The Influence of Estradiol Supplementation During the Luteal in Patients Undergoing IVF Treatment
Blinded Randomised Trial About the Influence of Estradiol Supplementation During the Luteal in Patients Undergoing in Vitro Fertilization (IVF) Treatment
To evaluate whether treatment with Estradiol supplementation during the luteal phase improves IVF outcomes
Patients undergoing IVF treatment with controlled ovarian hyperstimulation using a GnRH analog will receive 4 mg estradiol valerate in the luteal phase.Patient's followup will include E2 progesterone and BHCG 14 days after embryo transfer and vaginal ultrasound on day 21 and 28 after embryo transfer
研究概览
详细说明
The study will include Patients undergoing IVF treatment with controlled ovarian hyperstimulation using a daily GnRH analog in a long protocol,older then 18, .The women will be randomised to two groups.Both groups will be given vaginal tabs of natural micronized progesterone(Uterogestan)
The study group will be given oral estradiol Valerate 4 mg.Prior to treatment, each patient will be signed on informed concent.
Patients will be excluded if they are older than 40, have any systemic illnesses or a personal or family history of a thromboembolic event.
Follow up:
Verification of pregnancy status and hormonal profile will be carried out on day fourteen after embryo transfer by means of serum hCG,P and E2. clinical pregnancy will be defined as the presence of a gestational sac on ultrasonography on day 21 after embryo transfer and fetal heart will be evaluated on day 28
研究类型
注册 (预期的)
阶段
- 阶段1
联系人和位置
学习地点
-
-
-
Zerifin、以色列
- Infertilty unit, Assaf-Harofeh Medical Center
-
-
参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
描述
Inclusion Criteria:
- Women treated for infertility with controlled ovarian hyperstimulation using daily GnRH agonist
Exclusion Criteria:
- Women younger then 18 or older then 40
- Women with systemic disease
- Women with a family or personal history of thromboembolic event
学习计划
研究是如何设计的？
设计细节
- 主要用途：治疗
- 分配：随机化
- 介入模型：交叉作业
- 屏蔽：无（打开标签）
研究衡量的是什么？
次要结果测量
结果测量 |
|---|
|
E2 and progesterone levels
|
合作者和调查者
调查人员
- 首席研究员：Rephael Ron-el, profesor、Assaf-Harofeh Medical Center
研究记录日期
研究主要日期
学习开始
研究完成 (预期的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.