Tobacco Smoke and Lead Exposure During Pregnancy
Tobacco Smoke and Lead Exposure During Pregnancy: Intervention to Reduce Effects on Birth-Weight and Gestational Age
This study will test whether a short interview session about lead and secondhand tobacco smoke can help pregnant women reduce their exposure to lead and secondhand smoke. Both lead and secondhand tobacco smoke can cause problems with a pregnancy. The best way to prevent exposure to lead and secondhand tobacco smoke is to recognize the sources and avoid them.
Non-smoking African-American and Hispanic pregnant women between 18 and 49 years of age who live in Washington, D.C. may be eligible for this study.
Participants are randomly assigned to one of two study groups. Both groups have a 30-minute one-on-one session with a member of the study staff. The content of the session differs between groups. In addition, all women undergo the following tests and procedures:
- Answer questions about themselves, their pregnancies, diet, home and smokers in the home.
- Requested to provide permission to obtain medical records of children older than 12 months of age who have ever been seen at Children's National Medical Center.
- Blood draws at least four times during the study: at the time of enrollment, during the second trimester of the pregnancy, during the third trimester, and at the time of delivery. Up to three optional blood samples may also be requested, one during each trimester of the pregnancy. Blood samples are used to measure lead, cotinine (a chemical the body makes out of nicotine) and hematocrit (a test for anemia).
- Collection of umbilical cord blood at the time of delivery.
- Answer questions after the delivery about the patient's health, the delivery and the baby.
研究概览
详细说明
研究类型
注册 (预期的)
联系人和位置
学习地点
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Maryland
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Bethesda、Maryland、美国、20892
- National Institute of Child Health and Human Development (NICHD), 9000 Rockville
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
描述
- INCLUSION CRITERIA:
Female
Pregnant
Age 18-49
Self-identified as African-American or Hispanic/Latino
Patient at participating clinic
DC resident at the time of enrollment
No tobacco use of any kind after week 13 of the current pregnancy
Able to read, write and understand English
Able to give informed consent
Able to cooperate with testing procedures
学习计划
研究是如何设计的?
设计细节
合作者和调查者
出版物和有用的链接
一般刊物
- Haddow JE, Knight GJ, Palomaki GE, McCarthy JE. Second-trimester serum cotinine levels in nonsmokers in relation to birth weight. Am J Obstet Gynecol. 1988 Aug;159(2):481-4. doi: 10.1016/s0002-9378(88)80114-5.
- Gonzalez-Cossio T, Peterson KE, Sanin LH, Fishbein E, Palazuelos E, Aro A, Hernandez-Avila M, Hu H. Decrease in birth weight in relation to maternal bone-lead burden. Pediatrics. 1997 Nov;100(5):856-62. doi: 10.1542/peds.100.5.856.
- Mannino DM, Homa DM, Matte T, Hernandez-Avila M. Active and passive smoking and blood lead levels in U.S. adults: data from the Third National Health and Nutrition Examination Survey. Nicotine Tob Res. 2005 Aug;7(4):557-64. doi: 10.1080/14622200500185264.
研究记录日期
研究主要日期
学习开始
研究完成
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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