

Sarcopenia risk will be evaluated with the SARC-F Questionnaire.
Year 5
Social insecurity
Ramy czasowe: Day 0

Social insecurity will be evaluated with the EPICES Score Questionnaire.
Day 0
Social insecurity
Ramy czasowe: Month 6

Social insecurity will be evaluated with the EPICES Score Questionnaire.
Month 6
Social insecurity
Ramy czasowe: Year 1

Social insecurity will be evaluated with the EPICES Score Questionnaire.
Year 1
Social insecurity
Ramy czasowe: Year 2

Social insecurity will be evaluated with the EPICES Score Questionnaire.
Year 2
Social insecurity
Ramy czasowe: Year 5

Social insecurity will be evaluated with the EPICES Score Questionnaire.
Year 5
Kinesiophobia
Ramy czasowe: Day 0

Kinesiophobia will be evaluated with the TAMPA Scale.
Day 0
Kinesiophobia
Ramy czasowe: Month 6

Kinesiophobia will be evaluated with the TAMPA Scale.
Month 6
Kinesiophobia
Ramy czasowe: Year 1

Kinesiophobia will be evaluated with the TAMPA Scale.
Year 1
Kinesiophobia
Ramy czasowe: Year 2

Kinesiophobia will be evaluated with the TAMPA Scale.
Year 2
Kinesiophobia
Ramy czasowe: Year 5

Kinesiophobia will be evaluated with the TAMPA Scale.
Year 5
Quality of life
Ramy czasowe: Day 0

Quality of life will be evaluated with the 36-Item Short Form Survey.
Day 0
Quality of life
Ramy czasowe: Month 6

Quality of life will be evaluated with the 36-Item Short Form Survey.
Month 6
Quality of life
Ramy czasowe: Year 1

Quality of life will be evaluated with the 36-Item Short Form Survey.
Year 1
Quality of life
Ramy czasowe: Year 2

Quality of life will be evaluated with the 36-Item Short Form Survey.
Year 2
Quality of life
Ramy czasowe: Year 5

Quality of life will be evaluated with the 36-Item Short Form Survey.
Year 5
: Balance confidence in performing various activities
Ramy czasowe: Day 0

Self-report balance confidence will be evaluated with the Activities-specific Balance Confidence (ABC) Scale.vey.
Day 0
: Balance confidence in performing various activities
Ramy czasowe: Month 6

Self-report balance confidence will be evaluated with the Activities-specific Balance Confidence (ABC) Scale.vey.
Month 6
: Balance confidence in performing various activities
Ramy czasowe: Year 1

Self-report balance confidence will be evaluated with the Activities-specific Balance Confidence (ABC) Scale.vey.
Year 1
: Balance confidence in performing various activities
Ramy czasowe: Year 2

Self-report balance confidence will be evaluated with the Activities-specific Balance Confidence (ABC) Scale.vey.
Year 2
: Balance confidence in performing various activities
Ramy czasowe: Year 5

Self-report balance confidence will be evaluated with the Activities-specific Balance Confidence (ABC) Scale.vey.
Year 5
Functioning in regards to activities of daily living.
Ramy czasowe: Day 0

Functioning will be evaluated with the Lawton Instrumental Activities of Daily Living (IADL) Scale.
Day 0
Functioning in regards to activities of daily living.
Ramy czasowe: Month 6

Functioning will be evaluated with the Lawton Instrumental Activities of Daily Living (IADL) Scale.
Month 6
Functioning in regards to activities of daily living.
Ramy czasowe: Year 1

Functioning will be evaluated with the Lawton Instrumental Activities of Daily Living (IADL) Scale.
Year 1
Functioning in regards to activities of daily living.
Ramy czasowe: Year 2

Functioning will be evaluated with the Lawton Instrumental Activities of Daily Living (IADL) Scale.
Year 2
Functioning in regards to activities of daily living.
Ramy czasowe: Year 5

Functioning will be evaluated with the Lawton Instrumental Activities of Daily Living (IADL) Scale.
Year 5
Exhaustion
Ramy czasowe: Day 0

Exhaustion will be evaluated with the FACIT-F Questionnaire.
Day 0
Exhaustion
Ramy czasowe: Month 6

Exhaustion will be evaluated with the FACIT-F Questionnaire.
Month 6
Exhaustion
Ramy czasowe: Year 1

Exhaustion will be evaluated with the FACIT-F Questionnaire.
Year 1
Exhaustion
Ramy czasowe: Year 2

Exhaustion will be evaluated with the FACIT-F Questionnaire.
Year 2
Exhaustion
Ramy czasowe: Year 5

Exhaustion will be evaluated with the FACIT-F Questionnaire.
Year 5
Patient's opinion about their knee and associated problems
Ramy czasowe: Day 0

: Outcomes will be evaluated with the Knee Injury and Osteoarthritis Outcome Score (KOOS).
Day 0
Patient's opinion about their knee and associated problems
Ramy czasowe: Month 6

: Outcomes will be evaluated with the Knee Injury and Osteoarthritis Outcome Score (KOOS).
Month 6
Patient's opinion about their knee and associated problems
Ramy czasowe: Year 1

: Outcomes will be evaluated with the Knee Injury and Osteoarthritis Outcome Score (KOOS).
Year 1
Patient's opinion about their knee and associated problems
Ramy czasowe: Year 2

: Outcomes will be evaluated with the Knee Injury and Osteoarthritis Outcome Score (KOOS).
Year 2
Patient's opinion about their knee and associated problems
Ramy czasowe: Year 5

: Outcomes will be evaluated with the Knee Injury and Osteoarthritis Outcome Score (KOOS).
Year 5
Patient's opinion about their hip and associated problems
Ramy czasowe: Day 0

Outcomes will be evaluated with the Hip Injury and Osteoarthritis Outcome Score (HOOS).
Day 0
Patient's opinion about their hip and associated problems
Ramy czasowe: Month 6

Outcomes will be evaluated with the Hip Injury and Osteoarthritis Outcome Score (HOOS).
Month 6
Patient's opinion about their hip and associated problems
Ramy czasowe: Year 1

Outcomes will be evaluated with the Hip Injury and Osteoarthritis Outcome Score (HOOS).
Year 1
Patient's opinion about their hip and associated problems
Ramy czasowe: Year 2

Outcomes will be evaluated with the Hip Injury and Osteoarthritis Outcome Score (HOOS).
Year 2
Patient's opinion about their hip and associated problems
Ramy czasowe: Year 5

Outcomes will be evaluated with the Hip Injury and Osteoarthritis Outcome Score (HOOS).
Year 5
Predicting discharge destination after total joint arthroplasty.
Ramy czasowe: Day 0

: Discharge destination will be evaluated with the Risk Assessment and Prediction Tool (RAPT);
Day 0
Predicting discharge destination after total joint arthroplasty.
Ramy czasowe: Month 6

: Discharge destination will be evaluated with the Risk Assessment and Prediction Tool (RAPT);
Month 6
Physical function in myositis patients
Ramy czasowe: Day 0

Physical function will be evaluated with the Stanford Health Assessment Questionnaire.
Day 0
Physical function in myositis patients
Ramy czasowe: Month 6

Physical function will be evaluated with the Stanford Health Assessment Questionnaire.
Month 6
Physical function in myositis patients
Ramy czasowe: Year 1

Physical function will be evaluated with the Stanford Health Assessment Questionnaire.
Year 1
Physical function in myositis patients
Ramy czasowe: Year 2

Physical function will be evaluated with the Stanford Health Assessment Questionnaire.
Year 2
Physical function in myositis patients
Ramy czasowe: Year 5

Physical function will be evaluated with the Stanford Health Assessment Questionnaire.
Year 5
Quality of life in Parkinson's Disease
Ramy czasowe: Day 0

Quality of life will be measured with the Parkinson's Disease Questionnaire-39 (PDQ-39).
Day 0
Quality of life in Parkinson's Disease
Ramy czasowe: Month 6

Quality of life will be measured with the Parkinson's Disease Questionnaire-39 (PDQ-39).
Month 6
Quality of life in Parkinson's Disease
Ramy czasowe: Year 1

Quality of life will be measured with the Parkinson's Disease Questionnaire-39 (PDQ-39).
Year 1
Quality of life in Parkinson's Disease
Ramy czasowe: Year 2

Quality of life will be measured with the Parkinson's Disease Questionnaire-39 (PDQ-39).
Year 2
Quality of life in Parkinson's Disease
Ramy czasowe: Year 5

Quality of life will be measured with the Parkinson's Disease Questionnaire-39 (PDQ-39).
Year 5
Actimetry.
Ramy czasowe: during 5 consecutive days after day 0

Actimetry data (energy expenditure, number of steps, sedentary time, total physical activity, etc.) will be obtained with the WGT3X-BT Actigraph inertial sensor unit.
during 5 consecutive days after day 0
Title: Muscle Cross-Sectional Area (CSA) of the quadriceps muscles (cm^2)
Ramy czasowe: Day 0

Cross-sectional area of the quadriceps muscles will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Day 0
Title: Muscle Cross-Sectional Area (CSA) of the quadriceps muscles (cm^2)
Ramy czasowe: Month 6

Cross-sectional area of the quadriceps muscles will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Month 6
Title: Muscle Cross-Sectional Area (CSA) of the quadriceps muscles (cm^2)
Ramy czasowe: Year 1

Cross-sectional area of the quadriceps muscles will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 1
Title: Muscle Cross-Sectional Area (CSA) of the quadriceps muscles (cm^2)
Ramy czasowe: Year 2

Cross-sectional area of the quadriceps muscles will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 2
Title: Muscle Cross-Sectional Area (CSA) of the quadriceps muscles (cm^2)
Ramy czasowe: Year 5

Cross-sectional area of the quadriceps muscles will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 5
Subcutaneous Adipose Tissue Thickness Over the Quadriceps (mm)
Ramy czasowe: Day 0

Thickness of the subcutaneous adipose tissue overlying the quadriceps muscles will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Day 0
Subcutaneous Adipose Tissue Thickness Over the Quadriceps (mm)
Ramy czasowe: Month 6

Thickness of the subcutaneous adipose tissue overlying the quadriceps muscles will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Month 6
Subcutaneous Adipose Tissue Thickness Over the Quadriceps (mm)
Ramy czasowe: Year 1

Thickness of the subcutaneous adipose tissue overlying the quadriceps muscles will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 1
Subcutaneous Adipose Tissue Thickness Over the Quadriceps (mm)
Ramy czasowe: Year 2

Thickness of the subcutaneous adipose tissue overlying the quadriceps muscles will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 2
Subcutaneous Adipose Tissue Thickness Over the Quadriceps (mm)
Ramy czasowe: Year 5

Thickness of the subcutaneous adipose tissue overlying the quadriceps muscles will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 5
Muscle Cross-Sectional Area (CSA) of the Medial Gastrocnemius (cm^2)
Ramy czasowe: Day 0

Cross-sectional area of the medial gastrocnemius muscle will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Day 0
Muscle Cross-Sectional Area (CSA) of the Medial Gastrocnemius (cm^2)
Ramy czasowe: Month 6

Cross-sectional area of the medial gastrocnemius muscle will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Month 6
Muscle Cross-Sectional Area (CSA) of the Medial Gastrocnemius (cm^2)
Ramy czasowe: Year 1

Cross-sectional area of the medial gastrocnemius muscle will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 1
Muscle Cross-Sectional Area (CSA) of the Medial Gastrocnemius (cm^2)
Ramy czasowe: Year 2

Cross-sectional area of the medial gastrocnemius muscle will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 2
Muscle Cross-Sectional Area (CSA) of the Medial Gastrocnemius (cm^2)
Ramy czasowe: Year 5

Cross-sectional area of the medial gastrocnemius muscle will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 5
Muscle Cross-Sectional Area (CSA) of the Lateral Gastrocnemius (cm^2)
Ramy czasowe: Day 0

Cross-sectional area of the lateral gastrocnemius muscle will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Day 0
Muscle Cross-Sectional Area (CSA) of the Lateral Gastrocnemius (cm^2)
Ramy czasowe: Month 6

Cross-sectional area of the lateral gastrocnemius muscle will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Month 6
Muscle Cross-Sectional Area (CSA) of the Lateral Gastrocnemius (cm^2)
Ramy czasowe: Year 1

Cross-sectional area of the lateral gastrocnemius muscle will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 1
Muscle Cross-Sectional Area (CSA) of the Lateral Gastrocnemius (cm^2)
Ramy czasowe: Year 2

Cross-sectional area of the lateral gastrocnemius muscle will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 2
Muscle Cross-Sectional Area (CSA) of the Lateral Gastrocnemius (cm^2)
Ramy czasowe: Year 5

Cross-sectional area of the lateral gastrocnemius muscle will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 5
Quadriceps muscles Quality Assessed by Shear Wave Elastography (kPa or m/s)
Ramy czasowe: Day 0

Muscle stiffness, reflecting muscle quality, will be assessed by Shear Wave Elastography (SWE) using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Day 0
Quadriceps muscles Quality Assessed by Shear Wave Elastography (kPa or m/s)
Ramy czasowe: Month 6

Muscle stiffness, reflecting muscle quality, will be assessed by Shear Wave Elastography (SWE) using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Month 6
Quadriceps muscles Quality Assessed by Shear Wave Elastography (kPa or m/s)
Ramy czasowe: Year 1

Muscle stiffness, reflecting muscle quality, will be assessed by Shear Wave Elastography (SWE) using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 1
Quadriceps muscles Quality Assessed by Shear Wave Elastography (kPa or m/s)
Ramy czasowe: Year 2

Muscle stiffness, reflecting muscle quality, will be assessed by Shear Wave Elastography (SWE) using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 2
Quadriceps muscles Quality Assessed by Shear Wave Elastography (kPa or m/s)
Ramy czasowe: Year 5

Muscle stiffness, reflecting muscle quality, will be assessed by Shear Wave Elastography (SWE) using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 5
Medial Gastrocnemius Quality Assessed by Shear Wave Elastography (kPa or m/s)
Ramy czasowe: Day 0

Muscle stiffness, reflecting muscle quality, will be assessed by Shear Wave Elastography (SWE) using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Day 0
Medial Gastrocnemius Quality Assessed by Shear Wave Elastography (kPa or m/s)
Ramy czasowe: Month 6

Muscle stiffness, reflecting muscle quality, will be assessed by Shear Wave Elastography (SWE) using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Month 6
Medial Gastrocnemius Quality Assessed by Shear Wave Elastography (kPa or m/s)
Ramy czasowe: Year 1

Muscle stiffness, reflecting muscle quality, will be assessed by Shear Wave Elastography (SWE) using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 1
Medial Gastrocnemius Quality Assessed by Shear Wave Elastography (kPa or m/s)
Ramy czasowe: Year 2

Muscle stiffness, reflecting muscle quality, will be assessed by Shear Wave Elastography (SWE) using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 2
Medial Gastrocnemius Quality Assessed by Shear Wave Elastography (kPa or m/s)
Ramy czasowe: Year 5

Muscle stiffness, reflecting muscle quality, will be assessed by Shear Wave Elastography (SWE) using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 5
Lateral Gastrocnemius Quality Assessed by Shear Wave Elastography (kPa or m/s)
Ramy czasowe: Day 0

Muscle stiffness, reflecting muscle quality, will be assessed by Shear Wave Elastography (SWE) using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Day 0
Lateral Gastrocnemius Quality Assessed by Shear Wave Elastography (kPa or m/s)
Ramy czasowe: Month 6

Muscle stiffness, reflecting muscle quality, will be assessed by Shear Wave Elastography (SWE) using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Month 6
Lateral Gastrocnemius Quality Assessed by Shear Wave Elastography (kPa or m/s)
Ramy czasowe: Year 1

Muscle stiffness, reflecting muscle quality, will be assessed by Shear Wave Elastography (SWE) using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 1
Lateral Gastrocnemius Quality Assessed by Shear Wave Elastography (kPa or m/s)
Ramy czasowe: Year 2

Muscle stiffness, reflecting muscle quality, will be assessed by Shear Wave Elastography (SWE) using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 2
Lateral Gastrocnemius Quality Assessed by Shear Wave Elastography (kPa or m/s)
Ramy czasowe: Year 5

Muscle stiffness, reflecting muscle quality, will be assessed by Shear Wave Elastography (SWE) using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 5
Quadriceps muscles Microvascularization Assessed by Superb Microvascular Imaging (SMI) (%)
Ramy czasowe: Day 0

Muscle microvascularization will be assessed using Superb Microvascular Imaging (SMI), a Doppler-based technique that detects very low-velocity blood flow without contrast agent injection, using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Day 0
Quadriceps muscles Microvascularization Assessed by Superb Microvascular Imaging (SMI) (%)
Ramy czasowe: Month 6

Muscle microvascularization will be assessed using Superb Microvascular Imaging (SMI), a Doppler-based technique that detects very low-velocity blood flow without contrast agent injection, using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Month 6
Quadriceps muscles Microvascularization Assessed by Superb Microvascular Imaging (SMI) (%)
Ramy czasowe: Year 1

Muscle microvascularization will be assessed using Superb Microvascular Imaging (SMI), a Doppler-based technique that detects very low-velocity blood flow without contrast agent injection, using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 1
Quadriceps muscles Microvascularization Assessed by Superb Microvascular Imaging (SMI) (%)
Ramy czasowe: Year 2

Muscle microvascularization will be assessed using Superb Microvascular Imaging (SMI), a Doppler-based technique that detects very low-velocity blood flow without contrast agent injection, using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 2
Quadriceps muscles Microvascularization Assessed by Superb Microvascular Imaging (SMI) (%)
Ramy czasowe: Year 5

Muscle microvascularization will be assessed using Superb Microvascular Imaging (SMI), a Doppler-based technique that detects very low-velocity blood flow without contrast agent injection, using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 5
Medial Gastrocnemius Microvascularization Assessed by Superb Microvascular Imaging (SMI) (%)
Ramy czasowe: Day 0

Muscle microvascularization will be assessed using Superb Microvascular Imaging (SMI), a Doppler-based technique that detects very low-velocity blood flow without contrast agent injection, using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Day 0
Medial Gastrocnemius Microvascularization Assessed by Superb Microvascular Imaging (SMI) (%)
Ramy czasowe: Month 6

Muscle microvascularization will be assessed using Superb Microvascular Imaging (SMI), a Doppler-based technique that detects very low-velocity blood flow without contrast agent injection, using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Month 6
Medial Gastrocnemius Microvascularization Assessed by Superb Microvascular Imaging (SMI) (%)
Ramy czasowe: Year 1

Muscle microvascularization will be assessed using Superb Microvascular Imaging (SMI), a Doppler-based technique that detects very low-velocity blood flow without contrast agent injection, using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 1
Medial Gastrocnemius Microvascularization Assessed by Superb Microvascular Imaging (SMI) (%)
Ramy czasowe: Year 2

Muscle microvascularization will be assessed using Superb Microvascular Imaging (SMI), a Doppler-based technique that detects very low-velocity blood flow without contrast agent injection, using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 2
Medial Gastrocnemius Microvascularization Assessed by Superb Microvascular Imaging (SMI) (%)
Ramy czasowe: Year 5

Muscle microvascularization will be assessed using Superb Microvascular Imaging (SMI), a Doppler-based technique that detects very low-velocity blood flow without contrast agent injection, using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 5
Lateral Gastrocnemius Microvascularization Assessed by Superb Microvascular Imaging (SMI) (%)
Ramy czasowe: Day 0

Muscle microvascularization will be assessed using Superb Microvascular Imaging (SMI), a Doppler-based technique that detects very low-velocity blood flow without contrast agent injection, using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Day 0
Lateral Gastrocnemius Microvascularization Assessed by Superb Microvascular Imaging (SMI) (%)
Ramy czasowe: Month 6

Muscle microvascularization will be assessed using Superb Microvascular Imaging (SMI), a Doppler-based technique that detects very low-velocity blood flow without contrast agent injection, using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Month 6
Lateral Gastrocnemius Microvascularization Assessed by Superb Microvascular Imaging (SMI) (%)
Ramy czasowe: Year 1

Muscle microvascularization will be assessed using Superb Microvascular Imaging (SMI), a Doppler-based technique that detects very low-velocity blood flow without contrast agent injection, using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 1
Lateral Gastrocnemius Microvascularization Assessed by Superb Microvascular Imaging (SMI) (%)
Ramy czasowe: Year 2

Muscle microvascularization will be assessed using Superb Microvascular Imaging (SMI), a Doppler-based technique that detects very low-velocity blood flow without contrast agent injection, using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 2
Lateral Gastrocnemius Microvascularization Assessed by Superb Microvascular Imaging (SMI) (%)
Ramy czasowe: Year 5

Muscle microvascularization will be assessed using Superb Microvascular Imaging (SMI), a Doppler-based technique that detects very low-velocity blood flow without contrast agent injection, using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 5
Quadriceps muscles Blood Flow Velocity Measured by Doppler Ultrasound (cm/s)
Ramy czasowe: Day 0

Muscle blood flow velocity will be measured using Doppler ultrasound with the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Day 0
Quadriceps muscles Blood Flow Velocity Measured by Doppler Ultrasound (cm/s)
Ramy czasowe: Month 6

Muscle blood flow velocity will be measured using Doppler ultrasound with the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Month 6
Quadriceps muscles Blood Flow Velocity Measured by Doppler Ultrasound (cm/s)
Ramy czasowe: Year 1

Muscle blood flow velocity will be measured using Doppler ultrasound with the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 1
Quadriceps muscles Blood Flow Velocity Measured by Doppler Ultrasound (cm/s)
Ramy czasowe: Year 2

Muscle blood flow velocity will be measured using Doppler ultrasound with the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 2
Quadriceps muscles Blood Flow Velocity Measured by Doppler Ultrasound (cm/s)
Ramy czasowe: Year 5

Muscle blood flow velocity will be measured using Doppler ultrasound with the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 5
Medial Gastrocnemius Blood Flow Velocity Measured by Doppler Ultrasound (cm/s)
Ramy czasowe: Day 0

Muscle blood flow velocity will be measured using Doppler ultrasound with the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Day 0
Medial Gastrocnemius Blood Flow Velocity Measured by Doppler Ultrasound (cm/s)
Ramy czasowe: Month 6

Muscle blood flow velocity will be measured using Doppler ultrasound with the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Month 6
Medial Gastrocnemius Blood Flow Velocity Measured by Doppler Ultrasound (cm/s)
Ramy czasowe: Year 1

Muscle blood flow velocity will be measured using Doppler ultrasound with the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 1
Medial Gastrocnemius Blood Flow Velocity Measured by Doppler Ultrasound (cm/s)
Ramy czasowe: Year 2

Muscle blood flow velocity will be measured using Doppler ultrasound with the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 2
Medial Gastrocnemius Blood Flow Velocity Measured by Doppler Ultrasound (cm/s)
Ramy czasowe: Year 5

Muscle blood flow velocity will be measured using Doppler ultrasound with the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 5
Lateral Gastrocnemius Blood Flow Velocity Measured by Doppler Ultrasound (cm/s)
Ramy czasowe: Day 0

Muscle blood flow velocity will be measured using Doppler ultrasound with the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Day 0
Lateral Gastrocnemius Blood Flow Velocity Measured by Doppler Ultrasound (cm/s)
Ramy czasowe: Month 6

Muscle blood flow velocity will be measured using Doppler ultrasound with the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Month 6
Lateral Gastrocnemius Blood Flow Velocity Measured by Doppler Ultrasound (cm/s)
Ramy czasowe: Year 1

Muscle blood flow velocity will be measured using Doppler ultrasound with the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 1
Lateral Gastrocnemius Blood Flow Velocity Measured by Doppler Ultrasound (cm/s)
Ramy czasowe: Year 2

Muscle blood flow velocity will be measured using Doppler ultrasound with the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 2
Lateral Gastrocnemius Blood Flow Velocity Measured by Doppler Ultrasound (cm/s)
Ramy czasowe: Year 5

Muscle blood flow velocity will be measured using Doppler ultrasound with the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 5

Współpracownicy i badacze

Tutaj znajdziesz osoby i organizacje zaangażowane w to badanie.

Sponsor

Sponsor

Organizacja lub osoba, która inicjuje badanie i która ma władzę i kontrolę nad badaniem.
University Hospital, Clermont-Ferrand

Współpracownicy

Współpracownicy

Organizacja inna niż sponsor, która zapewnia wsparcie dla badania klinicznego. Wsparcie to może obejmować działania związane z finansowaniem, projektowaniem, wdrażaniem, analizą danych lub raportowaniem.
I-SITE Cap 20-25 project

Śledczy

Śledczy

Badacz biorący udział w badaniu klinicznym. Terminy pokrewne obejmują głównego badacza ośrodka, badacza pomocniczego ośrodka, kierownika badania i głównego badacza badania.
  • Główny śledczy: Frédéric Costes, University Hospital, Clermont-Ferrand

Daty zapisu na studia

Daty te śledzą postęp w przesyłaniu rekordów badań i podsumowań wyników do ClinicalTrials.gov. Zapisy badań i zgłoszone wyniki są przeglądane przez National Library of Medicine (NLM), aby upewnić się, że spełniają określone standardy kontroli jakości, zanim zostaną opublikowane na publicznej stronie internetowej.

Główne daty studiów

Rozpoczęcie studiów (Rzeczywisty)

Rozpoczęcie studiów

Rzeczywista data włączenia pierwszego uczestnika do badania klinicznego. „Przewidywana” data rozpoczęcia badania to data, którą naukowcy uważają za datę rozpoczęcia badania.
27 sierpnia 2020

Zakończenie podstawowe (Szacowany)

Zakończenie podstawowe

Data, w której ostatni uczestnik badania klinicznego został przebadany lub otrzymał interwencję w celu zebrania ostatecznych danych dla głównego pomiaru wyniku. To, czy badanie kliniczne zakończyło się zgodnie z protokołem, czy też zostało zakończone, nie ma wpływu na tę datę. W przypadku badań klinicznych z więcej niż jedną miarą wyniku pierwotnego i różnymi datami zakończenia termin ten odnosi się do daty zakończenia gromadzenia danych dla wszystkich miar wyniku pierwotnego. „Przewidywana” data ukończenia podstawowego badania to data, którą naukowcy uważają za pierwotną datę zakończenia badania.
26 sierpnia 2035

Ukończenie studiów (Szacowany)

Ukończenie studiów

Data, w której ostatni uczestnik badania klinicznego został przebadany lub otrzymał interwencję/leczenie w celu zebrania ostatecznych danych dotyczących głównych miar wyników, drugorzędowych miar wyników i zdarzeń niepożądanych (tj. ostatnia wizyta ostatniego uczestnika). „Przewidywana” data zakończenia badania to data, którą naukowcy uważają za datę zakończenia badania.
26 sierpnia 2035

Daty rejestracji na studia

Pierwszy przesłany

Pierwszy przesłany

Data, w której sponsor badania lub badacz po raz pierwszy przesłał dokumentację badania do ClinicalTrials.gov. Zwykle występuje kilkudniowe opóźnienie między pierwszą przesłaną datą a udostępnieniem rekordu na ClinicalTrials.gov (pierwsza data opublikowania).
27 kwietnia 2020

Pierwszy przesłany, który spełnia kryteria kontroli jakości

Pierwszy przesłany, który spełnia kryteria kontroli jakości

Data, w której sponsor badania lub badacz po raz pierwszy przesłał zapis badania zgodny z kryteriami przeglądu kontroli jakości (QC) National Library of Medicine (NLM). Sponsor lub badacz może być zmuszony do zmiany i przedłożenia dokumentacji badania raz lub kilka razy, zanim zostaną spełnione kryteria przeglądu kontroli jakości NLM. Obowiązkiem sponsora lub badacza jest upewnienie się, że zapis badania jest zgodny z kryteriami przeglądu NLM QC.
4 maja 2020

Pierwszy wysłany (Rzeczywisty)

Pierwszy wysłany

Data pierwszego udostępnienia zapisu badania na stronie ClinicalTrials.gov po zakończeniu przeglądu kontroli jakości (QC) National Library of Medicine (NLM). Zwykle występuje kilkudniowe opóźnienie między datą przesłania dokumentacji badania przez sponsora badania lub badacza a datą pierwszego zaksięgowania.
5 maja 2020

Aktualizacje rekordów badań

Ostatnia wysłana aktualizacja (Rzeczywisty)

Ostatnia wysłana aktualizacja

Najnowsza data udostępnienia zmian w rekordzie badania na stronie ClinicalTrials.gov. Może wystąpić opóźnienie między momentem przesłania zmian do ClinicalTrials.gov przez sponsora badania lub badacza (data ostatniego przesłania aktualizacji) a datą ostatniego opublikowania aktualizacji.
4 listopada 2026

Ostatnia przesłana aktualizacja, która spełniała kryteria kontroli jakości

Ostatnia przesłana aktualizacja, która spełniała kryteria kontroli jakości

Najnowsza data, w której sponsor badania lub badacz przesłał zmiany w rekordzie badania, które są zgodne z kryteriami przeglądu kontroli jakości (QC) National Library of Medicine (NLM). Obowiązkiem sponsora lub badacza jest upewnienie się, że zapis badania jest zgodny z kryteriami przeglądu NLM QC.
2 listopada 2026

Ostatnia weryfikacja

Ostatnia weryfikacja

Najnowsza data, w której sponsor badania lub badacz potwierdził, że informacje o badaniu klinicznym na stronie ClinicalTrials.gov są dokładne i aktualne. Jeśli badanie ze statusem rekrutacji to rekrutacja; jeszcze nie rekrutacja; lub aktywny, brak rekrutacji nie został potwierdzony w ciągu ostatnich 2 lat, status rekrutacji do badania jest pokazany jako nieznany.
1 października 2026

Więcej informacji

Terminy związane z tym badaniem

Słowa kluczowe

Dodatkowe istotne warunki MeSH

Inne numery identyfikacyjne badania

Inne numery identyfikacyjne badania

Identyfikatory lub numery identyfikacyjne inne niż numer NCT, które są przypisane do badania klinicznego przez sponsora badania, podmioty finansujące lub inne osoby. Numery te mogą zawierać unikalne identyfikatory z innych rejestrów badań i numery grantów National Institutes of Health.
  • RBHP 2019 COSTES
  • 2019-A01017-50 (Inny identyfikator: 2019-A01017-50)

Informacje o lekach i urządzeniach, dokumenty badawcze

Bada produkt leczniczy regulowany przez amerykańską FDA

Nie

Bada produkt urządzenia regulowany przez amerykańską FDA

Nie

Te informacje zostały pobrane bezpośrednio ze strony internetowej clinicaltrials.gov bez żadnych zmian. Jeśli chcesz zmienić, usunąć lub zaktualizować dane swojego badania, skontaktuj się z register@clinicaltrials.gov. Gdy tylko zmiana zostanie wprowadzona na stronie clinicaltrials.gov, zostanie ona automatycznie zaktualizowana również na naszej stronie internetowej .

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