Improving Symptoms of Schizophrenia and Schizoaffective Disorder by Supplementing Medications With Pravastatin

Inclusion Criteria:

• Diagnosis of schizophrenia or schizoaffective disorder
• Male and female subjects; age 18-65 years inclusive
• Ability to provide informed consent
• No psychiatric hospitalization in the last 30 days prior to randomization
• PANSS score at study entry between 80 and 120 inclusive, OR those who continue to experience some residual positive and/or negative symptoms and are not at their baseline level of functioning.
• Current psychiatric medications stable for at least 30 days
• Currently receiving only one antipsychotic medication
• Female subjects of child-bearing age must use an acceptable method of birth control

Exclusion Criteria:

• Active, uncontrolled, or chronic liver disease
• Heart failure
• Current alcohol abuse or dependence
• Female subjects who are pregnant, lactating or plan to become pregnant during the study period
• History of allergic reaction with any statin in the past
• Kidney disorder or other evidence of renal dysfunction
• Uncontrolled diabetes
• Untreated hyperlipidemia
• Concurrently receiving treatment with cyclosporine, gemfibrozil, clofibrate, fenofibrate, niacin, macrolide antibiotics, erythromycin, HIV protease inhibitors, nefazodone, or verapamil